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11. 发明申请

US20050020556A1 Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes 审中-公开
标题翻译：使用HSP90抑制剂与铂配位配合物联合治疗疾病的方法
公开(公告)号：US20050020556A1
公开(公告)日：2005-01-27
申请号：US10856344
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/28 , A61K31/33 , A61K33/24 , A61K45/06
CPC分类号： A61K33/24 , A61K31/28 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and a platinum coordination complex, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of a platinum coordination complex in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of a platinum coordination complex. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of a platinum coordination complex and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法涉及施用HSP90抑制剂和铂配位络合物，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用铂配位复合物的剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一剂HSP90抑制剂治疗受试者，随后用一定剂量的铂配位复合物处理。在本发明的另一方面，提供一种治疗癌症的方法，其中首先用一定剂量的铂配位复合物处理受试者，随后用剂量的HSP90抑制剂治疗。

12. 发明申请

US20050009820A1 Thiochromenones used to combat painful conditions and neurodegenerative diseases 审中-公开
标题翻译：用于治疗疼痛状况和神经退行性疾病的硫代色素
公开(公告)号：US20050009820A1
公开(公告)日：2005-01-13
申请号：US10479189
申请日：2002-05-21
申请人： Heinrich Meier , Swen Allerheilingen , Michael Gerisch , Rudolfd Schohe-Loop , Arnd Voerste , Frank Mauler , Jean Marie de Vry , Thomas Muller , Christoph Methfessel
发明人： Heinrich Meier , Swen Allerheilingen , Michael Gerisch , Rudolfd Schohe-Loop , Arnd Voerste , Frank Mauler , Jean Marie de Vry , Thomas Muller , Christoph Methfessel
IPC分类号： A61K31/382 , A61K31/395 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/41 , A61K31/4155 , A61K31/4178 , A61K31/4245 , A61K31/428 , A61K31/4436 , A61K31/453 , A61K31/4535 , A61K31/496 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/55 , A61P1/08 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P19/08 , A61P21/04 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P29/00 , A61P31/04 , A61P31/12 , A61P43/00 , C07D335/04 , C07D335/16 , C07D409/04 , C07D409/10 , C07D409/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D491/10 , C07D491/113 , C07D495/02
CPC分类号： C07D409/04 , A61K31/382 , C07D335/04 , C07D335/16 , C07D409/10 , C07D409/12 , C07D413/04 , C07D413/12 , C07D491/10
摘要： The invention relates to novel thiochromenones and processes for their preparation, to their use for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of states of pain and neurodegenerative disorders.
摘要翻译：本发明涉及新的硫代色烯酮及其制备方法，用于治疗和/或预防疾病，特别是用于治疗和/或预防疼痛和神经退行性疾病状态。

13. 发明授权

US06726294B1 Cabinet locking system 有权
标题翻译：柜锁系统
公开(公告)号：US06726294B1
公开(公告)日：2004-04-27
申请号：US09674582
申请日：2001-01-08
申请人： Thomas Muller , Bruno Hasler
发明人： Thomas Muller , Bruno Hasler
IPC分类号： E05B6546
CPC分类号： E05B65/462 , E05B47/00
摘要： A cabinet locking system includes at least one cabinet having a housing and a plurality of separately openable compartments in the housing. The system has an interlocking device locking the compartments, that device including separate switchable locking devices mounted in the housing and assigned to the compartments as well as an access authorization device into which identification codes corresponding to the compartments may be entered. An electronic processing unit that is connected to the interlocking device and the access authorization device controls the locking devices in accordance with codes entered into the access authorization device so that by entering selected codes into that device, corresponding ones of the compartments are unlocked. The system also includes an interlock responsive to the opening of one unlocked compartment for preventing the opening of any other unlocked compartment.
摘要翻译：机柜锁定系统包括至少一个机柜，其具有壳体和壳体中的多个可单独打开的隔间。该系统具有锁定隔间的互锁装置，该装置包括安装在壳体中并分配给隔间的单独的可切换锁定装置以及可以输入与隔间相对应的识别代码的访问授权装置。连接到互锁装置和访问授权装置的电子处理单元根据输入到访问授权装置的代码来控制锁定装置，以便通过将选择的代码输入到该装置中，对应的这些隔间被解锁。该系统还包括响应于一个解锁室的打开的联锁，以防止任何其他未锁定隔间的打开。

14. 发明授权

US06566305B1 Phytosanitary treatment by foliar absorption using a modified oil 失效
标题翻译：使用改性油进行叶面吸收的植物检疫处理
公开(公告)号：US06566305B1
公开(公告)日：2003-05-20
申请号：US09720982
申请日：2001-04-05
申请人： Alain Milius , Christian Gauvrit , Thomas Muller , Nathalie Okori
发明人： Alain Milius , Christian Gauvrit , Thomas Muller , Nathalie Okori
IPC分类号： A01N302
CPC分类号： A01N37/12 , A01N25/02 , A01N47/22 , A01N39/04 , A01N25/30 , A01N2300/00
摘要： The subject of the invention is a method of plant-protection treatment by leaf absorption, characterized in that it uses a composition comprising at least one plant-protection active ingredient and at least one modified oil, a composition comprising at least one plant-protection active ingredient, at least one modified vegetable oil and at least one unmodified vegetable oil as well as an alkoxylated vegetable oil containing x% of glycerol.
摘要翻译：本发明的主题是通过叶吸收进行植物保护处理的方法，其特征在于其使用包含至少一种植物保护活性成分和至少一种改性油的组合物，组合物包含至少一种植物保护活性物质至少一种改性植物油和至少一种未改性植物油以及含有x％甘油的烷氧基化植物油。

15. 发明授权

US5932770A Process for recovery of phosphine oxides and alklylsarylphosphines from reaction mixtures of a homogeneous hydroformylation 失效
标题翻译：从均相加氢甲酰化反应混合物回收氧化膦和烷芳基膦的方法
公开(公告)号：US5932770A
公开(公告)日：1999-08-03
申请号：US909234
申请日：1997-08-11
申请人： Helmut Bahrmann , Thomas Muller
发明人： Helmut Bahrmann , Thomas Muller
IPC分类号： C07B63/00 , B01J31/40 , C07C45/50 , C07F9/02 , C07F9/50 , C07F9/53
CPC分类号： B01J31/4046 , B01J31/1875 , B01J31/2404 , B01J31/2409 , B01J31/2452 , B01J31/4015 , B01J31/4061 , C07C45/50 , C07F9/025 , B01J2231/321 , B01J2531/0266 , B01J2531/822 , B01J31/0201 , C07C2103/68 , Y02P20/584
摘要： A process for separating off phosphine oxides and alkylarylphosphines from an organic reaction mixture of a homogeneous hydroformylation carried out with the use of a catalyst system, which reaction mixture contains organometallic complex compounds and, in a molar excess, ammonium salts of aromatic phosphines as ligands comprising subjecting the organic reaction mixture to an extraction treatment with a 0.001-0.5% strength by weight of an alkali metal hydroxide or alkaline earth metal hydroxide solution and separating off the aqueous phase containing the phosphine oxides and alkylarylphosphines to decrease markedly the concentration of the phosphine oxides and alkylarylphosphines in the hydroformylation mixture, which process is particularly suitable for continuously operated hydroformylations.
摘要翻译：从使用催化剂体系进行的均相加氢甲酰化的有机反应混合物中分离出氧化膦和烷基芳基膦的方法，该反应混合物含有有机金属络合物，以摩尔过量形式的芳族膦的铵盐作为配体包括使有机反应混合物用碱金属氢氧化物或碱土金属氢氧化物溶液重量的0.001-0.5％的重量萃取处理，并分离出含有氧化膦和烷基芳基膦的水相，显着降低氧化膦的浓度和加氢甲酰化混合物中的烷基芳基膦，该方法特别适用于连续操作的加氢甲酰化。

16. 发明授权

US5880284A Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：环状脲衍生物，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5880284A
公开(公告)日：1999-03-09
申请号：US864528
申请日：1997-05-28
申请人： Frank Himmelsbach , Volkhard Austel , Gunter Linz , Helmut Pieper , Brian Guth , Thomas Muller , Johannes Weisenberger
发明人： Frank Himmelsbach , Volkhard Austel , Gunter Linz , Helmut Pieper , Brian Guth , Thomas Muller , Johannes Weisenberger
IPC分类号： A61K31/41 , A61K31/395 , A61K31/415 , A61K31/4166 , A61K31/435 , A61K31/4427 , A61K31/445 , A61P7/02 , A61P9/10 , A61P35/00 , A61P43/00 , C07C281/06 , C07D233/02 , C07D233/32 , C07D233/36 , C07D233/44 , C07D233/70 , C07D233/72 , C07D235/26 , C07D239/10 , C07D249/12 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D417/06 , C07D453/02 , C07D487/08
CPC分类号： C07D401/04 , C07D233/36 , C07D233/44 , C07D233/70 , C07D233/72 , C07D235/26 , C07D239/10 , C07D249/12 , C07D401/06 , C07D401/10 , C07D417/06 , C07D453/02
摘要： The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein R.sub.a, R.sub.b, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, preferably aggregation inhibiting effects, and to drugs containing the compounds and processes for preparing them.
摘要翻译：本发明涉及通式I（I）的环脲衍生物，其中Ra，Rb，X和Y如权利要求1所定义，其互变异构体，立体异构体和盐，特别是其与无机或有机物的生理上可接受的盐具有有价值的药理学性质，优选聚集抑制作用的酸或碱，以及含有这些化合物的药物及其制备方法。

17. 发明授权

US5744194A Process and device for coating at least one optical waveguide 失效
标题翻译：用于涂覆至少一个光波导的工艺和装置
公开(公告)号：US5744194A
公开(公告)日：1998-04-28
申请号：US666395
申请日：1996-06-21
申请人： Thomas Muller , Frank Renner , Wilfried Reissenweber , Reiner Schneider
发明人： Thomas Muller , Frank Renner , Wilfried Reissenweber , Reiner Schneider
IPC分类号： G02B6/44 , B05D5/06
CPC分类号： G02B6/4483
摘要： A process for coating at least one optical waveguide with a filling compound has at least two successive filling stages separated by a wiping device of reduced cross section. In the region of the wiping device, a proportion of the filling compound which is thus wiped off is led past the wiping device by a bypass and is fed once more to coat the optical waveguide in the second filling stage.
摘要翻译： PCT No.PCT / DE94 / 01511 Sec。 371日期：1996年6月21日 102（e）1996年6月21日PCT 1994年12月20日PCT PCT。出版物WO95 / 17694 日期：1995年6月29日一种用填充化合物涂覆至少一个光波导的方法具有至少两个连续的填充阶段，其由横截面减小的擦拭装置分开。在擦拭装置的区域中，将被擦去的填充化合物的比例通过旁路引导通过擦拭装置，并在第二填充阶段中再次进料以涂覆光波导。

18. 发明授权

US5681961A Arylsulphonamides, pharmaceutical compositions containing these compounds and processes for preparing them 失效
标题翻译：芳基磺酰胺，含有这些化合物的药物组合物及其制备方法
公开(公告)号：US5681961A
公开(公告)日：1997-10-28
申请号：US407180
申请日：1995-03-21
申请人： Armin Heckel , Josef Nickl, deceased , Rainer Soyka , Wolfgang Eisert , Thomas Muller , Johannes Weisenberger , Christopher Meade , Gojko Muacevic
发明人： Armin Heckel , Josef Nickl, deceased , Rainer Soyka , Wolfgang Eisert , Thomas Muller , Johannes Weisenberger , Christopher Meade , Gojko Muacevic
IPC分类号： C07D213/55 , A61K31/145 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61P7/02 , A61P9/00 , A61P9/10 , A61P11/00 , A61P37/08 , A61P43/00 , C07D213/56 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D213/16
CPC分类号： C07D401/06 , C07D213/55 , C07D213/56 , C07D409/06 , C07D409/12
摘要： The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R.sub.1 to R.sub.6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R.sub.4 and R.sub.5 together represent a carbon-carbon bond, and the addition salts thereof, more particularly for pharmaceutical use the physiologically acceptable addition salts thereof with inorganic or organic bases, if R.sub.6 represents a hydroxy group) which have useful pharmacological properties, particularly antithrombotic activities and thromboxane-mediating activities. Furthermore, the new compounds are also thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSH). They also have an effect on PGE.sub.2 production.
摘要翻译：本发明涉及新的式（I）芳基磺酰胺（其中A，B和R 1至R 6如权利要求1中所定义，其对映异构体，顺式和反式异构体，其中R 4和R 5一起代表碳碳键和其加成盐，更特别是药物用途，其与无机或有机碱的生理上可接受的加成盐，如果R6表示羟基），其具有有用的药理学特性，特别是抗血栓形成活性和血栓烷烷介导活性。此外，新化合物还是血栓烷拮抗剂（TRA）和血栓烷合成抑制剂（TSH）。它们也对PGE2产生影响。

19. 发明授权

US5174899A Process for separating organometallic compounds and/or metal carbonyls from their solutions in organic media 失效
标题翻译：从有机介质中将有机金属化合物和/或金属羰基从溶液中分离的方法
公开(公告)号：US5174899A
公开(公告)日：1992-12-29
申请号：US724463
申请日：1991-06-26
申请人： Helmut Bahrmann , Michael Haubs , Willi Kreuder , Thomas Muller
发明人： Helmut Bahrmann , Michael Haubs , Willi Kreuder , Thomas Muller
IPC分类号： B01D61/02 , B01D61/14 , B01D61/24 , B01D71/64 , B01J31/40 , B01J37/00 , B01J38/00 , B01J38/48 , C07B61/00 , C07B63/00 , C07C45/49 , C07C45/50 , C07C45/68 , C07C45/78 , C07C45/80 , C07C47/34 , C07F7/00 , C07F9/00 , C07F11/00 , C07F13/00 , C07F15/00 , C07F15/02 , C07F15/04 , C07F15/06 , C07F19/00
CPC分类号： B01J31/20 , B01D61/02 , B01D61/14 , B01D61/243 , B01J31/24 , B01J31/2404 , B01J31/2452 , B01J31/4015 , B01J31/4023 , B01J31/4046 , B01J31/4061 , B01J37/009 , B01J38/00 , B01J38/48 , C07C45/49 , C07C45/50 , C07C45/68 , C07C45/786 , C07C45/80 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008 , C07F15/045 , C07F19/005 , B01J2231/321 , B01J2531/0208 , B01J2531/31 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/845 , B01J2531/847 , B01J31/181 , B01J31/2239 , B01J31/2295 , Y02P20/584
摘要： Organometallic compounds and/or metal carbonyls are separated from their solutions in organic media with the aid of semi-permeable membranes made of aromatic polyamides.
摘要翻译：借助于由芳族聚酰胺制成的半透膜，有机金属化合物和/或金属羰基化合物在有机介质中与其溶液分离。

20. 发明授权

US4870076A Sulphonamidoethyl compounds, pharmaceutical compositions comprising these compounds and processes for preparing them 失效
标题翻译：磺酰氨基乙基化合物，包含这些化合物的药物组合物及其制备方法
公开(公告)号：US4870076A
公开(公告)日：1989-09-26
申请号：US92742
申请日：1987-09-03
申请人： Armin Heckel , Josef Nickl , Erich Muller , Berthold Narr , Johannes Weisenberger , Wolfgang Eisert , Thomas Muller
发明人： Armin Heckel , Josef Nickl , Erich Muller , Berthold Narr , Johannes Weisenberger , Wolfgang Eisert , Thomas Muller
IPC分类号： A61K31/40 , A61P9/12 , C07D207/32 , C07D207/335 , C07D207/337 , C07D307/52 , C07D307/54 , C07D333/20 , C07D333/24 , C07D405/04 , C07D409/04 , C07D409/12
CPC分类号： C07D207/335 , C07D207/337 , C07D307/52 , C07D307/54 , C07D333/20 , C07D333/24 , C07D405/04 , C07D409/04
摘要： The invention relates to new sulphonamido-ethyl compounds having the following structure: ##STR1## wherein R.sub.1 is substituted or unsubstituted phenyl, benzyl, nitrophenyl, acetamidophenyl or thienyl, R.sub.2 is hydroxycarbonyl or alkoxycarbonyl bonded via alkylene or alkenylene, or a 4,5-dihydro-pyridazin-3-one-6-yl or pyridazin-3-on-6-yl group optionally substituted on a ring carbon by C.sub.1 -C.sub.3 alkyl and X is substituted or unsubstituted imino, oxygen or sulphur, which compounds may be used to prevent arteriosclerosis or tumor metastasis, and are antitrombotic and thromboxane antagonists.
摘要翻译：本发明涉及具有以下结构的新型磺酰氨基乙基化合物：其中R1是取代或未取代的苯基，苄基，硝基苯基，乙酰氨基苯基或噻吩基，R2是通过亚烷基或亚烯基键合的羟基羰基或烷氧基羰基，二环哒嗪-3-酮-6-基或哒嗪-3-基-6-基，任选在环碳上被C 1 -C 3烷基取代，X是取代或未取代的亚氨基，氧或硫，可以使用该化合物以防止动脉硬化或肿瘤转移，并且是抗血栓形成和血栓素拮抗剂。

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