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1. 发明授权

US09340416B2 Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems 有权
标题翻译：多核苷酸和相关的纳米组件，结构，布置，方法和系统
公开(公告)号：US09340416B2
公开(公告)日：2016-05-17
申请号：US12540052
申请日：2009-08-12
申请人： Hareem T. Maune , Si-Ping Han , Robert D. Barish , Marc W. Bockrath , William A. Goddard, III , Paul W. K. Rothemund , Erik Winfree
发明人： Hareem T. Maune , Si-Ping Han , Robert D. Barish , Marc W. Bockrath , William A. Goddard, III , Paul W. K. Rothemund , Erik Winfree
IPC分类号： C07H21/02 , C40B40/04 , B82B1/00 , B82Y30/00
CPC分类号： B82B1/00 , B82Y30/00
摘要： A linker polynucleotide for attaching a nanomaterial to a polynucleotidic platform and related nanoassemblies, arrangements, structures, methods and systems.
摘要翻译：用于将纳米材料附着到多核苷酸平台和相关纳米组件，布置，结构，方法和系统的接头多核苷酸。

2. 发明授权

US09102520B2 Nanocomposite structures and related methods and systems 有权
标题翻译：纳米复合结构及相关方法和系统
公开(公告)号：US09102520B2
公开(公告)日：2015-08-11
申请号：US12540027
申请日：2009-08-12
申请人： Si-Ping Han , Hareem Maune , Robert D. Barish , William A. Goddard, III
发明人： Si-Ping Han , Hareem Maune , Robert D. Barish , William A. Goddard, III
IPC分类号： C07H21/02 , C40B40/04 , B82B1/00 , B82Y30/00
CPC分类号： B82B1/00 , B82Y30/00
摘要： The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation between nanomaterials such as carbon nanotubes.
摘要翻译：本公开涉及纳米管复合结构及相关方法和系统。特别地，本文提供了结构，方法和系统，以允许诸如碳纳米管之类的纳米材料之间的精确的，可调节的分离。

3. 发明授权

US09029524B2 Signal activated RNA interference 有权
公开(公告)号：US09029524B2
公开(公告)日：2015-05-12
申请号：US12316372
申请日：2008-12-10
申请人： Si-Ping Han , Robert D. Barish , William A. Goddard, III
发明人： Si-Ping Han , Robert D. Barish , William A. Goddard, III
IPC分类号： C07H21/04 , C07H21/02 , C12N15/11
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/141 , C12N2310/3517 , C12N2310/3519 , C12N2310/53 , C12N2320/10
摘要： The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form and an active form upon covalent or non-covalent interaction with one or more specific chemical signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize diseased states of the cell. The interaction between the subject polynucleotides and the signals is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a substrate that can be processed by proteins of the RNAi pathway (such as Dicer). The input and output of multiple different polynucleotides of the invention can form an in vivo signaling network. In addition, the multiple input signals can be integrated to modulate the activity of the subject polynucleotides.

4. 发明申请

US20100048421A1 NANOCOMPOSITE STRUCTURES AND RELATED METHODS AND SYSTEMS 有权
标题翻译：纳米复合结构及相关方法和系统
公开(公告)号：US20100048421A1
公开(公告)日：2010-02-25
申请号：US12540027
申请日：2009-08-12
申请人： Si-Ping HAN , Hareem Maune , Robert D. Barish , William A. Goddard, III
发明人： Si-Ping HAN , Hareem Maune , Robert D. Barish , William A. Goddard, III
IPC分类号： C40B40/04 , C07H21/00 , C40B50/14
CPC分类号： B82B1/00 , B82Y30/00
摘要： The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation between nanomaterials such as carbon nanotubes.
摘要翻译：本公开涉及纳米管复合结构及相关方法和系统。特别地，本文提供了结构，方法和系统，以允许诸如碳纳米管之类的纳米材料之间的精确的，可调节的分离。

5. 发明授权

US08710199B2 Signal activated molecular delivery 有权
标题翻译：信号激活分子递送
公开(公告)号：US08710199B2
公开(公告)日：2014-04-29
申请号：US13167672
申请日：2011-06-23
申请人： Si-Ping Han , William A. Goddard, III , Lisa Scherer , John J. Rossi
发明人： Si-Ping Han , William A. Goddard, III , Lisa Scherer , John J. Rossi
IPC分类号： C07H21/00 , C12N15/113
CPC分类号： C12N15/87 , C12N15/111 , C12N2310/14 , C12N2310/3519 , C12N2320/32 , C12N2320/50
摘要： Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.
摘要翻译：本文提供了用于酶辅助递送分子和相关组分的信号激活分子构建体，例如传感器结构域，组合物，方法和系统。

6. 发明申请

US20110184204A1 CATALYTIC SYSTEMS FOR THE CONVERSION OF HYDROCARBONS TO FUNCTIONALIZED PRODUCTS 审中-公开
标题翻译：用于将碳氢化合物转化为功能化产品的催化体系
公开(公告)号：US20110184204A1
公开(公告)日：2011-07-28
申请号：US13022434
申请日：2011-02-07
申请人： ROY A. PERIANA , William A. Goddard, III
发明人： ROY A. PERIANA , William A. Goddard, III
IPC分类号： C07F17/02 , C07C27/16 , C07C37/60 , G01N33/20
CPC分类号： C07C29/48 , B01J27/0573 , B01J31/1805 , C07B33/00 , C07C37/58 , C07C37/60 , Y02P20/52 , C07C31/04 , C07C39/04
摘要： This invention discloses methods and processes for selectively converting hydrocarbons such as methane to materials such as alcohols or other materials containing more reactive functionalities.
摘要翻译：本发明公开了用于选择性地将诸如甲烷的烃转化为诸如醇或其它含有更多反应性官能团的材料的材料的方法和方法。

7. 发明授权

US5939503A Group IV zwitterion ansa metallocene (ZAM) catalysts for .alpha.-olefin polymerization 失效
标题翻译：用于α-烯烃聚合的第IV族两性离子金属茂（ZAM）催化剂
公开(公告)号：US5939503A
公开(公告)日：1999-08-17
申请号：US907395
申请日：1997-08-07
申请人： William A. Goddard, III , Christopher Brandow
发明人： William A. Goddard, III , Christopher Brandow
IPC分类号： B01J31/00 , C07F7/24 , C07F9/00 , C07F11/00 , C07F15/00 , C07F17/00 , C08F4/06 , C08F4/44 , C08F4/639 , C08F10/00
CPC分类号： C07F17/00 , C08F10/00 , C08F4/63908
摘要： Single component metallocene catalysts for .alpha.-olefin polymerization are disclosed. Prior art cation metallocene catalysts have required a separate anion co-catalyst like methyl aluminoxane (MAO). However, because the inventive zwitterion ansa metallocene (ZAM) catalysts have a "built-in" anion co-catalyst functionality, the need for a separate anion co-catalyst is eliminated.
摘要翻译：公开了用于α-烯烃聚合的单组分茂金属催化剂。现有技术的阳离子茂金属催化剂需要单独的阴离子助催化剂，如甲基铝氧烷（MAO）。然而，由于本发明的两性离子金属茂（ZAM）催化剂具有“内置”阴离子助催化剂官能度，因此消除了对单独阴离子助催化剂的需要。

8. 发明申请

US20110166039A1 Methods of Discovering or Developing Novel Materials and Molecules 审中-公开
标题翻译：发现或开发新材料和分子的方法
公开(公告)号：US20110166039A1
公开(公告)日：2011-07-07
申请号：US11628258
申请日：2005-06-03
申请人： Yongchun Tang , William A. Goddard, III , Roy Periana
发明人： Yongchun Tang , William A. Goddard, III , Roy Periana
IPC分类号： C40B30/08
CPC分类号： B01J31/1815 , B01J31/2226 , B01J31/2234 , B01J31/2243 , B01J31/226 , B01J2231/46 , B01J2231/70 , B01J2531/008 , B01J2531/0244 , B01J2531/827 , B01J2540/22
摘要： The present inventions relates to methods of discovering or developing novel material or compound. In particular, the methods include the steps of using of general expert knowledge to identify currently available molecules, setting forth desired properties for a target molecule, designing a set of test molecule from the currently available molecule using computational methods (the test molecules having desired properties in the computational models); synthesizing the test molecules, testing the test molecules in real experiments, and identifying the target molecule which is the test molecule that has the desired properties.
摘要翻译：本发明涉及发现或开发新材料或化合物的方法。特别地，所述方法包括以下步骤：使用一般专家知识来鉴定当前可用的分子，为靶分子确定所需的性质，使用计算方法（所述测试分子具有所需性质）从当前可用分子设计一组测试分子在计算模型中）; 合成测试分子，在实验中测试测试分子，并鉴定作为具有所需性质的测试分子的靶分子。

9. 发明申请

US20110144966A1 METHODS FOR PREDICTION OF BINDING POSES OF A MOLECULE 审中-公开
标题翻译：用于预测分子结合位置的方法
公开(公告)号：US20110144966A1
公开(公告)日：2011-06-16
申请号：US12944700
申请日：2010-11-11
申请人： William A. Goddard, III , Ravinder Abrol , Ismet C. Tanrikulu , Adam R. Griffith
发明人： William A. Goddard, III , Ravinder Abrol , Ismet C. Tanrikulu , Adam R. Griffith
IPC分类号： G06G7/58
CPC分类号： G16B15/00
摘要： A method for prediction of binding poses of a binding molecule to a target molecule is provided. The method involves a step of providing, clustering, and evaluating binding poses of the binding molecule. The providing and clustering of the poses is performed by a single or multiple iteration procedure. The evaluation of the poses is determined from interaction energies between particular poses and the target molecule.
摘要翻译：提供了一种用于预测结合分子与靶分子的结合姿势的方法。该方法包括提供，聚集和评估结合分子的结合姿势的步骤。姿势的提供和聚类通过单次或多次迭代过程进行。姿势的评估由特定姿势与目标分子之间的相互作用能确定。

10. 发明授权

US07943401B2 Detection and reduction of dielectric breakdown in semiconductor devices 有权
标题翻译：检测和减少半导体器件中的介质击穿
公开(公告)号：US07943401B2
公开(公告)日：2011-05-17
申请号：US12114587
申请日：2008-05-02
申请人： Jamil Tamir-Kheli , William A. Goddard, III , Masayasu Miyata
发明人： Jamil Tamir-Kheli , William A. Goddard, III , Masayasu Miyata
IPC分类号： H01L21/66
CPC分类号： G01N21/66 , H01L22/00 , H01L22/24
摘要： Methods for detecting the breakdown potential of a semiconductor device having a thin dielectric layer are disclosed. The method includes measuring a spectroscopy of the thin dielectric layer and determining whether the spectroscopy exhibits the presence of a breakdown precursor (H2, H interstitial radical, H attached radical, and H attached dimer). Preferably, the method is carried out in the presence of a substantially significant applied electric field across dielectric layer. A semiconductor device tested in accordance with this method is also disclosed. Additionally, methods for reducing dielectric breakdown of a semiconductor device having a thin dielectric layer involving the substitution of a second molecule for H2 molecules present in the dielectric. This second molecule preferably does not react with Si or O to form an undesired attached state and may be an inert gas having a molecular size approximating that of a Hydrogen atom, such as Helium. A semiconductor device made using this method is also disclosed.
摘要翻译：公开了一种用于检测具有薄介电层的半导体器件的击穿电位的方法。该方法包括测量薄介电层的光谱，并确定光谱是否表现出分解前体（H2，H间隙自由基，H连接基团和H连接的二聚体）的存在。优选地，该方法在跨介电层的基本上有效的施加电场的存在下进行。还公开了根据该方法测试的半导体器件。另外，用于减少具有薄介电层的半导体器件的电介质击穿的方法涉及电介质中存在的用于H 2分子的第二分子的取代。该第二分子优选不与Si或O反应以形成不期望的附着状态，并且可以是分子大小接近氢原子如氦的惰性气体。还公开了使用该方法制造的半导体器件。

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