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11. 发明申请

US20120041519A1 SAFETY CONTROL SYSTEM FOR IMPLANTABLE NEURAL STIMULATOR 有权
标题翻译：可植入神经刺激物的安全控制系统
公开(公告)号：US20120041519A1
公开(公告)日：2012-02-16
申请号：US13282325
申请日：2011-10-26
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/37
摘要： A neural stimulation system includes a safety control system that prevents delivery of neural stimulation pulses from causing potentially harmful effects. The neural stimulation pulses are delivered to one or more nerves to control the physiological functions regulated by the one or more nerves. Examples of such harmful effects include unintended effects in physiological functions associated with autonomic neural stimulation and nerve injuries caused by excessive delivery of the neural stimulation pulses.
摘要翻译：神经刺激系统包括防止神经刺激脉冲传递引起潜在有害影响的安全控制系统。将神经刺激脉冲输送到一个或多个神经以控制由一个或多个神经调节的生理功能。这种有害影响的实例包括与神经刺激脉冲的过度递送引起的自主神经刺激和神经损伤相关的生理功能中的意想不到的影响。

12. 发明授权

US08053740B2 Method and apparatus for radiation effects detection 失效
标题翻译：辐射效应检测方法和装置
公开(公告)号：US08053740B2
公开(公告)日：2011-11-08
申请号：US13044003
申请日：2011-03-09
申请人： Jeffrey E. Stahmann , William J. Linder , Scott R. Stubbs , Keith R. Maile
发明人： Jeffrey E. Stahmann , William J. Linder , Scott R. Stubbs , Keith R. Maile
IPC分类号： G01T1/00
CPC分类号： A61N1/37 , A61N1/3718
摘要： An implantable medical apparatus comprises a solid state electronic circuit, an ionizing radiation exposure sensor, an ionizing radiation dose rate sensor, and a controller circuit. The ionizing radiation exposure sensor is configured to detect an exposure of the solid state electronic circuit to ionizing radiation, and generate an indication of a non-single-event-upset (non-SEU) effect to the solid state electronic circuit from the exposure to ionizing radiation, wherein the sensor comprises an accumulated ionizing radiation exposure sensor. The controller circuit is configured to blank the indication from the accumulated ionizing radiation exposure sensor when the radiation dose rate sensor indicates that flux ionizing radiation exceeds a flux ionizing radiation threshold.
摘要翻译：一种可植入医疗装置，包括固态电子电路，电离辐射曝光传感器，电离辐射剂量率传感器和控制器电路。电离辐射曝光传感器被配置为检测固态电子电路对电离辐射的曝光，并且产生对固态电子电路的非单事件不适（非SEU）效应的指示，从曝光到电离辐射，其中所述传感器包括累积的电离辐射曝光传感器。控制器电路被配置为当辐射剂量率传感器指示通量电离辐射超过通量电离辐射阈值时，从累积的电离辐射曝光传感器中消除指示。

13. 发明授权

US08046080B2 Telemetry duty cycle management system for an implantable medical device 有权
标题翻译：可植入医疗器械的遥测占空比管理系统
公开(公告)号：US08046080B2
公开(公告)日：2011-10-25
申请号：US12713669
申请日：2010-02-26
申请人： Jeffrey A. Von Arx , Ron Balczewski , Scott T. Mazar , William J. Linder , William R. Mass
发明人： Jeffrey A. Von Arx , Ron Balczewski , Scott T. Mazar , William J. Linder , William R. Mass
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/08 , A61N1/37223 , A61N1/3956
摘要： An implantable medical device comprising a far field RF transmitter and receiver, a controller circuit communicatively coupled to the RF transmitter and receiver, and a wakeup timer circuit integral to, or communicatively coupled to, the controller. The controller is configured to initiate power up of the RF transmitter and receiver during a wakeup interval defined by the wakeup timer circuit, detect a digital key received from a second device during the wakeup interval, transmit a response using the RF transmitter when the digital key is received, and receive a communication from the second device and resynchronize the wake-up timer according to a time of the communication.
摘要翻译：一种可植入医疗装置，包括远场RF发射器和接收器，通信地耦合到RF发射器和接收器的控制器电路，以及与控制器集成或通信耦合到控制器的唤醒定时器电路。控制器被配置为在由唤醒定时器电路定义的唤醒间隔期间启动RF发射机和接收机的上电，在唤醒间隔期间检测从第二设备接收的数字密钥，当数字密钥发送使用RF发射机的响应并且从第二设备接收通信，并且根据通信的时间重新同步唤醒定时器。

14. 发明授权

US08041432B2 Implantable medical device with two or more telemetry systems 有权
标题翻译：具有两个或更多遥测系统的可植入医疗设备
公开(公告)号：US08041432B2
公开(公告)日：2011-10-18
申请号：US12950359
申请日：2010-11-19
申请人： Jeffrey A. Von Arx , Keith Johnson , Scott T. Mazar , William J. Linder
发明人： Jeffrey A. Von Arx , Keith Johnson , Scott T. Mazar , William J. Linder
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/37223 , A61N1/37229
摘要： An implantable medical device comprises a near field telemetry module to wirelessly receive first information into the IMD, a far field telemetry module to wirelessly receive second information into the IMD, and a processor in electrical communication with the near field telemetry module and the far field telemetry module. The processor is configured to establish, in relation to a communication signal received by the near field telemetry module, a time period during which communication via the far field telemetry module is available, and operate the IMD according to the received second information upon receiving third information via the near field telemetry link.
摘要翻译：可植入医疗装置包括近场遥测模块，用于将IMD中的第一信息无线地接收，将远程遥测模块无线地接收到IMD中的第二信息;以及处理器，其与近场遥测模块和远场遥测模块。处理器被配置为关于由近场遥测模块接收的通信信号建立经由远场遥测模块的通信可用的时间段，并且在接收到第三信息时根据接收到的第二信息来操作IMD 通过近场遥测链路。

15. 发明申请

US20110112592A1 NEURAL STIMULATION SYSTEM TO PREVENT SIMULTANEOUS ENERGY DISCHARGES 有权
标题翻译：神经刺激系统，以防止同时进行的能量消耗
公开(公告)号：US20110112592A1
公开(公告)日：2011-05-12
申请号：US13007739
申请日：2011-01-17
申请人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
发明人： Imad Libbus , Andrew P. Kramer , William J. Linder , Jeffrey E. Stahmann
IPC分类号： A61N1/36 , A61N1/362 , A61N1/39
CPC分类号： A61N1/36114 , A61N1/3962
摘要： Various aspects of the present subject matter relate to a system. Various embodiments of the system comprise at least one port to connect to at least one lead with at least one electrode, at least one stimulator circuit and at least one controller. The at least one stimulator circuit is connected to the at least one port and is adapted to deliver neural stimulation to a neural stimulation target using the at least one electrode. The at least one controller is adapted to determine when another energy discharge other than the neural stimulation to the neural stimulation target is occurring and to prevent delivery of the neural stimulation simultaneously with the other energy discharge. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面涉及系统。系统的各种实施例包括至少一个端口，以连接至少一个引线与至少一个电极，至少一个刺激器电路和至少一个控制器。所述至少一个刺激器电路连接到所述至少一个端口，并且适于使用所述至少一个电极将神经刺激递送到神经刺激靶。所述至少一个控制器适于确定何时发生除了对神经刺激靶的神经刺激以外的其他能量放电，并且防止神经刺激与另一能量放电同时传送。本文提供了其它方面和实施例。

16. 发明授权

US07860574B2 Implantable medical device with two or more telemetry systems 有权
标题翻译：具有两个或更多遥测系统的可植入医疗设备
公开(公告)号：US07860574B2
公开(公告)日：2010-12-28
申请号：US12648687
申请日：2009-12-29
申请人： Jeffrey A. Von Arx , Keith Johnson , Scott T. Mazar , William J. Linder
发明人： Jeffrey A. Von Arx , Keith Johnson , Scott T. Mazar , William J. Linder
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/37223 , A61N1/37229
摘要： An implantable medical device comprises a near field telemetry module, a far field telemetry module, and a processor in electrical communication with the near field telemetry module and the far field telemetry module. The processor is configured to establish, in relation to a communication signal received by the near field telemetry module, a time period during which communication via the far field telemetry module is available, authenticate a far field communication session using the far field telemetry module, and communicate using the far field telemetry module upon authentication of the communication session.
摘要翻译：可植入医疗装置包括近场遥测模块，远场遥测模块和与近场遥测模块和远场遥测模块电通信的处理器。处理器被配置为关于由近场遥测模块接收的通信信号建立通过远场遥测模块的通信可用的时间段，使用远场遥测模块认证远场通信会话，以及在通信会话认证时使用远场遥测模块进行通信。

17. 发明申请

US20090192563A1 METHOD AND APPARATUS FOR ADJUSTING CARDIAC EVENT DETECTION THRESHOLD BASED ON DYNAMIC NOISE ESTIMATION 有权
标题翻译：基于动态噪声估计调整心脏事件检测阈值的方法和装置
公开(公告)号：US20090192563A1
公开(公告)日：2009-07-30
申请号：US12415619
申请日：2009-03-31
申请人： William J. Linder , Jeremy Maniak , Ron A. Balczewski
发明人： William J. Linder , Jeremy Maniak , Ron A. Balczewski
IPC分类号： A61N1/37
CPC分类号： A61B5/04017 , A61N1/3704 , A61N1/3925 , A61N1/3962 , Y10S128/901
摘要： An implantable cardiac rhythm management (CRM) device includes a sensing and detection circuit that senses at least one cardiac signal and detects cardiac electrical events from the sensed cardiac signal using a detection threshold that is adjusted based on a dynamic noise estimation. The sensed cardiac signal is filtered to produce a filtered cardiac signal having a signal frequency band and a noise signal having a noise frequency band. The noise frequency band is substantially different from the signal frequency band. A dynamic noise floor is produced based on the noise signal and used as the minimum value for the detection threshold. A cardiac electrical is detected when the amplitude of the filtered cardiac signal exceeds the detection threshold.
摘要翻译：可植入心律管理（CRM）装置包括感测和检测电路，其感测至少一个心脏信号并且使用基于动态噪声估计调整的检测阈值从所感测的心脏信号检测心脏电气事件。所感测的心脏信号被滤波以产生具有信号频带的滤波心脏信号和具有噪声频带的噪声信号。噪声频带与信号频带基本不同。基于噪声信号产生动态底噪，并将其用作检测阈值的最小值。当过滤的心脏信号的幅度超过检测阈值时，检测心电。

18. 发明授权

US07522956B2 Apparatus and method for treating ventricular tachyarrhythmias 有权
公开(公告)号：US07522956B2
公开(公告)日：2009-04-21
申请号：US11073818
申请日：2005-03-07
申请人： David B. Krig , James O. Gilkerson , Robert D. Dreher , Jan D. Wald , William J. Linder , William L. Zimmer
发明人： David B. Krig , James O. Gilkerson , Robert D. Dreher , Jan D. Wald , William J. Linder , William L. Zimmer
IPC分类号： A61N1/39
CPC分类号： A61N1/3622 , A61N1/395 , A61N1/3962
摘要： A system and method for selectively treating a ventricular tachycardia based on sensed atrial and ventricular intervals from the patient's heart. A detection window of the ten most recent atrial and ventricular intervals are analyzed for the occurrence of either tachycardia or fibrillation. When a majority of the sensed intervals are satisfied, the apparatus starts a duration time interval. Ventricular intervals and atrial intervals are compare, ventricular interval greater than the atrial interval by a bias factor the system delivers tachycardia therapy to the heart. Alternatively, the method withholds tachycardia therapy to the heart when the atrial rate is classified as atrial fibrillation and the ventricular response is unstable.

19. 发明授权

US06761728B2 Reforming wet-tantalum capacitors in implantable defibrillators and other medical devices 有权
公开(公告)号：US06761728B2
公开(公告)日：2004-07-13
申请号：US09900595
申请日：2001-07-06
申请人： Robert S. Harguth , Ron Balczewski , William J. Linder , Gregory Scott Munson , Michael Wesley Paris
发明人： Robert S. Harguth , Ron Balczewski , William J. Linder , Gregory Scott Munson , Michael Wesley Paris
IPC分类号： A61N100
CPC分类号： A61N1/3956
摘要： Miniature defibrillators and cardioverters detect abnormal heart rhythms and automatically apply electrical therapy to restore normal heart function. Critical components in these devices are aluminum electrolytic capacitors, which store and deliver one or more life-saving bursts of electric charge to a heart of a patient. This type of capacitor requires regular “reform” to preserve its charging efficiency over time. Because reform expends valuable battery life, manufacturers developed wet-tantalum capacitors, which are generally understood not to require reform. Yet, the present inventors discovered through extensive study that wet-tantalum capacitors exhibit progressively worse charging efficiency over time. Accordingly, to address this problem, the inventors devised unique reform techniques for wet-tantalum capacitors. One exemplary technique entails charging wet-tantalum capacitors to a voltage equal to about 90% of their rated voltage and maintaining this voltage for about five minutes before discharging them.

20. 发明授权

US06597950B2 Cardiac rhythm management system with painless defibrillation lead impedance measurement 有权
标题翻译：心脏节律管理系统具有无痛除颤引线阻抗测量
公开(公告)号：US06597950B2
公开(公告)日：2003-07-22
申请号：US09776306
申请日：2001-02-02
申请人： William J. Linder , Keith R. Maile
发明人： William J. Linder , Keith R. Maile
IPC分类号： A61N139
CPC分类号： A61N1/3925
摘要： A cardiac rhythm management system includes a defibrillation lead impedance measurement system by which defibrillation lead impedance is measured using a test current source different from the defibrillation output supply. A resulting voltage is measured to determine the defibrillation lead impedance. Using low amplitude test currents (e.g., 10-20 milliamperes) avoids patient discomfort. Charge-balanced test currents avoids charge build-up that may interfere with sensing and avoids electrode degeneration. Different current amplitudes and resulting measured voltages provide a differential defibrillation lead impedance measurement for canceling undesired effects. Bidirectional test currents account for polarity effects on the defibrillation lead impedance measurement. A calibration/correction technique uses measurements of known resistances to correct a measurement of an unknown defibrillation lead impedance measurement.
摘要翻译：心律管理系统包括除颤引线阻抗测量系统，通过该除颤引线阻抗测量系统使用不同于除颤输出电源的测试电流源来测量除颤引线阻抗。测量得到的电压以确定除颤引线阻抗。使用低振幅测试电流（例如10-20毫安）避免患者不适。电荷平衡测试电流避免电荷积聚，可能会干扰感测并避免电极退化。不同的电流幅度和所得到的测量电压提供差分除颤引线阻抗测量，以消除不良影响。双向测试电流对除颤引线阻抗测量的极性影响。校准/校正技术使用已知电阻的测量来校正未知除颤导线阻抗测量的测量。

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