专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO1997032584A1 SLOW-RELEASE PHARMACEUTICAL FORMULATIONS CONTAINING MIZOLASTIN 审中-公开
标题翻译：含有MIZOLASTIN的缓释药物制剂
公开(公告)号：WO1997032584A1
公开(公告)日：1997-09-12
申请号：PCT/FR1997000355
申请日：1997-02-28
申请人： SYNTHELABO , CHARIOT, Maryvonne , LEWIS, Gareth , MONTEL, Jean
发明人： SYNTHELABO
IPC分类号： A61K31/495
CPC分类号： A61K31/506 , A61K9/2013 , A61K9/2866
摘要： A slow-release pharmaceutical formulation containing mizolastin and characterised in that it comprises a core consisting of a slow-release tablet comprising mizolastin combined with a fatty matrix and an organic acid, said tablet being coated, is disclosed.
摘要翻译：含有咪唑斯汀的缓释药物制剂，其特征在于其包含由包含与脂肪基质组合的咪唑斯汀和有机酸的缓释片组成的核心，所述片剂被包被。

12. 发明申请

WO1996034870A1 AZACYCLOALCANE DERIVATIVES, PREPARATION THEREOF AND THEIR APPLICATIONS IN THERAPY 审中-公开
标题翻译：亚卡环素衍生物，其制剂及其在治疗中的应用
公开(公告)号：WO1996034870A1
公开(公告)日：1996-11-07
申请号：PCT/FR1996000555
申请日：1996-04-12
申请人： SYNTHELABO , BEDOYA ZURITA, Manuel , DIAZ MARTIN, Juan Antonio , DEL SOL MORENO, Gregorio , MARTIN ESCUDERO PEREZ, Ulpiano , JIMENEZ BARGUENO, Maria Dolores , ROMANACH FERRER, Magali
发明人： SYNTHELABO
IPC分类号： C07D495/04
CPC分类号： C07D491/04 , C07D209/44 , C07D217/06 , C07D495/04
摘要： Azacycloalcane derivatives having general formula (I) wherein R1 and R2 represent a hydrogen atom, an alkyl group or a phenyl group, or R1 and R2 form together an oxo group, R3 is a hydrogen atom or an alkyl group, or R3 forms a methylene group, R4 is an aromatic group or, when R3 forms a methylene group, R4 is a phenylene group of which a carbon atom is bound to Y and another carbon atom adjacent to the former carbon atom is bound to said methylene group, R5 is either a group OR7 where R7 is a hydrogen atom or a benzyl group, or a group N4-methyl-piperazinyl, or else a group NHR8 wherein R8 is a hydroxyl, pyridinylmethyl or phenylmethyl group, A is an optionally substituted aromatic cycle, n is 1 or 2, X is CH, O or N, and Y is CH2, O or S, their preparation process and their applications in therapy.
摘要翻译：通式（I）的氮杂环烷烃衍生物，其中R 1和R 2表示氢原子，烷基或苯基，或者R 1和R 2一起形成氧代基，R 3是氢原子或烷基，或者R 3形成亚甲基基团，R 4为芳基，或者，当R 3为亚甲基时，R 4为碳原子与Y结合的亚苯基，与前述碳原子相邻的另一碳原子与所述亚甲基结合，R 5为 OR 7，其中R 7为氢原子或苄基或N 4 - 甲基 - 哌嗪基，或其中R 8为羟基，吡啶基甲基或苯甲基的基团NHR 8，A为任选取代的芳环，n为1 或2，X为CH，O或N，Y为CH2，O或S，其制备方法及其在治疗中的应用。

13. 发明申请

WO1990016061A1 ULTRASONIC SCANNING SENSOR 审中-公开
标题翻译：超声波扫描传感器
公开(公告)号：WO1990016061A1
公开(公告)日：1990-12-27
申请号：PCT/FR1990000408
申请日：1990-06-11
申请人： SYNTHELABO , FLEURY, Gérard , NORMAND, Gérard
发明人： SYNTHELABO
IPC分类号： G10K11/00
CPC分类号： G10K11/355
摘要： An ultrasonic scanning sensor (2), comprising a casing (30, 31), a head (4) mounted near the end of said casing (30) and near the organ to be explored, said head (4) comprising a cell for transmitting and receiving a wave beam, a first shaft (11), rotating around a first axis (X-X) and driven by a drive unit (6) located in said casing (31) and linking means of said head connected to said shaft, in order to allow said wave beam to scan the organ to be explored. According to the invention, said head is mounted in a body (30) which is removably connected to a handle (5) comprising a driving motor (6) for said head (4).

14. 发明申请

WO1998011881A1 PHARMACEUTICAL COMPOSITIONS CONTAINING AMISULPRIDE AND THEIR THERAPEUTIC APPLICATIONS 审中-公开
标题翻译：含有AMISULPRIDE的药物组合物及其治疗应用
公开(公告)号：WO1998011881A1
公开(公告)日：1998-03-26
申请号：PCT/FR1997001633
申请日：1997-09-17
申请人： SYNTHELABO , ANDRIEU, Véronique , CUINE, Alain , MONTEL, Jean
发明人： SYNTHELABO
IPC分类号： A61K09/48
CPC分类号： A61K9/4858 , A61K9/1075 , A61K31/40
摘要： The invention concerns a pharmaceutical composition, particularly to be orally administered, containing a lipophilic phase and at least one active principle consisting of amisulpride, one of its laevo-rotary and dextro-rotary isomers or an amisulpride derivative selected among its additive salts with phamaceutically acceptable acids, its quaternary ammonium salts, its oxides and their leavo-rotary and dextro-rotary isomers. The invention has useful therapeutic applications.
摘要翻译：本发明涉及包含亲脂相的药物组合物，特别是经口给药的药物组合物，以及至少一种活性成分，由活性成分组成，所述活性成分包括：其滑膜旋转和右旋旋转异构体之一，其选自其药物学上可接受的添加剂中的氨磺沙星衍生物酸，其季铵盐，其氧化物和它们的旋转和右旋旋转异构体。本发明具有有用的治疗应用。

15. 发明申请

WO1998008515A1 TABLET WITH CONTROLLED RELEASE OF ALFUZOSINE CHLORYDRATE 审中-公开
标题翻译：控制释放ALFUZOSINE CHLORYDRATE的药片
公开(公告)号：WO1998008515A1
公开(公告)日：1998-03-05
申请号：PCT/FR1997001515
申请日：1997-08-22
申请人： SYNTHELABO , JAGOTEC AG , MAGGI, Lauretta , CONTE, Ubaldo , GRENIER, Pascal , VERGNAULT, Guy , DUFOUR, Alain , JARREAU, François, Xavier , RAUCH-DESANTI, Clémence
发明人： SYNTHELABO , JAGOTEC AG
IPC分类号： A61K31/505
CPC分类号： A61K9/2086 , A61K31/517
摘要： The invention concerns a pharmaceutical tablet for oral administration, for the controlled release of alfuzosine chlorhydrate at the proximal segments of the gastrointestinal tract, characterised in that it consists of: a) a first layer (1) capable of swelling noticeably and rapidly in contact with aqueous biological liquids, said layer being produced by a mixture or a granule containing hydrophilic polymers constituting 5.0 to 90 % and preferably 10 to 85 % of the layer weight; b) a second layer (2) adjacent to or superposed on the first layer, in which is carried the alfuzosine chlorhydrate, this layer being formed with hydrophilic polymers and other auxiliary substances, so as to give to the preparation suitable compressibility properties and to enable the release of the alfuzosine chlorhydrate in a predetermined lapse of time; c) and optionally a third layer (3) obtained by compression and applied on layer (2), generally consisting in particular of hydrophilic polymers which gel and/or swell and then can be optionally eroded and acting as a barrier modulating the release of the alfuzosine of layer (2), layer (3) being almost impermeable to the passage of the active substance. The invention is applicable to a pharmaceutical composition.
摘要翻译：本发明涉及一种用于口服给药的药物片剂，用于在胃肠道的近端节段控制释放盐酸阿夫福兹，其特征在于，其包括：a）能够明显和快速地溶胀的第一层（1），其与水性生物液体，所述层由含有构成层重量的5.0〜90％，优选为10〜85％的亲水性聚合物的混合物或颗粒制成; b）邻近或重叠在第一层上的第二层（2），其中载有氢氟酸低聚水合物，该层由亲水性聚合物和其它辅助物质形成，以便制备合适的可压缩性，并使得在预定的时间内释放氢氟酸阿福佐星; c）和任选的通过压缩获得并施加在层（2）上的第三层（3），其通常特别地由亲水性聚合物组成，所述亲水性聚合物凝胶化和/或膨胀，然后可以任选地被侵蚀并且用作调节释放层（2）的阿夫福星，层（3）对于活性物质的通过几乎是不可渗透的。本发明可应用于药物组合物。

16. 发明申请

WO1998005664A1 6,7,8,9-TETRAHYDRO-5H-IMIDAZO[1,2-a]AZEPINE-3-ACETIC ACID DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF 审中-公开
标题翻译： 6,7,8,9-四氢-5H-咪唑并[1,2-a]亚甲基-3-乙酸衍生物，其制备方法及其治疗用途
公开(公告)号：WO1998005664A1
公开(公告)日：1998-02-12
申请号：PCT/FR1997001365
申请日：1997-07-23
申请人： SYNTHELABO , DE PERETTI, Danièle , EVANNO, Yannick , LEGALLOUDEC, Odette , SEVRIN, Mireille , GEORGE, Pascal
发明人： SYNTHELABO
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of general formula (I), wherein Z is either a phenyl group optionally substituted by one or two atoms or groups selected from halogens and C1-4 alkyl groups, methoxy, methylthio, methylsulphinyl and methylsulphonyl, or a 5-methylthien-2-yl group, R1 is a hydrogen atom or a C1-4 alkyl group, a cyclopropylmethyl group, a phenylmethyl group or a pyridinylmethyl group, and R2 is a hydrogen atom or a C1-4 alkyl group; and the therapeutical use thereof, are disclosed.
摘要翻译：通式（I）的化合物，其中Z是任选被一个或两个选自卤素和C 1-4烷基的基团的取代基的苯基，甲氧基，甲硫基，甲基亚磺酰基和甲基磺酰基，或5-甲基噻吩-2-基， R 1为氢原子或C 1-4烷基，环丙基甲基，苯甲基或吡啶基甲基，R 2为氢原子或C 1-4烷基; 及其治疗用途。

17. 发明申请

WO1997040052A1 PROPAGYLGLYCINE DERIVATIVES, PREPARATION AND UTILISATION THEREOF AS SYNTHESIS INTERMEDIATES 审中-公开
标题翻译：丙酮衍生物，作为合成中间体的制备和利用
公开(公告)号：WO1997040052A1
公开(公告)日：1997-10-30
申请号：PCT/FR1997000700
申请日：1997-04-18
申请人： SYNTHELABO , CARDINAUD, Isabelle , CHEKROUN, Isaac , ROSSEY, Guy , CREMER, Gérard , GOBERVILLE, Pascale , HOORNAERT, Christian
发明人： SYNTHELABO
IPC分类号： C07D521/00
CPC分类号： C07D233/64 , C07D233/54 , C07D401/06 , C07D401/12 , C07D401/14
摘要： Compounds of formula (I) wherein R2 is -CH2C=CH or -CH2C=C-Het where Het is a 2-aminopyridyl, 2-aminopyrimidyl, 6-aminopyridazinyl, imidazol-4-yl group, R3 and R4 each represent hydrogen, (C1-C4)alkyl, (C1-C4)alkoxycarbonyl, ArCH2CO2- or ArSO2- where Ar is an aryl group, or a group (a) where R7 is hydrogen or -COR, R being straight or branched (C1-C7) alkyl, -(CH2)nOCH3 or -CH2O(C2H4O)nCH3 (n is 1, 2 or 3) and A is chosen among the phenyl, pyrimidyl, pyridinyl, thienyl, thiazolyl and furyl groups, R6 represents either a straight or branched (C1-C4) alkoxy group, or a benzyloxy group or a group (b) where R12 is a hydrogen atom or a carboxylic or (C1-C4)alkoxycarbonyl group and R13 is a straight or branched (C1-C4)alkyl group. They constitute synthesis intermediates.
摘要翻译：其中R2是-CH2C = CH或-CH2C = C-Het的式（Ⅰ）化合物，其中Het是2-氨基吡啶基，2-氨基嘧啶基，6-氨基哒嗪基，咪唑-4-基，R3和R4各自代表氢，（C 1 -C 4）烷基，（C 1 -C 4）烷氧基羰基，ArCH 2 CO 2 - 或ArSO 2 - ，其中Ar为芳基，或（ⅰ）其中R 7为氢或-COR，R为直链或支链烷基， - （CH2）nOCH3或-CH2O（C2H4O）nCH3（n为1,2或3），A选自苯基，嘧啶基，吡啶基，噻吩基，噻唑基和呋喃基，R6表示直链或支链 C1-C4）烷氧基或苄氧基或基团（b），其中R12是氢原子或羧基或（C1-C4）烷氧基羰基，R13是直链或支链（C1-C4）烷基。它们构成合成中间体。

18. 发明申请

WO1997024123A1 USE OF POLYAMINE SITE ANTAGONIST FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF ISCHEMIC DISORDERS OF THE EYE 审中-公开
标题翻译：用于制造治疗眼科疾病的药物的聚氨基酸位点拮抗剂的使用
公开(公告)号：WO1997024123A1
公开(公告)日：1997-07-10
申请号：PCT/EP1996005671
申请日：1996-12-17
申请人： SYNTHELABO
发明人： SYNTHELABO , KAPIN, Michael, A. , DESANTIS, Louis, Jr. , SCATTON, Bernard , LANGER, Salomon
IPC分类号： A61K31/445
CPC分类号： A61K31/445 , Y10S514/912
摘要： The use of polyamine site antagonists in treating ischemic disorders of the retina and optic nerve head are disclosed. Especially preferred are certain 1-phenyl-2-piperidinoalkanol derivatives, such as eliprodil and ifenprodil.
摘要翻译：公开了使用多胺位点拮抗剂治疗视网膜和视神经头的缺血性疾病。特别优选的是1-苯基-2-哌啶子基链烷醇衍生物，例如厄洛替丁和伊芬生。

19. 发明申请

WO1996041635A1 PHARMACEUTICAL COMPOSITIONS CONTAINING A DICLOFENAC SALT AND THIOCOLCHICOSIDE 审中-公开
标题翻译：含有DICLOFENAC盐和三羟甲基氯化物的药物组合物
公开(公告)号：WO1996041635A1
公开(公告)日：1996-12-27
申请号：PCT/FR1996000885
申请日：1996-06-12
申请人： SYNTHELABO , POUCHAIN, Denis , JACOB, Etienne , LEWIS, Gareth , MONTEL, Jean
发明人： SYNTHELABO
IPC分类号： A61K31/70
CPC分类号： A61K31/704 , A61K31/195 , A61K31/70 , A61K45/06 , A61K31/196 , A61K2300/00
摘要： Pharmaceutical compositions containing, in solid form, a diclofenac salt and thiocolchicoside combined with at least one pharmaceutically acceptable carrier are provided for use in therapy.
摘要翻译：提供含有固体形式的与双氯芬酸盐和硫代秋水仙碱组合至少一种药学上可接受的载体的药物组合物用于治疗。

20. 发明申请

WO1998015552A1 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS 审中-公开
标题翻译： 1H-吡啶并[3,4-b]吲哚-4-羧酰胺衍生物，其在治疗中的制备和应用
公开(公告)号：WO1998015552A1
公开(公告)日：1998-04-16
申请号：PCT/FR1997001750
申请日：1997-10-03
申请人： SYNTHELABO , EVANNO, Yannick , SEVRIN, Mireille , MALOIZEL, Christian , LEGALLOUDEC, Odette , GEORGE, Pascal
发明人： SYNTHELABO
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention concerns compounds of general formula (I) in which X represents hydrogen or an halogen or an alkyl, alkoxy, trifluoromethyl or phenylmethoxy group, R1 represents hydrogen or an alkyl, cyclopropyl or phenylmethyl group, R2 represents either an alkyl group optionally substituted, or a phenylalkyl group optionally substituted, or a cyclohexylmethyl group, or a thienylmethyl group, or a pyridinylmethyl group, or a phenyl group optionally substituted, or a pyridinyl group, or a 5-methyl-1,2-oxazolyl group, or a 5-methyl-1,3,4-thiadiazolylgroup, or a naphtalenyl group, R3 and R4 each represent hydrogen or an alkyl, 2-methoxyethyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl or phenylalkyl group, or form together, with the nitrogen atom which carries them, either a pyrrolidinyl group optionally substituted or a piperidinyl group, or a morpholinyl group, or a 4-methylpiperazinyl group, or an azetidinyl group, or a thiazolidinyl group, and the bond between the carbon atoms in positions 3 and 4 is simple or double. The invention is applicable in therapeutics.
摘要翻译：本发明涉及通式（I）的化合物，其中X表示氢或卤素或烷基，烷氧基，三氟甲基或苯基甲氧基，R 1表示氢或烷基，环丙基或苯基甲基，R 2表示任选取代的烷基，或任选取代的苯基烷基，或环己基甲基，或噻吩基甲基或吡啶基甲基，或任选取代的苯基，或吡啶基或5-甲基-1,2-恶唑基或5 - 甲基-1,3,4-噻二唑基或萘基，R3和R4各自表示氢或烷基，2-甲氧基乙基，羟基烷基，羧基烷基，烷氧基羰基烷基或苯基烷基，或与携带它们的氮原子一起形成，任选取代的吡咯烷基或哌啶基，或吗啉基或4-甲基哌嗪基，或氮杂环丁烷基或噻唑烷基，以及碳原子之间的键位置3和4是简单或双重。本发明适用于治疗。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式