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11. 发明授权

US06548607B2 High density, miniaturized arrays and methods of manufacturing same 有权
公开(公告)号：US06548607B2
公开(公告)日：2003-04-15
申请号：US10060798
申请日：2002-01-30
申请人： Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen
发明人： Kurt J. Halverson , Sanjay L. Patil , Jerald K. Rasmussen
IPC分类号： C08F830
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00664 , B01J2219/00677 , B01J2219/00702 , B01J2219/00722 , C12Q1/6837 , C40B40/06 , Y10T428/24174 , Y10T428/31667 , Y10T428/31902 , Y10T428/3192 , Y10T428/31938
摘要： High-density, miniaturized arrays including high surface areas. Arrays described include substrate with a coating of linking agents, as well as arrays with reactants affixed to the substrates. Methods of manufacturing high-density arrays of reactants. The methods include the use of oriented, heat shrink films and elastomeric materials. Methods of functionalizing a substrate with linking agents for subsequent affixation of reactants are also disclosed herein.

12. 发明授权

US08969029B2 Biological sterilization indicator, system, and methods of using same 有权
标题翻译：生物灭菌指标，系统及使用方法
公开(公告)号：US08969029B2
公开(公告)日：2015-03-03
申请号：US13063945
申请日：2009-10-12
申请人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
发明人： Sailaja Chandrapati , Jeffrey C. Pederson , Heather M. Webb , Jeffrey D. Smith , Kurt J. Halverson , Bryan S. Behun , Peter D. Ludowise
IPC分类号： C12Q1/22 , C12M1/00 , C12Q1/68 , A61L2/28
CPC分类号： A61L2/28 , C12Q1/22
摘要： A biological sterilization indicator, system, and methods of determining the effectiveness of a sterilization process. The biological sterilization indicator can include a locus of spores, a reservoir containing a liquid, and a sterilant path positioned to provide fluid communication between ambience and the locus of spores. The reservoir can have a closed state in which the reservoir is not in fluid communication with the locus of spores and an open state in which the reservoir is in fluid communication with the locus of spores. The biological sterilization indicator system can include the biological sterilization indicator and a detection device adapted to be coupled to the biological sterilization indicator. In some embodiments, the method can include assaying the spores for a detectable change in a characteristic, and detecting substantially all of the detectable change.
摘要翻译：一种生物灭菌指标，系统和确定灭菌过程有效性的方法。生物灭菌指示剂可以包括孢子的位点，含有液体的储存器和定位成在气氛和孢子的位置之间提供流体连通的消毒剂通道。储存器可以具有闭合状态，其中储存器不与孢子的轨迹流体连通，并且储存器与孢子的轨迹流体连通的打开状态。生物灭菌指示器系统可以包括生物灭菌指示器和适于联接到生物灭菌指示器的检测装置。在一些实施方案中，该方法可以包括测定孢子以获得特征的可检测变化，并且检测基本上所有可检测的变化。

13. 发明授权

US08753834B2 Microbial detection article 有权
标题翻译：微生物检测文章
公开(公告)号：US08753834B2
公开(公告)日：2014-06-17
申请号：US13519284
申请日：2010-12-30
申请人： Jesse D. Miller , Stephanie J. Moeller , Kurt J. Halverson
发明人： Jesse D. Miller , Stephanie J. Moeller , Kurt J. Halverson
IPC分类号： C12Q1/04
CPC分类号： G01N33/56911 , C12M23/20 , C12M25/02 , C12M41/36 , C12Q1/04 , C12Q1/06 , G01N33/569
摘要： The disclosure provides an article for the detection of a microorganism in a liquid sample. The article comprises a microporous membrane and a barrier layer to selectively regulate the contact between the sample and a detection reagent. A method of use is also provided.
摘要翻译：本公开提供了用于检测液体样品中的微生物的制品。该制品包括微孔膜和阻挡层，以选择性地调节样品与检测试剂之间的接触。还提供了一种使用方法。

14. 发明授权

US08609330B2 Live Bioload detection using microparticles 有权
标题翻译：使用微粒进行活体生物负载检测
公开(公告)号：US08609330B2
公开(公告)日：2013-12-17
申请号：US13142290
申请日：2009-12-31
申请人： Raj Rajagopal , Kurt J. Halverson , Manjiri T. Kshirsagar , James E. Aysta
发明人： Raj Rajagopal , Kurt J. Halverson , Manjiri T. Kshirsagar , James E. Aysta
IPC分类号： C12Q1/00 , C12Q1/02 , C12Q1/04
CPC分类号： C12Q1/04 , A61B10/0045 , A61B10/02 , B01L3/5082 , B01L2200/026 , B01L2200/10 , C12M23/08 , C12M23/32 , C12M23/34 , C12M33/02 , G01N33/56916 , G01N2333/245
摘要： The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.
摘要翻译：本发明提供了将细胞浓缩到微粒上，浓缩微粒并检测细胞的方法。本发明还包括根据该方法使用的单一样品制备和检测装置。

15. 发明授权

US08569072B2 Sample preparation container and method 有权
标题翻译：样品制备容器和方法
公开(公告)号：US08569072B2
公开(公告)日：2013-10-29
申请号：US12743449
申请日：2008-11-19
申请人： Kurt J. Halverson , Stephen C. P. Joseph , Raj Rajagopal , Matthew D. Reier , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati
发明人： Kurt J. Halverson , Stephen C. P. Joseph , Raj Rajagopal , Matthew D. Reier , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati
IPC分类号： G01N1/00
CPC分类号： G01N1/38
摘要： A system and method for preparing and delivering samples for analyte testing. The system can include a sample preparation system and a sample delivery system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample delivery system can include a valve positioned in fluid communication with the reservoir and adapted to control the removal of a sample from the sample preparation system. The method can include applying pressure to the deformable self-supporting receptacle to remove a sample from the sample preparation system via the sample delivery system.
摘要翻译：用于制备和递送样品以进行分析物测试的系统和方法。该系统可以包括与样品制备系统耦合的样品制备系统和样品递送系统。样品制备系统可以包括可变形的自支撑容器，其包括适于容纳包含源和稀释剂的液体组合物的储存器。样品输送系统可以包括定位成与储存器流体连通的阀，并适于控制样品从样品制备系统中的去除。该方法可以包括向可变形的自支撑容器施加压力，以经由样品输送系统从样品制备系统移除样品。

16. 发明申请

US20130230876A1 METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY 有权
标题翻译：检测生物活性的方法和组合物
公开(公告)号：US20130230876A1
公开(公告)日：2013-09-05
申请号：US13883620
申请日：2011-10-28
申请人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
发明人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/04
摘要： Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.
摘要翻译：提供了包含水，可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。第一指示剂可以包括具有选自伞形酮，7-氨基香豆素，β-萘胺，β-萘酚，荧光素，再次吸收的9H-（1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮），罗丹明110，任何前述荧光团的衍生物，以及任何上述荧光团的组合。颗粒能够从水性液体中接收和保留第一生物衍生物。第一种生物衍生物可以指示微生物。组合物还可以包含胶凝剂。还提供了使用组合物来检测样品中微生物的存在或不存在的方法。

17. 发明申请

US20130210067A1 METHOD OF DETECTING A BIOLOGICAL ACTIVITY 有权
标题翻译：检测生物活性的方法
公开(公告)号：US20130210067A1
公开(公告)日：2013-08-15
申请号：US13825881
申请日：2011-10-28
申请人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Kurt J. Halverson , Brian R. Engel
发明人： Sailaja Chandrapati , Heather M. Webb , Jeffrey C. Pederson , Kurt J. Halverson , Brian R. Engel
IPC分类号： G01N21/64
CPC分类号： C12M37/06 , C12M23/32 , C12M25/06 , C12Q1/04 , C12Q1/22 , G01N21/6486
摘要： The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative.
摘要翻译：本发明提供了检测预定生物活性的方法。该方法包括使用包含具有第一吸收光谱的第一指示剂和第二指示剂试剂的含水混合物。第二指示剂通过预定的生物活性转化为具有第二发射光谱的第二生物衍生物。第一吸收光谱包括在第二发射光谱中存在的波长的至少一部分中的可检测吸光度。第一指示剂被含水液体接收并通过底物浓缩，便于检测第二生物衍生物。

18. 发明申请

US20100248216A1 SAMPLE PREPARATION CONTAINER AND METHOD 有权
标题翻译：样品制备容器和方法
公开(公告)号：US20100248216A1
公开(公告)日：2010-09-30
申请号：US12743459
申请日：2008-11-19
申请人： Kurt J. Halverson , Stephen C.P. Joseph , Raj Rajagopal , Matthew D. Reier , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati
发明人： Kurt J. Halverson , Stephen C.P. Joseph , Raj Rajagopal , Matthew D. Reier , David J. Velasquez , Cynthia D. Zook , Sailaja Chandrapati
IPC分类号： C12Q1/70 , C12M1/34 , C12Q1/02 , C12Q1/68
CPC分类号： G01N1/38 , B01L3/505 , Y10T436/25
摘要： A system and method for preparing and analyzing samples. The system can include a sample preparation system and a sample detection system coupled to the sample preparation system. The sample preparation system can include a deformable self-supporting receptacle comprising a reservoir adapted to contain a liquid composition comprising a source and a diluent. The sample detection system can be positioned in fluid communication with the reservoir, and can be adapted to analyze a sample of the liquid composition for an analyte of interest. The system can further include a fluid path defined at least partially by the reservoir and the sample detection system. The method can include applying pressure to the deformable self-supporting receptacle to move a sample of the liquid composition in the fluid path to the sample detection system, and analyzing the sample for the analyte of interest with the sample detection system.
摘要翻译：一种用于准备和分析样品的系统和方法。该系统可以包括样品制备系统和与样品制备系统耦合的样品检测系统。样品制备系统可以包括可变形的自支撑容器，其包括适于容纳包含源和稀释剂的液体组合物的储存器。样品检测系统可以定位成与储存器流体连通，并且可以适于分析用于感兴趣的分析物的液体组合物的样品。该系统还可以包括至少部分地由储存器和样本检测系统限定的流体路径。该方法可以包括向可变形的自支撑容器施加压力以将流体路径中的液体组合物的样品移动到样品检测系统，并且用样品检测系统分析样品的感兴趣的分析物。

19. 发明授权

US06391578B2 Method and devices for partitioning biological sample liquids into microvolumes 有权
标题翻译：将生物样品液体分解成微量体积的方法和装置
公开(公告)号：US06391578B2
公开(公告)日：2002-05-21
申请号：US09824160
申请日：2001-04-02
申请人： Michael G. Williams , Kurt J. Halverson , Gary E. Krejcarek , Ai-Ping Wei , James G. Berg , Peter D. Wickert , Clyde D. Calhoun , Mark K. Debe , Jean Qiu
发明人： Michael G. Williams , Kurt J. Halverson , Gary E. Krejcarek , Ai-Ping Wei , James G. Berg , Peter D. Wickert , Clyde D. Calhoun , Mark K. Debe , Jean Qiu
IPC分类号： C12Q106
CPC分类号： B01L3/5085 , C12M23/12 , C12M23/20 , C12M23/44 , C12M25/04 , C12M41/36
摘要： A method for partitioning an aqueous biological liquid sample into discrete microvolumes for detection and enumeration of microorganisms is described. The method involves distributing microvolumes of a sample to a plurality of hydrophilic liquid-retaining zones of a culture device, where each liquid-retaining zone is surrounded by a portion of a hydrophobic “land” area. Also disclosed are devices for carrying out these methods.
摘要翻译：描述了将水性生物液体样品分成用于微生物检测和计数的离散微量体积的方法。该方法包括将样品的微量体积分配到培养装置的多个亲水性液体保持区，其中每个液体保持区被疏水性“陆地”区域的一部分包围。还公开了用于执行这些方法的装置。

20. 发明授权

US09435739B2 Methods and compositions to detect a biological activity 有权
标题翻译：检测生物活性的方法和组合物
公开(公告)号：US09435739B2
公开(公告)日：2016-09-06
申请号：US13883620
申请日：2011-10-28
申请人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
发明人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
IPC分类号： C12Q1/44 , G01N21/64 , C12Q1/04
CPC分类号： G01N21/6486 , C12Q1/04
摘要： Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.
摘要翻译：提供了包含水，可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。第一指示剂可以包含具有选自伞形酮，7-氨基香豆素，β-萘胺，β-萘酚，荧光素，再利用者，9H-（1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮），罗丹明110，任何前述荧光团的衍生物，以及任何上述荧光团的组合。颗粒能够从水性液体中接收和保留第一生物衍生物。第一种生物衍生物可以指示微生物。组合物还可以包含胶凝剂。还提供了使用组合物来检测样品中微生物的存在或不存在的方法。

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