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11. 发明授权

US07236814B2 Optical member for biological information measurement, biological information calculation apparatus, biological information calculation method, computer-executable program, and recording medium 有权
标题翻译：生物信息测量用光学构件，生物信息计算装置，生物信息计算方法，计算机可执行程序和记录介质
公开(公告)号：US07236814B2
公开(公告)日：2007-06-26
申请号：US11200461
申请日：2005-08-09
申请人： Masahiko Shioi , Shinji Uchida
发明人： Masahiko Shioi , Shinji Uchida
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/682 , A61B5/6834 , G01N21/01 , G01N21/35 , G01N21/359 , G01N21/552 , G01N2201/021
摘要： An optical member for biological information measurement has a prism, which has a light incident surface being injected with emitted light, a living body tissue measuring section which a living body tissue contacts, and a light emitting surface which emits the light reflected by the living body tissue measuring section which the living body tissue contacts, or the light which has passed the living body tissue through the living body tissue measuring section which the living body tissue has contacted. A prism cover is provided so as to expose the living body tissue measuring section and to surround all or a part of the outer circumferential portion of the prism.
摘要翻译：用于生物信息测量的光学构件具有棱镜，其具有注射发射光的光入射面，生物体组织接触的生物体组织测量部和发射由生物体反射的光的发光面生物体组织接触的组织测量部，或通过生物体组织测定部已经接触的活体组织的光。棱镜罩被设置成露出活体组织测量部分并围绕棱镜的外圆周部分的全部或一部分。

12. 发明申请

US20110001976A1 METHOD AND APPARATUS FOR BIOGENIC SUBSTANCE CONCENTRATION MEASUREMENT 有权
标题翻译：用于生物物质浓度测量的方法和装置
公开(公告)号：US20110001976A1
公开(公告)日：2011-01-06
申请号：US12828775
申请日：2010-07-01
申请人： Masaru MINAMIGUCHI , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru MINAMIGUCHI , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01N21/55
CPC分类号： G01N21/554 , G01N21/553 , G01N21/648 , G01N21/658 , G01N33/54373
摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.
摘要翻译：本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上，多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

13. 发明授权

US08548545B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08548545B2
公开(公告)日：2013-10-01
申请号：US13458544
申请日：2012-04-27
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating a substantially-parallel light from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate a reflected light; inclining the light source and calculating the concentration of the biogenic substance on the basis of the difference of signals before and after the inclination.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施例提供了一种测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的基本上平行的光照射到植入皮肤的颗粒上，产生反射光; 基于倾斜前后的信号差，倾斜光源并计算生物来源物质的浓度。

14. 发明申请

US20120029326A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120029326A1
公开(公告)日：2012-02-02
申请号：US13267625
申请日：2011-10-06
申请人： Tatsurou KAWAMURA , Masahiko Shioi , Masaru Minamiguchi
发明人： Tatsurou KAWAMURA , Masahiko Shioi , Masaru Minamiguchi
IPC分类号： A61B5/1455
CPC分类号： G01N21/658 , A61B5/14532 , A61B5/14558 , A61B5/6861
摘要： The object of the present invention is to provide a method for measuring concentration of a biological substance contained in a living body in which deterioration of the accuracy due to the reflected light and the interruption component is suppressed. Linear-polarized light is emitted to a particle chip implanted in the skin with modulating its modulating direction continuously. A surface enhanced Raman scattering light of the biological substance generated on the particle chip. A concentration of the biological substance is calculated based on the received signal. The receiving signal satisfy the following equation (III). [Math. 3] R(t)=Am·sin(t)+D (III) R(t): received signal Am: amplitude t: time D: a constant number
摘要翻译：本发明的目的是提供一种用于测量生物体中包含的生物体的浓度的方法，其中抑制了由反射光和中断成分引起的精度的劣化。线性偏振光通过调制其调制方向连续地发射到植入皮肤中的粒子碎片。颗粒上产生生物物质的表面增强拉曼散射光。基于接收到的信号计算生物物质的浓度。接收信号满足下式（III）。 [数学。 3] R（t）= Am·sin（t）+ D（III）R（t）：接收信号Am：幅度t：时间D：常数

15. 发明申请

US20090316137A1 LIVING BODY INGREDIENT CONCENTRATION MEASURING INSTRUMENT 有权
标题翻译：生命体成分浓度测量仪器
公开(公告)号：US20090316137A1
公开(公告)日：2009-12-24
申请号：US11915889
申请日：2007-03-08
申请人： Masahiko Shioi
发明人： Masahiko Shioi
IPC分类号： G01N21/35 , G01J3/00
CPC分类号： A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/6817 , G01J1/04 , G01J1/0448 , G01J1/0451 , G01J2003/1213 , G01N21/35
摘要： A device for measuring the concentration of a biological constituent based on infrared radiation emitted by a subject's eardrum with the influence of the eardrum's thickness taken into account is provided.The biological constituent concentration measuring device includes: a detecting section for detecting infrared radiation emitted by an eardrum; an acquisition section for acquiring thickness information about the thickness of the eardrum; and a computing section for figuring out the concentration of the biological constituent based on the infrared radiation detected and the thickness information acquired. The infrared radiation emitted by the eardrum is subject to the influence of the subject's eardrum thickness. Therefore, by calculating the biological constituent concentration based on not only the infrared radiation detected but also the eardrum thickness information, the biological constituent concentration can be measured highly accurately.
摘要翻译：提供了一种用于根据所考虑的鼓膜厚度的影响来测量基于被检体耳膜发射的红外辐射的生物成分浓度的装置。所述生物体成分浓度测定装置包括：检测部，其检测由鼓膜发射的红外线辐射; 用于获取关于所述鼓膜厚度的厚度信息的获取部分; 以及计算部，用于基于所检测的红外辐射和获取的厚度信息来计算生物成分的浓度。由鼓膜发射的红外辐射受到受试者耳膜厚度的影响。因此，通过不仅检测出红外辐射而且基于鼓膜厚度信息计算生物成分浓度，所以可以高精度地测定生物成分浓度。

16. 发明授权

US08867032B2 Surface enhanced optical detection substrate for sensing purposes and methods for manufacturing 有权
标题翻译：用于感测目的的表面增强光学检测基板和制造方法
公开(公告)号：US08867032B2
公开(公告)日：2014-10-21
申请号：US13634620
申请日：2011-03-22
申请人： Pol Van Dorpe , Kristof Lodewijks , Masahiko Shioi , Jian Ye
发明人： Pol Van Dorpe , Kristof Lodewijks , Masahiko Shioi , Jian Ye
IPC分类号： G01J3/44 , B82Y30/00 , B82Y15/00 , G01N21/65 , G01N21/64 , G01N21/55 , B22F1/00
CPC分类号： G01N21/658 , B22F2001/0029 , B82Y15/00 , B82Y30/00 , G01N21/553 , G01N21/554 , G01N21/648 , Y10S977/773 , Y10T428/25
摘要： A substrate is described that is suitable for surface enhanced optical detection. The substrate comprises an electrically conductive layer The substrate further comprises at least one nanoparticle comprising an electrically conductive portion. The electrically conductive portion may provide an opening to an underlying material. Such at least one nanoparticles may be a nanoring, a nanodisc, or a non-spherical nanoshell. The substrate further comprises a dielectric spacer for spacing the electrically conductive layer from the at least one nanoparticles. The dielectric spacer is a dielectric material substantially only present under the at least one nanoparticle, leaving the electrically conductive layer uncovered from dielectric material at positions away from the nanoparticles. The at least one nanoparticle and the dielectric spacer are interfaced along a first major surface and the at least one nanoparticle comprises an upstanding surface not in line with an upstanding surface of the dielectric spacer.
摘要翻译：描述了适用于表面增强光学检测的衬底。衬底包括导电层。衬底还包括至少一个包含导电部分的纳米颗粒。导电部分可以提供到下面的材料的开口。这样的至少一种纳米颗粒可以是纳米级，纳米型或非球形纳米壳。衬底还包括用于将导电层与至少一种纳米颗粒间隔开的介质间隔物。电介质间隔物是基本上只存在于至少一个纳米颗粒下的电介质材料，留下导电层在远离纳米颗粒的位置处不与电介质材料覆盖。所述至少一个纳米颗粒和电介质间隔物沿着第一主表面接合，并且所述至少一个纳米颗粒包括不与所述电介质间隔物的直立表面一致的直立表面。

17. 发明授权

US08735170B2 Method for measuring concentration of antigen contained in test solution 有权
标题翻译：测定溶液中含有的抗原浓度的方法
公开(公告)号：US08735170B2
公开(公告)日：2014-05-27
申请号：US13483790
申请日：2012-05-30
申请人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01N33/566 , G01N33/551 , G01N33/553 , G01N21/64
CPC分类号： G01N33/551 , G01N21/21 , G01N21/553 , G01N21/648 , G01N33/553
摘要： A biogenic substance concentration measuring apparatus includes an optical measuring apparatus for measuring optical properties of a first substrate and a second substrate by using a cell for biogenic substance concentration measurement that includes: the first substrate on which a plurality of first metallic nanorods, each of which is modified with a substance that bonds specifically to a test substance, are immobilized such that the long axes thereof are aligned in the same direction; and the second substrate on which a plurality of second metallic nanorods, each of which is modified with a blocking substance, are immobilized such that the long axes thereof are aligned perpendicularly to the long axes of the first metallic nanorods on the first substrate, and calculates a biogenic substance concentration with high accuracy from the optical properties.
摘要翻译：一种生物来源物质浓度测量装置，包括：用于通过使用生物源物质浓度测量用的细胞测量第一基板和第二基板的光学特性的光学测量装置，其包括：第一基板，多个第一金属纳米棒，用特异性结合试验物质的物质进行了改性，被固定成使其长轴在同一方向上排列; 并且其上固定有多个第二金属纳米棒的第二基板，每个第二金属纳米棒被阻挡物质改性，使得其长轴垂直于第一基板上的第一金属纳米棒的长轴取向，并且计算一种具有高精度的光学性质的生物物质浓度。

18. 发明授权

US08509868B2 Method for measuring a concentration of a biogenic substance contained in a living body 有权
标题翻译：用于测量生物体中所含生物物质浓度的方法
公开(公告)号：US08509868B2
公开(公告)日：2013-08-13
申请号：US13483756
申请日：2012-05-30
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/686 , G01N21/554 , G01N21/658
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的不同聚焦光照射到植入皮肤的颗粒上，以产生相应的反射光; 基于从反射光获得的信号的差异来计算生物来源物质的浓度。

19. 发明申请

US20120265038A1 METHOD FOR MEASURING A CONCENTRATION OF A BIOGENIC SUBSTANCE CONTAINED IN A LIVING BODY 有权
标题翻译：测定生活体内含有生物体的浓度的方法
公开(公告)号：US20120265038A1
公开(公告)日：2012-10-18
申请号：US13483756
申请日：2012-05-30
申请人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
发明人： Tatsurou Kawamura , Masaru Minamiguchi , Masahiko Shioi
IPC分类号： A61B5/1455
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/686 , G01N21/554 , G01N21/658
摘要： One of the purposes of the present invention is to provide a biogenic substance concentration measuring method with improved measuring accuracy. An embodiment of the present invention provides a method for measuring a concentration of a biogenic substance contained in a living body, the method comprises steps of preparing a measuring device, wherein the measuring device comprises a light source, an optical filter, and a light receiver; irradiating different focused lights from the light source onto a particle chip implanted in a skin though a position on the surface of the skin to generate corresponding reflected lights; calculating the concentration of the biogenic substance on the basis of the difference of signals obtained from the reflected lights.
摘要翻译：本发明的目的之一是提供具有改进的测量精度的生物源物质浓度测量方法。本发明的一个实施方案提供了一种用于测量生物体中包含的生物体的浓度的方法，所述方法包括制备测量装置的步骤，其中所述测量装置包括光源，滤光器和光接收器 ; 通过皮肤表面上的位置将来自光源的不同聚焦光照射到植入皮肤的颗粒上，以产生相应的反射光; 基于从反射光获得的信号的差异来计算生物来源物质的浓度。

20. 发明授权

US07884934B2 Method and apparatus for biogenic substance concentration measurement 有权
标题翻译：生物来源物质浓度测定方法和装置
公开(公告)号：US07884934B2
公开(公告)日：2011-02-08
申请号：US12828775
申请日：2010-07-01
申请人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
发明人： Masaru Minamiguchi , Tatsurou Kawamura , Masahiko Shioi , Atsushi Matsubara
IPC分类号： G01J4/00 , G01N21/00
CPC分类号： G01N21/554 , G01N21/553 , G01N21/648 , G01N21/658 , G01N33/54373
摘要： The present invention provides an apparatus for biogenic substance concentration measurement including: a cell including therein a first region, a second region, and a test solution retention space; a light source; a polarizing plate; and a photoreceiver, in which a plurality of first metallic nanorods each having a first antibody on a surface thereof are immobilized on the first region, a plurality of second metallic nanorods each having a second antibody on a surface thereof are immobilized on the second region, the respective long axes of the plurality of first metallic nanorods are aligned in the same direction, the respective long axes of the plurality of second metallic nanorods are aligned in the same direction, the long-axis direction of the first metallic nanorod is orthogonal to the long-axis direction of the second metallic nanorod, and at least one of the polarizing plate and the cell is capable of rotation with an optical axis as the rotation axis.
摘要翻译：本发明提供一种用于生物源物质浓度测量的装置，包括：包含第一区域，第二区域和测试溶液保留空间的单元; 光源; 偏振片; 以及光接收器，其中在其表面上分别具有第一抗体的多个第一金属纳米棒固定在第一区域上，在其表面上分别具有第二抗体的多个第二金属纳米棒被固定在第二区域上，多个第一金属纳米棒的各自的长轴在同一方向上排列，多个第二金属纳米棒的各个长轴在相同的方向上排列，第一金属纳米棒的长轴方向与第二金属纳米棒的长轴方向，并且偏振板和单元中的至少一个能够以光轴作为旋转轴旋转。

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