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1. 发明申请

US20140140890A1 AUTOMATIC ANALYSIS DEVICE 有权
标题翻译：自动分析装置
公开(公告)号：US20140140890A1
公开(公告)日：2014-05-22
申请号：US14116177
申请日：2012-05-09
申请人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
发明人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
IPC分类号： G01N35/02
CPC分类号： G01N35/025 , G01N21/51 , G01N21/82 , G01N2021/4711 , G01N2035/0453
摘要： The automatic analysis device measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.
摘要翻译：自动分析装置测量作为反应过程数据的散射光量的时间序列数据，并且从光量的变化定量地确定分析物的浓度。自动分析装置具有从通过使用多个不同角度的光接收器的测量获得的反应过程数据中选择要用于定量确定的反应过程数据的功能。作为使用该功能的结果，从根据分析物的浓度以不同角度通过使用多个光接收器的测量获得的反应过程数据中选择数据，以及在灵敏度的情况下是否优先考虑高灵敏度优先或动态范围，并显示定量确定的结果。

2. 发明授权

US09645160B2 Automatic analysis device 有权
公开(公告)号：US09645160B2
公开(公告)日：2017-05-09
申请号：US14116177
申请日：2012-05-09
申请人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
发明人： Sakuichiro Adachi , Tomonori Mimura , Hajime Yamazaki , Masaki Shiba
IPC分类号： G01N35/02 , G01N21/51 , G01N21/82 , G01N21/47 , G01N35/04
CPC分类号： G01N35/025 , G01N21/51 , G01N21/82 , G01N2021/4711 , G01N2035/0453
摘要： The automatic analysis device measures time sequential data on a scattered light amount as reaction process data, and quantitatively determines the concentration of an analyte from a change in light amount. The automatic analysis device has a function of selecting reaction process data to be used for quantitative determination from the reaction process data obtained by measurement using a plurality of light receivers at different angles. As a result of using this function, data is selected from the reaction process data obtained by measurement using the plurality of light receivers at different angles in accordance with the concentration of the analyte and whether the priority is given to high sensitivity in the case where sensitivity is prioritized or a dynamic range, and the result of the quantitative determination is displayed.

3. 发明申请

US20130132022A1 AUTOMATIC ANALYZER AND AUTOMATIC ANALYSIS METHOD 审中-公开
标题翻译：自动分析仪和自动分析方法
公开(公告)号：US20130132022A1
公开(公告)日：2013-05-23
申请号：US13702196
申请日：2011-06-15
申请人： Takuo Tamura , Masaki Shiba , Sakuichiro Adachi
发明人： Takuo Tamura , Masaki Shiba , Sakuichiro Adachi
IPC分类号： G01N21/51 , G06F17/00
摘要： An automatic analyzer is capable of reducing the influence of scattered light having noise components to enhance the S/N ratio properties of a light reception signal. Data is obtained at a plurality of angles by a plurality of detectors and a signal obtained by one detector selected from among the detectors is selected as a reference signal. An approximation is applied by an approximation selection unit, and an approximation calculation unit calculates an approximation using the selected approximation. A degree of variability of the reference signal is determined and a data correction unit corrects the signal of the detector by dividing the signal of the detector by the degree of variability of the reference signal. A concentration calculation processing unit performs the concentration calculation by use of the corrected signal data, and a result output unit outputs the results on a display.
摘要翻译：自动分析仪能够减少具有噪声分量的散射光的影响，以提高光接收信号的S / N比特性。通过多个检测器以多个角度获得数据，并且选择从检测器中选出的一个检测器获得的信号作为参考信号。近似值由近似选择单元施加，近似计算单元使用所选择的近似来计算近似值。确定参考信号的可变性程度，并且数据校正单元通过将检测器的信号除以参考信号的变化程度来校正检测器的信号。浓度计算处理单元通过使用校正的信号数据进行浓度计算，结果输出单元将显示结果输出。

4. 发明申请

US20130108509A1 AUTOMATIC ANALYSIS DEVICE 审中-公开
标题翻译：自动分析装置
公开(公告)号：US20130108509A1
公开(公告)日：2013-05-02
申请号：US13805594
申请日：2011-06-13
申请人： Masaki Shiba , Takuo Tamura , Sakuichiro Adachi
发明人： Masaki Shiba , Takuo Tamura , Sakuichiro Adachi
IPC分类号： G01N21/47
CPC分类号： G01N21/47 , G01N21/51 , G01N35/025 , G01N2021/4711 , G01N2021/825
摘要： Disclosed is an automatic analysis device including light detectors that detect scattered light, whereby highly reliable analysis results can be obtained by reduction of the effect of noise components. Highly reliable concentration analysis with little effect from noise components can be achieved by calculating the correlation between scattered light detected by a plurality of light detectors before calculating concentration, and by performing concentration analysis using scattered light with high correlation.
摘要翻译：公开了一种包括检测散射光的光检测器的自动分析装置，通过降低噪声成分的影响，可以获得高可靠性的分析结果。通过在计算浓度之前计算由多个光检测器检测到的散射光之间的相关性，并且通过使用具有高相关性的散射光进行浓度分析，可以实现对噪声成分影响很小的高度可靠的浓度分析。

5. 发明申请

US20110104810A1 AUTOMATIC ANALYZER 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20110104810A1
公开(公告)日：2011-05-05
申请号：US12996414
申请日：2009-05-12
申请人： Masaki Shiba , Tomonori Mimura , Yuko Hamazumi
发明人： Masaki Shiba , Tomonori Mimura , Yuko Hamazumi
IPC分类号： G01N35/00
CPC分类号： G01N35/1002 , G01N35/1011 , G01N2035/00673 , G01N2035/1025 , Y10T436/115831
摘要： It is checked whether a liquid undulation prevention mechanism is present or absent in a reagent vessel at the start of an operation (steps 601 and 602). When the liquid leakage prevention mechanism is absent in the reagent vessel, the size of the opening of the reagent vessel is judged (step 604). A nozzle is inserted and lowered into the reagent vessel to judge the contact of the nozzle to the liquid surface. When the opening is larger size, a capacitance method is used (step 607). When the opening is small size, a pressure detection is used (step 608). When the liquid leakage prevention mechanism is present, the size of the opening is judged (step 604). When the opening is larger size, a capacitance method is used (step 605). When the opening is small size, a pressure detection is used (step 606).
摘要翻译：在操作开始时检查试剂容器中是否存在液体波动防止机构（步骤601和602）。当试剂容器中不存在防漏液机构时，判断试剂容器的开口尺寸（步骤604）。将喷嘴插入和下降到试剂容器中以判断喷嘴与液体表面的接触。当开口尺寸较大时，使用电容法（步骤607）。当开口尺寸小时，使用压力检测（步骤608）。当存在防漏液机构时，判断开口尺寸（步骤604）。当开口尺寸较大时，使用电容法（步骤605）。当开口尺寸小时，使用压力检测（步骤606）。

6. 发明授权

US08158058B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US08158058B2
公开(公告)日：2012-04-17
申请号：US10844375
申请日：2004-05-13
申请人： Masaki Shiba , Masaaki Hanawa , Masaharu Nishida , Hitoshi Otake
发明人： Masaki Shiba , Masaaki Hanawa , Masaharu Nishida , Hitoshi Otake
IPC分类号： G01N35/04
CPC分类号： G01N35/025 , G01N35/00584 , G01N35/00663 , G01N35/0092 , G01N35/1002 , G01N2035/00673 , G01N2035/0443 , Y10T436/11 , Y10T436/114165
摘要： An automatic analyzer is disclosed that includes a supplementary reagent storage section and reagent bottle transfer mechanism besides an analysis reagent storage section, and that, by managing information on reagents stored in these two reagent storage sections, is capable of automating reagent management such as reagent replacing work, thereby reducing the burden on an operator, minimizing the interruption of an analysis due to reagent registration and reagent replacement, mounting many reagents thereon, and achieving a high throughput.
摘要翻译：公开了一种自动分析仪，其包括除了分析试剂储存部分之外的补充试剂储存部分和试剂瓶转移机构，并且通过管理存储在这两个试剂储存部分中的试剂的信息，能够自动化试剂管理，如试剂替代工作，从而减轻操作者的负担，最小化由于试剂注册和试剂更换导致的分析中断，在其上安装许多试剂，并实现高产量。

7. 发明申请

US20130294974A1 AUTOMATIC ANALYZER 审中-公开
标题翻译：自动分析仪
公开(公告)号：US20130294974A1
公开(公告)日：2013-11-07
申请号：US13991467
申请日：2011-11-29
申请人： Masaki Shiba , Manabu Ando
发明人： Masaki Shiba , Manabu Ando
IPC分类号： G01N21/59
CPC分类号： G01N21/59 , G01N21/253 , G01N21/51 , G01N21/82 , G01N35/00594 , G01N35/025
摘要： A light source radiates light onto a reaction vessel in which a sample is caused to react with a reagent. A transmissive-light receiver, located across from the light source with the reaction vessel located therebetween, measures the intensity of transmissive light passing through the reaction vessel. Scattered-light receivers, located on the side of the transmissive-light receiver, are used to measure the intensities of scattered light and scattered light generated from the reaction vessel. Based on the results of the measurement by the scattered-light receivers, the light intensity of the light source is corrected. This allows correction of the intensity of the light incident on the reaction vessel even when an analysis involves the use of scattered light. The use of such analyzers prevents analysis results from varying from analyzer to analyzer due to inaccurate measurement of the incident light.
摘要翻译：光源将光照射到使样品与试剂反应的反应容器上。透射光接收器，位于光源两侧，反应容器位于它们之间，测量透过反应容器的透射光的强度。位于透射光接收器一侧的散射光接收器用于测量由反应容器产生的散射光和散射光的强度。基于散射光接收机的测量结果，校正光源的光强度。这允许校正入射在反应容器上的光的强度，即使当分析涉及使用散射光时。使用这种分析仪可以防止由于入射光的测量不准确而导致从分析仪到分析仪的分析结果不同。

8. 发明授权

US09513302B2 Reagent transfer device 有权
标题翻译：试剂转移装置
公开(公告)号：US09513302B2
公开(公告)日：2016-12-06
申请号：US13423651
申请日：2012-03-19
申请人： Masaki Shiba , Masaaki Hanawa , Masaharu Nishida , Hitoshi Otake
发明人： Masaki Shiba , Masaaki Hanawa , Masaharu Nishida , Hitoshi Otake
IPC分类号： G01N35/10 , G01N35/04 , G01N35/00
CPC分类号： G01N35/025 , G01N35/00584 , G01N35/00663 , G01N35/0092 , G01N35/1002 , G01N2035/00673 , G01N2035/0443 , Y10T436/11 , Y10T436/114165
摘要： The automatic analyzer includes: a first reagent container storage section storing a plurality of reagent containers; a regent dispensing mechanism for dispensing a reagent from a reagent container stored in the first reagent container storage section; a second reagent container storage section storing a plurality of reagent containers; a reagent container transfer mechanism for transferring a reagent container selected from among reagent containers stored in the second reagent container storage section to the first reagent container storage section; and a controller configured to control the reagent container transfer mechanism to transfer a reagent container from the second reagent container storage section to the first reagent container storage section on the basis of a predetermined priority condition. The predetermined priority condition is one of a reagent provided with an effective calibration curve result, a number of remaining tests, and an expiration date of a reagent.
摘要翻译：所述自动分析装置具备：容纳多个试剂容器的第一试剂容器收容部; 用于从存储在第一试剂容器储存部中的试剂容器分配试剂的摄取分配机构; 存储多个试剂容器的第二试剂容器收纳部; 用于将选自存储在第二试剂容器储存部分的试剂容器中的试剂容器转移到第一试剂容器存储部分的试剂容器转移机构; 以及控制器，其被配置为基于预定的优先级条件来控制试剂容器转移机构，以将试剂容器从第二试剂容器储存部分转移到第一试剂容器储存部。预定优先条件是具有有效校准曲线结果，剩余测试次数和试剂有效期的试剂之一。

9. 发明申请

US20050175503A1 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US20050175503A1
公开(公告)日：2005-08-11
申请号：US11033383
申请日：2005-01-12
申请人： Masaki Shiba , Hideyuki Yanami , Masaharu Nishida , Hitoshi Ohtake
发明人： Masaki Shiba , Hideyuki Yanami , Masaharu Nishida , Hitoshi Ohtake
IPC分类号： G01N35/02 , G01N35/00 , G01N35/04 , G01N35/10
CPC分类号： G01N35/00663 , G01N35/0092 , G01N35/1002 , G01N2035/00673
摘要： An automatic analyzer capable of replenishing a reagent even during an analysis and minimizing a suspension of the analysis. The automatic analyzer includes a plurality of reaction cells and a unit for holding reagents used in analyses. A plurality of reagents are dispensed to a sample in each reaction cell with a time difference to develop a reaction, and a liquid after the reaction is measured. After temporarily stopping the operation of dispensing the sample for a preset time during the analysis, the sample dispensing operation is restarted. Then, the sample dispensing operation is temporarily stopped again for the preset time at the timing in the dispensing of the reagent corresponding to the timing at which the sample dispensing operation was temporarily stopped. In the automatic analyzer, therefore, an analysis suspension due to registration and replacement of reagents during the analysis can be minimized, a larger number of reagents can be loaded, and a throughput per unit time can be increased.
摘要翻译：即使在分析过程中也能补充试剂的自动分析仪，并使分析的暂停最小化。自动分析仪包括多个反应池和用于分析中使用的试剂的单元。将多个试剂以时间差分配到每个反应池中的样品以产生反应，并测量反应后的液体。在分析过程中临时停止分配样品预定时间的操作之后，重新开始样品分配操作。然后，在与试样分注操作暂时停止的定时相对应的试剂分配的定时，试样分注操作再次临时停止预定时间。因此，在自动分析装置中，可以将分析过程中的试剂注册和更换的分析悬浮液最小化，可以加载更多的试剂，并且可以提高每单位时间的通过量。

10. 发明授权

US07776264B2 Automatic analyzer 有权
标题翻译：自动分析仪
公开(公告)号：US07776264B2
公开(公告)日：2010-08-17
申请号：US11033383
申请日：2005-01-12
申请人： Masaki Shiba , Hideyuki Yanami , Masaharu Nishida , Hitoshi Ohtake
发明人： Masaki Shiba , Hideyuki Yanami , Masaharu Nishida , Hitoshi Ohtake
IPC分类号： G01N35/00 , G01N35/02
CPC分类号： G01N35/00663 , G01N35/0092 , G01N35/1002 , G01N2035/00673
摘要： An automatic analyzer capable of replenishing a reagent even during an analysis and minimizing a suspension of the analysis. The automatic analyzer includes a plurality of reaction cells and a unit for holding reagents used in analyses. A plurality of reagents are dispensed to a sample in each reaction cell with a time difference to develop a reaction, and a liquid after the reaction is measured. After temporarily stopping the operation of dispensing the sample for a preset time during the analysis, the sample dispensing operation is restarted. Then, the sample dispensing operation is temporarily stopped again for the preset time at the timing in the dispensing of the reagent corresponding to the timing at which the sample dispensing operation was temporarily stopped. In the automatic analyzer, therefore, an analysis suspension due to registration and replacement of reagents during the analysis can be minimized, a larger number of reagents can be loaded, and a throughput per unit time can be increased.
摘要翻译：即使在分析过程中也能补充试剂的自动分析装置，并使分析的暂停最小化。自动分析仪包括多个反应池和用于分析中使用的试剂的单元。将多个试剂以时间差分配到每个反应池中的样品以产生反应，并测量反应后的液体。在分析过程中临时停止分配样品预定时间的操作之后，重新开始样品分配操作。然后，在与试样分注操作暂时停止的定时相对应的试剂分配的定时，试样分注操作再次临时停止预定时间。因此，在自动分析装置中，可以将分析过程中的试剂注册和更换的分析悬浮液最小化，可以加载更多的试剂，并且可以提高每单位时间的通过量。

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