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11. 发明授权

US09340416B2 Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems 有权
标题翻译：多核苷酸和相关的纳米组件，结构，布置，方法和系统
公开(公告)号：US09340416B2
公开(公告)日：2016-05-17
申请号：US12540052
申请日：2009-08-12
申请人： Hareem T. Maune , Si-Ping Han , Robert D. Barish , Marc W. Bockrath , William A. Goddard, III , Paul W. K. Rothemund , Erik Winfree
发明人： Hareem T. Maune , Si-Ping Han , Robert D. Barish , Marc W. Bockrath , William A. Goddard, III , Paul W. K. Rothemund , Erik Winfree
IPC分类号： C07H21/02 , C40B40/04 , B82B1/00 , B82Y30/00
CPC分类号： B82B1/00 , B82Y30/00
摘要： A linker polynucleotide for attaching a nanomaterial to a polynucleotidic platform and related nanoassemblies, arrangements, structures, methods and systems.
摘要翻译：用于将纳米材料附着到多核苷酸平台和相关纳米组件，布置，结构，方法和系统的接头多核苷酸。

12. 发明授权

US09029524B2 Signal activated RNA interference 有权
公开(公告)号：US09029524B2
公开(公告)日：2015-05-12
申请号：US12316372
申请日：2008-12-10
申请人： Si-Ping Han , Robert D. Barish , William A. Goddard, III
发明人： Si-Ping Han , Robert D. Barish , William A. Goddard, III
IPC分类号： C07H21/04 , C07H21/02 , C12N15/11
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/3517 , C12N2310/3519 , C12N2310/53 , C12N2320/10
摘要： The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize diseased states of the cell. The interaction between the subject polynucleotides and the signals is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a substrate that can be processed by proteins of the RNAi pathway (such as Dicer). The input and output of multiple different polynucleotides of the invention can form an in vivo signaling network. In addition, the multiple input signals can be integrated to modulate the activity of the subject polynucleotides.

13. 发明申请

US20100048421A1 NANOCOMPOSITE STRUCTURES AND RELATED METHODS AND SYSTEMS 有权
标题翻译：纳米复合结构及相关方法和系统
公开(公告)号：US20100048421A1
公开(公告)日：2010-02-25
申请号：US12540027
申请日：2009-08-12
申请人： Si-Ping HAN , Hareem Maune , Robert D. Barish , William A. Goddard, III
发明人： Si-Ping HAN , Hareem Maune , Robert D. Barish , William A. Goddard, III
IPC分类号： C40B40/04 , C07H21/00 , C40B50/14
CPC分类号： B82B1/00 , B82Y30/00
摘要： The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation between nanomaterials such as carbon nanotubes.
摘要翻译：本公开涉及纳米管复合结构及相关方法和系统。特别地，本文提供了结构，方法和系统，以允许诸如碳纳米管之类的纳米材料之间的精确的，可调节的分离。

14. 发明授权

US07074270B2 Method for predicting the behavior of dopant and defect components 失效
标题翻译：用于预测掺杂剂和缺陷组分的行为的方法
公开(公告)号：US07074270B2
公开(公告)日：2006-07-11
申请号：US10406033
申请日：2003-04-02
申请人： Yuzuru Sato , Masamitsu Uehara , Gyeong S. Hwang , William A. Goddard, III
发明人： Yuzuru Sato , Masamitsu Uehara , Gyeong S. Hwang , William A. Goddard, III
IPC分类号： C30B1/00
CPC分类号： H01L21/26513 , G06F17/5018 , G06F2217/10 , H01L21/26566 , H01L21/2658
摘要： Techniques for predicting the behavior of dopant and defect components in a substrate lattice formed from a substrate material can be implemented in hardware or software. Fundamental data for a set of microscopic processes that can occur during one or more material processing operations is obtained. Such data can include data representing the kinetics of processes in the set of microscopic processes and the energetics and structure of possible states in the material processing operations. From the fundamental data and a set of external conditions, distributions of dopant and defect components in the substrate lattice are predicted. The distributions of one or more fast components are each predicted by calculating the concentration of the particular fast component for a time period before that fast component reaches its pseudo steady state by solving a first relationship and calculating the concentration of that fast component after the time period by solving a second relationship based on other components, the pseudo steady state of a fast component being a state in which the concentration of that fast component is determined by concentrations of other components. The distribution of Bs3Bi, in addition to the distributions of Bs, BsI, BsI2, BsI3, BsBi, BsBi2, BsBi3, BsBiI, BsBiI2, Bs2Bi, Bs2Bi2, I and In, are calculated by solving the first relationship to predict the distribution of boron after annealing, where Bs and Bi represent substitutional boron and interstitial boron, respectively, and I and In represent interstitial silicon and a cluster of n I's, respectively.
摘要翻译：用于预测由衬底材料形成的衬底晶格中的掺杂剂和缺陷组分的行为的技术可以在硬件或软件中实现。获得可在一个或多个材料加工操作期间发生的一组微观工艺的基本数据。这样的数据可以包括表示微观过程集合中的过程的动力学的数据，以及材料处理操作中可能状态的能量学和结构。从基础数据和一组外部条件，预测衬底晶格中的掺杂剂和缺陷组分的分布。一个或多个快速分量的分布各自通过在该快速分量达到其伪稳态之前的时间段内计算特定快速分量的浓度来求解第一关系并计算该时间段之后该快分量的浓度通过解决基于其他成分的第二关系，快速成分的伪稳定状态是通过其他成分的浓度来确定该快速成分的浓度的状态。除了Bs，BsI，BsI2，BsI3，BsBi，BsBi，BsBi，BsBi， 2，BsBi 3，BsBiI，BsBi1 2，Bs2 Bi，Bs2 Bi，通过求解第一关系来计算退火后硼的分布，其中Bs和Bi分别代表取代硼和间隙硼，并且 I和I分别表示间隙硅和n I的簇。

15. 发明授权

US06777510B1 Internal Lewis acid single site catalyst family for polymerization of polar monomers 失效
标题翻译：用于极性单体聚合的内部路易斯酸单位点催化剂族
公开(公告)号：US06777510B1
公开(公告)日：2004-08-17
申请号：US09954518
申请日：2001-09-12
申请人： Dean M. Philipp , Richard P. Muller , William A. Goddard, III
发明人： Dean M. Philipp , Richard P. Muller , William A. Goddard, III
IPC分类号： C08F470
CPC分类号： C08F20/12 , C08F10/00 , C08F4/7006
摘要： Rational combinatorial computational methods use accurate quantum mechanical and molecular modeling techniques to identify optimum polymerization catalysts for polar olefins. Using mechanistic information to model the polymerization reaction, the methods systematically vary components of a catalyst template to calculate a potential energy surface for a number of catalyst candidates. The potential energy surfaces are compared to identify a catalyst for the catalytic polymerization reaction. Internal Lewis acid single site polar olefin polymerization catalyst compositions and compounds for polymerizing polar olefins are also described.
摘要翻译：理性组合计算方法使用精确的量子力学和分子模拟技术来鉴定极性烯烃的最佳聚合催化剂。使用机械信息来模拟聚合反应，该方法系统地改变催化剂模板的组分以计算许多催化剂候选物的势能表面。比较势能表面以鉴定用于催化聚合反应的催化剂。还描述了内部路易斯酸单位极性烯烃聚合催化剂组合物和用于聚合极性烯烃的化合物。

16. 发明授权

US09272051B2 Methods and systems for modulating hormones and related methods, agents and compositions 有权
标题翻译：用于调节激素和相关方法，药剂和组合物的方法和系统
公开(公告)号：US09272051B2
公开(公告)日：2016-03-01
申请号：US14320159
申请日：2014-06-30
申请人： William A. Goddard, III , Mark Menna , Stephen Pandol , Ravinder Abrol
发明人： William A. Goddard, III , Mark Menna , Stephen Pandol , Ravinder Abrol
IPC分类号： A61K31/513 , A61K31/704 , A61K31/352 , A61K31/122 , A61K31/12 , A61K31/353 , A61K47/48 , A61K31/10 , A61K31/167 , A61K31/205 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/7016 , G01N33/566 , A61K31/17
CPC分类号： G01N33/566 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/167 , A61K31/17 , A61K31/205 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/513 , A61K31/7016 , A61K31/704 , A61K47/61 , G01N2333/705
摘要： Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
摘要翻译：本文提供了苦味味受体配体，相关试剂，组合，组合物，方法和系统，用于在个体的胃肠道的细胞体外或体内调节代谢激素的释放。

17. 发明授权

US08796233B2 Methods and systems for modulating hormones and related methods, agents and compositions 有权
标题翻译：用于调节激素和相关方法，药剂和组合物的方法和系统
公开(公告)号：US08796233B2
公开(公告)日：2014-08-05
申请号：US13163638
申请日：2011-06-17
申请人： William A. Goddard, III , Mark Menna , Stephen Pandol , Ravinder Abrol
发明人： William A. Goddard, III , Mark Menna , Stephen Pandol , Ravinder Abrol
IPC分类号： A61K31/704 , A61K31/10 , A61K31/12 , A61K31/122 , A61K47/48
CPC分类号： G01N33/566 , A61K31/10 , A61K31/12 , A61K31/122 , A61K31/167 , A61K31/17 , A61K31/205 , A61K31/352 , A61K31/353 , A61K31/365 , A61K31/4375 , A61K31/4745 , A61K31/513 , A61K31/7016 , A61K31/704 , A61K47/61 , G01N2333/705
摘要： Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of the GI tract of an individual.
摘要翻译：本文提供了苦味味受体配体，相关试剂，组合，组合物，方法和系统，用于在个体的胃肠道的细胞体外或体内调节代谢激素的释放。

18. 发明授权

US08710199B2 Signal activated molecular delivery 有权
标题翻译：信号激活分子递送
公开(公告)号：US08710199B2
公开(公告)日：2014-04-29
申请号：US13167672
申请日：2011-06-23
申请人： Si-Ping Han , William A. Goddard, III , Lisa Scherer , John J. Rossi
发明人： Si-Ping Han , William A. Goddard, III , Lisa Scherer , John J. Rossi
IPC分类号： C07H21/00 , C12N15/113
CPC分类号： C12N15/87 , C12N15/111 , C12N2310/14 , C12N2310/3519 , C12N2320/32 , C12N2320/50
摘要： Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.
摘要翻译：本文提供了用于酶辅助递送分子和相关组分的信号激活分子构建体，例如传感器结构域，组合物，方法和系统。

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