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11. 发明申请

US20050259261A1 Sample analyzer 失效
标题翻译：样品分析仪
公开(公告)号：US20050259261A1
公开(公告)日：2005-11-24
申请号：US11132291
申请日：2005-05-19
申请人： Kunio Harada , Sakuichiro Adachi , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
发明人： Kunio Harada , Sakuichiro Adachi , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
IPC分类号： G01N21/27 , G01N21/31 , G01N21/33 , G01N21/35 , G01N21/3577 , G01N21/359 , G01N21/59 , G01N21/00
CPC分类号： G01N21/3151 , G01N21/5907
摘要： The adverse effect on measurement accuracy brought about by the transmission of light beams through portions of a liquid sample with different concentrations, i.e., a concentration distribution in the vertical direction of a container, is prevented by using semiconductor light sources of two different types with different wavelengths. The semiconductor light sources (2, 4) of two different types are housed in the same package (5) such that a detector (9) can capture the light beams emitted by the light sources after their optical axes have intersected with one another. The multiple light beams can be thus caused to pass through portions with substantially the same concentration and therefore can be detected without being influenced by the difference in concentration of the sample in the container.
摘要翻译：通过使用具有不同浓度的液体样品的一部分（即，容器的垂直方向上的浓度分布），通过使用具有不同浓度的两种不同类型的半导体光源来传输光束所产生的对测量精度的不利影响波长。两种不同类型的半导体光源（2,4）被容纳在相同的封装（5）中，使得检测器（9）在光轴彼此相交之后能够捕获由光源发射的光束。因此，可以使多个光束通过具有基本相同浓度的部分，因此可以不受样品在容器中的浓度差的影响而被检测。

12. 发明授权

US09664678B2 Automated analyzer and analyzing method 有权
公开(公告)号：US09664678B2
公开(公告)日：2017-05-30
申请号：US14238060
申请日：2012-09-03
申请人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
发明人： Takeshi Yogi , Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki
IPC分类号： G01N21/51 , G01N33/543 , G01N21/82 , G01N35/02 , G01N21/47 , G01N35/04
CPC分类号： G01N33/54366 , G01N21/47 , G01N21/51 , G01N21/82 , G01N33/54313 , G01N35/025 , G01N2021/825 , G01N2035/0441 , G01N2035/0443 , G01N2035/0444 , G01N2800/24
摘要： An analyzer provides conditions suitable for a reagent for performing latex immunoassay with a high sensitivity using a method of measuring scattered light. Irradiation light having a wavelength in the range of 0.65 to 0.75 μm is used, and scattered light generated from a reaction solution is received at a light-receiving angle of 15° to 35° with respect to the irradiation direction during the rotational movement of the reaction container. The reagent contains latex particles the average peak particle diameter of which ranges from 0.3 μm to 0.43 μm and to which antibodies are sensitized. The reaction solution contains latex particles at a concentration at which the absorbance to irradiation light having a wavelength of 0.7 μm is 0.25 abs to 1.10 abs, and a change in the amount of scattered light caused by the aggregation of the latex particles through antigens in a sample is measured and quantified.

13. 发明授权

US09645160B2 Automatic analysis device 有权
公开(公告)号：US09645160B2
公开(公告)日：2017-05-09
申请号：US14116177
申请日：2012-05-09
申请人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
发明人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
IPC分类号： G01N35/02 , G01N21/51 , G01N21/82 , G01N21/47 , G01N35/04
CPC分类号： G01N35/025 , G01N21/51 , G01N21/82 , G01N2021/4711 , G01N2035/0453
摘要： The automatic analysis device measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.

14. 发明授权

US09395298B2 Blood coagulation analyzer 有权
标题翻译：凝血分析仪
公开(公告)号：US09395298B2
公开(公告)日：2016-07-19
申请号：US13509661
申请日：2010-11-19
申请人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
发明人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
IPC分类号： G01N33/50 , G01N21/00 , G01N21/51 , G01N33/49 , G01N33/86 , G01N21/53 , G01N21/82 , G01N33/18
CPC分类号： G01N21/51 , G01N21/532 , G01N21/82 , G01N33/18 , G01N33/1826 , G01N33/4905 , G01N33/86 , G01N2021/4711 , G01N2021/825
摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.
摘要翻译：一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。分析仪具有反应容器。提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

15. 发明申请

US20120039748A1 AUTOMATIC ANALYSIS APPARATUS 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20120039748A1
公开(公告)日：2012-02-16
申请号：US13202337
申请日：2010-02-24
申请人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
发明人： Tomonori Mimura , Akihisa Makino , Sakuichiro Adachi
IPC分类号： G01N33/00
CPC分类号： G01N35/025 , G01N2035/0455
摘要： An automatic analysis apparatus capable of testing a plurality of items with high accuracy and at low cost without increasing the size of the apparatus is provided. An automatic analysis apparatus 1 having test mechanisms for a plurality of items including a photometric mechanism 70 and flow analysis mechanisms 40a and 40b is provided with a common disk (disk for reaction and pretreatment) 20. In the common disk 20, fixed containers 21 fixed to the common disk 20 and detachably-provided disposable containers 22 are disposed. Therefore, while achieving the downsizing of the apparatus, the containers to be used can be selected in accordance with the test items in such a manner that the fixed containers 21 are used as high-accuracy containers to be cleaned and reused and the disposable containers 22 are used as low-cost disposable containers.
摘要翻译：提供了一种能够在不增加设备尺寸的情况下以高精度和低成本测试多个项目的自动分析装置。具有包括测光机构70和流量分析机构40a，40b的多个项目的测试机构的自动分析装置1设置有公共盘（反应和预处理盘）20。在普通盘20中，固定容器21固定配置在普通盘20上，可拆卸地设置一次性容器22。因此，在实现装置的小型化的同时，可以根据试验项目来选择要使用的容器，使得固定容器21用作待清洁和重复使用的高精度容器，并且一次性容器22 被用作低成本的一次性容器。

16. 发明授权

US07767147B2 Substrate for transporting liquid, a system for analysis and a method for analysis 有权
标题翻译：用于运输液体的基材，分析系统和分析方法
公开(公告)号：US07767147B2
公开(公告)日：2010-08-03
申请号：US11258230
申请日：2005-10-26
申请人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
发明人： Sakuichiro Adachi , Kunio Harada , Hideo Enoki , Hironobu Yamakawa , Tomonori Mimura
IPC分类号： G01N21/00 , G01N1/10 , B01L3/00 , B01L3/02
CPC分类号： G01N21/253 , B01L3/502784 , B01L2200/027 , B01L2200/0673 , B01L2300/0654 , B01L2300/0816 , B01L2300/0845 , B01L2300/089 , B01L2400/0427 , G01N35/08 , Y10T436/2575
摘要： Conventional liquid transport substrates having a fluid channel formed along an array of electrodes have a problem in which throughput decreases, depending on driving conditions. In order to avoid two-way passage in a fluid channel from the inlet to a measuring section and a fluid channel from the measuring section to the outlet, the measuring section is located in the middle of the fluid channel connecting the inlet and the outlet, so that manipulation from the inlet to the outlet takes place in one direction on the substrate. Even when analyzing a large number of sample droplets, by transport of the droplets substantially in one direction, it is possible to complete measurement in a short time.
摘要翻译：具有沿着电极阵列形成的流体通道的常规液体输送基板具有根据驱动条件的生产率下降的问题。为了避免从入口到测量部分的流体通道和从测量部分到出口的流体通道的双向通道，测量部分位于连接入口和出口的流体通道的中间，使得从入口到出口的操作在基板上沿一个方向发生。即使当分析大量的样品液滴时，通过基本上沿一个方向输送液滴，可以在短时间内完成测量。

17. 发明申请

US20060166373A1 Chemical analysis apparatus and analysis device 审中-公开
标题翻译：化学分析装置及分析装置
公开(公告)号：US20060166373A1
公开(公告)日：2006-07-27
申请号：US11319714
申请日：2005-12-29
申请人： Hideo Enoki , Hironobu Yamakawa , Kunio Harada , Sakuichiro Adachi , Tomonori Mimura
发明人： Hideo Enoki , Hironobu Yamakawa , Kunio Harada , Sakuichiro Adachi , Tomonori Mimura
IPC分类号： G01N1/00
CPC分类号： B01L3/0241 , B01L3/502792 , B01L2200/10 , B01L2300/089 , B01L2400/027 , B01L2400/0427 , G01N35/1016 , G01N2035/00158 , G01N2035/00237 , Y10T436/2575
摘要： There are provided a chemical analysis apparatus and an analysis device in which predetermined quantities of a sample and a reagent are presicely pipetted, then are subjected to various processes, and are tested by a test device. Thus, the chemical analysis apparatus comprises the analysis device, an oil supply portion, a sample pipetting portion and a reagent pipetting portion. The analysis device comprises an upper board provided with a common electrode, and a lower board provided with a drive electrode including a train of a plurality of electrodes. Oil is filled in a space defined between the two boards, and liquid drops of the sample, the reagent and the like are formed in the oil. The common electrode is applied thereto with a negative voltage or is grounded while a positive voltage is applied to electrodes on the drive electrode side in order to decrease a contact angle in a zone where the voltage are applied to the electrodes, and accordingly, the wettability is enhanced, thereby it is possible to displace the liquid drops.
摘要翻译：提供了一种化学分析装置和分析装置，其中预先抽取预定量的样品和试剂，然后进行各种处理，并通过测试装置进行测试。因此，化学分析装置包括分析装置，供油部，样品吸移部和试剂吸移部。分析装置包括设置有公共电极的上板和设置有包括多个电极列的驱动电极的下板。油被填充在两个板之间限定的空间中，并且在油中形成样品的液滴，试剂等。为了降低向电极施加电压的区域的接触角，公共电极以负电压施加到其上，或接地，同时向驱动电极侧的电极施加正电压，因此，润湿性被增强，从而可以移位液滴。

18. 发明授权

US08675187B2 Photometer and analyzing system provided with photometer 有权
标题翻译：配有光度计的光度计和分析系统
公开(公告)号：US08675187B2
公开(公告)日：2014-03-18
申请号：US13141378
申请日：2009-12-22
申请人： Kunio Harada , Sakuichiro Adachi , Isao Yamazaki
发明人： Kunio Harada , Sakuichiro Adachi , Isao Yamazaki
IPC分类号： G01J1/00
CPC分类号： G01N21/59 , G01J3/02 , G01J3/0208 , G01J3/021 , G01J3/10 , G01N21/0332 , G01N2201/062
摘要： In an analysis system for detecting amounts of components contained in samples, many samples can be measured simultaneously in the whole of the system by use of compact inexpensive photometers. An LED with low heat generation and a long life span is used as a light source. Compactness is achieved by bended optical axis instead of a straight one. Components for bending an optical axis and components for condensing light to ensure an amount of light are in common use to reduce the number of components. Compactness, reduction of the number of components, and integration achieve easy optical axis alignment and precise measurement.
摘要翻译：在用于检测样品中包含的组分量的分析系统中，可以通过使用紧凑廉价的光度计在整个系统中同时测量许多样品。使用具有低发热和长寿命的LED作为光源。通过弯曲光学轴而不是直线实现紧凑性。用于弯曲光轴的部件和用于聚光的部件以确保一定量的光通常用于减少部件的数量。紧凑，减少部件数量，集成实现轻松对准和精确测量。

19. 发明授权

US09194793B2 Sample analysis device 有权
标题翻译：样品分析装置
公开(公告)号：US09194793B2
公开(公告)日：2015-11-24
申请号：US13002664
申请日：2009-07-30
申请人： Sakuichiro Adachi , Kunio Harada , Isao Yamazaki , Masaharu Kiyama , Takeshi Fujita
发明人： Sakuichiro Adachi , Kunio Harada , Isao Yamazaki , Masaharu Kiyama , Takeshi Fujita
IPC分类号： G01N21/59 , G01N21/25 , G01N35/02 , G01N21/03 , G01N35/00 , G01N35/04
CPC分类号： G01N21/253 , G01N21/0332 , G01N21/255 , G01N35/025 , G01N2035/00386 , G01N2035/0455 , G01N2201/0231 , G01N2201/0415 , G01N2201/0453 , G01N2201/0624 , G01N2201/0627
摘要： Using an LED element as a light source, a photometric unit including the light source, a light receiving element and other components therebetween is reduced in size. A holder 30 detachable from the device as a unit holds a light emission unit 15 formed of an LED and a light receiving element 21, and the holder is placed inside a thermostatic chamber 18 which holds a constant temperature fluid 17. Thus, the photometric unit is reduced in size.
摘要翻译：使用LED元件作为光源，包括光源，光接收元件和其间的其它部件的光度单元的尺寸减小。从装置作为一个单元可拆卸的保持器30保持由LED和光接收元件21形成的发光单元15，并且保持器放置在保持恒温流体17的恒温室18内部。因此，测光单元尺寸减小。

20. 发明申请

US20110110822A1 SAMPLE ANALYSIS DEVICE 有权
标题翻译：样品分析装置
公开(公告)号：US20110110822A1
公开(公告)日：2011-05-12
申请号：US13002664
申请日：2009-07-30
申请人： Sakuichiro Adachi , Kunio Harada , Isao Yamazaki , Masaharu Kiyama , Takeshi Fujita
发明人： Sakuichiro Adachi , Kunio Harada , Isao Yamazaki , Masaharu Kiyama , Takeshi Fujita
IPC分类号： G01N21/59
CPC分类号： G01N21/253 , G01N21/0332 , G01N21/255 , G01N35/025 , G01N2035/00386 , G01N2035/0455 , G01N2201/0231 , G01N2201/0415 , G01N2201/0453 , G01N2201/0624 , G01N2201/0627
摘要： Using an LED element as a light source, a photometric unit including the light source, a light receiving element and other components therebetween is reduced in size. A holder 30 detachable from the device as a unit holds a light emission unit 15 formed of an LED and a light receiving element 21, and the holder is placed inside a thermostatic chamber 18 which holds a constant temperature fluid 17. Thus, the photometric unit is reduced in size.
摘要翻译：使用LED元件作为光源，包括光源，光接收元件和其间的其它部件的光度单元的尺寸减小。从装置作为一个单元可拆卸的保持器30保持由LED和光接收元件21形成的发光单元15，并且保持器放置在保持恒温流体17的恒温室18内部。因此，测光单元尺寸减小。

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