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11. 发明专利

JP2009142661A Flexible microchip device for ophthalmic and other applications 有权
标题翻译：柔性微型手术用于眼科和其他应用
公开(公告)号：JP2009142661A
公开(公告)日：2009-07-02
申请号：JP2009000222
申请日：2009-01-05
申请人： Microchips Inc , マイクロチップス・インコーポレーテッド
发明人： SANTINI JOHN T JR , CIMA MICHAEL J , LANGER ROBERT S , AUSIELLO DENNIS , SHEPPARD NORMAN F JR , HERMAN STEPHEN J
IPC分类号： A61F9/007 , A61K9/00 , A61K9/70 , A61M31/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： PROBLEM TO BE SOLVED: To provide microchip device arrays that can conform to a curved surface for the controlled release or exposure of reservoir contents. SOLUTION: The arrays comprise two or more microchip device elements 54, each of the two or more microchip device elements includes a plurality of reservoirs 62 that contain molecules for controlled release or components for selective exposure, and a means for flexibly connecting the device elements. The reservoirs can contain one or more drugs and/or one or more secondary devices (for example, sensors or elements thereof). Preferably, this microchip devices contain and controllably release therapeutic, prophylactic, and diagnostic molecules on and into the eye of a patient in need thereof. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供可以符合弯曲表面的微芯片器件阵列，用于控制释放或暴露储层内容物。阵列包括两个或多个微芯片器件元件54，两个或更多个微芯片器件元件中的每一个包括多个储存器62，其包含用于控制释放的分子或用于选择性曝光的部件，以及用于灵活地连接设备元素。储存器可以包含一种或多种药物和/或一个或多个次要装置（例如，传感器或其元件）。优选地，该微芯片装置在有需要的患者眼中含有并可控地释放治疗，预防和诊断分子。版权所有（C）2009，JPO＆INPIT

12. 发明申请

WO0230401A3 MICROCHIP RESERVOIR DEVICES AND FACILITATED CORROSION OF ELECTRODES 审中-公开
标题翻译：微电极储存器件和电极的腐蚀性腐蚀
公开(公告)号：WO0230401A3
公开(公告)日：2003-01-16
申请号：PCT/US0142698
申请日：2001-10-11
申请人： MICROCHIPS INC
发明人： SHEPPARD NORMAN F JR , FEAKES CHRISTINA M , SANTINI JOHN T JR
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0024 , A61K9/0009 , A61K9/0097 , A61M5/14276 , A61M2205/0244
摘要： Methods and devices are provided for enhancing corrosion of an electrode in a biocompatible fluid. The method comprises (1) placing a primary electrode and a counter electrode in an electroconductive biocompatible fluid to form an electrochemical cell; and (2) applying a time-varying potential, through the electrochemical cell, to the primary electrode. In a preferred embodiment, the primary electrode is metal and comprises a reservoir cap of a microchip device for the release of molecules or exposure of device reservoir contents. The potential preferably is characterized by a waveform having a maximum potential effectively anodic to meet or exceed the corrosion potential of the primary electrode. Also, the minimum potential preferably is effectively cathodic to be below the value where redeposition of metal ions on the metal electrode can substantially occur, thereby corroding the metal electrode.
摘要翻译：提供了用于增强生物相容性流体中的电极腐蚀的方法和装置。该方法包括（1）将主电极和对电极放置在导电生物相容性流体中以形成电化学电池; 和（2）通过电化学电池将时变电位施加到初级电极。在优选实施例中，主电极是金属并且包括用于释放分子的微芯片装置的储存器盖或装置储存器内容物的暴露。该电位优选的特征在于具有有效地阳极以满足或超过初级电极的腐蚀电位的最大电位的波形。此外，最小电位优选有效地为阴极，低于金属电极上的金属离子可以基本上发生再沉积，从而腐蚀金属电极的值。

13. 发明专利

CA2577709C MULTI-CAP RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 未知
公开(公告)号：CA2577709C
公开(公告)日：2013-04-16
申请号：CA2577709
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T JR , SBIAA ZOUHAIR , COPPETA JONATHAN R , UHLAND SCOTT A , SHEPPARD NORMAN F JR
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.

14. 发明专利

DE602005013253D1 未知
公开(公告)号：DE602005013253D1
公开(公告)日：2009-04-23
申请号：DE602005013253
申请日：2005-09-01
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T , SBIAA ZOUHAIR , COPPETA JONATHAN R , UHLAND SCOTT , SHEPPARD NORMAN F JR
IPC分类号： B01L3/00 , A61K9/00 , A61M37/00
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

15. 发明专利

AU2007200736A1 Controlled release device and method 未知
公开(公告)号：AU2007200736A1
公开(公告)日：2007-03-08
申请号：AU2007200736
申请日：2007-02-20
申请人： MICROCHIPS INC
发明人： SHEPPARD NORMAN F JR , HERMAN STEPHEN J , MALONEY JOHN M , UHLAND SCOTT A , POLITO BENJAMIN F , YOMTOV BARRY M
IPC分类号： A61K9/00 , A61M5/14

16. 发明专利

AU2003303288A1 CONTROLLED RELEASE DEVICE AND METHOD USING ELECTROTHERMAL ABLATION 未知
公开(公告)号：AU2003303288A1
公开(公告)日：2004-09-06
申请号：AU2003303288
申请日：2003-08-15
申请人： MICROCHIPS INC
发明人： HERMAN STEPHEN J , YOMTOV BARRY M , UHLAND SCOTT A , POLITO BENJAMIN F , MALONEY JOHN M , SHEPPARD NORMAN F JR
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/042 , A61K9/00 , A61M5/14 , A61M5/142 , A61M37/00 , A61N1/32
摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a substrate, a plurality of reservoirs in the substrate, reservoir contents disposed in the reservoirs, discrete reservoir caps covering each reservoir to seal the reservoir contents in the reservoirs, and control circuitry for selectively disintegrating the reservoir caps to release or expose the reservoir contents in vivo. At least one of the reservoir caps comprises a first electrically conductive layer coated with one or more protective layers. In one embodiment, the control circuitry comprises an electrical input lead and an electrical output lead connected to and directly contacting each of said reservoir caps and a source of electric power for applying an electrical current through each reservoir cap in an amount effective to rupture each of the reservoir caps.

17. 发明专利

AU2445302A Microchip reservoir devices and facilitated corrosion of electrodes 未知
公开(公告)号：AU2445302A
公开(公告)日：2002-04-22
申请号：AU2445302
申请日：2001-10-11
申请人： MICROCHIPS INC
发明人： SHEPPARD NORMAN F JR , PEAKES CHRISTINA M , SANTINI JOHN T JR
IPC分类号： A61K9/00 , A61K9/22

18. 发明专利

AU5289001A Microfabricated devices for the storage and selective exposure of chemicals and devices 未知
公开(公告)号：AU5289001A
公开(公告)日：2001-09-12
申请号：AU5289001
申请日：2001-03-02
申请人： MICROCHIPS INC
发明人： SANTINI JOHN T JR , SHEPPARD NORMAN F JR , YOUNG CHUNG CHANG , LANGER ROBERT S
IPC分类号： G01N21/64 , A61K9/00 , A61K38/28 , A61P3/10 , B01J19/00 , B01L3/00 , B01L99/00 , B81B1/00 , C40B60/14 , G01N21/27 , G01N21/41 , G01N27/12 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/66 , G01N35/00
摘要： A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.

19. 发明专利

CA2399842A1 MICROFABRICATED DEVICES FOR THE STORAGE AND SELECTIVE EXPOSURE OF CHEMICALS AND DEVICES 未知
公开(公告)号：CA2399842A1
公开(公告)日：2001-09-07
申请号：CA2399842
申请日：2001-03-02
申请人： MICROCHIPS INC
发明人： LANGER ROBERT S , YOUNG CHUNG CHANG , SHEPPARD NORMAN F JR , SANTINI JOHN T JR
IPC分类号： G01N21/64 , A61K9/00 , A61K38/28 , A61P3/10 , B01J19/00 , B01L3/00 , B01L99/00 , B81B1/00 , C40B60/14 , G01N21/27 , G01N21/41 , G01N27/12 , G01N27/28 , G01N27/327 , G01N27/416 , G01N33/66 , G01N35/00
摘要： Microchip devices are provided which include a substrate having a plurality of reservoirs containing a secondary device, a reacting component, or a combination thereof. At least one barrier layer covers each reservoir to isolate the reservoir contents from one or more environmental components outside the reservoirs. The barrier layer can be selectively disintegrated o r permeabilized to expose the isolated contents to the one or more environment al components. The secondary device preferably includes a sensor or sensing component, for example, a biosensor, or a light detection or imaging device, such as an optical fiber. Preferred reacting components include catalyst and reagent, which may be immobilized in the reservoirs.

20. 发明公开

EP2608715A4 IMPLANTABLE BIOSENSOR DEVICE AND METHODS OF USE THEREOF 有权
标题翻译：植入式生物传感器及使用方法
公开(公告)号：EP2608715A4
公开(公告)日：2014-09-10
申请号：EP11820380
申请日：2011-08-12
申请人： MICROCHIPS INC
发明人： COPPETA JONATHAN R , FARRA ROBERT , HILTS KENNETH L , SHEPPARD NORMAN F JR
IPC分类号： A61B5/05
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/046 , A61B2562/066

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