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1. 发明申请

US20050054589A1 Method for treating diseases using HSP90-inhibiting agents in combination with antibiotics 审中-公开
标题翻译：使用HSP90抑制剂与抗生素联合治疗疾病的方法
公开(公告)号：US20050054589A1
公开(公告)日：2005-03-10
申请号：US10857605
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/33 , A61K31/70 , A61K31/704
CPC分类号： A61K31/704 , A61K31/33 , A61K31/395 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antibiotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antibiotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antibiotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antibiotic and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和抗生素，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用抗生素的剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一种剂量的HSP90抑制剂治疗受试者，随后用一定剂量的抗生素治疗。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一种抗生素剂量治疗受试者，随后用一定剂量的HSP90抑制剂治疗。

2. 发明申请

US20050020534A1 Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites 审中-公开
标题翻译：使用HSP90抑制剂与抗代谢药联合治疗疾病的方法
公开(公告)号：US20050020534A1
公开(公告)日：2005-01-27
申请号：US10856342
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/33 , A61K31/395 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/525 , A61K31/7072 , A61K45/06
CPC分类号： A61K31/513 , A61K31/395 , A61K31/522 , A61K31/525 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimetabolite, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimetabolite in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimetabolite. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimetabolite and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和抗代谢物，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用抗代谢药剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一种剂量的HSP90抑制剂治疗受试者，并随后用一种抗代谢药物剂量治疗。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用抗体代谢物剂量治疗受试者，随后用剂量的HSP90抑制剂治疗。

3. 发明申请

US20050020556A1 Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes 审中-公开
标题翻译：使用HSP90抑制剂与铂配位配合物联合治疗疾病的方法
公开(公告)号：US20050020556A1
公开(公告)日：2005-01-27
申请号：US10856344
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/28 , A61K31/33 , A61K33/24 , A61K45/06
CPC分类号： A61K33/24 , A61K31/28 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and a platinum coordination complex, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of a platinum coordination complex in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of a platinum coordination complex. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of a platinum coordination complex and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法涉及施用HSP90抑制剂和铂配位络合物，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用铂配位复合物的剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一剂HSP90抑制剂治疗受试者，随后用一定剂量的铂配位复合物处理。在本发明的另一方面，提供一种治疗癌症的方法，其中首先用一定剂量的铂配位复合物处理受试者，随后用剂量的HSP90抑制剂治疗。

4. 发明申请

US20050054625A1 Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors 审中-公开
标题翻译：使用HSP90抑制剂与核输出抑制剂组合治疗疾病的方法
公开(公告)号：US20050054625A1
公开(公告)日：2005-03-10
申请号：US10856703
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/33 , A61K31/35
CPC分类号： A61K31/33 , A61K31/35
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and a nuclear export inhibitor, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of a nuclear export inhibitor in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of a nuclear export inhibitor. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of a nuclear export inhibitor and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法涉及施用HSP90抑制剂和核出口抑制剂，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用一种核出口抑制剂的剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一剂HSP90抑制剂治疗受试者，随后用一定剂量的核输出抑制剂治疗。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一定剂量的核输出抑制剂治疗受试者，随后用一定剂量的HSP90抑制剂治疗。

5. 发明申请

US20050026893A1 Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants 审中-公开
标题翻译：使用HSP90抑制剂与免疫抑制剂组合治疗疾病的方法
公开(公告)号：US20050026893A1
公开(公告)日：2005-02-03
申请号：US10857166
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/33 , A61K31/395 , A61K31/40 , A61K31/4745
CPC分类号： A61K45/06
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an immunosuppressant, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an immunosuppressant in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an immunosuppressant. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an immunosuppressant and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和免疫抑制剂，其中组合给药提供协同效应。在本发明的一个方面，提供一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一步中使用免疫抑制剂的剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一定剂量的HSP90抑制剂处理受试者，随后用一定剂量的免疫抑制剂处理。在本发明的另一方面，提供了一种治疗癌症的方法，其中受试者首先用免疫抑制剂的剂量治疗，随后用一定剂量的HSP90抑制剂治疗。

6. 发明申请

US20050020558A1 Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics 失效
标题翻译：使用HSP90抑制剂与抗虚型药物组合治疗疾病的方法
公开(公告)号：US20050020558A1
公开(公告)日：2005-01-27
申请号：US10856742
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K31/427 , A61K31/535 , A61K45/06
CPC分类号： A61K45/06 , A61K31/427
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an antimitotic, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an antimitotic in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an antimitotic. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an antimitotic and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和抗有丝分裂剂，其中组合给药提供协同效应。在本发明的一个方面，提供了一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量治疗受试者，另一个步骤中一种抗有丝分裂剂量。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用受试者的HSP90抑制剂治疗并随后用剂量的抗有丝分裂剂治疗。在本发明的另一方面，提供一种治疗癌症的方法，其中首先用一种抗有丝分裂的剂量治疗受试者，随后用剂量的HSP90抑制剂治疗。

7. 发明申请

US20050020557A1 Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors 审中-公开
标题翻译：使用HSP90抑制剂与酶抑制剂组合治疗疾病的方法
公开(公告)号：US20050020557A1
公开(公告)日：2005-01-27
申请号：US10856696
申请日：2004-05-27
申请人： Robert Johnson , Yiqing Zhou , Thomas Muller
发明人： Robert Johnson , Yiqing Zhou , Thomas Muller
IPC分类号： A61K20060101 , A61K31/19 , A61K31/33
CPC分类号： A61K31/165 , A61K31/395 , A61K31/517
摘要： The present invention provides a method for treating cancer. The method involves the administration of an HSP90 inhibitor and an enzyme inhibitor, where the combined administration provides a synergistic effect. In one aspect of the invention, a method of treating cancer is provided where a subject is treated with a dose of an HSP90 inhibitor in one step and a dose of an enzyme inhibitor in another step. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an HSP90 inhibitor and subsequently treated with a dose of an enzyme inhibitor. In another aspect of the invention, a method of treating cancer is provided where a subject is first treated with a dose of an enzyme inhibitor and subsequently treated with a dose of an HSP90 inhibitor.
摘要翻译：本发明提供一种治疗癌症的方法。该方法包括施用HSP90抑制剂和酶抑制剂，其中组合给药提供协同效应。在本发明的一个方面，提供一种治疗癌症的方法，其中在一个步骤中用一种HSP90抑制剂的剂量和另一步骤中的酶抑制剂的剂量来治疗受试者。在本发明的另一方面，提供了一种治疗癌症的方法，其中首先用一种剂量的HSP90抑制剂治疗受试者，并随后用一定剂量的酶抑制剂治疗。在本发明的另一方面，提供一种治疗癌症的方法，其中首先用一定剂量的酶抑制剂处理受试者，随后用一定剂量的HSP90抑制剂处理。

8. 发明申请

US20060252740A1 Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either in combination with a proteasome inhibitor 审中-公开
标题翻译：使用17-AAG或17-AG或与蛋白酶体抑制剂组合的前药治疗多发性骨髓瘤的方法
公开(公告)号：US20060252740A1
公开(公告)日：2006-11-09
申请号：US11412299
申请日：2006-04-26
申请人： Robert Johnson , Alison Hannah , Gillian Cropp , Yiqing Zhou , J. Sherrill
发明人： Robert Johnson , Alison Hannah , Gillian Cropp , Yiqing Zhou , J. Sherrill
IPC分类号： A61K31/395
CPC分类号： C07D225/06 , A61K31/395 , A61K45/06 , A61K2300/00
摘要： A method for treating multiple myeloma in a subject by administering to the subject 17-allylamino-17-demethoxy-geldanamycin or 17-amino geldanamycin, or a pro drug of either 17-AAG or 17-AG, in combination with a proteasome inhibitor.
摘要翻译：一种通过向受试者施用17-烯丙基氨基-17-脱甲氧基 - 格尔德霉素或17-氨基格尔德霉素或17-AAG或17-AG的原药与蛋白酶体抑制剂组合来治疗受试者中的多发性骨髓瘤的方法。

9. 发明申请

US20060252739A1 Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either 失效
标题翻译：使用17-AAG或17-AG或其前体药物治疗多发性骨髓瘤的方法
公开(公告)号：US20060252739A1
公开(公告)日：2006-11-09
申请号：US11412298
申请日：2006-04-26
申请人： Robert Johnson , Alison Hannah , Gillian Cropp , Yiqing Zhou , J. Sherrill
发明人： Robert Johnson , Alison Hannah , Gillian Cropp , Yiqing Zhou , J. Sherrill
IPC分类号： A61K31/395
CPC分类号： A61K31/395
摘要： A method for treating multiple myeloma in a subject by administering 17-allylamino-17-demethoxy-geldanamycin or 17-amino geldanamycin, or a prodrug of either 17-AAG or 17-AG, to the subject.
摘要翻译：通过向受试者施用17-烯丙基氨基-17-脱甲氧基 - 格尔德霉素或17-氨基格尔德霉素或17-AAG或17-AG的前药，治疗受试者中的多发性骨髓瘤的方法。

10. 发明申请

US20090197852A9 Method of treating breast cancer using 17-AAG or 17-AG or a prodrug of either in combination with a HER2 inhibitor 审中-公开
标题翻译：使用17-AAG或17-AG或与HER2抑制剂组合的前药治疗乳腺癌的方法
公开(公告)号：US20090197852A9
公开(公告)日：2009-08-06
申请号：US11542960
申请日：2006-10-03
申请人： Robert Johnson , Alison Hannah , Gillian Cropp , Yiqing Zhou , J. Sherrill
发明人： Robert Johnson , Alison Hannah , Gillian Cropp , Yiqing Zhou , J. Sherrill
IPC分类号： A61K31/395
CPC分类号： A61K31/395 , A61K39/39558 , A61K2039/545 , C07K16/32 , A61K2300/00
摘要： A method for treating a breast cancer in a subject by administering 17-allylamino-17-demethoxy-geldanamycin (17-AAG) or 17-amino-17-demethoxygeldanamycin (17-AG), or a prodrug of either 17-AAG or 17-AG, in combination with a HER2 inhibitor.
摘要翻译：通过给予17-烯丙基氨基-17-去甲氧基 - 格尔德霉素（17-AAG）或17-氨基-17-去甲氧基格尔德霉素（17-AG）或17-AAG或17 -AG，与HER2抑制剂组合。

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