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11. 发明专利

CA3098880A1 QUICK RELEASE CAPSULES 未知
公开(公告)号：CA3098880A1
公开(公告)日：2019-11-21
申请号：CA3098880
申请日：2019-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , NOVO NORDISK AS
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , DELLAL DAVID , STEIGER CHRISTOPH WINFRIED JOHANNES , ROXHED NICLAS , CAFFAREL SALVADOR ESTER , SOARES VANCE , MINAHAN DANIEL , FREDERIKSEN MORTEN REVSGAARD
IPC分类号： A61J3/07 , A61M31/00
摘要： Articles for rapid release of components including, for example, quick release capsules, are generally provided. Advantageously, in some embodiments, the articles described herein may be configured to prevent fluid from contacting a component contained therein (e.g., tissue interfacing component) or payload contained therein until a desired time, e.g., the time at which the component is configured to release from the article to a location internal to a subject (e.g., localize to a tissue wall in the subject). In some embodiments, the article comprises a first compartment and a second compartment not in fluid communication with the first compartment. In some embodiments, the first compartment and second compartment are fluidically isolated. For example, in some cases, the first compartment comprises a mechanism for releasing a component contained within the article and the second compartment comprises the component.

12. 发明专利

CA3063711A1 SELF-RIGHTING SYSTEMS, METHODS, AND RELATED COMPONENTS 未知
公开(公告)号：CA3063711A1
公开(公告)日：2018-11-22
申请号：CA3063711
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

13. 发明专利

CA3057577A1 MACRO TISSUE EXPLANT, METHODS AND USES THEREFOR 未知
公开(公告)号：CA3057577A1
公开(公告)日：2018-09-27
申请号：CA3057577
申请日：2018-03-23
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , VON ERLACH THOMAS CHRISTIAN , LANGER ROBERT S , SAXTON SARAH , MINAHAN DANIEL
IPC分类号： C12N5/071 , G01N33/50
摘要： Tissue explants of the gastrointestinal tract are provided. Methods of making and using the tissue explants are also provided, along with substrates designed for the tissue explants described.

14. 发明专利

CA2951902C ENTERIC ELASTOMERS 未知
公开(公告)号：CA2951902C
公开(公告)日：2022-08-23
申请号：CA2951902
申请日：2015-06-11
申请人： MASSACHUSETTS INST TECHNOLOGY , THE BRIGHAM & WOMENS HOSPITAL INC , TOKITAE LLC
发明人： BELLINGER ANDREW , TRAVERSO CARLO GIOVANNI , LANGER ROBERT S , GLETTIG DEAN LIANG , WOOD LOWELL L JR , ECKHOFF PHILIP A , ZHANG SHIYI
IPC分类号： C08L33/26 , A61K9/00 , A61K47/32 , A61L27/26 , C08L33/02 , C08L33/08
摘要： Enteric elastomers and related methods are generally provided. In some embodiments, the enteric elastomer is a polymer composite. Certain embodiments comprise a polymer composite in which hydrogen bonds within two carboxyl group-containing polymers cross-link the polymer networks into an elastic and pH-responsive polymer composite. Advantageously, this polymer composite has the capacity of being stable and elastic in an acidic environment such as that of the stomach but can be dissolved in a neutral pH environment such as that of the small and large intestines. In some embodiments, the polymer composites described herein comprise a mixture of two or more polymers with carboxyl functionality such that the two or more polymers form hydrogen bonds. In certain embodiments, the polymer composite has both enteric and elastic properties.

15. 发明专利

AU2019269636A1 Systems for electrical stimulation 未知
公开(公告)号：AU2019269636A1
公开(公告)日：2020-11-19
申请号：AU2019269636
申请日：2019-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , DELLAL DAVID
IPC分类号： A61N1/05 , A61B5/00 , A61M31/00 , A61N1/372 , A61N1/375
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In certain embodiments, the self-righting article a tissue- interfacing components. In some embodiments, each tissue-interfacing component may comprise an electrically-conductive portion configured for electrical communication with tissue and an insulative portion configured to not be in electrical communication with tissue.

16. 发明专利

AU2018375145A1 Gastric resident electronics 未知
公开(公告)号：AU2018375145A1
公开(公告)日：2020-06-18
申请号：AU2018375145
申请日：2018-11-28
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , TRAVERSO CARLO GIOVANNI , KONG YONG LIN
IPC分类号： A61B5/07 , A61B5/00
摘要： Gastric resident electronics, devices, systems, and related methods are generally provided. Some embodiments comprise administering (e.g., orally) an (electronic) resident structure to a subject (e.g., a patient) such that the (electronic) resident structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before exiting said location internal to the subject. In some embodiments, the resident structure is a gastric resident electronic. That is to say, in some embodiments, the resident structure is configured for relatively long gastric residence and comprises an electronic component. In some embodiments, the structures and components described herein may comprise one or more components configured for the delivery of an active substance(s) (e.g., a pharmaceutical agent) to the subject. In some embodiments, the device has a modular design, combining an electronic component(s) with materials configured for controlled and/or tunable degradation/dissolution to determine the time at which (gastric) residence is lost and the device exits the location internal to the subject. For example, in some embodiments, the resident structure comprises an electronic component and one or more additional components associated with the electronic component such that the resident structure is configured to be retained at a location internal to a subject for greater than or equal to 24 hours.

17. 发明专利

PE20200305A1 SISTEMAS AUTOENDEREZABLES Y COMPONENTES Y METODOS RELACIONADOS 未知
公开(公告)号：PE20200305A1
公开(公告)日：2020-02-06
申请号：PE2019002414
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , NOVO NORDISK AS
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61K9/00 , A61J3/07 , A61M5/00 , A61M5/14
摘要： Se proporcionan de manera general articulos autoenderezable, como capsulas autoenderezable para la administracion a un sujeto. En algunas modalidades, el articulo autoenderezable puede configurarse de modo que el articulo pueda orientarse en relacion con una superficie (por ejemplo, una superficie de un tejido de un sujeto). Los articulos autoenderezables descritos en el presente documento pueden comprender una o mas superficies de enganche de tejido configuradas para contactarse (por ejemplo, interactuar con, inyectarse, anclarse) con una superficie (por ejemplo, una superficie de un tejido de un sujeto). En algunas modalidades, el articulo autoenderezable puede tener una forma particular y/o distribucion de densidad (o masa) que, por ejemplo, permite el comportamiento de autoenderezado del articulo. En algunas modalidades, el articulo autoenderezable puede comprender un componente de interfaz de tejido y/o un agente farmaceutico (por ejemplo, para la administracion del agente farmaceutico activo a una ubicacion interior del sujeto). En algunos casos, tras el contacto del tejido con la superficie de contacto con el tejido del articulo, el articulo autoenderezable puede configurarse para liberar uno o mas componentes de interfaz del tejido. En algunos casos, el componente de interfaz de tejido esta asociado con un componente autoaccionable. Por ejemplo, el articulo autoenderezable puede comprender un componente autoaccionable configurado, tras la exposicion a un fluido, para liberar el componente de interfaz de tejido del articulo autoenderezable. En algunos casos, el componente de interfaz de tejido puede comprender y/o estar asociado con el agente farmaceutico (por ejemplo, para la entrega a una ubicacion interna de un sujeto).

18. 发明专利

AU2018269556A1 Tissue anchoring articles 未知
公开(公告)号：AU2018269556A1
公开(公告)日：2019-11-28
申请号：AU2018269556
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , DELLAL DAVID , LANGER ROBERT S
IPC分类号： A61M31/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

19. 发明专利

AU2018269544A1 Self-righting articles 未知
公开(公告)号：AU2018269544A1
公开(公告)日：2019-11-28
申请号：AU2018269544
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61K9/20 , A61K9/22 , A61K9/48
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

20. 发明专利

CA3079421A1 COMPOSITIONS AND METHODS TO ENHANCE ULTRASOUND-MEDIATED DELIVERY OF PHARMACEUTICAL AGENTS 未知
公开(公告)号：CA3079421A1
公开(公告)日：2019-04-25
申请号：CA3079421
申请日：2018-10-16
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： LANGER ROBERT S , MINAHAN DAN , BENSEL TAYLOR A , VON ERLACH THOMAS , TRAVERSO CARLO GIOVANNI , SCHOELLHAMMER CARL MAGNUS
IPC分类号： A61K49/22 , A61B10/02
摘要： Disclosed herein are compositions comprising a pharmaceutical agent and an ultrasound enhancing agent. The compositions are useful in combination with ultrasound to enhance delivery of a pharmaceutical agent to, for example, tissue of a subject in need thereof. Accordingly, also provided herein are methods involving ultrasound for delivering a pharmaceutical agent to a subject, e.g., a subject that has inflammatory bowel disease or proctitis.

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