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11. 发明申请

US20090306055A1 PHENYLAZOLE COMPOUNDS, PRODUCTION PROCESS AND ANTIOXIDANTS 审中-公开
标题翻译：苯并噻唑化合物，生产工艺和抗氧化剂
公开(公告)号：US20090306055A1
公开(公告)日：2009-12-10
申请号：US12466919
申请日：2009-05-15
申请人： Nobuhiro Umeda , Nobuo Mochizuki , Seiichi Uchida , Mitsumasa Takada , Seiichi Ikeyama , Shiro Tsubokura , Yasuyuki Shiinoki , Fumie Shirato , Hiroko Moroe
发明人： Nobuhiro Umeda , Nobuo Mochizuki , Seiichi Uchida , Mitsumasa Takada , Seiichi Ikeyama , Shiro Tsubokura , Yasuyuki Shiinoki , Fumie Shirato , Hiroko Moroe
IPC分类号： A61K31/496 , C07D405/10 , C07D471/04 , A61K31/453 , A61K31/4525 , A61K31/551 , A61K31/4433 , A61K31/443 , A61K31/4178 , A61K31/4155 , A61K31/437
CPC分类号： C07D471/04 , C07D405/12 , C07D405/14
摘要： The present invention is directed to compounds represented by the formula (1):B-D-Z (1), wherein B represent the following formula (B-1), A represents an optionally substituted imidazole or pyrazole group; E represents the following formula (1a): X represents an oxygen atom, the formula: SOu, or the formula: N—R9; Y represents a carbon atom or a nitrogen atom; D represents an oxygen atom, a sulfur atom or the formula (1a); Z represents (a chroman-2-yl group, a chroman-4-yl group, a 2,3-dihydrobenzofuran-2-yl group, a 2,3-dihydrobenzofuran-3-yl group, etc.) which is substituted with NHR10 or OR11)] or pharmaceutically acceptable salts thereof, and to antioxidants, therapeutic agents for kidney diseases or cerebrovascular disorder, and retinal oxidative damage inhibitors, which include the compounds as the active ingredient.
摘要翻译：本发明涉及由式（1）表示的化合物：B-D-Z（1），其中B表示下式（B-1），A表示任选取代的咪唑或吡唑基; E表示下式（1a）：X表示氧原子，式：SOu或式：N-R 9; Y表示碳原子或氮原子; D表示氧原子，硫原子或式（1a）; Z表示（苯并二氢吡喃-2-基，苯并二氢吡喃-4-基，2,3-二氢苯并呋喃-2-基，2,3-二氢苯并呋喃-3-基等），其被 NHR10或OR11）]或其药学上可接受的盐，以及抗氧化剂，肾脏疾病或脑血管障碍的治疗剂和视网膜氧化损伤抑制剂，其包括作为活性成分的化合物。

12. 发明授权

US06462195B1 Methods for highly selectively o-alkylating amide compounds with the use of copper salts 有权
标题翻译：使用铜盐高度选择性O-烷基化酰胺化合物的方法
公开(公告)号：US06462195B1
公开(公告)日：2002-10-08
申请号：US09622906
申请日：2000-09-05
申请人： Mitsuru Takase , Yasuyuki Miyazawa , Shiro Tsubokura
发明人： Mitsuru Takase , Yasuyuki Miyazawa , Shiro Tsubokura
IPC分类号： C07D23952
CPC分类号： C07D239/52
摘要： Compounds having one or more structures represented by general formula (I) as partial structure thereof, which are typified by pyrimidone and pyridone compounds, have two or more reaction sites in alkylation reactions. Accordingly, there is no process for producing O-alkylated products of these compounds at a high selectivity or such processes, if any, are applicable exclusively to those having limited structures. A process for selectivity O-alkylating such a compound as described above by converting it into the copper salt by using a monovalent copper compound such as copper suboxide and then reacting it with an alkylating agent having a leaving group in the presence of a phosphorus compound such as a phosphite. Pyrimidyloxy derivatives or pyridyloxy derivatives obtained by this reaction is useful as intermediates of pesticides or drugs.
摘要翻译：具有一种或多种由通式（I）表示的结构的化合物作为其部分结构，以嘧啶酮和吡啶酮化合物为代表，在烷基化反应中具有两个或多个反应位点。因此，没有高选择性地生产这些化合物的O-烷基化产物的方法，或者这些方法（如果有的话）仅专门用于具有有限结构的方法。通过使用一价铜化合物如低辛氧化物将其转化为铜盐，然后在磷化合物存在下使其与具有离去基团的烷基化剂反应，将上述化合物选择性O-烷基化的方法O-烷基化，作为亚磷酸酯。通过该反应获得的嘧啶氧基衍生物或吡啶氧基衍生物可用作农药或药物的中间体。

13. 发明申请

US20130012713A1 COMPOUND CONTAINING PYRIDINE RING AND METHOD FOR PRODUCING HALOGENATED PICOLINE DERIVATIVE AND TETRAZOLYLOXIME DERIVATIVE 有权
标题翻译：含有吡啶环的化合物和用于生产氢化吡喃衍生物和四氢呋喃衍生物的方法
公开(公告)号：US20130012713A1
公开(公告)日：2013-01-10
申请号：US13583733
申请日：2011-03-11
申请人： Hidekazu Miyazaki , Satoru Yanaka , Shiro Tsubokura , Tadashi Sugiura , Kaoru Noda , Kengo Suzuki
发明人： Hidekazu Miyazaki , Satoru Yanaka , Shiro Tsubokura , Tadashi Sugiura , Kaoru Noda , Kengo Suzuki
IPC分类号： C07D213/75 , C07D401/12 , C07D405/12
CPC分类号： C07D213/75 , C07D401/12 , C07D405/12
摘要： Disclosed is a compound containing a pyridine ring that can be synthesized in an industrially advantageous manner, and is useful as an intermediate for producing tetrazolyloxime derivatives that exhibit fungicidal activity (wherein R0 represents a C1-6 alkoxy group, C1-6 alkoxy-C1-6 alkoxy group or the like, R1 represents a C1-2 alkoxycarbonyl group, acetyl group or the like, Z represents a halogen atom, cyano group or the like, X represents a halogen atom, and n represents an integer of 0 to 3), and industrially advantageous production methods for producing 2-substituted amino-6-halomethylpyridine derivatives and tetrazolyloxime derivatives.
摘要翻译：公开了含有可以工业上有利的方式合成的吡啶环的化合物，可用作生产具有杀真菌活性的四唑基肟衍生物的中间体（其中R 0表示C1-6烷氧基，C1-6烷氧基C1- 6烷氧基等，R 1表示C 1-2烷氧基羰基，乙酰基等，Z表示卤素原子，氰基等，X表示卤素原子，n表示0〜3的整数）以及用于生产2-取代的氨基-6-卤甲基吡啶衍生物和四唑基肟衍生物的工业上有利的制备方法。

14. 发明授权

US07553837B2 Phenylazole compounds production process and antioxidants 失效
标题翻译：苯唑化合物生产工艺及抗氧化剂
公开(公告)号：US07553837B2
公开(公告)日：2009-06-30
申请号：US10566820
申请日：2004-07-30
申请人： Nobuhiro Umeda , Nobuo Mochizuki , Seiichi Uchida , Mitsumasa Takada , Seiichi Ikeyama , Shiro Tsubokura , Yasuyuki Shiinoki , Fumie Shirato , Hiroko Momoe
发明人： Nobuhiro Umeda , Nobuo Mochizuki , Seiichi Uchida , Mitsumasa Takada , Seiichi Ikeyama , Shiro Tsubokura , Yasuyuki Shiinoki , Fumie Shirato , Hiroko Momoe
IPC分类号： A61K31/497 , A61K31/445 , A01N43/40 , C07D241/04 , C07D295/00 , C07D211/00
CPC分类号： C07D471/04 , C07D405/12 , C07D405/14
摘要： The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1), (B-2) or (B-3); A represents an optionally substituted imidazole or pyrazole group; E represents the following formula (1a); X represents an oxygen atom, the formula: SOu, or the formula: N—R9; Y represents a carbon atom or a nitrogen atom; D represents an oxygen atom, a sulfur atom or the formula (1a); Z represents (a chroman-2-yl group, a chroman-4-yl group, a 2,3-dihydrobenzofuran-2-yl group, a 2,3-dihydrobenzofuran-3-yl group, etc.) which is substituted with NHR10 or OR11)] or pharmaceutically acceptable salts thereof, and to antioxidants, therapeutic agents for kidney diseases or cerebrovascular disorder, and retinal oxidative damage inhibitors, which include the compounds as the active ingredient.
摘要翻译：本发明涉及由式（1）表示的化合物：B-D-Z（1），其中B表示下式（B-1），（B-2）或（B-3）; A表示任选取代的咪唑或吡唑基; E表示下式（1a）; X表示氧原子，分子式为：SOu或式：N-R 9; Y表示碳原子或氮原子; D表示氧原子，硫原子或式（1a）; Z表示（苯并二氢吡喃-2-基，苯并二氢吡喃-4-基，2,3-二氢苯并呋喃-2-基，2,3-二氢苯并呋喃-3-基等），其被 NHR10或OR11）]或其药学上可接受的盐，以及抗氧化剂，肾脏疾病或脑血管障碍的治疗剂和视网膜氧化损伤抑制剂，其包括作为活性成分的化合物。

15. 发明授权

US08691996B2 Compound containing pyridine ring and method for producing halogenated picoline derivative and tetrazolyloxime derivative 有权
公开(公告)号：US08691996B2
公开(公告)日：2014-04-08
申请号：US13583733
申请日：2011-03-11
申请人： Hidekazu Miyazaki , Satoru Yanaka , Shiro Tsubokura , Tadashi Sugiura , Kaoru Noda , Kengo Suzuki
发明人： Hidekazu Miyazaki , Satoru Yanaka , Shiro Tsubokura , Tadashi Sugiura , Kaoru Noda , Kengo Suzuki
IPC分类号： C07D213/75
摘要： Disclosed is a compound containing a pyridine ring that can be synthesized in an industrially advantageous manner, and is useful as an intermediate for producing tetrazolyloxime derivatives that exhibit fungicidal activity (wherein R0 represents a C1-6 alkoxy group, C1-6 alkoxy-C1-6 alkoxy group or the like, R1 represents a C1-2 alkoxycarbonyl group, acetyl group or the like, Z represents a halogen atom, cyano group or the like, X represents a halogen atom, and n represents an integer of 0 to 3), and industrially advantageous production methods for producing 2-substituted amino-6-halomethylpyridine derivatives and tetrazolyloxime derivatives.

16. 发明申请

US20130023664A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND METHOD FOR PRODUCING SAME 有权
标题翻译：含氮杂环化合物及其生产方法
公开(公告)号：US20130023664A1
公开(公告)日：2013-01-24
申请号：US13638700
申请日：2011-03-28
申请人： Koichi Kutose , Hiroki Inoue , Shiro Tsubokura
发明人： Koichi Kutose , Hiroki Inoue , Shiro Tsubokura
IPC分类号： C07D213/75 , C07D213/89
CPC分类号： C07D213/89 , C07D213/75
摘要： There are provided a nitrogen-containing heterocyclic compound such as a substituted amino-pyridine-N-oxide compound represented by formula (1), which is useful as a synthetic intermediate for an agrochemical and the like; and a method for producing the nitrogen-containing heterocyclic compound. (In formula (1), R1 and R2 each represents a hydrogen atom or an unsubstituted or substituted alkyl group; R3 represents a hydrogen atom, an unsubstituted or substituted alkylcarbonyl group or the like; R4 represents an unsubstituted or substituted alkylcarbonyl group, an unsubstituted or substituted arylcarbonyl group or the like; A represents a hydroxyl group, a thiol group or the like; m represents any one of integers of 1 to 4; k represents any one of integers of 0 to 3; and k+m≦4.)
摘要翻译：提供了可用作农药等的合成中间体的含氮杂环化合物，例如由式（1）表示的取代的氨基 - 吡啶-N-氧化物化合物; 和含氮杂环化合物的制造方法。（式（1）中，R 1和R 2各自表示氢原子或未取代或取代的烷基; R 3表示氢原子，未取代或取代的烷基羰基等; R 4表示未取代或取代的烷基羰基，未取代的或取代的芳基羰基等; A表示羟基，硫醇基等; m表示1〜4的整数中的任一个; k表示0〜3的整数中的任一个; k + m＆lt; 1l; 4。）

17. 发明申请

US20060189673A1 Phenylazole compound, production process therefor and antioxidant 审中-公开
标题翻译：苯唑化合物，其生产工艺及抗氧化剂
公开(公告)号：US20060189673A1
公开(公告)日：2006-08-24
申请号：US10553108
申请日：2004-04-13
申请人： Nobuo Mochizuki , Nobuhiro Umeda , Seiichi Uchida , Seiichi Ikeyama , Shiro Tsubokura , Mitsumasa Takada
发明人： Nobuo Mochizuki , Nobuhiro Umeda , Seiichi Uchida , Seiichi Ikeyama , Shiro Tsubokura , Mitsumasa Takada
IPC分类号： A61K31/4164 , A61K31/415
CPC分类号： C07D405/12 , A61K31/4155 , A61K31/4178 , C07D409/12 , C07D411/12
摘要： The present invention relates to a compound represented by formula (1): (wherein R represents a hydrogen atom or a C1-6 alkyl group which may be substituted, A represents an imidazolyl group or a pyrazolyl group, B represents a group represented by the following formula: (wherein R5 and R6 each independently represents a hydrogen atom, a cyano group, a hydroxyl group, a halogen atom, a C1-6 alkyl group, a C1-6 alkoxy group, or the like, k represents 0 or an integer of 1 to 15, and R5 and R6 may be identical or different from each other, when k is 2 or more), and Z represents a substituted chroman-2-yl group, a substituted 2,3-dihydrobenzofuran-2-yl, a substituted thiochroman-2-yl group, a substituted 2,3-dihydrobenzothiophene-2-yl group, or a substituted 1,3-benzoxathiol-2-yl group).
摘要翻译：本发明涉及由式（1）表示的化合物：其中R表示氢原子或可被取代的C 1-6烷基，A表示咪唑基或吡唑基 B表示由下式表示的基团：（其中，R 5和R 6各自独立地表示氢原子，氰基，羟基，卤素原子，C 1-6烷基， C 1-6烷氧基等，k表示0或1〜15的整数，R 5和R 6可以相同或不同，k为2以上时） Z表示取代的苯并二氢吡喃-2-基，取代的2,3-二氢苯并呋喃-2-基，取代的二氢苯并噻喃-2-基，取代的2,3-二氢苯并噻吩-2-基或取代的 1,3-苯并硫代-2-基）。

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