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11. 发明申请

US20090194705A1 Producing Time Variation In Emanating Light 有权
标题翻译：在发光时产生时间变化
公开(公告)号：US20090194705A1
公开(公告)日：2009-08-06
申请号：US12023436
申请日：2008-01-31
申请人： Peter Kiesel , Markus Beck , Michael Bassler , Noble M. Johnson
发明人： Peter Kiesel , Markus Beck , Michael Bassler , Noble M. Johnson
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01N21/6486 , G01N2021/6419
摘要： An excitation component or arrangement can provide excitation to a moving object so that information is encoded in time variation of light emanating from the object. For example, in each of a sequence of segments, it can provide a respective non-binary excitation spectrum, and the spectra can be different with a non-interference-like transition between them; because the object emanates light differently in response to the different spectra, photosensing results can be obtained that include encoded information about the object. The non-binary spectra could be different intermediate intensities, such as different gray levels or different intensities of one color or could be different colors. The excitation can be provided in a pattern with non-interference-like transitions between regions, and object motion can also be controlled. In another approach, a trigger signal can cause a time-varying excitation in a region, with non-interference-like transitions between intervals of excitation, such as black/white, multiple colors, or gray levels.
摘要翻译：激励分量或排列可以向移动物体提供激励，使得信息在从对象发出的光的时间变化中被编码。例如，在片段序列的每一个中，它可以提供相应的非二元激励光谱，并且光谱可以与它们之间的非干扰状的转变不同; 因为物体响应于不同的光谱不同地发出光，所以可以获得包括关于物体的编码信息的光敏结果。非二进制光谱可以是不同的中间强度，例如不同的灰度级或一种颜色的不同强度，或者可以是不同的颜色。激励可以以区域之间的非干涉状态的转变的模式提供，并且还可以控制物体运动。在另一种方法中，触发信号可以在区域中引起时变激励，在激发间隔（例如黑/白，多种颜色或灰度级）之间具有非干扰状的过渡。

12. 发明授权

US08373860B2 Transmitting/reflecting emanating light with time variation 有权
标题翻译：发射/反射发光随时间变化
公开(公告)号：US08373860B2
公开(公告)日：2013-02-12
申请号：US12762702
申请日：2010-04-19
申请人： Peter Kiesel , Markus Beck , Noble M. Johnson , Michael Bassler
发明人： Peter Kiesel , Markus Beck , Noble M. Johnson , Michael Bassler
IPC分类号： G01N21/25
CPC分类号： G01N21/05 , G01N21/255 , G01N21/645 , G01N2021/0346
摘要： A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. One or more mask arrangements can be configured to receive the emanating light and in response provide encoded emanating light.
摘要翻译：滤波器装置可以发射和/或反射从移动物体发出的光，使得发射光具有时间变化，并且时间变化可以包括关于物体的信息，例如其类型。例如，可以通过路径的区段发出光，并通过过滤器组件的位置进行透射/反射，并且位置的透射函数可以充分地不同，从而在区间之间的发光中发生时间变化。或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射，使得根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。一个或多个掩模布置可以被配置为接收发射光并且作为响应提供编码的发射光。

13. 发明申请

US20110222062A1 ANALYZERS WITH TIME VARIATION BASED ON COLOR-CODED SPATIAL MODULATION 有权
标题翻译：基于颜色编码空间调制的时变分析器
公开(公告)号：US20110222062A1
公开(公告)日：2011-09-15
申请号：US13113021
申请日：2011-05-20
申请人： Joerg Martini , Peter Kiesel , Malte Huck , Marshall Bern , Noble M. Johnson , Michael Bassler , Markus Beck
发明人： Joerg Martini , Peter Kiesel , Malte Huck , Marshall Bern , Noble M. Johnson , Michael Bassler , Markus Beck
IPC分类号： G01N21/25 , G01N21/64
CPC分类号： G01N21/25 , G01J3/26 , G01J3/28 , G01J3/2803 , G01J2003/1213 , G01N21/05 , G01N21/255 , G01N21/645 , G01N2021/0346 , G02B21/16 , G02B27/46
摘要： A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.
摘要翻译：滤波器装置可以发射和/或反射从移动物体发出的光，使得发射光具有时间变化，并且时间变化可以包括关于物体的信息，例如其类型。例如，可以通过路径的区段发出光，并通过过滤器组件的位置进行透射/反射，并且位置的透射函数可以充分地不同，从而在区间之间的发光中发生时间变化。或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射，使得根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。可以使用许多过滤装置，例如过滤器组件可以包括过滤器组件，其可以具有更简单的不均匀传输功能之一。可以比较感测结果中的时变波形，以获得光谱差异。在实用的商业实施例中，过滤器装置可以制造为一次性的，并且用于实际上在任何地方，以低成本使用的点护理装置，并且也可以在在线监测系统中实现。

14. 发明授权

US07763856B2 Producing time variation in emanating light 有权
标题翻译：产生发光的时间变化
公开(公告)号：US07763856B2
公开(公告)日：2010-07-27
申请号：US12023436
申请日：2008-01-31
申请人： Peter Kiesel , Markus Beck , Michael Bassler , Noble M. Johnson
发明人： Peter Kiesel , Markus Beck , Michael Bassler , Noble M. Johnson
IPC分类号： G01N21/85 , G01N21/63
CPC分类号： G01N21/645 , G01N21/6486 , G01N2021/6419
摘要： An excitation component or arrangement can provide excitation to a moving object so that information is encoded in time variation of light emanating from the object. For example, in each of a sequence of segments, it can provide a respective non-binary excitation spectrum, and the spectra can be different with a non-interference-like transition between them; because the object emanates light differently in response to the different spectra, photosensing results can be obtained that include encoded information about the object. The non-binary spectra could be different intermediate intensities, such as different gray levels or different intensities of one color or could be different colors. The excitation can be provided in a pattern with non-interference-like transitions between regions, and object motion can also be controlled. In another approach, a trigger signal can cause a time-varying excitation in a region, with non-interference-like transitions between intervals of excitation, such as black/white, multiple colors, or gray levels.
摘要翻译：激励分量或排列可以向移动物体提供激励，使得信息在从对象发出的光的时间变化中被编码。例如，在片段序列的每一个中，它可以提供相应的非二元激励光谱，并且光谱可以与它们之间的非干扰状的转变不同; 因为物体响应于不同的光谱不同地发出光，所以可以获得包括关于物体的编码信息的光敏结果。非二进制光谱可以是不同的中间强度，例如不同的灰度级或一种颜色的不同强度，或者可以是不同的颜色。激励可以以区域之间的非干涉状态的转变的模式提供，并且还可以控制物体运动。在另一种方法中，触发信号可以在区域中引起时变激励，在激发间隔（例如黑/白，多种颜色或灰度级）之间具有非干扰状的过渡。

15. 发明申请

US20100155572A1 Obtaining Sensing Results and/or Data in Response to Object Detection 有权
标题翻译：获取响应对象检测的感知结果和/或数据
公开(公告)号：US20100155572A1
公开(公告)日：2010-06-24
申请号：US12337771
申请日：2008-12-18
申请人： Peter Kiesel , Markus Beck , Joerg Martini , Michael Bassler , Noble M. Johnson
发明人： Peter Kiesel , Markus Beck , Joerg Martini , Michael Bassler , Noble M. Johnson
IPC分类号： G01J1/44 , G01J1/20
CPC分类号： G01J3/2803 , G01J3/02 , G01J3/027 , G01N15/12 , G01N15/1429 , G01N15/1459 , G01N2015/1075 , G01N2021/1734
摘要： An encoder/sensor can obtain sensing results from objects in an encoding/sensing region; a trigger detector can respond to objects in a trigger detection region, providing respective trigger signals; and a relative motion component can cause relative motion of objects into the trigger detection region, from it into the encoding/sensing region, and within the encoding/sensing region. In response to an object's trigger signal, control circuitry can cause the encoder/sensor and/or the relative motion component to operate so that the encoder/sensor obtains sensing results indicating a time-varying waveform and processing circuitry can obtain data from the sensing results indicating a time-varying waveform. The time-varying waveform can include information resulting from the relative motion within the encoding/sensing region. The encoder/sensor and trigger detector can be implemented, for example, with discrete components or as sets of cells in a photosensing array on an integrated circuit.
摘要翻译：编码器/传感器可以从编码/感测区域中的对象获得感测结果; 触发检测器可以响应触发检测区域中的对象，提供相应的触发信号; 并且相对运动分量可以引起物体进入触发检测区域的相对运动，从而进入编码/感测区域，并且在编码/感测区域内。响应于物体的触发信号，控制电路可以使编码器/传感器和/或相对运动分量运行，使得编码器/传感器获得指示时变波形的感测结果，并且处理电路可以从感测结果获得数据表示时变波形。时变波形可以包括由编码/感测区域内的相对运动产生的信息。编码器/传感器和触发检测器可以例如利用集成电路中的光敏阵列中的分立组件或单元组来实现。

16. 发明授权

US08629981B2 Analyzers with time variation based on color-coded spatial modulation 有权
标题翻译：基于颜色编码空间调制的时间变化分析仪
公开(公告)号：US08629981B2
公开(公告)日：2014-01-14
申请号：US13113021
申请日：2011-05-20
申请人： Joerg Martini , Peter Kiesel , Malte Huck , Marshall W. Bern , Noble M. Johnson , Michael Bassler , Markus Beck
发明人： Joerg Martini , Peter Kiesel , Malte Huck , Marshall W. Bern , Noble M. Johnson , Michael Bassler , Markus Beck
IPC分类号： G01N21/25 , G01P3/36
CPC分类号： G01N21/25 , G01J3/26 , G01J3/28 , G01J3/2803 , G01J2003/1213 , G01N21/05 , G01N21/255 , G01N21/645 , G01N2021/0346 , G02B21/16 , G02B27/46
摘要： A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences.
摘要翻译：滤波器装置可以发射和/或反射从移动物体发出的光，使得发射光具有时间变化，并且时间变化可以包括关于物体的信息，例如其类型。例如，可以通过路径的区段发出光，并通过过滤器组件的位置进行透射/反射，并且位置的透射函数可以充分地不同，从而在区间之间的发光中发生时间变化。或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射，使得根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。可以使用许多过滤装置，例如过滤器组件可以包括过滤器组件，其可以具有更简单的不均匀传输功能之一。可以比较感测结果中的时变波形，以获得光谱差异。

17. 发明申请

US20100201988A1 Transmitting/Reflecting Emanating Light With Time Variation 有权
标题翻译：发射/反射发光随时间变化
公开(公告)号：US20100201988A1
公开(公告)日：2010-08-12
申请号：US12762702
申请日：2010-04-19
申请人： Peter Kiesel , Markus Beck , Noble M. Johnson , Michael Bassler
发明人： Peter Kiesel , Markus Beck , Noble M. Johnson , Michael Bassler
IPC分类号： G01N21/25 , G01N21/85
CPC分类号： G01N21/05 , G01N21/255 , G01N21/645 , G01N2021/0346
摘要： A filter arrangement can transmit and/or reflect light emanating from a moving object so that the emanating light has time variation, and the time variation can include information about the object, such as its type. For example, emanating light from segments of a path can be transmitted/reflected through positions of a filter assembly, and the transmission functions of the positions can be sufficiently different that time variation occurs in the emanating light between segments. Or emanating light from a segment can be transmitted/reflected through a filter component in which simpler transmission functions are superimposed, so that time variation occurs in the emanating light in accordance with superposition of two simpler non-uniform transmission functions. Many filter arrangements could be used, e.g. the filter component could include the filter assembly, which can have one of the simpler non-uniform transmission functions. Time-varying waveforms from sensing results can be compared to obtain spectral differences. The filter arrangement, in a practical commercial embodiment, can be manufactured to be disposable, and used in a point-of-care device for use practically anywhere, at low cost, and can also be implemented in an in-line monitoring system.
摘要翻译：滤波器装置可以发射和/或反射从移动物体发出的光，使得发射光具有时间变化，并且时间变化可以包括关于物体的信息，例如其类型。例如，可以通过路径的区段发出光，并通过过滤器组件的位置进行透射/反射，并且位置的透射函数可以充分地不同，从而在区间之间的发光中发生时间变化。或者发射来自光束的光可以通过其中叠加更简单的透射函数的滤光器部件被透射/反射，使得根据两个更简单的不均匀透射函数的叠加在发射光中发生时间变化。可以使用许多过滤装置，例如过滤器组件可以包括过滤器组件，其可以具有更简单的不均匀传输功能之一。可以比较感测结果中的时变波形，以获得光谱差异。在实用的商业实施例中，过滤器装置可以制造为一次性的，并且用于实际上在任何地方，以低成本使用的点护理装置，并且也可以在在线监测系统中实现。

18. 发明申请

US20100155577A1 Obtaining Sensing Results Indicating Time Variation 有权
标题翻译：获取传感结果指示时间变化
公开(公告)号：US20100155577A1
公开(公告)日：2010-06-24
申请号：US12337737
申请日：2008-12-18
申请人： Peter Kiesel , Joerg Martini , Michael Bassler , Markus Beck , Noble M. Johnson
发明人： Peter Kiesel , Joerg Martini , Michael Bassler , Markus Beck , Noble M. Johnson
IPC分类号： G01J1/42 , G06F15/00 , G01N21/00
CPC分类号： G01N15/1429 , G01N15/1056 , G01N15/12 , G01N15/1459 , G01N2015/1006 , G01N2015/1037 , G01N2015/1075
摘要： In response to objects having relative motion within an encoding/sensing region relative to an encoder/sensor that, e.g., photosenses emanating light or performs impedance-based sensing, sensing results can indicate sensed time-varying waveforms with information about the objects, about their relative motion, about excitation characteristics, about environmental characteristics, and so forth. An encoder/sensor can include, for example, a non-periodic arrangement of sensing elements; a longitudinal sequence of sensing elements with a combined sensing pattern that approximates a superposition or scaled superposition of simpler sensing patterns; and/or IC-implemented sensing elements that include photosensing arrays on ICs and readout/combine circuitry that reads out photosensed quantities from cells in groups in accordance with cell-group sensing patterns and combines the readout photosensed quantities to obtain the sensing results. Objects can move fluidically as in flow cytometry, through scanning movement as in document scanning, or in other ways.
摘要翻译：响应于在编码/感测区域内相对于编码器/传感器具有相对运动的物体，例如，发出光的光照或执行基于阻抗的感测，感测结果可以指示感测到的具有关于物体的信息的时变波形，关于它们相对运动，关于激发特性，关于环境特性等。编码器/传感器可以包括例如感测元件的非周期性布置; 具有组合感测图案的感测元件的纵向序列，其近似于更简单的感测图案的叠加或缩放叠加; 和/或IC实现的感测元件，其包括IC上的光敏阵列和读出/组合电路，其根据单元组感测图案从组中的单元读出光照量，并组合读出的光照量以获得感测结果。物体可以像流式细胞仪一样流动地进行扫描运动，如文档扫描或其他方式。

19. 发明授权

US08320983B2 Controlling transfer of objects affecting optical characteristics 有权
标题翻译：控制影响光学特性的物体的传递
公开(公告)号：US08320983B2
公开(公告)日：2012-11-27
申请号：US11957610
申请日：2007-12-17
申请人： Joerg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
发明人： Joerg Martini , Jeffrey Roe , Peter Kiesel , Michael Bassler , Alan Bell , Richard H. Bruce , Noble M. Johnson
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/14532 , G01N21/03 , G01N21/39 , G01N21/8507
摘要： An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.
摘要翻译：诸如制品，装置或系统的可植入产品可以包括可以作为光腔操作的部件中的分析物和非分析物容器。该产品还可以包括流体组件，例如过滤器组件，其控制影响或移动光谱特征或特性的物体的转移，例如通过移动透射模式峰值或反射模式谷，移动相位，减小最大值或对比度，或增加中等强度宽度，作为全宽半最大值（FWHM）。分析物，例如葡萄糖分子可以主要包括在一组物体中，其比其它物体更快地转移到分析物容器中，并且可以具有可忽略或零速率的转移到非分析物容器中; 将更快速地转移到非分析物容器中的物体可以包括比分析物小的物体或一组选定类型的分子，包括例如氯化钠。因此，来自容器的输出光包括关于分析物的信息。

20. 发明授权

US08821799B2 Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity 有权
标题翻译：实现空间调制激发或发射的方法和系统，用于增强灵敏度的粒子表征
公开(公告)号：US08821799B2
公开(公告)日：2014-09-02
申请号：US11698409
申请日：2007-01-26
申请人： Michael Bassler , Peter Kiesel , Oliver Schmidt , Noble M. Johnson
发明人： Michael Bassler , Peter Kiesel , Oliver Schmidt , Noble M. Johnson
IPC分类号： G01N33/00 , G01N21/75 , C12Q1/68
CPC分类号： G01N21/6486 , G01N15/1427 , G01N15/147 , G01N2015/1447 , G01N2015/1454 , Y10T436/143333 , Y10T436/17
摘要： A method and system for using spatially modulated excitation/emission and relative movement between a particle (cell, molecule, aerosol, . . . ) and an excitation/emission pattern are provided. In at least one form, an interference pattern of the excitation light with submicron periodicity perpendicular to the particle flow is used. As the particle moves along the pattern, emission is modulated according to the speed of the particle and the periodicity of the stripe pattern. A single detector, which records the emission over a couple of stripes, can be used. The signal is recorded with a fast detector read-out in order to capture the “blinking” of the particles while they are moving through the excitation pattern. This concept enables light detection with high signal-to-noise ratio and high spatial resolution without the need of expensive and bulky optics.
摘要翻译：提供了使用空间调制的激发/发射和颗粒（细胞，分子，气溶胶等）和激发/发射图案之间的相对运动的方法和系统。在至少一种形式中，使用具有垂直于颗粒流的亚微米周期的激发光的干涉图案。当颗粒沿着图案移动时，根据颗粒的速度和条纹图案的周期性来调制发射。可以使用记录两条条纹上的发射的单个检测器。用快速检测器读出来记录信号，以便在它们移动通过激励图案时捕获颗粒的“闪烁”。这个概念能够实现高信噪比和高空间分辨率的光检测，而不需要昂贵和庞大的光学元件。

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