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1. 发明授权

US5703959A Method and device for analyzing particles 失效
标题翻译：分析颗粒的方法和装置
公开(公告)号：US5703959A
公开(公告)日：1997-12-30
申请号：US368053
申请日：1995-01-03
申请人： Kaoru Asano , Kimiyo Kubo
发明人： Kaoru Asano , Kimiyo Kubo
IPC分类号： G01N15/12 , G01N15/10 , G01N15/14 , G01N33/49 , G06F15/18 , G06N3/00 , G06N99/00 , G06K9/62
CPC分类号： G01N15/10 , G01N15/1031 , G01N15/12 , G01N15/14 , G01N2015/1037 , G01N2015/1062
摘要： When a mixture of different kinds of particles, such as blood, is passed through a particle detector such as a flow cytometer to measure various characteristics of each particle and the measurements of two characteristics are plotted oh a two-dimensional rectangular co-ordinate, for example, the resultant dots tend to part into groups (clusters) corresponding to the kinds of the particles. This invention relates to a method and a device for presuming informations of the position of center of gravity, variances, number of dots and likes of each cluster by learning and, based upon these informations, presuming a specific cluster or category to which each measured particle should belong from the corresponding measurements of the particle, and it intends to execute such information processing by a fuzzy clustering technique using a neural network.
摘要翻译：当诸如血液的不同种类的颗粒的混合物通过诸如流式细胞仪的颗粒检测器以测量每个颗粒的各种特性时，两个特征的测量结果绘制为二维矩形坐标，用于例如，所得到的点倾向于分成对应于颗粒种类的组（簇）。本发明涉及一种用于通过学习来确定每个聚类的重心位置，方差，点数等的信息的方法和装置，并且基于这些信息，假设每个测量的粒子应该属于相应的粒子测量，并且打算通过使用神经网络的模糊聚类技术执行这种信息处理。

2. 发明申请

US20050096520A1 Extracting device, extracting method, analyzer and analyzing method 审中-公开
标题翻译：提取装置，提取方法，分析仪和分析方法
公开(公告)号：US20050096520A1
公开(公告)日：2005-05-05
申请号：US10982101
申请日：2004-11-04
申请人： Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Seiki Okada , Kanako Nagaoka , Kaoru Asano
发明人： Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Seiki Okada , Kanako Nagaoka , Kaoru Asano
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1468 , A61B10/00
CPC分类号： A61B5/14546 , A61B5/14514 , A61B5/14532 , A61B2010/008
摘要： Extraction devices for extracting analyte through the skin of a living body are disclosed that includes first and second extraction units which are placed on the skin and in which analyte is extracted; electrode unit placed on the skin; and a power source unit for outputting a first current flowing through the electrode unit, the living body, and the first extraction unit, and a second current flowing through the electrode unit, the living body, and the second extraction unit.
摘要翻译：公开了通过生物体的皮肤提取分析物的提取装置，其包括放置在皮肤上并且分析物被提取的第一和第二提取单元; 放置在皮肤上的电极单元; 以及电源单元，用于输出流过电极单元，生物体和第一提取单元的第一电流和流过电极单元，生物体和第二提取单元的第二电流。

3. 发明授权

US5555196A Method of counting particles using degree of membership in clustering data points into subgroups 失效
标题翻译：使用聚类数据点成员数目的粒子计数子群的方法
公开(公告)号：US5555196A
公开(公告)日：1996-09-10
申请号：US900449
申请日：1992-06-18
申请人： Kaoru Asano
发明人： Kaoru Asano
IPC分类号： G01N15/10 , G01N15/12 , G01N15/14 , G06M11/00 , G06T7/60 , G01N27/27
CPC分类号： G06T7/606 , G06K9/0014 , G06M11/00 , G01N2015/0069 , G01N2015/008 , G01N2015/1062 , G01N2015/129 , G06T2207/30024
摘要： A method of seeking the number of particles of each kind in a group of particles in which plural kinds of particles are intermixed, by measuring, for example, two kinds of properties of each particle by a suitable method or device, plotting each particle on a rectangular coordinate system using the measured properties as its X and Y co-ordinates to obtain a distribution diagram, drafting boundaries to partition the distribution into clusters of the respective kinds and counting the number of particles within the boundary of each cluster, which, especially, even when the clusters of the respective particles are mutually overlapping, can reduce any deviation of the count of particles from its true value as small as possible by defining an optimum boundary. In this method, a center of gravity of each cluster is determined, a degree of attribution of each particle to each cluster is calculated based upon a distance of each particle from the center of gravity and the number of particles belonging to each cluster is counted in consideration of the degree of attribution.
摘要翻译：通过适当的方法或装置测量例如每种颗粒的两种性质，在多个颗粒混合的一组颗粒中寻求各种颗粒的数量的方法，将每个颗粒在一个使用测量属性作为其X和Y坐标的直角坐标系统来获得分布图，绘制边界以将分布划分成各种类型的簇并且计数每个簇的边界内的粒子数，即使当各个颗粒的簇相互重叠时，也可以通过限定最佳边界来减小颗粒计数与其真实值的偏差尽可能小。在该方法中，确定每个簇的重心，基于每个粒子与重心的距离计算每个粒子对每个簇的归属度，并且将属于每个簇的粒子的数量计数在考虑归属程度。

4. 发明授权

US5532943A Particle analyzing apparatus and method therefor 失效
标题翻译：粒子分析装置及方法
公开(公告)号：US5532943A
公开(公告)日：1996-07-02
申请号：US174249
申请日：1993-12-28
申请人： Kaoru Asano , Yukimi Ikekita
发明人： Kaoru Asano , Yukimi Ikekita
IPC分类号： G01N15/10 , G01N15/12 , G01N15/14 , G01N33/49
CPC分类号： G01N15/12 , G01N15/1459 , G01N2015/008 , G01N2015/1037 , G01N2015/129 , G01N2015/1477
摘要： A particle analyzing apparatus includes a particle detector for measuring each of many particles to obtain at least one kind of data for each particle, a conversion unit for converting the obtained data into distribution data, a data base memory for storing reference distribution data relative to the distribution data, and a calculating unit for calculating the degree of similarity .delta. of the distribution data with respect to the reference distribution data.
摘要翻译：粒子分析装置包括：粒子检测器，用于测量多个粒子中的每一个以获得每个粒子的至少一种数据;转换单元，用于将获得的数据转换成分布数据;数据库，用于存储参考分布数据相对于分发数据，以及计算单元，用于计算分配数据相对于参考分布数据的相似度的变化程度。

5. 发明授权

US5974338A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5974338A
公开(公告)日：1999-10-26
申请号：US60080
申请日：1998-04-15
申请人： Kaoru Asano , Yasuhiro Kouchi
发明人： Kaoru Asano , Yasuhiro Kouchi
IPC分类号： A61B5/00
CPC分类号： A61B5/14535 , A61B5/1455 , A61B5/14551
摘要： A non-invasive blood analyzer includes a light source unit for irradiating a portion of a living body, the portion including a blood vessel, and includes an image capturing unit for capturing an image of the irradiated portion. An analyzing unit is included for setting an analysis region in the captured image and analyzing a blood vessel portion in the set analysis region. The image capturing unit captures images of the irradiated portion of the living body a plurality of times and the analyzing unit specifies analysis regions including the same blood vessel portions with respect to the captured images. The analyzing unit determines these regions based upon a position of a feature in sequential images and calculates at least one of blood vessel width, blood component concentration and blood component concentration ratio with respect to the blood vessel portion in each specified analysis region.
摘要翻译：非侵入性血液分析仪包括用于照射生物体的一部分的光源单元，该部分包括血管，并且包括用于捕获照射部分的图像的图像捕获单元。包括分析单元，用于设置拍摄图像中的分析区域并分析设定分析区域中的血管部分。图像拍摄单元多次拍摄生物体的照射部分的图像，并且分析单元针对捕获的图像指定包括相同血管部分的分析区域。分析单元基于连续图像中的特征的位置来确定这些区域，并且计算每个指定分析区域中的血管部分的血管宽度，血液成分浓度和血液成分浓度比中的至少一个。

6. 发明授权

US5934278A Non-invasive blood analyzer 失效
标题翻译：非侵入性血液分析仪
公开(公告)号：US5934278A
公开(公告)日：1999-08-10
申请号：US442654
申请日：1995-05-16
申请人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
发明人： Ken Ishihara , Kaoru Asano , Yasunori Maekawa
IPC分类号： A61B5/145 , A61B5/00 , A61B5/026 , A61B5/1455 , G01N15/14 , G01N33/48 , A61B6/00
CPC分类号： G01N15/147 , A61B5/0261 , A61B5/1455
摘要： A non-invasive blood analyzer includes a light applying device for applying light to a detection region including a blood vessel in a living body and a capturing device for capturing an image of the detection region to which the light is applied. Finally, an analyzing device is included for further processing the captured image to analyze blood cells in the blood vessel included in the detection region. Preferably, the analyzing device includes a reference image forming device for forming a reference image by using at least one of a plurality of images which the capturing device repeatedly captures with respect to the same detection region. In addition, it includes a differential image forming device for calculating a difference in pixel information between the reference image and one of the plurality of images to form a differential image by using the calculated difference as pixel information. Finally, a blood cell image detecting device is included for detecting a blood cell image from the differential image.
摘要翻译：非侵入式血液分析仪包括：用于对包括生物体中的血管的检测区域进行光照射的光施加装置和用于拍摄被施加光的检测区域的图像的拍摄装置。最后，包括分析装置，用于进一步处理所捕获的图像，以分析检测区域中包括的血管中的血细胞。优选地，分析装置包括用于通过使用捕获装置相对于相同检测区域重复捕获的多个图像中的至少一个来形成参考图像的参考图像形成装置。此外，它包括差分图像形成装置，用于通过使用所计算的差分作为像素信息来计算参考图像和多个图像中的一个图像之间的像素信息的差异，以形成差分图像。最后，包括用于从差分图像检测血细胞图像的血细胞图像检测装置。

7. 发明授权

US5675760A Apparatus and method for displaying normalized clinical test data 失效
标题翻译：用于显示标准化临床测试数据的装置和方法
公开(公告)号：US5675760A
公开(公告)日：1997-10-07
申请号：US303205
申请日：1994-09-08
申请人： Berend Houwen , Shigeo Kanamori , Kaoru Asano
发明人： Berend Houwen , Shigeo Kanamori , Kaoru Asano
IPC分类号： G06Q50/22 , G06F19/00 , G06T11/00
CPC分类号： G06F19/3487 , G01N2035/00891 , G06F19/3406 , G06F19/345
摘要： A calculator selects desired data out of a set of data obtained by analyzing a sample, such as blood or urine, and normalizes the selected data with respect to a predetermined level. The normalized values obtained by the calculator may be displayed as values and/or graphs. The graphical display may show a partition line set according to the experiences of the laboratory, so the graph may be quickly understood.
摘要翻译：计算器通过分析诸如血液或尿液的样品而获得的一组数据中的所需数据，并相对于预定水平对所选数据进行归一化。由计算器获得的归一化值可以显示为值和/或图。图形显示可以根据实验室的经验显示分割线集合，因此可以快速了解图形。

8. 发明授权

US5555198A Apparatus for counting particles 失效
标题翻译：颗粒计数装置
公开(公告)号：US5555198A
公开(公告)日：1996-09-10
申请号：US466371
申请日：1995-06-06
申请人： Kaoru Asano
发明人： Kaoru Asano
IPC分类号： G01N15/10 , G01N15/12 , G01N15/14 , G06M11/00 , G06T7/60 , G01N27/27
CPC分类号： G06T7/606 , G06K9/0014 , G06M11/00 , G01N2015/0069 , G01N2015/008 , G01N2015/1062 , G01N2015/129 , G06T2207/30024
摘要： A method of seeking the number of particles of each kind in a group of particles in which plural kinds of particles are intermixed, by measuring, for example, two kinds of properties of each particle by a suitable method or device, plotting each particle on a rectangular co-ordinate system using the measured properties as its X and Y co-ordinates to obtain a distribution diagram, drafting boundaries to partition the distribution into clusters of the respective kinds and counting the number of particles within the boundary of each cluster, which, especially, even when the clusters of the respective particles are mutually overlapping, can reduce any deviation of the count of particles from its true value as small as possible by defining an optimum boundary. In this method, a center of gravity of each cluster is determined, a degree of attribution of each particle to each cluster is calculated based upon a distance of each particle from the center of gravity and the number of particles belonging to each cluster is counted in consideration of the degree of attribution.
摘要翻译：通过适当的方法或装置测量例如每种颗粒的两种性质，在多个颗粒混合的一组颗粒中寻求每种颗粒数量的方法，将每个颗粒在一个使用测量属性作为其X和Y坐标的矩形坐标系来获得分布图，绘制边界以将分布划分为各种类型的簇并且计数每个簇的边界内的粒子数，特别是，即使当各个颗粒的簇相互重叠时，也可以通过限定最佳边界来减小颗粒计数与其真实值的任何偏差尽可能小。在该方法中，确定每个簇的重心，基于每个粒子与重心的距离计算每个粒子对每个簇的归属度，并且将属于每个簇的粒子的数量计数在考虑归属程度。

9. 发明授权

US07857759B2 Extraction device, analyzer, extraction method, and analysis method 有权
标题翻译：提取装置，分析仪，提取方法和分析方法
公开(公告)号：US07857759B2
公开(公告)日：2010-12-28
申请号：US10810412
申请日：2004-03-25
申请人： Kaoru Asano , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Seiki Okada
发明人： Kaoru Asano , Yasunori Maekawa , Kennichi Sawa , Toshiyuki Sato , Seiki Okada
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/14514 , A61B5/14532 , A61N1/30 , A61N1/325
摘要： Extraction device for extracting an analyte from living tissue through skin are described that include: (a) a first electrode part having a contact area with the skin of less than about 50 mm2; (b) a through-current electrode part; and (c) a power supply part for supplying electrical energy to the first electrode part and the through-current electrode part, and for extracting an analyte in the first electrode part. Analyzers, extraction methods, and analysis methods are also described.
摘要翻译：描述了通过皮肤从活组织提取分析物的提取装置，其包括：（a）具有小于约50mm 2的与皮肤接触面积的第一电极部分; （b）直通电极部分; 以及（c）用于向第一电极部分和贯通电极部分提供电能并用于提取第一电极部分中的分析物的电源部分。还描述了分析仪，提取方法和分析方法。

10. 发明申请

US20060129035A1 Devices, methods, and systems for measuring analytes extracted through skin 审中-公开
标题翻译：用于测量通过皮肤提取的分析物的装置，方法和系统
公开(公告)号：US20060129035A1
公开(公告)日：2006-06-15
申请号：US10745443
申请日：2003-12-23
申请人： Kaoru Asano , Takeshi Mizuno , Yasunori Maekawa , Kenichi Sawa
发明人： Kaoru Asano , Takeshi Mizuno , Yasunori Maekawa , Kenichi Sawa
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/1495 , A61B10/0045 , A61B2010/008
摘要： Measuring devices for measuring an analyte extracted through skin of a living body are described that include: a noninvasive sampling unit for extracting the analyte from the living body through analyte transmission paths formed in an extracting region of the skin; an analyte detection unit for detecting a quantity of extracted analyte; and a control unit for obtaining a corrected analyte quantity based on the quantity of the extracted analyte and number of analyte transmission paths in the extracting region. Methods and systems for measuring analytes extracted through skin are also described.
摘要翻译：描述了用于测量通过生物体的皮肤提取的分析物的测量装置，其包括：非侵入式取样单元，用于通过形成在皮肤提取区域中的分析物传播路径从活体提取分析物; 用于检测提取的分析物的量的分析物检测单元; 以及控制单元，用于基于所提取的分析物的量和提取区域中的分析物传播路径的数量来获得校正的分析物量。还描述了通过皮肤提取的测量分析物的方法和系统。

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