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11. 发明专利

JPH06205653A MINERAL SORPTION PROMOTOR CONTAINING LACTULOSE OLIGOSACCHARIDE AS ACTIVE INGREDIENT 失效
公开(公告)号：JPH06205653A
公开(公告)日：1994-07-26
申请号：JP1685693
申请日：1993-01-08
申请人： SNOW BRAND MILK PROD CO LTD
发明人： TAKADA YUKIHIRO , YANAGIDAIRA SHUICHI , AOE SEIICHIRO , MORITA MINORU , KOBAYASHI TOMOKO , KATO TAKESHI
IPC分类号： A23L33/16 , A61K31/70 , A61K31/702 , A61P3/00 , A61P3/02 , C07H3/06 , A23L1/30 , A23L1/304
摘要： PURPOSE:To obtain a mineral sorption promotor containing a lactulose oligosaccharide as an active ingredient. CONSTITUTION:This mineral sorption promotor contains a lactulose oligosaccharide expressed by the general formula (Gal)n-Fru [Gal is galactose residue and Fr is fructose residue; (n) is integer of 2-3] as an active ingredient. The promotor is useful in prevention and treatment of osteoporosis and other bone diseases, because the promotor can enhance sorption of the minerals by oral administration.

12. 发明专利

JPH0586799B2 失效
公开(公告)号：JPH0586799B2
公开(公告)日：1993-12-14
申请号：JP1338786
申请日：1986-01-24
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YANAGIDAIRA SHUICHI , SHUTSUKE SAKANORI , AHIKO KENKICHI
IPC分类号： C12N1/38 , A23C9/13 , C07H3/06 , C12R1/01

13. 发明专利

JPH0547198B2 失效
公开(公告)号：JPH0547198B2
公开(公告)日：1993-07-16
申请号：JP2968789
申请日：1989-02-10
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SUGURI TOSHIAKI , YANAGIDAIRA SHUICHI , SHUTSUKE SAKANORI
IPC分类号： C12P19/00 , C07H3/06 , C12P19/14

14. 发明专利

JPH0338593A NOVEL OLIGOSACCHARIDE, ITS PRODUCTION AND USE THEREOF 失效
公开(公告)号：JPH0338593A
公开(公告)日：1991-02-19
申请号：JP17160889
申请日：1989-07-03
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SUGURI TOSHIAKI , YANAGIDAIRA SHUICHI , SHUKKE SAKANORI
IPC分类号： C12P19/00 , A61K31/70 , A61K31/702 , A61P1/00 , A61P1/12 , C07H3/06 , C12P19/14
摘要： NEW MATERIAL:O-beta-D-galactopyranosyl-(1 3)-O-beta-D-galactopyranosyl-(1 4)-D- fructose. USE:Bifidus-proliferation promoting agent and constipationameliorating agent. PREPARATION:Lactulose or a lactulose-containing material is treated with beta-glucosidase to effect galactose-transfer reaction.

15. 发明专利

JPH02250834A THERAPEUTIC AGENT FOR DEMYELINATING DISEASES 失效
公开(公告)号：JPH02250834A
公开(公告)日：1990-10-08
申请号：JP7246689
申请日：1989-03-24
申请人： SNOW BRAND MILK PROD CO LTD
发明人： WASHIDA NAOHIRO , FUJI KENTARO , YOSHIDA NORIKO , YANAGIDAIRA SHUICHI , HANAGATA GORO , KOBAYASHI TOMOKO
IPC分类号： A61K31/715 , A61P25/00
摘要： PURPOSE:To obtain a therapeutic agent for demyelinating diseases of high safety with no side effect by using lactosyl ceramide as an active ingredient. CONSTITUTION:A compound of the formula (R1 is an aliphatic group which has 9 to 22 carbon atoms in its straight chain moiety and may have one or more double bonds and/or side-chain methyl and/or hydroxyl; R2 is an acyl group derived from a fatty acid which has an alkyl group of 12 to 30 carbon atoms, saturated or having 1 or more unsaturated bonds and/or hydroxyl groups, occurring in animal tissue such as bovine spleen or human tumors or cow milk. The compound is obtained by extraction from milk or chemical synthesis and the effective dose is 0.1 to 4mg/kg/day in injection or oral administration.

16. 发明专利

JP2008061545A Oligonucleotide for judging coagulase type of staphylococcus aureus 有权
标题翻译：用于判断凝血酶类型的黄连素的寡核苷酸
公开(公告)号：JP2008061545A
公开(公告)日：2008-03-21
申请号：JP2006241576
申请日：2006-09-06
申请人： Juntendo , Snow Brand Milk Prod Co Ltd , 学校法人順天堂 , 雪印乳業株式会社
发明人： SAKAI FUMIHIKO , TAKEMOTO ATSUNORI , IGARASHI HIDEO , AOYAMA KENJI , YANAGIDAIRA SHUICHI , WATANABE MASAYA , ITOU TERUYO
IPC分类号： C12N15/09 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To provide a method for quickly and easily judging the coagulase type of Staphylococcus aureus.
SOLUTION: The method for judging the coagulase type of Staphylococcus aureus comprises conducting a gene amplification using, as primers, oligonucleotide chains nearly specific to a gene of each of coagulase I-VIII types. This method is characterized in comprising specifically amplifying part of the target coagulase gene in DNA in a specimen with at least two oligonucleotides as the primers for the coagulase types.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供一种快速且容易地判断金黄色葡萄球菌的凝固酶类型的方法。解决方案：用于判断金黄色葡萄球菌凝固酶类型的方法包括使用几乎特异于凝固酶I-VIII型基因的寡核苷酸链作为引物进行基因扩增。该方法的特征在于，将具有至少两个寡核苷酸的样本中的DNA中的部分靶凝固酶基因特异性扩增作为凝固酶类型的引物。版权所有（C）2008，JPO＆INPIT

17. 发明专利

JP2001269169A NEW alpha-L-FUCOSIDASE 失效
公开(公告)号：JP2001269169A
公开(公告)日：2001-10-02
申请号：JP2000085199
申请日：2000-03-24
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SAKAI FUMIHIKO , MORITA MINORU , SERIZAWA ATSUSHI , YANAGIDAIRA SHUICHI
IPC分类号： C12N9/24
摘要： PROBLEM TO BE SOLVED: To obtain a new α-L-fucosidase having a new substrate specificity and to provide a method for producing the new α-L-fucosidase economically and advantageously. SOLUTION: This method for producing the α-L-fucoside comprises extracting the α-L-fucosidase from the internal organ of sea urchin with an aqueous medium to give an extracted solution and purifying the extracted solution. The α-L-fucosidase hydrolyzes an α-L-fucoside bond of p-nitrophenyl-α-L-fucoside or a saccharide containing a fucose residue bonded through an α-1-3 bond to a sugar chain reducing end as a substrate and liberates L-fucose. The α-L- fucosidase has the optimum pH in the vicinity of 2.5 and 6.5 in the case of p-nitrophenyl-α-L-fucoside as a substrate, about 52,000 molecular weight by a polyacrylamide gel electrophoresis method and about 200,000 by a gel filtration method. The α-L-fucosidase is industrially advantageously produced from the internal organ of sea urchin and the substrate specificity of the α-L-fucosidase is used for structural analysis of complex carbohydrate sugar chain and functional study of sugar chain.

18. 发明专利

JP2001158735A AGENT FOR PREVENTING AND IMPROVING PERIODONTAL DISEASE 失效
公开(公告)号：JP2001158735A
公开(公告)日：2001-06-12
申请号：JP34017499
申请日：1999-11-30
申请人： SNOW BRAND MILK PROD CO LTD
发明人： TAKADA YUKIHIRO , MATSUBARA NORIYOSHI , YANAGIDAIRA SHUICHI , KAWAKAMI HIROSHI , AOE SEIICHIRO
IPC分类号： A23L1/30 , A61K8/00 , A61K8/42 , A61K8/68 , A61K31/164 , A61K31/688 , A61K31/7032 , A61P1/02 , A61P19/00 , A61Q11/00 , A61K7/16
摘要： PROBLEM TO BE SOLVED: To provide an agent for preventing and improving periodontal disease, and to provide a drink, food or feed to which an effect for preventing and improving the periodontal disease is imparted. SOLUTION: This agent for preventing or improving the periodontal disease, containing a sphingosine skeleton-having compound such as ceramide, sphingomyelin, a sphingoglycolipid or ganglioside as an active ingredient, or containing the sphingosine skeleton-having compound and further suitably one or more substances selected from calcium agents, vitamin D and vitamin K.

19. 发明专利

JP2000300184A THICKENING STABILIZER 失效
公开(公告)号：JP2000300184A
公开(公告)日：2000-10-31
申请号：JP11323399
申请日：1999-04-21
申请人： SNOW BRAND MILK PROD CO LTD
发明人： MORITA MINORU , SERIZAWA ATSUSHI , MOCHIJI WATARU , YAMAMOTO HARUTAKA , YANAGIDAIRA SHUICHI
IPC分类号： A23J3/00 , A23J3/04 , A23J3/08 , A23J3/16 , C09K3/00
摘要： PROBLEM TO BE SOLVED: To obtain a thickening stabilizer for protein capable of imparting a protein-containing solution or a protein-containing gel with thickening stability by the addition of an extremely small amount by using urea as an active component. SOLUTION: The objective thickening stabilizer for protein is produced by using urea as an active component. The urea to be used in the stabilizer may be chemically synthesized or collected from a natural source such as a urea- containing composition obtained by treating milk, etc. with a nano-filtration membrane or reverse osmosis membrane. Different from conventional thickening stabilizer, urea does not exhibit the thickening stabilizing effect by itself and the effect is developed only in the case of using together with protein. The thickening stabilizing effect of urea can be attained at an extremely small amount. The concentration sufficient for attaining the effect is as low as 0.001-0.1% based on the protein-containing solution or the protein-containing gel having a protein content of >=0.5% and, in most cases, the effect can be attained even at a concentration of

20. 发明专利

JPH07316177A NEW OLIGOSACCHARIDE, PRODUCTION AND USE THEREOF 失效
公开(公告)号：JPH07316177A
公开(公告)日：1995-12-05
申请号：JP32652594
申请日：1994-12-28
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YANAGIDAIRA SHUICHI , SUGURI TOSHIAKI , IKEUCHI YOSHIHIRO , MATSUBARA NORIYOSHI , AOE SEIICHIRO
IPC分类号： A23L1/30 , A61K31/70 , A61K31/7008 , A61K31/702 , A61K31/7024 , A61P3/00 , A61P43/00 , C07H3/06 , C07H5/06 , C07H13/04
摘要： PURPOSE:To obtain a new oligosaccharide bound to N-acetylneuramic acid, capable of increasing mineral absorbing property by oral administration and useful for preventing and treating osteoporosis and other bone diseases. CONSTITUTION:An oligosaccharide bound to N-acetylneuramic acid of the formula (Gal)n-Neu5Ac [Gal is galactose; Neu5Ac is N-acetylneuramic acid; (n) is an integral of 1-2]. The oligosaccharide is blended to provide a machine, a food or beverage or a feed enhanced in absorption of mineral. The oligosaccharide bound to N-acetylneuramic acid can be produced by reacting lactic acid and N-acetylneuramic acid with beta-galactosidase to carry out galactose transfer reaction.

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