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1. 发明申请

WO1998005664A1 6,7,8,9-TETRAHYDRO-5H-IMIDAZO[1,2-a]AZEPINE-3-ACETIC ACID DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF 审中-公开
标题翻译： 6,7,8,9-四氢-5H-咪唑并[1,2-a]亚甲基-3-乙酸衍生物，其制备方法及其治疗用途
公开(公告)号：WO1998005664A1
公开(公告)日：1998-02-12
申请号：PCT/FR1997001365
申请日：1997-07-23
申请人： SYNTHELABO , DE PERETTI, Danièle , EVANNO, Yannick , LEGALLOUDEC, Odette , SEVRIN, Mireille , GEORGE, Pascal
发明人： SYNTHELABO
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Compounds of general formula (I), wherein Z is either a phenyl group optionally substituted by one or two atoms or groups selected from halogens and C1-4 alkyl groups, methoxy, methylthio, methylsulphinyl and methylsulphonyl, or a 5-methylthien-2-yl group, R1 is a hydrogen atom or a C1-4 alkyl group, a cyclopropylmethyl group, a phenylmethyl group or a pyridinylmethyl group, and R2 is a hydrogen atom or a C1-4 alkyl group; and the therapeutical use thereof, are disclosed.
摘要翻译：通式（I）的化合物，其中Z是任选被一个或两个选自卤素和C 1-4烷基的基团的取代基的苯基，甲氧基，甲硫基，甲基亚磺酰基和甲基磺酰基，或5-甲基噻吩-2-基， R 1为氢原子或C 1-4烷基，环丙基甲基，苯甲基或吡啶基甲基，R 2为氢原子或C 1-4烷基; 及其治疗用途。

2. 发明申请

WO1998015552A1 1H-PYRIDO[3,4-b]INDOLE-4-CARBOXAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPEUTICS 审中-公开
标题翻译： 1H-吡啶并[3,4-b]吲哚-4-羧酰胺衍生物，其在治疗中的制备和应用
公开(公告)号：WO1998015552A1
公开(公告)日：1998-04-16
申请号：PCT/FR1997001750
申请日：1997-10-03
申请人： SYNTHELABO , EVANNO, Yannick , SEVRIN, Mireille , MALOIZEL, Christian , LEGALLOUDEC, Odette , GEORGE, Pascal
发明人： SYNTHELABO
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention concerns compounds of general formula (I) in which X represents hydrogen or an halogen or an alkyl, alkoxy, trifluoromethyl or phenylmethoxy group, R1 represents hydrogen or an alkyl, cyclopropyl or phenylmethyl group, R2 represents either an alkyl group optionally substituted, or a phenylalkyl group optionally substituted, or a cyclohexylmethyl group, or a thienylmethyl group, or a pyridinylmethyl group, or a phenyl group optionally substituted, or a pyridinyl group, or a 5-methyl-1,2-oxazolyl group, or a 5-methyl-1,3,4-thiadiazolylgroup, or a naphtalenyl group, R3 and R4 each represent hydrogen or an alkyl, 2-methoxyethyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl or phenylalkyl group, or form together, with the nitrogen atom which carries them, either a pyrrolidinyl group optionally substituted or a piperidinyl group, or a morpholinyl group, or a 4-methylpiperazinyl group, or an azetidinyl group, or a thiazolidinyl group, and the bond between the carbon atoms in positions 3 and 4 is simple or double. The invention is applicable in therapeutics.
摘要翻译：本发明涉及通式（I）的化合物，其中X表示氢或卤素或烷基，烷氧基，三氟甲基或苯基甲氧基，R 1表示氢或烷基，环丙基或苯基甲基，R 2表示任选取代的烷基，或任选取代的苯基烷基，或环己基甲基，或噻吩基甲基或吡啶基甲基，或任选取代的苯基，或吡啶基或5-甲基-1,2-恶唑基或5 - 甲基-1,3,4-噻二唑基或萘基，R3和R4各自表示氢或烷基，2-甲氧基乙基，羟基烷基，羧基烷基，烷氧基羰基烷基或苯基烷基，或与携带它们的氮原子一起形成，任选取代的吡咯烷基或哌啶基，或吗啉基或4-甲基哌嗪基，或氮杂环丁烷基或噻唑烷基，以及碳原子之间的键位置3和4是简单或双重。本发明适用于治疗。

3. 发明专利

SK278142B6 2-(AMINOALKYL)-5-(ARYLALKYL)-1,3-DIOXANES DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE IN THERAPY 未知
公开(公告)号：SK278142B6
公开(公告)日：1996-02-07
申请号：SK183791
申请日：1991-06-14
申请人： RAIZON BERNARD , EVANNO YANNICK , LEGALLOUDEC ODETTE
发明人： RAIZON BERNARD , EVANNO YANNICK , LEGALLOUDEC ODETTE
IPC分类号： A61K31/335 , A61K31/357 , A61P25/08 , A61P25/24 , A61P25/26 , C07D319/06
摘要： Compounds of general formula I, in which m means 0 or 1, n means 1,2,3 or 4, R1 means either atom of hydrogen or methylgroup, R2 means either atom of hydrogen or methylgroup or alkanyle group alkanoyl group of general formula COR' in which R1 means atom of hydrogen or linear or branched of alkyl group with 1 to 4 atoms of carbon, or alkoxycarbonyl group of general formula COOR'', in which R'' means alkyl group, linear or branched, with 1 to 4 atoms of carbon and Ar means either phenyl group, which can carry one or two substituents from group including halogen atoms, alkyl groups with 1 to 4 atoms of carbon, methoxy group and trifluoromethyl group, or 1-naphtyl or 2-naphthyl group, which can carry substituent chosen from group including halogen atoms and methyl, methoxy and cyclopropyl methoxy group. In this article is described method of preparation of these derivatives and their use in therapy a.e.by epilepsy treating.

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