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11. 发明授权

US09636426B2 Polymer-type fluorescent molecule probe 有权
公开(公告)号：US09636426B2
公开(公告)日：2017-05-02
申请号：US14342879
申请日：2012-09-05
申请人： Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
发明人： Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
IPC分类号： A61Q5/12 , A61K49/00 , A61B1/04 , A61B1/313 , G01N33/574 , G01N33/58 , A61K41/00 , G01N21/33 , G01N21/64 , A61K47/48
CPC分类号： A61K49/0082 , A61B1/043 , A61B1/313 , A61K41/0057 , A61K41/0071 , A61K47/58 , A61K49/0017 , A61K49/0034 , A61K49/005 , A61K49/0054 , G01N21/33 , G01N21/6447 , G01N33/574 , G01N33/582 , G01N33/585
摘要： The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatibie macromolecule.

12. 发明申请

US20140294735A1 POLYMER-TYPE FLUORESCENT MOLECULE PROBE 有权
标题翻译：聚合物型荧光分子探针
公开(公告)号：US20140294735A1
公开(公告)日：2014-10-02
申请号：US14342879
申请日：2012-09-05
申请人： Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
发明人： Hiroshi Maeda , Makoto Hashizume , Jun Fang , Hideaki Nakamura , Haibo Qin , Steffen Hackbarth , Masaharu Murata
IPC分类号： A61K49/00
CPC分类号： A61K49/0082 , A61B1/043 , A61B1/313 , A61K41/0057 , A61K41/0071 , A61K47/58 , A61K49/0017 , A61K49/0034 , A61K49/005 , A61K49/0054 , G01N21/33 , G01N21/6447 , G01N33/574 , G01N33/582 , G01N33/585
摘要： The present invention provides a fluorescent molecular probe for efficient fluorescent detection (visualization) of tumors or for implementing fluorescent detection and photodynamic treatment, more specifically, the present invention provides a macromolecular fluorescent molecular probe for fluorescent detection of tumor, comprising a complex comprising a fluorescent molecule and a biocompatibie macromolecule.
摘要翻译：本发明提供了一种用于有效荧光检测（可视化）肿瘤或用于实现荧光检测和光动力学治疗的荧光分子探针，更具体地，本发明提供了用于肿瘤荧光检测的大分子荧光分子探针，其包含荧光分子和生物相容性大分子。

13. 发明授权

US08513844B2 Motor 有权
标题翻译：发动机
公开(公告)号：US08513844B2
公开(公告)日：2013-08-20
申请号：US12989949
申请日：2009-04-30
申请人： Eisuke Ohshima , Hideaki Nakamura
发明人： Eisuke Ohshima , Hideaki Nakamura
IPC分类号： H02K7/06 , H01R39/38
CPC分类号： B06B1/16 , H02K1/17 , H02K1/30 , H02K3/527 , H02K5/145 , H02K5/1677 , H02K5/225 , H02K7/063 , H02K23/04
摘要： In the invention, in order for a brush assembly to be easily built in a motor, the motor includes an aligning means for aligning a main body portion of the brush assembly relative to a lower case engaging the main body portion with the lower case and a guide means for guiding the brush assembly in a direction which is at right angles to a rotational axis L after the main body portion has been aligned relative to the lower case.
摘要翻译：在本发明中，为了将电刷组装容易地构建在电动机中，电动机包括对准装置，用于将电刷组件的主体部分相对于与主体部分与下壳体接合的下壳体和引导装置，用于在主体部分相对于下壳体对准之后沿与旋转轴线L成直角的方向引导刷组件。

14. 发明申请

US20100004559A1 BIOSENSOR CARTRIDGE, METHOD OF USING BIOSENSOR CARTRIDGE, BIOSENSOR DEVICE, AND NEEDLE INTEGRAL SENSOR 审中-公开
标题翻译： BIOSENSOR CARTRIDGE，使用BIOSENSOR CARTRIDGE的方法，生物传感器设备和针式集成传感器
公开(公告)号：US20100004559A1
公开(公告)日：2010-01-07
申请号：US12519916
申请日：2007-12-17
申请人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
发明人： Tsuyoshi Fujimura , Hideaki Nakamura , Masao Gotoh , Isao Karube , Tomoko Ishikawa , Takahiko Kitamura , Shingo Kaimori , Hiroto Nakajima , Hiroshi Hayami , Toshifumi Hosoya
IPC分类号： A61B5/151
CPC分类号： A61B5/1519 , A61B5/150022 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/150549 , A61B5/150618 , A61B5/150717 , A61B5/15113 , A61B5/15117
摘要： A biosensor cartridge capable of making the collected amount of a sample required for measurement into a small quantity to reduce a user's burden, and easily collecting and measuring a sample of a puncture hole without requiring the operation of bringing a sample collection opening close to the puncture hole is provided. When one end portion of biosensor chip is pushed against subject, elastic body is compressed, and puncturing tool can protrude and perform puncturing. Additionally, if a pushing force is weakened, puncturing tool is extracted from subject by the restoring force of elastic body, and blood (sample) flows out of the puncture hole. In this case, since the puncture hole, and sample collection opening provided at biosensor chip are contained in enclosed half-open space formed by elastic body, even a small amount of blood (sample) can also be easily collected. Additionally, elastic body is formed with a groove which forms a ventilation passage, so that enclosed half-open space can be opened to the atmosphere.
摘要翻译：一种生物传感器盒，其能够将少量测量所需的样本的收集量减少到用户的负担，并且容易地收集和测量穿孔的样本，而不需要使样本收集开口靠近穿刺的操作提供孔。当生物传感器芯片的一个端部被压住物体时，弹性体被压缩，并且穿刺工具可以伸出并进行穿刺。此外，如果推力减弱，则通过弹性体的恢复力从被检体取出穿刺工具，血液（样品）从穿刺孔流出。在这种情况下，由于设置在生物传感器芯片上的穿刺孔和样本收集开口包含在由弹性体形成的封闭半开放空间中，所以即使少量的血液（样品）也可以容易地收集。此外，弹性体形成有形成通风通道的槽，使得封闭的半开放空间可以打开到大气。

15. 发明申请

US20090299225A1 BIOSENSOR CHIP 审中-公开
标题翻译：生物传感器芯片
公开(公告)号：US20090299225A1
公开(公告)日：2009-12-03
申请号：US12297387
申请日：2007-04-17
申请人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
发明人： Takahiko Kitamura , Shingo Kaimori , Akira Harada , Toshifumi Hosoya , Tsuyoshi Fujimura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
IPC分类号： A61B5/151
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150229 , A61B5/150358 , A61B5/150389 , A61B5/150412 , A61B5/150442 , A61B5/150503 , A61B5/150511 , A61B5/150549 , A61B5/150717 , A61B5/15186
摘要： There is provided a biosensor chip where the collecting amount necessary for the measurement is made small whereby burden of a user is reduced and, at the same time, a sample at a puncture opening is able to be easily collected and measured without an operation of making the sample collection opening nearer the puncture opening. When an end of a main body chip is pushed onto a test body, an elastic body installed at an end of the main body chip is compressed and a device for puncture is produced whereby the test body is able to be punctured. When the pushing force is made weak, the device for puncture is pulled out from the test body due to resilience of the elastic body and a sample is flown out from the puncture opening. At that time, since the puncture opening and the sample collection opening installed in the main body chip are enclosed in a tightly-closed space formed by the elastic body, even small amount of the sample is able to be easily collected by the sample collection opening without conducting the positioning of the sample collection opening.
摘要翻译：提供了一种生物传感器芯片，其中使得测量所需的收集量变小，从而减少了使用者的负担，并且同时，能够容易地收集和测量穿刺开口处的样本而不进行操作样品收集开口更靠近穿刺孔。当主体芯片的一端被推到测试体上时，安装在主体芯片的端部的弹性体被压缩，并且产生用于穿刺的装置，由此能够刺破测试体。当推力变弱时，由于弹性体的弹性，用于穿刺的装置从测试体被拉出，并且样品从穿刺孔流出。此时，由于安装在主体芯片上的穿刺开口和样本收集开口被包围在由弹性体形成的紧密封闭的空间中，所以即使少量的样本能够容易地被样本收集开口收集而不进行样品收集开口的定位。

16. 外观设计

USD599300S1 Terminal for motor 有权
标题翻译：电机端子
公开(公告)号：USD599300S1
公开(公告)日：2009-09-01
申请号：US29323546
申请日：2008-08-27
申请人： Eisuke Ohshima , Hideaki Nakamura
设计人： Eisuke Ohshima , Hideaki Nakamura

17. 发明申请

US20090093695A1 BIOSENSOR 审中-公开
标题翻译：生物传感器
公开(公告)号：US20090093695A1
公开(公告)日：2009-04-09
申请号：US11993911
申请日：2006-06-27
申请人： Hideaki Nakamura , Masao Gotoh , Isao Karube
发明人： Hideaki Nakamura , Masao Gotoh , Isao Karube
IPC分类号： A61B5/1468 , G01N27/26 , G01N33/49
CPC分类号： A61B5/157 , A61B5/0002 , A61B5/14532 , A61B5/1486 , A61B5/14865 , A61B5/150022 , A61B5/150099 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/1519 , A61B5/15194 , G01N27/3272
摘要： There is provided a biosensor (which is integrated with a needle) with a high precision where an assembling is easy and reproducibility of the prepared biosensor (integrated with a needle) is good.There is provided with a biosensor comprising: two sheets of electrically insulating substrates connected by a connecting part, and an electrode and a spacer formed on one of or both of the two sheets of electrically insulating substrates, wherein the two sheets of the electrically insulating substrates are folded along the connecting part, and the electrode and the spacer are positioned between the electrically insulating substrates. In this biosensor (integrated with a needle), a biosensor (integrated with a needle) is able to be easily prepared by folding two sheets of electrically insulating substrates which are connected by a connecting part and, therefore, it achieves excellent effects that the product is able to be easily manufactured without such a troublesome step where each biosensor material is correctly layered and that the biosensor (integrated with a needle) manufactured as such has a good reproducibility and a high precision.
摘要翻译：提供了具有高精度的生物传感器（其与针一体化），其中组装容易且制备的生物传感器（与针一体化）的再现性良好。设置有生物传感器，其包括：通过连接部连接的两片电绝缘基板，以及形成在两片电绝缘基板之一或两者上的电极和间隔件，其中两片电绝缘基板沿着连接部分折叠，并且电极和间隔件位于电绝缘基板之间。在该生物传感器（与针集成）中，通过折叠通过连接部连接的两片电绝缘基板，能够容易地制造生物传感器（与针一体化），因此实现了良好的效果，能够容易地制造没有这样的麻烦的步骤，其中每个生物传感器材料被正确分层，并且制造的生物传感器（与针一体化）具有良好的再现性和高精度。

18. 发明申请

US20080129280A1 Coupled Member Made of a Plurality of Sensor Chips and Manufacturing Method Thereof 审中-公开
标题翻译：传感器芯片制造的耦合构件及其制造方法
公开(公告)号：US20080129280A1
公开(公告)日：2008-06-05
申请号：US11795902
申请日：2006-01-23
申请人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
发明人： Shingo Kaimori , Toshifumi Hosoya , Moriyasu Ichino , Hideaki Nakamura , Masao Gotoh , Fumiyo Kurusu , Tomoko Ishikawa , Isao Karube
IPC分类号： G01N27/327
CPC分类号： B82Y5/00 , G01N33/4875 , Y10T29/49002
摘要： A coupled member made of a plurality of sensor chips is featured by that adjacent sensor chips are coupled to each other under cuttable condition; the respective sensor chips can be cut and piece-separated from the coupled member in a higher efficiency; and even after the sensor chips are piece-separated, these sensor chips can be readily and quickly stored in containers thereof; and furthermore, the sensor chips can be easily checked and failure chips can be readily removed. More specifically, a method for manufacturing a coupled member made of the plurality of sensor chips is provided in which such sensor chips are coupled to each other under cuttable conditions, while each of these sensor chips includes: a base plate; a cover layer; a hollow reaction portion provided between the base plate and the cover layer; a sensing member provided in the hollow reaction portion; an output terminal for outputting a signal sensed by the sensing member to the outside; and a sample introducing port for introducing a sample to the hollow reaction portion.
摘要翻译：由多个传感器芯片制成的耦合构件的特征在于相邻的传感器芯片在可切割的状态下彼此耦合; 相应的传感器芯片可以以更高的效率从耦合部件切割和分离; 并且即使在传感器芯片被分离之后，这些传感器芯片也可以容易且快速地存储在容器中; 此外，可以容易地检测传感器芯片，并且可以容易地去除故障芯片。更具体地说，提供了一种用于制造由多个传感器芯片制成的耦合构件的方法，其中这些传感器芯片在可切割的条件下彼此耦合，而这些传感器芯片中的每一个包括：基板; 覆盖层; 设置在所述基板和所述覆盖层之间的中空反应部; 设置在所述中空反应部中的检测部件; 输出端子，用于将由感测构件感测的信号输出到外部; 以及用于将样品引入中空反应部的样品引入口。

19. 外观设计

USD548347S1 Device for measuring constituents in the blood 有权
标题翻译：用于测量血液中成分的装置
公开(公告)号：USD548347S1
公开(公告)日：2007-08-07
申请号：US29253418
申请日：2006-02-07
申请人： Moriyasu Ichino , Toshifumi Hosoya , Kazuhiro Kuwa , Nobuyuki Matsumura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa
设计人： Moriyasu Ichino , Toshifumi Hosoya , Kazuhiro Kuwa , Nobuyuki Matsumura , Isao Karube , Masao Gotoh , Hideaki Nakamura , Tomoko Ishikawa

20. 发明授权

US5754966A Method and apparatus for steering rear wheel for four wheel steering vehicle 失效
标题翻译：用于转向四轮转向车后轮的方法和装置
公开(公告)号：US5754966A
公开(公告)日：1998-05-19
申请号：US513738
申请日：1995-08-10
申请人： Toshiro Ichikawa , Hideaki Nakamura
发明人： Toshiro Ichikawa , Hideaki Nakamura
IPC分类号： B62D7/15 , B62D6/00
CPC分类号： B62D7/159
摘要： A rear wheel steer control method and apparatus for a four wheel steer vehicle executes an opposite phase steer control on the basis of detected values of a front wheel steer angle sensor and a vehicle speed sensor during a low vehicle speed. The opposite phase steering is stopped for a predetermined distance from a start of straight running, then the rear wheel steer angle is controlled by a primary delay control. When the front wheel steer angle is decreased, the primary delay control is stopped in a predetermined condition. Therefore, the four wheel steer vehicle gives a smooth steer feeling to a driver in every driven condition.
摘要翻译：用于四轮转向车的后轮转向控制方法和装置在低车速下基于前轮转向角传感器和车速传感器的检测值执行相反转向控制。相反的转向停止从直线行驶开始一预定距离，则后轮转向角度通过一次延迟控制来控制。当前轮转向角减小时，一次延迟控制在预定状态下停止。因此，四轮转向车在每个驱动条件下给予驾驶员平稳的转向感。

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