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11. 发明申请

WO2006074482A2 METHODS AND ARTICLES FOR STRAND-SPECIFIC POLYNUCLEOTIDE DETECTION WITH CATIONIC MULTICHROMOPHORES 审中-公开
标题翻译：用于具有阳离子多重色素的特异性多核苷酸检测的方法和文章
公开(公告)号：WO2006074482A2
公开(公告)日：2006-07-13
申请号：PCT/US2006000928
申请日：2006-01-10
申请人： UNIV CALIFORNIA , BAZAN GUILLERMO , LIU BIN
发明人： BAZAN GUILLERMO , LIU BIN
CPC分类号： C12Q1/6818 , C12Q2563/119 , C12Q2565/101 , C12Q2565/519 , C12Q2565/607 , C12Q2523/313
摘要： The invention further relates to polycationic multichromophores, which may be conjugated polymers, and methods, articles and compositions employing them as described herein. In some aspects, the invention relates to methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assay include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate. The methods can be performed in an array format on a substrate, which can be a sensor. In some embodiments, detection assays are provided employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. hi some aspects biological assays are provided in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations. The multichromophore may interact at least in part electrostatically with the sensor and/or the target, and an increase in energy transfer with the polymer may occur upon binding of the sensor and the target. Other variations of the inventions are described further herein.
摘要翻译：本发明还涉及可以是共轭聚合物的阳离子多色素，以及如本文所述使用它们的方法，制品和组合物。在一些方面，本发明涉及用于检测和分析样品中生物分子的方法，制品和组合物。提供的测定包括确定样品中目标生物分子的存在或其相对量的那些，或者测定可以是定量或半定量的。该方法可以在衬底上进行。这些方法可以以阵列格式在基底上进行，其可以是传感器。在一些实施方案中，使用不包含能够与阳离子多重色素交换能量的荧光团的传感器生物分子来提供检测测定。在一些方面，提供生物测定法，其中在所有排列中能量在一个或多个多色素，目标生物分子上的标记，传感器生物分子上的标记和/或多核苷酸特异的荧光染料之间转移。多重色淀可以至少部分地与传感器和/或靶相互作用，并且当传感器和目标物结合时，聚合物的能量传递的增加可能发生。本文进一步描述了本发明的其它变型。

12. 发明申请

WO2004077014A3 METHODS AND COMPOSITIONS FOR DETECTION AND ANALYSIS OF POLYNUCLEOTIDE-BINDING PROTEIN INTERACTIONS USING LIGHT HARVESTING MULTICHROMOPHORES 审中-公开
标题翻译：使用光收集多色素检测和分析多核苷酸结合蛋白质相互作用的方法和组合物
公开(公告)号：WO2004077014A3
公开(公告)日：2005-07-14
申请号：PCT/US2004004286
申请日：2004-02-13
申请人： UNIV CALIFORNIA , BAZAN GUILLERMO , LIU BIN , WANG SHU
发明人： BAZAN GUILLERMO , LIU BIN , WANG SHU
IPC分类号： C07F5/02 , C07H21/00 , C07H21/04 , C08G63/48 , C08G63/91 , C12Q1/68 , G01N20060101
CPC分类号： C12Q1/6818 , Y10T436/143333 , C12Q2565/101
摘要： Methods, compositions and articles of manufacture for assaying a sample for a target polynucleotide are provided. A sample suspected of containing the target polynucleotide is contacted with a polycationic multichromophore and a sensor PBP that can bind to the target polynucleotide. The sensor PBP comprises a signaling chromophore to absorb energy from the excited multichromophore and emit light in the presence of the target polynucleotide. The methods can be used in multiplex form. Kits comprising reagents for performing such methods are also provided.
摘要翻译：提供了用于测定靶多核苷酸样品的方法，组合物和制品。将怀疑含有靶多核苷酸的样品与聚阳离子多重色素和可与靶多核苷酸结合的传感器PBP接触。传感器PBP包括信号发色团，以吸收来自激发的多色素的能量并在靶多核苷酸的存在下发光。该方法可以多路复用形式使用。还提供了包含用于执行这些方法的试剂的试剂盒。

13. 发明申请

WO2004074506A3 POLYNUCLEOTIDE SEQUENCES AND CORRESPONDING ENCODED POLYPEPTIDES OF PARTICULAR SECRETED AND MEMBRANE-BOUND PROTEINS OVEREXPRESSED IN CERTAIN CANCERS 审中-公开
标题翻译：特异性分泌和膜结合蛋白的多核苷酸序列和相关编码多肽在某些癌症中的表达
公开(公告)号：WO2004074506A3
公开(公告)日：2005-04-14
申请号：PCT/US2004003030
申请日：2004-01-30
申请人： MERGEN LTD , HU QIANJIN , PENG ALLAN , LIU BIN , LOVE JAMES ROBERT , HAO XIAOFENG , REN MIN , SHENG ZHUMEI
发明人： HU QIANJIN , PENG ALLAN , LIU BIN , LOVE JAMES ROBERT , HAO XIAOFENG , REN MIN , SHENG ZHUMEI
IPC分类号： C12Q20060101 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57415
摘要： The present invention relates to the identification of the over expression of certain genes encoding certain secreted and membrane-bound proteins in breast, lung, colon and kidney cancers. Knowledge that these genes are over expressed in the cancers is useful for the detection, diagnosis, prevention and treatment of the specific cancers.
摘要翻译：本发明涉及鉴定乳腺癌，肺癌，结肠癌和肾癌中某些分泌和膜结合蛋白的某些基因的过度表达。这些基因在癌症中过表达的知识对于特异性癌症的检测，诊断，预防和治疗是有用的。

14. 发明申请

WO9928465A3 PIAS MOLECULES THAT RECOGNIZE AND BIND STAT PROTEINS AND USES THEREOF 审中-公开
标题翻译： PIAS分子识别和结合STAT蛋白及其用途
公开(公告)号：WO9928465A3
公开(公告)日：1999-10-07
申请号：PCT/US9825316
申请日：1998-11-27
申请人： UNIV CALIFORNIA , SHUAI KE , CHUNG CHAN D , LIAO JIAYU , LIU BIN , RAO XIAOPING
发明人： SHUAI KE , CHUNG CHAN D , LIAO JIAYU , LIU BIN , RAO XIAOPING
IPC分类号： C07K14/47 , C12N15/12
CPC分类号： C07K14/4703
摘要： The invention provides a family of proteins named PIAS which function as specific inhibitors of STAT proteins. Methods of using PIAS molecules are also provided to regulate STAT proteins.
摘要翻译：本发明提供了称为PIAS的蛋白家族，其作为STAT蛋白的特异性抑制剂起作用。还提供了使用PIAS分子的方法来调节STAT蛋白。

15. 发明申请

WO2015188197A2 POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS 审中-公开
标题翻译：具有生物多样性和不可生物群的多核苷酸结构
公开(公告)号：WO2015188197A2
公开(公告)日：2015-12-10
申请号：PCT/US2015034749
申请日：2015-06-08
申请人： SOLSTICE BIOLOG LTD , BRADSHAW CURT W , SAKAMURI SUKUMAR , ELTEPU LAXMAN , LAM SON , LIU DINGGUO , MEADE BRYAN , IACONO GIUSEPPE DELLO , STOCK JOSEPH , LIU BIN
发明人： BRADSHAW CURT W , SAKAMURI SUKUMAR , ELTEPU LAXMAN , LAM SON , LIU DINGGUO , MEADE BRYAN , IACONO GIUSEPPE DELLO , STOCK JOSEPH , LIU BIN
IPC分类号： C12N15/85 , C07H21/04
CPC分类号： C12N15/113 , C07H19/10 , C07H19/20 , C07H21/02 , C07H21/04 , C12N15/85 , C12N2310/14 , C12N2310/31 , C12N2310/32 , C12N2310/346 , C12N2310/3513 , C12N2310/3515 , C12N2330/30
摘要： The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3'-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5'-terminal, a 3'-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5'-terminal, a 3'-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.
摘要翻译：本发明的特征在于含有载体链，可加载到RISC复合物中的引导链和（i）引导链中的3'端或核苷酸非生物可逆组的杂交多核苷酸构建体; 或（ii）乘客链中的5'端，3'端或核苷酸非生物逆转基团，以及引物中的5'末端，3'末端或核苷酸间二硫键生物逆转组绞线或乘客绳。本发明还涉及使用杂交的多核苷酸构建体将多核苷酸递送至细胞的方法。本发明还涉及使用杂交的多核苷酸构建体减少细胞中多肽表达的方法。

16. 发明申请

WO2009136352A8 ANTI-ANGIOGENIC COMPOUNDS 审中-公开
标题翻译：抗生素化合物
公开(公告)号：WO2009136352A8
公开(公告)日：2010-11-25
申请号：PCT/IB2009051820
申请日：2009-05-04
申请人： COVX TECHNOLOGIES IRELAND LTD , DOPPALAPUDI VENKATA RAMANA , LAI JING-YU , LIU BIN , LIU DINGGUO , DESHARNAIS JOEL , BHAT ABHIJIT SURESH , FU YANWEN , OATES BRYAN DOUGLAS , CHEN GANG , BRADSHAW CURT WILLIAM
发明人： DOPPALAPUDI VENKATA RAMANA , LAI JING-YU , LIU BIN , LIU DINGGUO , DESHARNAIS JOEL , BHAT ABHIJIT SURESH , FU YANWEN , OATES BRYAN DOUGLAS , CHEN GANG , BRADSHAW CURT WILLIAM
IPC分类号： A61K47/48 , C07K14/71
CPC分类号： A61K47/48215 , A61K47/48246 , A61K47/48415 , A61K47/48507 , A61K47/60 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07K14/71
摘要： The present invention provides VEGF binding peptides. In addition, the invention provides VEGF peptides conjugated to antibodies alone and in conjunction with other anti-angiogenic molecules. Various uses of the peptides and compounds are provided, including methods to treat disorders assoiated with abnormal angiogenesis.
摘要翻译：本发明提供VEGF结合肽。此外，本发明提供了与单独的抗体和其它抗血管生成分子结合的VEGF肽。提供了肽和化合物的各种用途，包括治疗与异常血管发生相关的疾病的方法。

17. 发明申请

WO2009130535A3 OPTICAL FIBRE SPLICING MODULE 审中-公开
标题翻译：光纤分离模块
公开(公告)号：WO2009130535A3
公开(公告)日：2010-02-25
申请号：PCT/IB2008004003
申请日：2008-04-28
申请人： SHENZHEN CENTURY MAN COMM EQUI , LIU XIN , ZENG BINQIANG , LIU BIN , GUO XIAOZHOU
发明人： LIU XIN , ZENG BINQIANG , LIU BIN , GUO XIAOZHOU
IPC分类号： G02B6/38 , G02B6/36
CPC分类号： G02B6/4454
摘要： An optical fiber splicing module comprises a base (1) and a cover board (2). An upper operation plane and an lower operation plane are arranged on the base (1). The upper operation plane is provided with an optical cable fiber core winding area, a bare fiber winding and fusion welding area and an idapter holder (3). The lower operation plane is provided with a fiber pigtail winding area. 16 or 32 bayonets are arranged on the adapter holder (3), the bayonets are longitudinally arranged along the vertical direction of the operation planes. The size of the bayonets is just suitably connected to the vertically placed adapters (5). Not only the number of the bayonets is increased to a number meeting the requirements of the optical splitter, but also the volume of the entire optical fiber splicing module can be ensured not to be increased by using the arrangement of the bayonets and the matching method of the bayonets with the vertically arranged adapters (5). Also, the integrity degree can be improved and the requirements of the optical splitter can be met, without changing the shape and size of existing adapters (5).
摘要翻译：光纤接合模块包括基座（1）和盖板（2）。上部操作平面和下部操作平面布置在基座（1）上。上操作平面设有光缆纤维芯绕组区域，裸光纤绕组和熔焊区域，以及一个夹持器（3）。下操作平面设有纤维尾纤缠绕区域。 16或32个卡口布置在适配器支架（3）上，卡口沿操作平面的垂直方向纵向布置。卡口的尺寸只适合连接到垂直放置的适配器（5）上。不仅将卡口的数量增加到满足分光器要求的数量，还可以通过使用卡口的布置和匹配方法来确保整个光纤拼接模块的体积不增加具有垂直布置的适配器（5）的卡口。此外，可以在不改变现有适配器（5）的形状和尺寸的情况下，提高完整性程度并满足光分路器的要求。

18. 发明申请

WO2005056628A3 METHODS AND DEVICES COMPRISING SOLUBLE CONJUGATED POLYMERS 审中-公开
标题翻译：包含可溶性共轭聚合物的方法和装置
公开(公告)号：WO2005056628A3
公开(公告)日：2006-03-09
申请号：PCT/US2004030566
申请日：2004-09-17
申请人： UNIV CALIFORNIA , BAZAN GUILLERMO C , LIU BIN
发明人： BAZAN GUILLERMO C , LIU BIN
IPC分类号： C08G61/02 , C08G61/10 , C08G61/12 , C08G73/02 , C08G73/08 , H01B1/12 , B05D1/36 , B05D3/12 , B05D5/12
CPC分类号： H01L51/0003 , C08G61/02 , C08G61/10 , C08G61/123 , C08G61/126 , C08G73/02 , C08G73/08 , H01B1/127 , H01B1/128 , H01L51/0007 , H01L51/0036 , H01L51/0038 , H01L51/0039 , H01L51/0043 , H01L51/56 , H01S3/168 , Y10T428/31504
摘要： Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.
摘要翻译：提供涉及可溶性共轭聚合物的方法，组合物和制品。共轭聚合物具有足够的极性取代基密度使其可溶于极性介质，例如水和/或甲醇。共轭聚合物可以理想地包括改变其导电性能的单体。在一些实施方案中，本发明人提供了包含增溶基团和导电基团的阳离子共轭聚合物（CCPs），导致可溶于极性介质的导电共轭聚合物。这些聚合物的不同的溶解性质使它们能够以其它共轭聚合物沉积在多层形式的溶液中。还提供了包含具有不同溶解度特性的多层共轭聚合物的制品。本文进一步描述本发明的实施例。

19. 发明申请

WO2012121939A3 AMINOPYRAZINE COMPOUNDS 审中-公开
标题翻译：氨基吡嗪化合物
公开(公告)号：WO2012121939A3
公开(公告)日：2014-04-24
申请号：PCT/US2012027066
申请日：2012-02-29
申请人： LOCUS PHARMACEUTICALS INC , SHETTY RUPA S , WONG DORA DO-YORK LEGAL REPRESENTATIVE HEIR OF MOR , KELLY MARTHA J , LIU BIN , ZOU JINMING , MOFFETT KRISTOFER K , LEE YOUNGHEE
发明人： SHETTY RUPA S , WONG DORA DO-YORK LEGAL REPRESENTATIVE HEIR OF MOR , KELLY MARTHA J , LIU BIN , ZOU JINMING , MOFFETT KRISTOFER K , LEE YOUNGHEE
IPC分类号： A01N43/56 , A61K31/415
CPC分类号： C07D413/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/14 , C07D409/14 , C07D417/14 , C07D487/04 , C07D491/056
摘要： A compound of formula (I): wherein all symbols have the same meanings as defined in the specification; a salt thereof, a solvate thereof, an N-oxide thereof, or a prodrug thereof, has an Itk inhibitory activity, and is useful as a method for preventing and/or treating atopic dermatitis, and the like.
摘要翻译：式（I）的化合物：其中所有符号具有与说明书中定义的相同的含义; 其盐，其溶剂合物，N-氧化物或其前药具有Itk抑制活性，可用作预防和/或治疗特应性皮炎等的方法。

20. 发明申请

WO2009039192A2 INTERNALIZING HUMAN MONOCLONAL ANTIBODIES TARGETING PROSTATE CANCER CELLS IN SITU 审中-公开
标题翻译：内化靶向前列腺癌细胞的人单克隆抗体
公开(公告)号：WO2009039192A2
公开(公告)日：2009-03-26
申请号：PCT/US2008076704
申请日：2008-09-17
申请人： UNIV CALIFORNINA , LIU BIN , MARKS JAMES D
发明人： LIU BIN , MARKS JAMES D
IPC分类号： A61K51/10
CPC分类号： C07K16/3069 , A61K47/48638 , A61K51/1072 , A61K2039/505 , C07K16/005 , C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/77 , G01N33/5044 , G01N33/57434 , G01N33/6845 , G01N33/6854
摘要： This invention provides a method that allows selection of antibodies against cells (e.g. tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.
摘要翻译：本发明提供了使用激光捕获显微切割在原位选择抗细胞（例如肿瘤细胞）的抗体的方法。通过将抗体选择限制于内化表位的结合物，产生靶向临床上表示的前列腺癌抗原的一组噬菌体抗体。

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