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11. 发明授权

US5675760A Apparatus and method for displaying normalized clinical test data 失效
标题翻译：用于显示标准化临床测试数据的装置和方法
公开(公告)号：US5675760A
公开(公告)日：1997-10-07
申请号：US303205
申请日：1994-09-08
申请人： Berend Houwen , Shigeo Kanamori , Kaoru Asano
发明人： Berend Houwen , Shigeo Kanamori , Kaoru Asano
IPC分类号： G06Q50/22 , G06F19/00 , G06T11/00
CPC分类号： G06F19/3487 , G01N2035/00891 , G06F19/3406 , G06F19/345
摘要： A calculator selects desired data out of a set of data obtained by analyzing a sample, such as blood or urine, and normalizes the selected data with respect to a predetermined level. The normalized values obtained by the calculator may be displayed as values and/or graphs. The graphical display may show a partition line set according to the experiences of the laboratory, so the graph may be quickly understood.
摘要翻译：计算器通过分析诸如血液或尿液的样品而获得的一组数据中的所需数据，并相对于预定水平对所选数据进行归一化。由计算器获得的归一化值可以显示为值和/或图。图形显示可以根据实验室的经验显示分割线集合，因此可以快速了解图形。

12. 发明授权

US5555198A Apparatus for counting particles 失效
标题翻译：颗粒计数装置
公开(公告)号：US5555198A
公开(公告)日：1996-09-10
申请号：US466371
申请日：1995-06-06
申请人： Kaoru Asano
发明人： Kaoru Asano
IPC分类号： G01N15/10 , G01N15/12 , G01N15/14 , G06M11/00 , G06T7/60 , G01N27/27
CPC分类号： G06T7/606 , G06K9/0014 , G06M11/00 , G01N2015/0069 , G01N2015/008 , G01N2015/1062 , G01N2015/129 , G06T2207/30024
摘要： A method of seeking the number of particles of each kind in a group of particles in which plural kinds of particles are intermixed, by measuring, for example, two kinds of properties of each particle by a suitable method or device, plotting each particle on a rectangular co-ordinate system using the measured properties as its X and Y co-ordinates to obtain a distribution diagram, drafting boundaries to partition the distribution into clusters of the respective kinds and counting the number of particles within the boundary of each cluster, which, especially, even when the clusters of the respective particles are mutually overlapping, can reduce any deviation of the count of particles from its true value as small as possible by defining an optimum boundary. In this method, a center of gravity of each cluster is determined, a degree of attribution of each particle to each cluster is calculated based upon a distance of each particle from the center of gravity and the number of particles belonging to each cluster is counted in consideration of the degree of attribution.
摘要翻译：通过适当的方法或装置测量例如每种颗粒的两种性质，在多个颗粒混合的一组颗粒中寻求每种颗粒数量的方法，将每个颗粒在一个使用测量属性作为其X和Y坐标的矩形坐标系来获得分布图，绘制边界以将分布划分为各种类型的簇并且计数每个簇的边界内的粒子数，特别是，即使当各个颗粒的簇相互重叠时，也可以通过限定最佳边界来减小颗粒计数与其真实值的任何偏差尽可能小。在该方法中，确定每个簇的重心，基于每个粒子与重心的距离计算每个粒子对每个簇的归属度，并且将属于每个簇的粒子的数量计数在考虑归属程度。

13. 发明授权

US07857759B2 Extraction device, analyzer, extraction method, and analysis method 有权
标题翻译：提取装置，分析仪，提取方法和分析方法
公开(公告)号：US07857759B2
公开(公告)日：2010-12-28
申请号：US10810412
申请日：2004-03-25
申请人： Kaoru Asano , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Seiki Okada
发明人： Kaoru Asano , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Seiki Okada
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14532 , A61N1/30 , A61N1/325
摘要： Extraction device for extracting an analyte from living tissue through skin are described that include: (a) a first electrode part having a contact area with the skin of less than about 50 mm2; (b) a through-current electrode part; and (c) a power supply part for supplying electrical energy to the first electrode part and the through-current electrode part, and for extracting an analyte in the first electrode part. Analyzers, extraction methods, and analysis methods are also described.
摘要翻译：描述了通过皮肤从活组织提取分析物的提取装置，其包括：（a）具有小于约50mm 2的与皮肤接触面积的第一电极部分; （b）直通电极部分; 以及（c）用于向第一电极部分和贯通电极部分提供电能并用于提取第一电极部分中的分析物的电源部分。还描述了分析仪，提取方法和分析方法。

14. 发明申请

US20060129035A1 Devices, methods, and systems for measuring analytes extracted through skin 审中-公开
标题翻译：用于测量通过皮肤提取的分析物的装置，方法和系统
公开(公告)号：US20060129035A1
公开(公告)日：2006-06-15
申请号：US10745443
申请日：2003-12-23
申请人： Kaoru Asano , Takeshi Mizuno , Yasunori Maekawa , Kenichi Sawa
发明人： Kaoru Asano , Takeshi Mizuno , Yasunori Maekawa , Kenichi Sawa
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/1495 , A61B10/0045 , A61B2010/008
摘要： Measuring devices for measuring an analyte extracted through skin of a living body are described that include: a noninvasive sampling unit for extracting the analyte from the living body through analyte transmission paths formed in an extracting region of the skin; an analyte detection unit for detecting a quantity of extracted analyte; and a control unit for obtaining a corrected analyte quantity based on the quantity of the extracted analyte and number of analyte transmission paths in the extracting region. Methods and systems for measuring analytes extracted through skin are also described.
摘要翻译：描述了用于测量通过生物体的皮肤提取的分析物的测量装置，其包括：非侵入式取样单元，用于通过形成在皮肤提取区域中的分析物传播路径从活体提取分析物; 用于检测提取的分析物的量的分析物检测单元; 以及控制单元，用于基于所提取的分析物的量和提取区域中的分析物传播路径的数量来获得校正的分析物量。还描述了通过皮肤提取的测量分析物的方法和系统。

15. 发明授权

US08046043B2 Extraction device, analyzer, extraction method, and analysis method 失效
标题翻译：提取装置，分析仪，提取方法和分析方法
公开(公告)号：US08046043B2
公开(公告)日：2011-10-25
申请号：US11280100
申请日：2005-11-16
申请人： Kaoru Asano , Yasunori Maekawa , Seiki Okada
发明人： Kaoru Asano , Yasunori Maekawa , Seiki Okada
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1486 , A61B5/14532 , A61N1/30
摘要： An extraction device for extracting an analyte from living tissue is disclosed that comprises a power source; a first electrode and second electrode connected to the power source; and a holding unit for holding a collecting medium for collecting analyte extracted from living tissue, wherein the collecting medium is in contact with both the first electrode and second electrode continuously. An analyzer comprising the extraction device, method for extracting an analyte, and method for extracting and analyzing an analyte are also described.
摘要翻译：公开了一种用于从活体组织提取分析物的提取装置，其包括电源; 连接到电源的第一电极和第二电极; 以及保持单元，用于保持用于收集从活体组织中提取的分析物的收集介质，其中所述收集介质与所述第一电极和所述第二电极连续地接触。还描述了包括提取装置，用于提取分析物的方法的分析器以及用于提取和分析分析物的方法。

16. 发明申请

US20080208024A1 Method of measuring skin conductance, method of analyzing component concentration, skin conductance measuring apparatus, and component concentration analyzer 审中-公开
标题翻译：皮肤电导率测定方法，成分浓度分析方法，皮肤电导率测定装置，成分浓度分析仪等
公开(公告)号：US20080208024A1
公开(公告)日：2008-08-28
申请号：US12074198
申请日：2008-02-28
申请人： Kei Hagino , Seiki Okada , Yasunori Maekawa , Kaoru Asano
发明人： Kei Hagino , Seiki Okada , Yasunori Maekawa , Kaoru Asano
IPC分类号： A61B5/053 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/0531 , A61B5/14514 , A61B5/1486 , A61N1/30
摘要： The present invention provides a method of measuring skin conductance which can obtain an accuracy measurement result, comprising the steps of: supplying a low conductivity medium as a medium for holding tissue fluid that contains a predetermined component of a subject to a medium containing part; disposing the medium containing part on an extraction region of a skin of the subject; extracting tissue fluid through the extraction region into the low conductivity medium within the medium containing part; supplying electric power between a first electrode for supplying electric power to the extraction region and a second electrode for supplying electric power to the skin outside the extraction region; and measuring the conductance of the extraction region based on the electric power supplied between the first electrode and second electrode. A method of analyzing a component concentration, a skin conductance measuring apparatus, and a component concentration analyzer are also disclosed.
摘要翻译：本发明提供一种测量皮肤电导率的方法，其可以获得精确度测量结果，该方法包括以下步骤：将含有预定组分的组织液的低电导率介质作为包含受试者的介质的培养基供应到介质容纳部分; 将所述培养基包含部分放置在所述对象的皮肤的提取区域上; 将组织液通过提取区域提取到介质容纳部分内的低电导率介质中; 在用于向提取区域提供电力的第一电极和用于向提取区域外部的皮肤供电的第二电极之间提供电力; 以及基于在第一电极和第二电极之间提供的电力来测量提取区域的电导。还公开了分析组分浓度的方法，皮肤电导率测量装置和组分浓度分析仪。

17. 发明授权

US5703959A Method and device for analyzing particles 失效
标题翻译：分析颗粒的方法和装置
公开(公告)号：US5703959A
公开(公告)日：1997-12-30
申请号：US368053
申请日：1995-01-03
申请人： Kaoru Asano , Kimiyo Kubo
发明人： Kaoru Asano , Kimiyo Kubo
IPC分类号： G01N15/12 , G01N15/10 , G01N15/14 , G01N33/49 , G06F15/18 , G06N3/00 , G06N99/00 , G06K9/62
CPC分类号： G01N15/10 , G01N15/1031 , G01N15/12 , G01N15/14 , G01N2015/1037 , G01N2015/1062
摘要： When a mixture of different kinds of particles, such as blood, is passed through a particle detector such as a flow cytometer to measure various characteristics of each particle and the measurements of two characteristics are plotted oh a two-dimensional rectangular co-ordinate, for example, the resultant dots tend to part into groups (clusters) corresponding to the kinds of the particles. This invention relates to a method and a device for presuming informations of the position of center of gravity, variances, number of dots and likes of each cluster by learning and, based upon these informations, presuming a specific cluster or category to which each measured particle should belong from the corresponding measurements of the particle, and it intends to execute such information processing by a fuzzy clustering technique using a neural network.
摘要翻译：当诸如血液的不同种类的颗粒的混合物通过诸如流式细胞仪的颗粒检测器以测量每个颗粒的各种特性时，两个特征的测量结果绘制为二维矩形坐标，用于例如，所得到的点倾向于分成对应于颗粒种类的组（簇）。本发明涉及一种用于通过学习来确定每个聚类的重心位置，方差，点数等的信息的方法和装置，并且基于这些信息，假设每个测量的粒子应该属于相应的粒子测量，并且打算通过使用神经网络的模糊聚类技术执行这种信息处理。

18. 发明申请

US20060116563A1 Extraction device, analyzer, extraction method, and analysis method 失效
标题翻译：提取装置，分析仪，提取方法和分析方法
公开(公告)号：US20060116563A1
公开(公告)日：2006-06-01
申请号：US11280100
申请日：2005-11-16
申请人： Kaoru Asano , Yasunori Maekawa , Seiki Okada
发明人： Kaoru Asano , Yasunori Maekawa , Seiki Okada
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/14532 , A61N1/30
摘要： An extraction device for extracting an analyte from living tissue is disclosed that comprises a power source; a first electrode and second electrode connected to the power source; and a holding unit for holding a collecting medium for collecting analyte extracted from living tissue, wherein the collecting medium is in contact with both the first electrode and second electrode continuously. An analyzer comprising the extraction device, method for extracting an analyte, and method for extracting and analyzing an analyte are also described.
摘要翻译：公开了一种用于从活体组织提取分析物的提取装置，其包括电源; 连接到电源的第一电极和第二电极; 以及保持单元，用于保持用于收集从活体组织中提取的分析物的收集介质，其中所述收集介质与所述第一电极和所述第二电极连续地接触。还描述了包括提取装置，用于提取分析物的方法的分析器以及用于提取和分析分析物的方法。

19. 发明授权

US5769076A Non-invasive blood analyzer and method using the same 失效
标题翻译：非侵入性血液分析仪及其使用方法
公开(公告)号：US5769076A
公开(公告)日：1998-06-23
申请号：US641828
申请日：1996-05-02
申请人： Yasunori Maekawa , Kaoru Asano , Yasuhiro Kochi , Ken Ishihara
发明人： Yasunori Maekawa , Kaoru Asano , Yasuhiro Kochi , Ken Ishihara
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , A61B5/1495
CPC分类号： A61B5/1455
摘要： A non-invasive blood analyzer contains a light applicator for illuminating a detection region under the skin of a living body including a blood vessel; a camera for capturing an image of the illuminated detection region; an analyzer for processing the captured image and analyzing at least a component of blood in the blood vessel; a transparent plate; and a support for supporting the transparent plate and contacting the transparent plate closely with the skin over the detection region. The light applicator and the camera are constructed to illuminate the detection region and capture the image of the detection region through the transparent plate. Further, a drive controller is included for driving the support to move the transparent plate contacted closely with the skin in order to adjust the detection region to thereby compensate for any change in position of the blood vessel.
摘要翻译：非侵入性血液分析仪包括用于照射包括血管的生物体的皮肤下的检测区域的光施加器; 用于捕获所述被照亮检测区域的图像的照相机; 用于处理所捕获的图像并分析血管中的血液的至少一部分的分析器; 透明板以及用于支撑透明板并使透明板与检测区域上的皮肤紧密接触的支撑件。光照射器和相机被构造为照亮检测区域并通过透明板捕获检测区域的图像。此外，包括用于驱动支撑件的驱动控制器以移动与皮肤紧密接触的透明板，以便调整检测区域，从而补偿血管位置的任何改变。

20. 发明授权

US5722398A Apparatus for measuring concentration of hemoglobin and method for the same 失效
标题翻译：用于测量血红蛋白浓度的装置及其方法
公开(公告)号：US5722398A
公开(公告)日：1998-03-03
申请号：US557573
申请日：1995-11-14
申请人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
发明人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
IPC分类号： G01B11/08 , A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1495 , G01N21/31 , G01N33/49
CPC分类号： A61B5/1455
摘要： An apparatus for measuring a concentration of hemoglobin includes a light application device for applying light to a detection region containing a blood vessel present in a living body; an image capturing device for capturing an image of the detection region to which the light is applied; and an analyzer for analyzing the concentration of hemoglobin in blood flowing through the blood vessel by processing the captured image. The analyzer includes a light intensity detector for detecting a light intensity of a body tissue and a light intensity of blood using the captured image. It further includes a calculator for calculating the concentration of hemoglobin from a ratio of the light intensity of the body tissue relative to the light intensity of blood thus detected.
摘要翻译：用于测量血红蛋白浓度的装置包括：用于将光照射到存在于生物体内的血管的检测区域的光施加装置; 用于捕获被施加光的检测区域的图像的图像捕获装置; 以及分析器，用于通过处理所捕获的图像分析血液中血红蛋白的浓度。该分析器包括用于使用捕获的图像检测身体组织的光强度和血液的光强度的光强度检测器。其还包括计算器，用于根据身体组织的光强度相对于这样检测的血液的光强度的比率计算血红蛋白的浓度。

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