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11. 发明授权

US08352026B2 Implantable pulse generators and methods for selective nerve stimulation 有权
标题翻译：植入脉冲发生器和选择性神经刺激的方法
公开(公告)号：US08352026B2
公开(公告)日：2013-01-08
申请号：US11866588
申请日：2007-10-03
申请人： Anthony DiUbaldi
发明人： Anthony DiUbaldi
IPC分类号： A61N1/00
CPC分类号： A61N1/0514 , A61N1/36007 , A61N1/36017 , A61N1/36071 , A61N1/36171 , A61N1/36196
摘要： An Implantable Pulse Generator (IPG) includes a surgically implantable housing, a battery, a first waveform generator, a second waveform generator, a modulator, and electrodes. The IPG produces a pulse envelope, a carrier waveform, and a modulated waveform. The pulse envelope is a low frequency waveform with specific pulse width, amplitude and shape to selectively stimulate a target nerve or body part. The carrier waveform is a high frequency waveform with properties such as amplitude, frequency and the like chosen so as to overcome tissue impedance and the stimulation threshold of the target nerve. The modulated waveform is the waveform obtained by modulating the carrier waveform by the pulse envelope.
摘要翻译：可植入脉冲发生器（IPG）包括手术可植入的壳体，电池，第一波形发生器，第二波形发生器，调制器和电极。 IPG产生脉冲包络，载波波形和调制波形。脉冲包络是具有特定脉冲宽度，幅度和形状的低频波形，以选择性地刺激目标神经或身体部位。载波波形是选择幅度，频率等特性的高频波形，以克服组织阻抗和目标神经的刺激阈值。调制波形是通过脉冲包络调制载波波形而获得的波形。

12. 发明申请

US20110264163A1 System and Method for Nerve Stimulation 有权
标题翻译：神经刺激的系统和方法
公开(公告)号：US20110264163A1
公开(公告)日：2011-10-27
申请号：US13094644
申请日：2011-04-26
申请人： Michael R. Tracey , Anthony DiUbaldi
发明人： Michael R. Tracey , Anthony DiUbaldi
IPC分类号： A61N1/36
CPC分类号： A61N1/36007 , A61B5/20 , A61B5/202 , A61B5/205 , A61B5/6874 , A61B2562/028 , A61N1/0492 , A61N1/0514 , A61N1/0521 , A61N1/36017 , A61N1/36021 , G06F19/00
摘要： A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.
摘要翻译：一种用于刺激神经的系统和方法，其中所述系统包括适于产生具有能够刺激哺乳动物的预定神经的频率的第一波形的第一波形发生器，适于生成具有频率能力的载波波形的第二波形发生器通过哺乳动物的组织的调制装置，电耦合到第一和第二波形发生器并适于调制第一和载波波形以产生调制波形的调制装置，以及电耦合到调制装置并基本上邻近皮肤定位的电极并且适于将调制波形应用于其。

13. 发明授权

US08588930B2 Piezoelectric stimulation device 有权
标题翻译：压电刺激装置
公开(公告)号：US08588930B2
公开(公告)日：2013-11-19
申请号：US12661949
申请日：2010-03-26
申请人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
发明人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
IPC分类号： A61N1/36
CPC分类号： A61N1/36014 , A61B5/6874 , A61B2562/028 , A61H23/0245 , A61H2201/5005 , A61N1/32 , A61N1/36007 , A61N1/36017 , A61N1/3787
摘要： A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets.
摘要翻译：一种使用包括由电源供电的外部非植入式发送装置的刺激装置来刺激诸如神经的预定身体部位并产生电波形信号的方法。表面电极经常地施加所生成的电波形信号。可植入式压电元件接收经过生成的施加的电波形信号，从而导致机械变形，导致可植入式压电元件的机械振动足以刺激预定的身体部位。电波形信号可以是高频连续波形或高频突发分组。

14. 发明授权

US08165695B2 System and method for selectively stimulating different body parts 有权
标题翻译：选择性刺激不同身体部位的系统和方法
公开(公告)号：US08165695B2
公开(公告)日：2012-04-24
申请号：US11343627
申请日：2006-01-31
申请人： Anthony DiUbaldi , Michael R. Tracey
发明人： Anthony DiUbaldi , Michael R. Tracey
IPC分类号： A61N1/00
CPC分类号： A61N1/0492 , A61N1/0551 , A61N1/36003 , A61N1/36007 , A61N1/36014 , A61N1/36017 , A61N1/36021
摘要： A device and method is provided for transdermally stimulating selected body parts of a mammal. The device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating a first predetermined body part, a second waveform generator adapted to generate a carrier waveform having a second frequency capable of passing through tissue of the mammal, and a third waveform generator adapted to generate a third waveform having a third frequency different from and out of phase with that of the first waveform, and capable of stimulating a second predetermined body part. The device further includes a modulation device electrically coupled to the first, second and third waveform generators and adapted to modulate the carrier, first, and third waveforms to create a modulated signal package, and a first electrode electrically coupled to the modulation device and positioned substantially adjacent to the skin of the mammal, and adapted to apply the modulated signal package thereto.
摘要翻译：提供了用于经皮刺激哺乳动物的选定身体部位的装置和方法。该装置包括适于产生具有能够刺激第一预定身体部位的第一频率的第一波形的第一波形发生器，适于产生能够通过哺乳动物组织的第二频率的载波波形的第二波形发生器，以及第三波形发生器，其适于产生具有与所述第一波形的第三频率不同且与所述第一波形不相位的第三频率的第三波形，并且能够刺激第二预定体部。该装置还包括电耦合到第一，第二和第三波形发生器并且适于调制载波，第一和第三波形以产生调制信号封装的调制装置，以及电耦合到调制装置并基本上位于与哺乳动物的皮肤相邻，并且适于将调制信号包施加到其上。

15. 发明授权

US08128576B2 System and method for urodynamic evaluation utilizing micro electro-mechanical system technology 有权
标题翻译：使用微机电系统技术进行尿动力学评估的系统和方法
公开(公告)号：US08128576B2
公开(公告)日：2012-03-06
申请号：US11635403
申请日：2006-12-07
申请人： Michael R. Tracey , Anthony DiUbaldi , Stephen Wahlgren , Rex O. Bare , Bradley J. Sargent
发明人： Michael R. Tracey , Anthony DiUbaldi , Stephen Wahlgren , Rex O. Bare , Bradley J. Sargent
IPC分类号： A61B5/00 , A61B1/307
CPC分类号： A61B5/14507 , A61B5/0031 , A61B5/205 , A61B5/208 , A61B5/6874 , A61B2562/028
摘要： An implantable urodynamic system includes an implantable first device deployable in a patient's bladder, an implantable second device deployable in a patient's vaginal canal, and a data acquisition and analysis module or processing unit external to the body of the patient. The first device includes a magnet and an inductive coil, and the second device includes a magnet, an inductive coil and a battery. When deployed in the patient's body, attraction between the magnets maintains the two devices in close proximity to one another to effect an inductive coupling between the coils so that the first device may be powered by the battery of the second device. The urodynamic system is intended to facilitate measurement, collection, and wireless transmission of real-time, or near real-time, data (bladder pressure, abdominal pressure, and temperature) from an ambulatory patient. This data is of value in diagnosing a number of abnormal bladder conditions, such as infection, overactive bladder, bladder spasms, and the like.
摘要翻译：可植入尿动力系统包括可部署在患者膀胱中的可植入第一装置，可植入患者阴道内的可植入第二装置，以及在患者身体外部的数据采集和分析模块或处理单元。第一装置包括磁体和感应线圈，并且第二装置包括磁体，感应线圈和电池。当部署在患者体内时，磁体之间的吸引力将两个装置彼此紧密地保持在彼此附近以实现线圈之间的感应耦合，使得第一装置可以由第二装置的电池供电。尿动力系统旨在便于来自流动患者的实时或近实时数据（膀胱压力，腹压和温度）的测量，收集和无线传输。该数据在诊断膀胱膀胱状况异常，例如感染，膀胱过度活动症，膀胱痉挛等中是有价值的。

16. 发明申请

US20080132962A1 SYSTEM AND METHOD FOR AFFECTING GATRIC FUNCTIONS 审中-公开
标题翻译：影响GATRIC功能的系统和方法
公开(公告)号：US20080132962A1
公开(公告)日：2008-06-05
申请号：US11565706
申请日：2006-12-01
申请人： Anthony DiUbaldi , Michael R. Tracey , Stephen B. Wahlgren
发明人： Anthony DiUbaldi , Michael R. Tracey , Stephen B. Wahlgren
IPC分类号： A61N1/05
CPC分类号： A61N1/36007 , A61N1/36014
摘要： A device for transcutaneous electrical stimulation device for affecting gastric function in a patient and a method for performing the same is provided. The device includes a first waveform generator adapted to generate a first waveform having a first frequency capable of stimulating a vagus nerve of the patient at a predetermined location, a second waveform generator adapted to generate a carrier waveform having a second frequency capable of passing from the surface of skin of the patient at the predetermined location, through tissue to the vagus nerve, a modulation device electrically coupled to the first, second and third waveform generators and adapted to modulate the first and carrier waveforms to create a modulated signal, and a first electrode electrically coupled to the modulation device and positioned substantially adjacent to the skin of the mammal, and adapted to apply the modulated signal thereto.
摘要翻译：提供了一种用于影响患者胃功能的经皮电刺激装置的装置及其执行方法。该装置包括：第一波形发生器，其适于产生具有能够在预定位置刺激患者的迷走神经的第一频率的第一波形;适于产生具有第二频率的载波波形的第二波形发生器，通过组织到迷走神经的预定位置处的患者皮肤表面，电耦合到第一，第二和第三波形发生器并适于调制第一和载波波形以产生调制信号的调制装置，以及第一电极电耦合到调制装置并且基本上邻近哺乳动物的皮肤定位，并且适于将调制信号施加到其上。

17. 发明授权

US08897885B2 Optimizing the stimulus current in a surface based stimulation device 有权
标题翻译：优化基于表面的刺激装置中的刺激电流
公开(公告)号：US08897885B2
公开(公告)日：2014-11-25
申请号：US12317193
申请日：2008-12-19
申请人： Anthony DiUbaldi , Stephen Wahlgren
发明人： Anthony DiUbaldi , Stephen Wahlgren
IPC分类号： A61N1/00 , A61N1/36
CPC分类号： A61N1/36014
摘要： A method and associated stimulation device for ensuring firing of an action potential in an intended physiological target activated by a stimulus pulse generated by an electrode of a non-invasive surface based stimulation device irrespective of skin-to-electrode impedance by: (i) increasing internal impedance of the stimulation device so as to widen a Chronaxie time period thereby ensuring firing of the action potential of the intended physiological target irrespective of the skin-to-electrode impedance; and/or (ii) generating a stimulation waveform that optimizes a non-zero average current (e.g., non-zero slope of the envelope of the stimulation waveform) during preferably substantially the entire current decay of the stimulus pulse.
摘要翻译：一种方法和相关联的刺激装置，用于确保由无创表面刺激装置的电极产生的刺激脉冲激活的预期生理目标中的动作电位的点火，而不管皮肤对电极的阻抗如何：（i）增加刺激装置的内部阻抗，以便扩大Chronaxie时间段，从而确保预期生理目标的动作电位的发射，而不管皮肤对电极的阻抗如何; 和/或（ii）在刺激脉冲的优选基本上整个电流衰减期间产生优化非零平均电流（例如，刺激波形的包络的非零斜率）的刺激波形。

18. 发明授权

US07979137B2 System and method for nerve stimulation 有权
标题翻译：神经刺激的系统和方法
公开(公告)号：US07979137B2
公开(公告)日：2011-07-12
申请号：US11146522
申请日：2005-06-07
申请人： Michael R. Tracey , Anthony DiUbaldi
发明人： Michael R. Tracey , Anthony DiUbaldi
IPC分类号： A61N1/40
CPC分类号： A61N1/36007 , A61B5/20 , A61B5/202 , A61B5/205 , A61B5/6874 , A61B2562/028 , A61N1/0492 , A61N1/0514 , A61N1/0521 , A61N1/36017 , A61N1/36021 , G06F19/00
摘要： A system and method for stimulating a nerve, wherein the system includes a first waveform generator adapted to generate a first waveform having a frequency capable of stimulating a predetermined nerve of the mammal, a second waveform generator adapted to generate a carrier waveform having a frequency capable of passing through tissue of the mammal, a modulation device electrically coupled to the first and second waveform generators and adapted to modulate the first and carrier waveforms to create a modulated waveform, and an electrode electrically coupled to the modulation device and positioned substantially adjacent to skin of the mammal, and adapted to apply the modulated waveform thereto.
摘要翻译：一种用于刺激神经的系统和方法，其中所述系统包括适于产生具有能够刺激哺乳动物的预定神经的频率的第一波形的第一波形发生器，适于生成具有频率能力的载波波形的第二波形发生器通过哺乳动物的组织的调制装置，电耦合到第一和第二波形发生器并适于调制第一和载波波形以产生调制波形的调制装置，以及电耦合到调制装置并基本上邻近皮肤定位的电极并且适于将调制波形应用于该哺乳动物。

19. 发明申请

US20100249677A1 Piezoelectric stimulation device 有权
标题翻译：压电刺激装置
公开(公告)号：US20100249677A1
公开(公告)日：2010-09-30
申请号：US12661949
申请日：2010-03-26
申请人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
发明人： Anthony DiUbaldi , Stephen Wahlgren , Michael R. Tracey
IPC分类号： A61H1/00
CPC分类号： A61N1/36014 , A61B5/6874 , A61B2562/028 , A61H23/0245 , A61H2201/5005 , A61N1/32 , A61N1/36007 , A61N1/36017 , A61N1/3787
摘要： A method for stimulating a predetermined body part such as a nerve using a stimulation device including an external non-implantable transmitting device powered by a power source and generating an electrical waveform signal. A surface electrode applies the generated electrical waveform signal transcutaneously. An implantable piezoelectric element receives the applied electrical waveform signal generated transcutaneously and, in turn, causes mechanical deformation resulting in mechanical vibration of the implantable piezoelectric element sufficient to stimulate the predetermined body part. The electrical waveform signal may be either a high frequency continuous waveform or high frequency burst packets.
摘要翻译：一种使用包括由电源供电的外部非植入式发送装置的刺激装置来刺激诸如神经的预定身体部位并产生电波形信号的方法。表面电极经常地施加所生成的电波形信号。可植入式压电元件接收经过生成的施加的电波形信号，从而导致机械变形，导致可植入式压电元件的机械振动足以刺激预定的身体部位。电波形信号可以是高频连续波形或高频突发分组。

20. 发明申请

US20100161001A1 Optimizing the stimulus current in a surface based stimulation device 有权
标题翻译：优化基于表面的刺激装置中的刺激电流
公开(公告)号：US20100161001A1
公开(公告)日：2010-06-24
申请号：US12317193
申请日：2008-12-19
申请人： Anthony DiUbaldi , Stephen Wahlgren
发明人： Anthony DiUbaldi , Stephen Wahlgren
IPC分类号： A61N1/08
CPC分类号： A61N1/36014
摘要： A method and associated stimulation device for ensuring firing of an action potential in an intended physiological target activated by a stimulus pulse generated by an electrode of a non-invasive surface based stimulation device irrespective of skin-to-electrode impedance by: (i) increasing internal impedance of the stimulation device so as to widen a Chronaxie time period thereby ensuring firing of the action potential of the intended physiological target irrespective of the skin-to-electrode impedance; and/or (ii) generating a stimulation waveform that optimizes a non-zero average current (e.g., non-zero slope of the envelope of the stimulation waveform) during preferably substantially the entire current decay of the stimulus pulse.
摘要翻译：一种方法和相关联的刺激装置，用于确保由无创表面刺激装置的电极产生的刺激脉冲激活的预期生理目标中的动作电位的点火，而不管皮肤对电极的阻抗如何：（i）增加刺激装置的内部阻抗，以便扩大Chronaxie时间段，从而确保预期生理目标的动作电位的发射，而不管皮肤对电极的阻抗如何; 和/或（ii）在刺激脉冲的优选基本上整个电流衰减期间产生优化非零平均电流（例如，刺激波形的包络的非零斜率）的刺激波形。

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