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11. 发明申请

WO2004035743A8 SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS 审中-公开
标题翻译： KETO氨基酸在蛋白质中的位点特异性引入
公开(公告)号：WO2004035743A8
公开(公告)日：2005-06-09
申请号：PCT/US0332576
申请日：2003-10-15
申请人： SCRIPPS RESEARCH INST , SCHULTZ PETER G , WANG LEI
发明人： SCHULTZ PETER G , WANG LEI
IPC分类号： C07K14/47 , C12N9/00 , C12N15/10 , C12N15/67 , C12P21/00 , C12N
CPC分类号： C12N15/67 , C12N9/93 , C12N15/10 , C12P21/005
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.
摘要翻译：提供了生产蛋白质生物合成机器组分的组合物和方法，所述组合物包括正交tRNA，正交氨酰-tRNA合成酶和正交配对的tRNA /合成酶，其将酮氨基酸掺入蛋白质中。还提供了用于鉴定这些正交配对的方法以及使用这些正交配对产生具有酮基氨基酸的蛋白质的方法。

12. 发明申请

WO2010059401A3 COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS 审中-公开
标题翻译：扩增造血干细胞的化合物
公开(公告)号：WO2010059401A3
公开(公告)日：2010-09-23
申请号：PCT/US2009062646
申请日：2009-10-29
申请人： IRM LLC , SCRIPPS RESEARCH INST , BOITANO ANTHONY , COOKE MICHAEL , PAN SHIFENG , SCHULTZ PETER G , TELLEW JOHN , WAN YONGQIN , WANG XING
发明人： BOITANO ANTHONY , COOKE MICHAEL , PAN SHIFENG , SCHULTZ PETER G , TELLEW JOHN , WAN YONGQIN , WANG XING
IPC分类号： A61K31/519 , A61K31/52 , A61P37/00 , C07D473/34 , C07D487/04
CPC分类号： A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
摘要： The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
摘要翻译：本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。本发明还涉及包含扩增的造血干细胞（HSC）的细胞群及其在自体或同种异体移植中的用途，用于治疗患有遗传性免疫缺陷和自身免疫疾病以及不同造血障碍的患者，以重建造血细胞谱系和免疫系统防御。

13. 发明申请

WO2005081632A3 ENZYMES, CELLS AND METHODS FOR SITE SPECIFIC RECOMBINATION AT ASYMMETRIC SITES 审中-公开
标题翻译：不对称站点特异性重组的酶，细胞和方法
公开(公告)号：WO2005081632A3
公开(公告)日：2009-09-03
申请号：PCT/IL2005000230
申请日：2005-02-24
申请人： ISRAEL STATE , SCRIPPS RESEARCH INST , CARMI NIR , EYAL YORAM , GIDONI DAVID , SCHULTZ PETER G , SANTORO STEPHEN W
发明人： CARMI NIR , EYAL YORAM , GIDONI DAVID , SCHULTZ PETER G , SANTORO STEPHEN W
IPC分类号： C12N9/22
CPC分类号： C12N9/00 , C12N15/902 , C12N2800/30
摘要： The present invention relates to enzymes, compositions and methods for catalyzing asymmetric recombination of non-palindromic recombination sites in a cell free system, in isolated cells or in living organisms. The enzymes and methods of the invention are suitable for mediating specific recombinations between DNA sequences comprising specific recombination sites without being limited to strict palindromic symmetry within each recombination site.
摘要翻译：本发明涉及在无细胞系统，分离的细胞或活生物体中催化非回归重组位点的不对称重组的酶，组合物和方法。本发明的酶和方法适用于介导包含特异性重组位点的DNA序列之间的特异性重组，而不限于每个重组位点内严格的回文对称性。

14. 发明申请

WO2009059056A3 A GENETICALLY ENCODED BORONATE AMINO ACID 审中-公开
标题翻译：一种基因编码的二硼酸氨基酸
公开(公告)号：WO2009059056A3
公开(公告)日：2009-08-20
申请号：PCT/US2008081868
申请日：2008-10-30
申请人： SCRIPPS RESEARCH INST , BRUSTAD ERIC , BUSHEY MARK L , SCHULTZ PETER G
发明人： BRUSTAD ERIC , BUSHEY MARK L , SCHULTZ PETER G
IPC分类号： C12N9/00
CPC分类号： C12P13/222 , C07K17/06 , C12N9/93 , C12N15/67 , C12P21/02
摘要： Provided are compositions comprising an aminoacyl tRNA synthetase that selectively recognizes a boronic amino acid. Methods of incorporating a boronic amino acid into a target polypeptides and target polypeptides produced by the methods are also provided. Methods of producing a protein, which methods comprise site-specifically encoding a boronic amino acid residue into a mutant protein and selectively converting the boronic amino acid residue into a natural amino acid residue are provided. Also provided are compositions comprising a solid phase matrix covalently bound to a polypeptide through a boronic amino acid residue. In addition, compositions comprising a purified population of polypeptide molecules that each comprise a borono amino acid at a selected site are provided.
摘要翻译：提供了包含选择性识别硼酸氨基酸的氨酰基tRNA合成酶的组合物。还提供了将硼酸氨基酸掺入靶多肽和通过该方法产生的靶多肽的方法。提供了产生蛋白质的方法，该方法包括将硼酸氨基酸残基特异性编码到突变蛋白中并选择性地将硼酸氨基酸残基转化成天然氨基酸残基。还提供了包含通过硼酸氨基酸残基与多肽共价结合的固相基质的组合物。此外，提供了包含纯化的多肽分子群的组合物，其各自包含选定位点的硼氢氨基酸。

15. 发明申请

WO2008073184A2 GENETIC INCORPORATION OF UNNATURAL AMINO ACIDS INTO PROTEINS IN MAMMALIAN CELLS 审中-公开
标题翻译：遗传性纳入氨基酸进入马马里亚细胞中的蛋白质
公开(公告)号：WO2008073184A2
公开(公告)日：2008-06-19
申请号：PCT/US2007022232
申请日：2007-10-17
申请人： SCRIPPS RESEARCH INST , LIU WENSHE , SCHULTZ PETER G
发明人： LIU WENSHE , SCHULTZ PETER G
IPC分类号： C12N5/10 , C12N5/16 , C12N5/18 , C12P21/04
CPC分类号： C12N9/93 , C12P21/02
摘要： The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins in mammalian host cells, for example, primate host cells and rodent host cells. The invention provides, for example but not limited to, translation systems that include host cells (e.g., primate or rodent cells), orthogonal aminoacyl-tRNA synthetases derived from eubacterial synthetases, orthogonal tRNAs, and the unnatural amino acid. The invention also relates to methods for producing proteins of interest comprising at least one unnatural amino acid in mammalian host cell systems.
摘要翻译：本发明涉及可将哺乳动物宿主细胞（例如灵长类动物宿主细胞和啮齿动物宿主细胞）中的蛋白质中含有非天然氨基酸的tRNA和氨酰-tRNA合成酶的正交对。本发明提供了例如但不限于包含宿主细胞（例如灵长类或啮齿动物细胞），衍生自真细菌合成酶，正交tRNA和非天然氨基酸的正交氨酰-tRNA合成酶的翻译系统。本发明还涉及用于在哺乳动物宿主细胞系统中生产包含至少一种非天然氨基酸的目的蛋白质的方法。

16. 发明申请

WO2004094593A3 EXPANDING THE EUKARYOTIC GENETIC CODE 审中-公开
标题翻译：扩展“原始遗传代码”
公开(公告)号：WO2004094593A3
公开(公告)日：2007-12-21
申请号：PCT/US2004011786
申请日：2004-04-16
申请人： SCRIPPS RESEARCH INST , CHIN JASON W , CROPP ASHTON T , ANDERSON CHRISTOPHER J , SCHULTZ PETER G
发明人： CHIN JASON W , CROPP ASHTON T , ANDERSON CHRISTOPHER J , SCHULTZ PETER G
IPC分类号： C12N9/10 , C07H21/04 , C12N20060101 , C12N9/16 , C12N9/22 , C12N15/00 , C12N15/10 , C12N15/12 , C12N15/54 , C12P21/00 , C12P21/06 , C12Q1/68
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译：本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。

17. 发明申请

WO2005116237A3 SITE SPECIFIC INCORPORATION OF HEAVY ATOM-CONTAINING UNNATURAL AMINO ACIDS INTO PROTEINS FOR CRYSTAL STRUCTURE DETERMINATION 审中-公开
标题翻译：含有重要氨基酸含量的氨基酸成为蛋白质结构测定的现场特异性
公开(公告)号：WO2005116237A3
公开(公告)日：2007-04-19
申请号：PCT/US2005018168
申请日：2005-05-24
申请人： SCRIPPS RESEARCH INST , IRM LLC , XIE JIANMING , WANG LEI , WU NING , SCHULTZ PETER G , SPRAGGON GLEN
发明人： XIE JIANMING , WANG LEI , WU NING , SCHULTZ PETER G , SPRAGGON GLEN
IPC分类号： C12N9/22 , C07H21/02 , C07H21/04 , C12N1/21 , C12N9/00 , C12N9/10 , C12N15/12 , C12N15/54 , C12N15/67 , C12P21/02 , C12P21/06 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： C12N9/93 , C07H21/04 , C12N15/67 , C12P21/02
摘要： Translation systems and other compositions including orthogonal aminoacyl tRNA-synthetases that preferentially charge an orthogonal tRNA with an iodinated or brominated amino acid are provided. Nucleic acids encoding such synthetases are also described, as are methods and kits for producing proteins including heavy atom-containing amino acids, e.g., brominated or iodinated amino acids. Methods of determining the structure of a protein, e.g., a protein into which a heavy atom has been site-specifically incorporated through use of an orthogonal tRNA/aminoacyl tRNA-synthetase pair, are also described.
摘要翻译：提供了翻译系统和包括正交氨酰基tRNA合成酶的其它组合物，其优先用碘化或溴化氨基酸对正交的tRNA进行充电。还描述了编码这种合成酶的核酸，以及用于产生蛋白质的方法和试剂盒，包括含重原子的氨基酸，例如溴化或碘化氨基酸。还描述了确定蛋白质结构的方法，例如通过使用正交的tRNA /氨基酰基tRNA-合成酶对将重原子特异性并入的蛋白质的蛋白质。

18. 发明申请

WO2005019415A3 COMPOSITIONS OF ORTHOGONAL LYSYL-TRNA AND AMINOACYL-TRNA SYNTHETASE PAIRS AND USES THEREOF 审中-公开
标题翻译：正交LYSYL-TRNA和氨基酸-TNA合成酶对的组成及其用途
公开(公告)号：WO2005019415A3
公开(公告)日：2007-01-25
申请号：PCT/US2004022187
申请日：2004-07-07
申请人： SCRIPPS RESEARCH INST , ANDERSON J CHRISTOPHER , WU NING , SANTORO STEPHEN , SCHULTZ PETER G
发明人： ANDERSON J CHRISTOPHER , WU NING , SANTORO STEPHEN , SCHULTZ PETER G
IPC分类号： C12P21/02 , C07H21/02 , C12N20060101 , C12N1/21 , C12N9/00 , C12N15/74 , C12P21/00
CPC分类号： C12P21/02 , C12N9/93 , C12N15/70 , C12P21/00
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of lysyl-tRNAs/synthetases, which incorporate homoglutamines into proteins are provided in response to a four base codon. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with homoglutamines using these orthogonal pairs.
摘要翻译：提供了蛋白质生物合成机理的组成和方法，其包括正交赖氨酰-tRNA，正交赖氨酰 - 酰基-tRNA合成酶和将高聚谷氨酰胺掺入蛋白质的正交对的赖氨酰-tRNA /合成酶，以响应于四碱基密码子。还提供用于鉴定这些正交对的方法以及使用这些正交对产生具有高谷氨酰胺的蛋白质的方法。

19. 发明申请

WO2006045116A2 IN VIVO SITE-SPECIFIC INCORPORATION OF N-ACETYL-GALACTOSAMINE AMINO ACIDS IN EUBACTERIA 审中-公开
标题翻译： N-乙酰半乳糖氨基酸氨基酸在体内的特异性结合
公开(公告)号：WO2006045116A2
公开(公告)日：2006-04-27
申请号：PCT/US2005038250
申请日：2005-10-20
申请人： SCRIPPS RESEARCH INST , SCHULTZ PETER G , HANSON SARAH R , XU RAN , ZHANG ZHIWEN , WONG CHI-HUEY
发明人： SCHULTZ PETER G , HANSON SARAH R , XU RAN , ZHANG ZHIWEN , WONG CHI-HUEY
IPC分类号： C12P21/06 , C07H21/04 , C12N1/21 , C12N9/22 , C12N15/74 , C12P19/34
CPC分类号： C12P21/005 , C12N9/93 , C12N15/67
摘要： Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-cetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
摘要翻译：提供了用于在体外和体内制备糖蛋白的方法和组合物。一种方法涉及将具有N-十六烷基半乳糖胺部分的非天然氨基酸掺入蛋白质中; 任选地，可以用另外的糖进一步修饰含有N-乙酰半乳糖胺的非天然氨基酸。

20. 发明申请

WO2005007624A3 COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF 审中-公开
标题翻译：正交谷氨酰-tRNA和氨基酸TRNA合成酶对的组成及其用途
公开(公告)号：WO2005007624A3
公开(公告)日：2006-03-30
申请号：PCT/US2004021813
申请日：2004-07-07
申请人： SCRIPPS RESEARCH INST , ANDERSON CHRISTOPHER J , SCHULTZ PETER G , SANTORO STEPHEN
发明人： ANDERSON CHRISTOPHER J , SCHULTZ PETER G , SANTORO STEPHEN
IPC分类号： C07D20060101 , C12N9/00 , C12N9/10 , C12N15/12 , C12N15/54 , C12P21/00
CPC分类号： C12N9/93
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of glutamyl tRNAs/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
摘要翻译：提供了包括谷氨酰正交tRNA，谷氨酰正交氨酰-tRNA合成酶和正戊基谷氨酰tRNA /合成酶对蛋白质生物合成机理成分的组合物和方法。还提供用于鉴定这些正交对的方法以及使用这些正交对产生蛋白质的方法。

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