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11. 发明授权

US07927822B2 Methods for screening cells and antibodies 失效
标题翻译：筛选细胞和抗体的方法
公开(公告)号：US07927822B2
公开(公告)日：2011-04-19
申请号：US11635934
申请日：2006-12-08
申请人： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , William C. Karl , Bo Lin
发明人： Christine C. Genick , Lance G. Laing , Peter Li , Timothy F. Smith , Lara Madison , William C. Karl , Bo Lin
IPC分类号： G01N33/543 , G01N33/545 , G01N33/551
CPC分类号： G01N33/543 , B01L3/5085 , C12Q1/6816 , C40B30/04 , C40B30/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/7743 , G01N33/5026 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/54373 , G02B5/1809 , Y10S436/805 , Y10S436/809
摘要： The invention provides methods of detecting a change in cell growth patterns, methods of screening many different antibodies in one receptacle, and methods of detecting specific binding of an antibody to a protein or cell, wherein the antibody is in a mixture of many different antibodies.
摘要翻译：本发明提供检测细胞生长模式变化的方法，在一个容器中筛选许多不同抗体的方法，以及检测抗体与蛋白质或细胞的特异性结合的方法，其中所述抗体是许多不同抗体的混合物。

12. 发明授权

US06284113B1 Apparatus and method for transferring liquids 有权
标题翻译：液体转移装置及方法
公开(公告)号：US06284113B1
公开(公告)日：2001-09-04
申请号：US09153814
申请日：1998-09-15
申请人： Torleif Ove Bjornson , Timothy F. Smith
发明人： Torleif Ove Bjornson , Timothy F. Smith
IPC分类号： G01N2726
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00317 , B01J2219/00351 , B01J2219/00358 , C40B60/14 , G01N35/1065 , G01N35/1074 , G01N2035/1037
摘要： The present invention concerns devices, apparatus and methods for transferring liquids. One aspect of the present invention is a device comprising a plate having a plurality of transfer elements. Each of the transfer elements comprises an aperture in the plate where the aperture is capable of being electrically activated. The plate has one of more attaching elements for attaching the plate to a multiwell plate to form a sealed system except for the apertures of the transfer elements. Usually, the device is adapted for sealing attachment to a multiwell plate. In a method in accordance with the present invention a quantity of liquid is disposed to a second side of a plate having a plurality of apertures in the plate. The apertures are capable of being electrically activated. The liquid is present in a closed well except for the apertures in the plate. To simultaneously expel liquid from the apertures, the apertures are electrically activated. Also disclosed are kits comprising a device in accordance with the present invention.
摘要翻译：本发明涉及用于转移液体的装置，装置和方法。本发明的一个方面是包括具有多个转移元件的板的装置。每个传送元件包括板中的孔，其中孔能够被电激活。板具有用于将板连接到多孔板以形成除了转移元件的孔之外的密封系统的更多附接元件之一。通常，该装置适于密封附着到多孔板。在根据本发明的方法中，一定量的液体被设置在板的具有多个孔的板的第二面上。孔能够被电活动。除了板中的孔之外，液体存在于封闭的井中。为了同时从孔中排出液体，孔被电激活。还公开了包括根据本发明的装置的试剂盒。

13. 发明授权

US06614030B2 Multiplexed fluorescent detection in microfluidic devices 有权
公开(公告)号：US06614030B2
公开(公告)日：2003-09-02
申请号：US10147940
申请日：2002-05-15
申请人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
发明人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , B01L3/5027 , B01L2200/14 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6478 , G01N2201/101
摘要： An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.

14. 发明授权

US06838680B2 Multiplexed fluorescent detection in microfluidic devices 有权
标题翻译：微流体装置中多重荧光检测
公开(公告)号：US06838680B2
公开(公告)日：2005-01-04
申请号：US10202298
申请日：2002-07-23
申请人： Kevin Maher , Timothy F. Smith , Torleif O. Bjornson
发明人： Kevin Maher , Timothy F. Smith , Torleif O. Bjornson
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/253 , G01N21/645 , G01N2021/0346 , G01N2021/6439
摘要： An optical detection and orientation device is provided comprising a housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focusing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and a moveable carrier for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in detecting fluorophores in the channel during operations involving fluorescent signals.

15. 发明授权

US06399952B1 Multiplexed fluorescent detection in microfluidic devices 有权
标题翻译：微流体装置中多重荧光检测
公开(公告)号：US06399952B1
公开(公告)日：2002-06-04
申请号：US09569963
申请日：2000-05-12
申请人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
发明人： Kevin Maher , Timothy F. Smith , Torleif Ove Bjornson
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , B01L3/5027 , B01L2200/14 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6478 , G01N2201/101
摘要： An optical detection and orientation device is provided comprising housing having an excitation light source, an optical element for reflecting the excitation light to an aspherical lens and transmitting light emitted by a fluorophore excited by said excitation light, a focussing lens for focusing the emitted light onto the entry of an optical fiber, which serves as a confocal aperture, and means for accurately moving said housing over a small area in relation to a channel in a microfluidic device. The optical detection and orientation device finds use in identifying the center of the channel and detecting fluorophores in the channel during operations involving fluorescent signals.
摘要翻译：提供了一种光学检测和取向装置，包括具有激发光源的壳体，用于将激发光反射到非球面透镜并透射由所述激发光激发的荧光团发射的光的光学元件，用于将发射的光聚焦到聚焦透镜用作共焦孔的光纤的进入以及用于相对于微流体装置中的通道在小的区域上精确地移动所述壳体的装置。光学检测和取向装置用于识别通道的中心并且在涉及荧光信号的操作期间检测通道中的荧光团。

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