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11. 发明授权

US08389091B2 Wrap film container and label adapted for use for the container and used for film holding section 失效
标题翻译：适用于容器的卷膜容器和标签，用于胶片保持部分
公开(公告)号：US08389091B2
公开(公告)日：2013-03-05
申请号：US12863255
申请日：2008-12-18
申请人： Michihiro Sato , Yoshikazu Amano
发明人： Michihiro Sato , Yoshikazu Amano
IPC分类号： B32B9/00 , B32B33/00 , B26F3/02 , B65H35/10
CPC分类号： B65D83/0882 , B32B7/06 , B32B7/12 , B32B27/32 , B32B2255/10 , B32B2255/26 , B32B2255/28 , B32B2519/00 , Y10T225/222 , Y10T225/238 , Y10T225/243 , Y10T225/246 , Y10T428/14 , Y10T428/1476
摘要： A wrapping film container, including: an elongated container body for housing therein a rolled self-tacky wrapping film, an opening provided to the container body along a longitudinal direction of the container body for pulling out a portion of the wrapping film therethrough, cutting means for cutting the pulled-out portion of the wrapping film and a film-holding section provided on a front face of the container body for preventing re-winding to an inside of the container, wherein the film-holding section comprises a laminate structure including a pressure-sensitive adhesive layer, a substrate layer, an adhesive layer and a self-tacky film layer, disposed sequentially from the container body side. The film-holding section is efficiently formed on the front face of the container body by using a label for forming film-holding section of a wrapping film container having a laminate structure including a self-tacky film layer, an adhesives layer, a base material layer, a pressure-sensitive adhesive layer and a separator layer, disposed sequentially from one side thereof, and exhibits a stable and consistent film-holding power.
摘要翻译：一种包装膜容器，包括：用于容纳滚动的自粘包装膜的细长容器主体，沿着容器主体的纵向方向设置到容器主体的开口，用于将一部分包裹膜拉出，切割装置用于切割包装膜的拉出部分和设置在容器主体前表面上的胶片保持部分，用于防止再卷绕到容器的内部，其中胶片保持部分包括层压结构，其包括压敏粘合剂层，基材层，粘合剂层和自粘膜层，从容器主体侧依次设置。通过使用具有层叠结构的包装膜容器的形成用保鲜部的标签，在容器主体的正面上有效地形成膜保持部，该层叠结构包括自粘膜层，粘合层，基材层，压敏粘合剂层和隔离层，从其一侧依次设置，并且表现出稳定且一致的膜保持力。

12. 发明申请

US20100320250A1 CUTTER BLADE FOR PACKING CONTAINER AND PACKING CONTAINER 有权
标题翻译：用于包装容器和包装容器的切割刀片
公开(公告)号：US20100320250A1
公开(公告)日：2010-12-23
申请号：US12740322
申请日：2008-11-26
申请人： Makoto Hideoka , Tadashi Umetsu , Asako Saeki , Yoshikazu Amano , Takayuki Seki , Makoto Unno , Shinichi Sekine , Kenichi Ishii
发明人： Makoto Hideoka , Tadashi Umetsu , Asako Saeki , Yoshikazu Amano , Takayuki Seki , Makoto Unno , Shinichi Sekine , Kenichi Ishii
IPC分类号： B26F3/02
CPC分类号： B65D83/0841 , B26D1/0006 , B26D2001/006 , B26F3/02 , B65H35/002 , B65H35/008 , B65H2301/51532 , B65H2301/5154 , Y10T225/282 , Y10T225/298
摘要： A center portion (30) of a V-shaped cutter blade (20) includes center large teeth (31) and center middle teeth 32 the tooth height of which is less than the tooth height of the center large teeth (31). End portions (50) of the cutter blade (20) each include first end teeth (51) and second end teeth (52) the tooth height of which is less than the tooth height of the first end teeth (51). Tooth tops of the first end teeth 51 of each end portion (50) are located on a straight line (L1), which extends through tooth tops of the center large teeth (31) located on one of the right half and the left half of the center portion (30).
摘要翻译： V形切割刀片（20）的中心部分（30）包括中心大齿（31）和中心中心齿32，齿中心齿的齿高小于中心大齿（31）的齿高。切割刀片（20）的端部（50）各自包括牙齿高度小于第一端齿（51）的牙齿高度的第一端齿（51）和第二端齿（52）。每个端部（50）的第一端齿51的齿顶位于直线（L1）上，该直线（L1）延伸穿过中心大齿（31）的齿顶位于位于右半部和右半部中心部分（30）。

13. 发明申请

US20060024770A1 Immunoassay element 失效
公开(公告)号：US20060024770A1
公开(公告)日：2006-02-02
申请号：US11230127
申请日：2005-09-19
申请人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
发明人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
IPC分类号： G01N33/537 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54386 , G01N2333/924 , Y10S435/966 , Y10S435/969 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase. Highly sensitive assay is realized with high accuracy and high reproducibility and good storage stability.

14. 发明授权

US5709837A Dry analytical element containing ampholyte 失效
标题翻译：含两性电解质的干分析元素
公开(公告)号：US5709837A
公开(公告)日：1998-01-20
申请号：US545233
申请日：1995-10-19
申请人： Toshihiro Mori , Masashi Ogawa , Yoshikazu Amano
发明人： Toshihiro Mori , Masashi Ogawa , Yoshikazu Amano
IPC分类号： G01N31/22 , G01N33/52 , G01N33/70 , G01N21/17
CPC分类号： G01N33/525 , Y10T436/147777 , Y10T436/171538
摘要： A dry analytical element comprising at least one water-permeable reagent layer and a porous spreading layer laminated in this order on a support, wherein at least one layer which is the water-permeable reagent layer, the porous spreading layer or an optional water-permeable layer contains a water-soluble polybasic amino carboxylic acid which is an ampholyte. By applying an analytical element of the invention, an analyte can be measured at a high sensitivity using a small amount of an enzyme, etc., and shelf file can be extended.
摘要翻译：一种干燥分析元件，其包括依次层叠在载体上的至少一个透水性试剂层和多孔扩散层，其中至少一层作为透水性试剂层，多孔扩散层或任选的透水性层含有两性电解质的水溶性多元氨基羧酸。通过应用本发明的分析元件，可以使用少量的酶等以高灵敏度测量分析物，并且可以延长搁架文件。

15. 发明申请

US20050095626A1 Method for separation and purification method of nucleic acid 审中-公开
标题翻译：核酸分离纯化方法
公开(公告)号：US20050095626A1
公开(公告)日：2005-05-05
申请号：US10932138
申请日：2004-09-02
申请人： Hiroyuki Komazawa , Yoshihide Iwaki , Yoshihiko Makino , Yoshikazu Amano
发明人： Hiroyuki Komazawa , Yoshihide Iwaki , Yoshihiko Makino , Yoshikazu Amano
IPC分类号： G01N33/53 , B01L3/00 , C12M1/00 , C12N15/09 , C12N15/10 , C12Q1/68 , G01N1/34 , G01N37/00
CPC分类号： C12Q1/6806 , B01J2219/00423 , B01J2219/00641 , B01L3/50255 , C12N15/1017 , C12Q1/6837 , G01N1/34 , C12Q2565/501 , C12Q2563/107 , C12Q2531/113 , C12Q2523/308
摘要： The invention provides a rapid, convenient, and automatable method for extracting a highly pure nucleic acid in order to carry out nucleic acid analysis smoothly with high accuracy in an array method. An analyzing method includes analyzing a nucleic acid by an array method, the nucleic acid being separated and purified by a separation and purification method which includes the steps of (a) to (f) identified in the specification.
摘要翻译：本发明提供一种用于提取高纯度核酸的快速，方便和自动化的方法，以便在阵列方法中以高精度平滑地进行核酸分析。分析方法包括通过阵列法分析核酸，所述核酸通过分离和纯化方法分离和纯化，所述分离和纯化方法包括说明书中确定的步骤（a）至（f）。

16. 发明授权

US06872577B2 Agglutination assay method and element in dry system 失效
标题翻译：干系统中的凝集测定方法和元素
公开(公告)号：US06872577B2
公开(公告)日：2005-03-29
申请号：US10021759
申请日：2001-10-22
申请人： Hiroshi Shinoki , Yoshikazu Amano
发明人： Hiroshi Shinoki , Yoshikazu Amano
IPC分类号： G01N33/531 , G01N33/543 , G01N33/546 , G01N33/547 , G01N33/548 , G01N33/553
CPC分类号： G01N33/54313 , G01N33/54393 , Y10S435/969 , Y10S436/805
摘要： An agglutination assay method for quantitatively determination of an analyte in a liquid sample using particles bearing an anti-analyte. A non-fluid substance which retains the particles while suppressing the diffusion of the particles therein is used as a medium which is to be a place where the agglutination of the particles takes place. Upon analysis, a solation agent is added to the non-fluid substance medium to increase the fluidity of the non-fluid substance, thereby the particles bearing the anti-analyte can diffuse in the medium to cause the agglutination with the analyte. Preferably, the solation agent is added to the non-fluid medium together with the sample. The non-fluid substance medium containing the particle-labeled anti-analyte can be stored with a higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.
摘要翻译：用于使用带有抗分析物的颗粒定量测定液体样品中的分析物的凝集测定方法。使用保持颗粒同时抑制颗粒扩散的非流体物质作为发生颗粒凝集的地方的介质。分析后，向非流体物质介质中加入溶剂，以增加非流体物质的流动性，从而带有抗分析物的颗粒可以在介质中扩散以引起与分析物的凝集。优选地，将溶剂与样品一起添加到非流体介质中。含有颗粒标记的抗分析物的非流体物质介质可以在干燥状态下以更高的稳定性储存。还提供了用于实现这种分析方法的干燥分析元件。

17. 发明授权

US06485927B2 Method for quantitatively determining bicarbonate ion in liquid and dry analysis device 有权
标题翻译：定量测定液体和干燥分析装置中碳酸氢根离子的方法
公开(公告)号：US06485927B2
公开(公告)日：2002-11-26
申请号：US09509610
申请日：2000-03-30
申请人： Hideaki Tanaka , Yoshikazu Amano
发明人： Hideaki Tanaka , Yoshikazu Amano
IPC分类号： C12Q132
CPC分类号： C12Q1/527 , C12Q1/32
摘要： This invention provides a method for the determination of bicarbonate ion existing in liquid using phosphenolpyruvate carboxylase and malate dehydrogenase as conjugate enzyme wherein thioNAD(P)H is used as substrate of malate dehydrogenase. The use of the thioNAD(P)H enables the measurement with visible light, and enables the simple and accurate determination of bicarbonate ion concentration of biological liquid sample in the clinical test.
摘要翻译：本发明提供了使用磷酸烯醇丙酮酸羧化酶和苹果酸脱氢酶作为其中使用thioNAD（P）H作为苹果酸脱氢酶底物的共轭酶的液体中存在的碳酸氢根离子的测定方法。使用thioNAD（P）H可以用可见光进行测量，并能够在临床试验中简单而准确地测定生物液体样品的碳酸氢根离子浓度。

18. 发明授权

US6027907A Method for immunological determination of hemoglobin derivative and treating reagent for use therein 失效
标题翻译：血红蛋白衍生物的免疫学测定方法和用于其中的试剂
公开(公告)号：US6027907A
公开(公告)日：2000-02-22
申请号：US767386
申请日：1996-12-16
申请人： Hiroshi Shinoki , Yoshikazu Amano
发明人： Hiroshi Shinoki , Yoshikazu Amano
IPC分类号： G01N33/53 , G01N33/531 , G01N33/543 , G01N33/72 , G01N1/18 , G01N33/539
CPC分类号： G01N33/721 , G01N33/723 , Y10S436/815 , Y10S530/829 , Y10T436/25375
摘要： A hemoglobin derivative-containing sample is treated with a treating reagent containing 2-butanol and then immunologically analyzed to determine the quantity of the hemoglobin derivative. By the treatment with 2-butanol, the immunological determination for the hemoglobin derivative, particularly HbA.sub.1c, can be attained with high sensitivity by a simple procedure. Since 2-butanol-containing treating reagent does not affect the enzymatic activity, the homogeneous enzyme immunoassay with high sensitivity is realized.
摘要翻译：含有血红蛋白衍生物的样品用含有2-丁醇的处理剂处理，然后进行免疫分析以确定血红蛋白衍生物的量。通过用2-丁醇处理，可以通过简单的程序以高灵敏度获得血红蛋白衍生物，特别是HbA1c的免疫学测定。由于含2-丁醇的处理试剂不影响酶活性，因此实现了高灵敏度的均相酶免疫测定。

19. 发明授权

US5496708A Reagent composition for quantitative analysis of inorganic phosphorous and dry analysis element utilizing the same 失效
标题翻译：用于定量分析无机磷和干分析元素的试剂组合物
公开(公告)号：US5496708A
公开(公告)日：1996-03-05
申请号：US259616
申请日：1994-06-14
申请人： Kazuya Kawasaki , Yoshikazu Amano , Osamu Seshimoto , Kiyoshi Yamada
发明人： Kazuya Kawasaki , Yoshikazu Amano , Osamu Seshimoto , Kiyoshi Yamada
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/48 , G01N31/22
CPC分类号： C12Q1/48 , Y10S435/805 , Y10S435/97
摘要： A reagent composition for the quantitative analysis of inorganic phosphorus, composted of xanthosine, purine nucleoside phosphorylase, xanthine oxidase and a color-former. The color-former is a precursor for forming a dye in the presence of hydrogen peroxide and peroxidase. The reagent composition of the invention is improved in storage stability and has a wider determination range. Also provided is a dry analysis element composed of reagent layer containing the inventive reagent composition.
摘要翻译：用于定量分析无机磷的试剂组合物，堆肥的黄嘌呤，嘌呤核苷磷酸化酶，黄嘌呤氧化酶和成色剂。成色剂是在过氧化氢和过氧化物酶存在下形成染料的前体。本发明的试剂组合物的贮存稳定性提高，判定范围更广。还提供了由包含本发明试剂组合物的试剂层组成的干分析元件。

20. 发明申请

US20050084953A1 Immunoassay element 审中-公开
标题翻译：免疫测定元件
公开(公告)号：US20050084953A1
公开(公告)日：2005-04-21
申请号：US10961459
申请日：2004-10-07
申请人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
发明人： Yoshiki Sakaino , Hitomi Ito , Toshihiro Mori , Osamu Seshimoto , Toshihisa Ito , Yoshikazu Amano
IPC分类号： G01N33/543 , G01N33/53
CPC分类号： G01N33/54386 , G01N2333/924 , Y10S435/966 , Y10S435/969 , Y10S435/97 , Y10S436/807 , Y10S436/81
摘要： The immunoassay element for quantitatively analyzing an antigen by determining the change in enzymatic activity of an enzyme-labelled antigen or antibody caused by an immunological reaction. The immunoassay element comprises a substrate layer containing a non-diffusible substrate which forms a diffusible material in the presence of the labelling enzyme, and a reagent layer containing a fragmenting enzyme for further fragmenting the diffusible material into a lower molecular weight product. As the non-diffusible substrate, a substrate capable of reacting solely with the lebelling enzyme and incapable of reacting the fragmenting enzyme is utilized. When an endo-active glucosidase is used as the labelling enzyme, and an exo-active glucosidase is used the fragmenting enzyme in the reagent layer, the non-diffusible substrate of the substrate layer is preferred to be an endo type selectively reactive substrate, which means a substrate having a reactivity specific to endo-active glucosidase. Highly sensitive assay is realized with high accuracy and high reproducibility and good storage stability.
摘要翻译：用于通过确定由免疫反应引起的酶标记的抗原或抗体的酶活性的变化来定量分析抗原的免疫测定元件。免疫测定元件包括含有在标记酶存在下形成可扩散材料的不扩散基底的底物层和含有用于进一步将可扩散材料分解成较低分子量产物的碎裂酶的试剂层。作为非扩散性底物，可以使用能够仅与前体酶反应并且不能使片段化酶反应的底物。当使用内源活性葡糖苷酶作为标记酶，并且使用外源活性葡糖苷酶时，试剂层中的断裂酶，底物层的非扩散性基质优选为内型选择性反应性底物，其中是指具有对内源性葡糖苷酶特异性的反应性的底物。高精度，高重现性和良好的储存稳定性实现了高灵敏度测定。

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