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1. 发明申请

WO2015188197A2 POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS 审中-公开
标题翻译：具有生物多样性和不可生物群的多核苷酸结构
公开(公告)号：WO2015188197A2
公开(公告)日：2015-12-10
申请号：PCT/US2015034749
申请日：2015-06-08
申请人： SOLSTICE BIOLOG LTD , BRADSHAW CURT W , SAKAMURI SUKUMAR , ELTEPU LAXMAN , LAM SON , LIU DINGGUO , MEADE BRYAN , IACONO GIUSEPPE DELLO , STOCK JOSEPH , LIU BIN
发明人： BRADSHAW CURT W , SAKAMURI SUKUMAR , ELTEPU LAXMAN , LAM SON , LIU DINGGUO , MEADE BRYAN , IACONO GIUSEPPE DELLO , STOCK JOSEPH , LIU BIN
IPC分类号： C12N15/85 , C07H21/04
CPC分类号： C12N15/113 , C07H19/10 , C07H19/20 , C07H21/02 , C07H21/04 , C12N15/85 , C12N2310/14 , C12N2310/31 , C12N2310/32 , C12N2310/346 , C12N2310/3513 , C12N2310/3515 , C12N2330/30
摘要： The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3'-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5'-terminal, a 3'-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5'-terminal, a 3'-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.
摘要翻译：本发明的特征在于含有载体链，可加载到RISC复合物中的引导链和（i）引导链中的3'端或核苷酸非生物可逆组的杂交多核苷酸构建体; 或（ii）乘客链中的5'端，3'端或核苷酸非生物逆转基团，以及引物中的5'末端，3'末端或核苷酸间二硫键生物逆转组绞线或乘客绳。本发明还涉及使用杂交的多核苷酸构建体将多核苷酸递送至细胞的方法。本发明还涉及使用杂交的多核苷酸构建体减少细胞中多肽表达的方法。

2. 发明专利

IL269970B Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use 未知
公开(公告)号：IL269970B
公开(公告)日：2022-09-01
申请号：IL26997019
申请日：2018-04-13
申请人： TALLAC THERAPEUTICS INC , SAKAMURI SUKUMAR , BRADSHAW CURT W , LAM SON , STOCK JOSEPH , HA EDWARD HYUNGSUK , ELTEPU LAXMAN , LIU DINGGUO , LIU BIN , DELLO IACONO GIUSEPPE , MEADE BRYAN R , KABAKIBI AYMAN
发明人： SAKAMURI SUKUMAR , BRADSHAW CURT W , LAM SON , STOCK JOSEPH , HA EDWARD HYUNGSUK , ELTEPU LAXMAN , LIU DINGGUO , LIU BIN , DELLO IACONO GIUSEPPE , MEADE BRYAN R , KABAKIBI AYMAN
IPC分类号： A61K31/7125 , A61K39/00 , A61K39/39 , A61K47/60 , A61K47/68 , A61P35/00 , C07H21/04 , C07K16/28 , C07K16/30 , C12N15/117
摘要： Immunomodulating polynucleotides are disclosed. The immunomodulating polynucleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to 16 nucleotides, and/or one or more abasic spacers and/or internucleoside phosphotriesters. Also disclosed are conjugates containing a targeting moiety and one or more immunomodulating polynucleotides. The immunomodulating polynucleotides and conjugates may further contain one or more auxiliary moieties. Also disclosed are compositions containing the immunomodulating polynucleotides or the conjugates containing one or more stereochemically enriched internucleoside phosphorothioates. Further disclosed are pharmaceutical compositions containing the immunomodulating polynucleotides or the conjugates and methods of their use.

3. 发明授权

US1053751A Vegetable-grinder. 失效
标题翻译：蔬菜砂轮。
公开(公告)号：US1053751A
公开(公告)日：1913-02-18
申请号：US1912710661
申请日：1912-07-20
申请人： STOCK JOSEPH
发明人： STOCK JOSEPH
CPC分类号： B02C18/26 , A47J43/255

4. 发明专利

GB191310586A Improvements in Vegetable Grinders. 未知
公开(公告)号：GB191310586A
公开(公告)日：1914-03-26
申请号：GB191310586D
申请日：1913-05-05
申请人： STOCK JOSEPH , BAKER JULIA
发明人： STOCK JOSEPH , BAKER JULIA
摘要： 10,586. Stock, J., and Baker, J. May 5. Roller-and-breast mills; roller mills; rasping- apparatus.-A machine for grinding vegetables consists of a casing 1, Figs. 4 and 5, containing a grinding-cylinder 10, which grinds the material against the edges of a shoot 7, and a chopping or cutting roller 17 co-operating with the grinder 10, a partition 9 guiding the ground material into a receptacle at the bottom of the casing. The lower end of the shoot 7 is braced by spacing-cleats 8 resting upon the upper end of and supporting the partition 9, which is parallel to the shoot 7. The cylinder 10 preferably has a grater-like surface and is mounted on its shaft 11 by means of heads 12, one of which is provided with a flange so that the cylinder can be taken apart for cleaning. The chopping-roller 17, which is provided with staggered knives or spikes 18, is mounted above and to one side of the cylinder 10, and is secured to its shaft 19 by means of pins 20 so that the shaft can be withdrawn and the roller removed. When it is desired to grind the vegetaules without chopping them, the roller 17 is removed and the vegetables are forced against the grater 10 by a hinged feed-door 22, which is provided with an enlarged portion 23 forming a concave face 24 and is pressed downwards by a spring 26 bearing against a cover 25 secured to the top of the casing by bnttons 31. The downward movement of the door 22 is limited by its bevelled face 27 coming against the shoot 7. The casing 1, shoot 7, and partition 9 are lined with sheet metal 32, and the upper portion of the casing has inclined end walls 40. The chopping-roller is driven from the shaft 11 of the grater, which is turned by means of a crank-handle. A removable door at one end of the casing has apertures provided with wearing- plates for the shafts 11, 19, and the casing is formed with diverging sides 2 at the bottom and fitted with a hinged door 3. Fig. 7 shows a machine with a side hopper 52 and a spring- pressed door 53 to force the vegetables against the grater 45, any material passing over the grater being engaged by the roller 56 and passed down into the shoots 46, 48.

5. 发明专利

CH37007A Zugregler für Feuerungen 未知
公开(公告)号：CH37007A
公开(公告)日：1907-03-31
申请号：CH37007D
申请日：1906-05-21
申请人： STOCK JOSEPH
发明人： STOCK JOSEPH

6. 发明专利

CA156777A VEGETABLE GRINDER 未知
公开(公告)号：CA156777A
公开(公告)日：1914-07-07
申请号：CA156777D
申请日：1913-10-06
申请人： STOCK JOSEPH
发明人： STOCK JOSEPH

7. 发明专利

GB190612999A Improvements in Draught-regulators for Furnaces and the like. 未知
公开(公告)号：GB190612999A
公开(公告)日：1907-04-11
申请号：GB190612999D
申请日：1906-06-05
申请人： STOCK JOSEPH
发明人： STOCK JOSEPH
摘要： 12,999. Stock, J. June 5. Dampers.-A draughtregulating device consists of a number of parallel plates b fixed between two revoluble plates a. The angle at which the parallel plates are adjusted determines the amount of obstruction to the draught.

8. 发明专利

AT29126B 未知
公开(公告)号：AT29126B
公开(公告)日：1907-07-10
申请号：AT29126D
申请日：1906-05-21
申请人： STOCK JOSEPH
发明人： STOCK JOSEPH

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