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1. 发明申请

US20080208024A1 Method of measuring skin conductance, method of analyzing component concentration, skin conductance measuring apparatus, and component concentration analyzer 审中-公开
标题翻译：皮肤电导率测定方法，成分浓度分析方法，皮肤电导率测定装置，成分浓度分析仪等
公开(公告)号：US20080208024A1
公开(公告)日：2008-08-28
申请号：US12074198
申请日：2008-02-28
申请人： Kei Hagino , Seiki Okada , Yasunori Maekawa , Kaoru Asano
发明人： Kei Hagino , Seiki Okada , Yasunori Maekawa , Kaoru Asano
IPC分类号： A61B5/053 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/0531 , A61B5/14514 , A61B5/1486 , A61N1/30
摘要： The present invention provides a method of measuring skin conductance which can obtain an accuracy measurement result, comprising the steps of: supplying a low conductivity medium as a medium for holding tissue fluid that contains a predetermined component of a subject to a medium containing part; disposing the medium containing part on an extraction region of a skin of the subject; extracting tissue fluid through the extraction region into the low conductivity medium within the medium containing part; supplying electric power between a first electrode for supplying electric power to the extraction region and a second electrode for supplying electric power to the skin outside the extraction region; and measuring the conductance of the extraction region based on the electric power supplied between the first electrode and second electrode. A method of analyzing a component concentration, a skin conductance measuring apparatus, and a component concentration analyzer are also disclosed.
摘要翻译：本发明提供一种测量皮肤电导率的方法，其可以获得精确度测量结果，该方法包括以下步骤：将含有预定组分的组织液的低电导率介质作为包含受试者的介质的培养基供应到介质容纳部分; 将所述培养基包含部分放置在所述对象的皮肤的提取区域上; 将组织液通过提取区域提取到介质容纳部分内的低电导率介质中; 在用于向提取区域提供电力的第一电极和用于向提取区域外部的皮肤供电的第二电极之间提供电力; 以及基于在第一电极和第二电极之间提供的电力来测量提取区域的电导。还公开了分析组分浓度的方法，皮肤电导率测量装置和组分浓度分析仪。

2. 发明申请

US20110040166A1 EXTRACTING KIT, EXTRACTING DEVICE, AND EXTRACTING METHOD 审中-公开
标题翻译：提取工具包，提取装置和提取方法
公开(公告)号：US20110040166A1
公开(公告)日：2011-02-17
申请号：US12909577
申请日：2010-10-21
申请人： Seiki Okada , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Kanako Nagaoka , Kei Hagino
发明人： Seiki Okada , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Kanako Nagaoka , Kei Hagino
IPC分类号： A61B5/145
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/14532 , A61M2037/0007 , A61N1/30 , A61N1/306
摘要： An extracting kits for extracting analyte through the skin of a living body are disclosed that comprises an inserting device comprising needles for forming a plurality of extraction holes in the skin through the stratum corneum but not reaching the subcutaneous tissue and an extracting device for extracting the analyte into a liquid supplied into the extraction holes by supplying the liquid into the plurality of extraction holes. An extracting device and extracting method are also described.
摘要翻译：公开了一种用于通过生物体的皮肤提取分析物的提取试剂盒，其包括插入装置，所述插入装置包括用于通过角质层在皮肤中形成多个提取孔但不到达皮下组织的针，以及用于提取分析物的提取装置通过将液体供给到多个提取孔中而供入到提取孔中的液体。还描述了提取装置和提取方法。

3. 发明申请

US20060029991A1 Analyzer, analyzing method, and blood-sugar level measuring device 审中-公开
标题翻译：分析仪，分析方法和血糖测量装置
公开(公告)号：US20060029991A1
公开(公告)日：2006-02-09
申请号：US11194462
申请日：2005-08-02
申请人： Kei Hagino , Yasunori Maekawa , Kennichi Sawa , Seiki Okada , Toshiyuki Sato , Yoshihiro Asakura
发明人： Kei Hagino , Yasunori Maekawa , Kennichi Sawa , Seiki Okada , Toshiyuki Sato , Yoshihiro Asakura
IPC分类号： C12Q1/54 , C12M1/34 , A61B5/05
CPC分类号： A61B5/681 , A61B5/0531 , A61B5/14514 , A61B5/14532 , A61N1/30
摘要： An analyzer including an electrical information acquiring section for acquiring an electrical information by supplying an electricity to a skin of a subject; and a controller for acquiring a component value relating to an amount of a predetermined component included in a tissue fluid extracted via the skin of the subject and converting the component value into a concentration of the predetermined component included in the tissue fluid in a body of the subject based on the electrical information acquired by the electrical information acquiring section is disclosed. An analyzing method and a blood-sugar level measuring device are also disclosed.
摘要翻译：一种分析器，包括：电信息获取部分，用于通过向对象的皮肤供电来获取电信息; 以及控制器，用于获取与经由经皮肤提取的组织液中包含的预定成分的量相关的成分值，并将成分值转换成包含在组织液中的预定成分的浓度公开了基于由电信息获取部获取的电信息的主体。还公开了分析方法和血糖水平测量装置。

4. 发明申请

US20050177037A1 Extracting kit, extracting device, and extracting method 审中-公开
标题翻译：提取试剂盒，提取装置和提取方法
公开(公告)号：US20050177037A1
公开(公告)日：2005-08-11
申请号：US11031722
申请日：2005-01-07
申请人： Seiki Okada , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Kanako Nagaoka , Kei Hagino
发明人： Seiki Okada , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Kanako Nagaoka , Kei Hagino
IPC分类号： A61B5/00 , A61N1/30 , A61B5/05
CPC分类号： A61B5/681 , A61B5/14514 , A61B5/14532 , A61M2037/0007 , A61N1/30 , A61N1/306
摘要： An extracting kits for extracting analyte through the skin of a living body are disclosed that comprises an inserting device comprising needles for forming a plurality of extraction holes in the skin through the stratum corneum but not reaching the subcutaneous tissue and an extracting device for extracting the analyte into a liquid supplied into the extraction holes by supplying the liquid into the plurality of extraction holes. An extracting device and extracting method are also described.
摘要翻译：公开了一种用于通过生物体的皮肤提取分析物的提取试剂盒，其包括插入装置，所述插入装置包括用于通过角质层在皮肤中形成多个提取孔但不到达皮下组织的针，以及用于提取分析物的提取装置通过将液体供给到多个提取孔中而供入到提取孔中的液体。还描述了提取装置和提取方法。

5. 发明申请

US20070232875A1 Analyzer and analyzing method 审中-公开
标题翻译：分析仪和分析方法
公开(公告)号：US20070232875A1
公开(公告)日：2007-10-04
申请号：US11731441
申请日：2007-03-30
申请人： Yasunori Maekawa , Toshiyuki Sato , Kenichi Sawa , Seiki Okada , Kei Hagino , Yoshihiro Asakura , Yasuhito Ohnishi
发明人： Yasunori Maekawa , Toshiyuki Sato , Kenichi Sawa , Seiki Okada , Kei Hagino , Yoshihiro Asakura , Yasuhito Ohnishi
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/14514
摘要： The present invention is to present an analyzer for analyzing a concentration of a predetermined component contained in tissue fluid of a subject, the analyzer being capable of mitigating the pain of the subject. The analyzer comprises: an extraction medium retainer for retaining an extraction medium for holding tissue fluid extracted through a skin of a subject; a component amount information obtainer for obtaining component amount information regarding amount of a predetermined component contained in the tissue fluid held in the extraction medium; an electrical information obtainer for obtaining electrical information related to amount of the extracted tissue fluid by supplying electrical power to the extraction medium which is holding the extracted tissue fluid; and a component concentration obtainer for obtaining a concentration of the predetermined component contained in body fluid of the subject based on the component amount information and the electrical information.
摘要翻译：本发明提供一种用于分析被检体的组织液中所含有的预定成分的浓度的分析装置，该分析装置能够减轻受试者的疼痛。分析仪包括：提取介质保持器，用于保持用于保持通过受试者皮肤提取的组织液的提取介质; 组分量信息获取器，用于获得关于包含在所述提取介质中保持的组织液中的预定成分的量的成分量信息; 电信息获取器，用于通过向正在保存所提取的组织液的提取介质提供电力来获得与所提取的组织液的量相关的电信息; 以及组分浓度获取器，用于基于组分量信息和电信息获得包含在对象体液中的预定成分的浓度。

6. 发明申请

US20050169799A1 Analyzer, cartridge, cartridge kit, and analyzing method 审中-公开
标题翻译：分析仪，墨盒，墨盒套件和分析方法
公开(公告)号：US20050169799A1
公开(公告)日：2005-08-04
申请号：US11049599
申请日：2005-02-02
申请人： Kennichi Sawa , Yasunori Maekawa , Toshiyuki Sato , Kanako Nagaoka , Seiki Okada , Kei Hagino
发明人： Kennichi Sawa , Yasunori Maekawa , Toshiyuki Sato , Kanako Nagaoka , Seiki Okada , Kei Hagino
IPC分类号： A61B5/00 , G01N31/00 , C12M3/00
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/1459
摘要： An analyzer for extracting and analyzing an analyte from a subject is disclosed that comprises a reservoir capable of holding a liquid for holding the analyte extracted from the subject; and a liquid supplying mechanism for holding a liquid to be supplied to the reservoir and supplying the liquid to the reservoir. A cartridge, cartridge kit, and analyzing method are also described.
摘要翻译：公开了一种用于提取和分析来自受试者的分析物的分析器，其包括能够容纳用于保持从被检体提取的分析物的液体的储存器; 以及液体供给机构，用于保持要供应到储存器的液体并将液体供应到储存器。还描述了墨盒，墨盒套件和分析方法。

7. 发明授权

US07806266B2 Micropore forming system, micropore forming device, chip container, and chip container kit 失效
标题翻译：微孔成型系统，微孔成型装置，芯片容器和芯片容器试剂盒
公开(公告)号：US07806266B2
公开(公告)日：2010-10-05
申请号：US11717308
申请日：2007-03-13
申请人： Kei Hagino , Yasunori Maekawa , Kenichi Sawa , Katsutoshi Mishima , Mitsuhiro Tatsuzumi
发明人： Kei Hagino , Yasunori Maekawa , Kenichi Sawa , Katsutoshi Mishima , Mitsuhiro Tatsuzumi
IPC分类号： A61B17/06 , B65D83/10
CPC分类号： A61B10/0045 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150595 , A61B5/150725 , A61B5/150748 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/157 , A61B2010/008
摘要： A micropore forming system comprising: a microneedle chip having microneedles for forming micropores in a skin of a living body; a chip container for detachably housing the microneedle chip; and a micropore forming device for detachably holding the microneedle chip and for contacting the microneedles of the microneedle chip to the skin.
摘要翻译：一种微孔形成系统，包括：具有用于在生物体的皮肤中形成微孔的微针的微针芯片; 用于可拆卸地容纳微针芯片的芯片容器; 以及微孔形成装置，用于可拆卸地保持微针芯片并使微针芯片的微针与皮肤接触。

8. 发明申请

US20070233011A1 Micropore forming system, micropore forming device, chip container, and chip container kit 失效
标题翻译：微孔成型系统，微孔成型装置，芯片容器和芯片容器试剂盒
公开(公告)号：US20070233011A1
公开(公告)日：2007-10-04
申请号：US11717308
申请日：2007-03-13
申请人： Kei Hagino , Yasunori Maekawa , Kenichi Sawa , Katsutoshi Mishima , Mitsuhiro Tatsuzumi
发明人： Kei Hagino , Yasunori Maekawa , Kenichi Sawa , Katsutoshi Mishima , Mitsuhiro Tatsuzumi
IPC分类号： A61M5/00
CPC分类号： A61B10/0045 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150595 , A61B5/150725 , A61B5/150748 , A61B5/150984 , A61B5/15113 , A61B5/15117 , A61B5/1513 , A61B5/1519 , A61B5/157 , A61B2010/008
摘要： A micropore forming system comprising: a microneedle chip having microneedles for forming micropores in a skin of a living body; a chip container for detachably housing the microneedle chip; and a micropore forming device for detachably holding the microneedle chip and for contacting the microneedles of the microneedle chip to the skin.
摘要翻译：一种微孔形成系统，包括：具有用于在生物体的皮肤中形成微孔的微针的微针芯片; 用于可拆卸地容纳微针芯片的芯片容器; 以及微孔形成装置，用于可拆卸地保持微针芯片并使微针芯片的微针与皮肤接触。

9. 发明申请

US20110034787A1 Device for Interstitial Fluid Extraction, Production Process Thereof and Analyzing Process of Interstitial Fluid Using the Device 审中-公开
标题翻译：用于间质液萃取的装置，其生产工艺和使用装置分析间隙液的过程
公开(公告)号：US20110034787A1
公开(公告)日：2011-02-10
申请号：US12849108
申请日：2010-08-03
申请人： Kei Hagino , Junko Kojima , Akihito Takezaki , Reona Koike , Kazuki Isobe
发明人： Kei Hagino , Junko Kojima , Akihito Takezaki , Reona Koike , Kazuki Isobe
IPC分类号： A61B5/00 , B32B37/02 , B29C65/14
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B10/0045 , A61B2010/008 , C08J3/075 , Y10T156/10
摘要： A device for interstitial fluid extraction, having a base material formed from a synthetic resin film, a pressure sensitive adhesive layer, a hydrogel layer formed from at least one hydrophilic polymer selected from the group consisting of polyvinyl alcohol and polyvinyl pyrrolidone, and a release layer, wherein the hydrogel layer has an area of a size that the pressure sensitive adhesive layer is exposed from around the hydrogel layer, does substantially not contain a sodium ion and causes no water separation.
摘要翻译：一种用于组织液提取的装置，具有由合成树脂膜形成的基材，压敏粘合剂层，由至少一种选自聚乙烯醇和聚乙烯吡咯烷酮的亲水性聚合物形成的水凝胶层和脱模层其中，所述水凝胶层的面积为所述压敏粘合剂层从所述水凝胶层周围露出的面积，基本上不含钠离子，不会产生水分离。

10. 发明申请

US20130345597A1 Device for Interstitial Fluid Extraction, Production Process Thereof and Analyzing Process of Interstitial Fluid Using the Device 审中-公开
标题翻译：用于间质液萃取的装置，其生产工艺和使用装置分析间隙液的过程
公开(公告)号：US20130345597A1
公开(公告)日：2013-12-26
申请号：US13975854
申请日：2013-08-26
申请人： Kei Hagino , Junko Kojima , Akihito Takezaki , Reona Koike , Kazuki Isobe
发明人： Kei Hagino , Junko Kojima , Akihito Takezaki , Reona Koike , Kazuki Isobe
IPC分类号： A61B5/145 , A61B10/00
CPC分类号： A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B10/0045 , A61B2010/008 , C08J3/075 , Y10T156/10
摘要： A device for interstitial fluid extraction, having a base material formed from a synthetic resin film, a pressure sensitive adhesive layer, a hydrogel layer formed from at least one hydrophilic polymer selected from the group consisting of polyvinyl alcohol and polyvinyl pyrrolidone, and a release layer, wherein the hydrogel layer has an area of a size that the pressure sensitive adhesive layer is exposed from around the hydrogel layer, does substantially not contain a sodium ion and causes no water separation.
摘要翻译：一种用于组织液提取的装置，具有由合成树脂膜形成的基材，压敏粘合剂层，由至少一种选自聚乙烯醇和聚乙烯吡咯烷酮的亲水性聚合物形成的水凝胶层和脱模层其中，所述水凝胶层的面积为所述压敏粘合剂层从所述水凝胶层周围露出的面积，基本上不含钠离子，不会产生水分离。

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