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11. 发明申请

US20060110296A1 Automatic separator/extractor and method of controlling same 审中-公开
标题翻译：自动分离器/提取器及其控制方法
公开(公告)号：US20060110296A1
公开(公告)日：2006-05-25
申请号：US11325075
申请日：2006-01-04
申请人： Hideji Tajima , Norihisa Sagawa , Toyosaku Sato , Masataka Morita , Hiroshi Hayasaka , Kouji Sato , Kahoru Takahashi
发明人： Hideji Tajima , Norihisa Sagawa , Toyosaku Sato , Masataka Morita , Hiroshi Hayasaka , Kouji Sato , Kahoru Takahashi
IPC分类号： B01L3/00 , G01N35/00
CPC分类号： G01N35/025 , G01N35/0099 , G01N2035/00504
摘要： The invention relates to an automatic separator/extractor and a method of controlling same, with the object, particularly in all manner of fields such as medical science, agricultural science, scientific fields, or pharmaceuticals, of being able to achieve at high speed and accuracy, extraction or separation of precipitate or supernatant at a high quality, accuracy and reliability, above that which can be achieved by manual means. The construction has a conveying device for conveying a mounted vessel along a closed path, a dispensing section for dispensing a reagent or the like into the vessel mounted on the conveying device, a liquid processing section for removing and/or extracting liquid other than a precipitate inside the vessel mounted on the conveying device, a separator for performing separation with respect to the contents inside a vessel which is mounted on the conveying device and/or a vessel which is installed away from the conveying device, a vessel moving device for bringing in and taking out the vessel with respect to the conveying device and/or separator, and an operation/control section for performing operation and control with respect to the conveying device, the dispensing section, the liquid processing section, the vessel moving device, and the separator.
摘要翻译：本发明涉及一种自动分离器/提取器及其控制方法，其目的尤其在医学，农业科学，科学领域或医药领域的各种领域中，能够高速准确地实现，以高质量，准确性和可靠性提取或分离沉淀物或上清液，高于可通过手动方式实现的沉淀物或上清液。该结构具有用于沿着封闭路径输送安装的容器的输送装置，用于将试剂等分配到安装在输送装置上的容器中的分配部分，用于去除和/或提取除了沉淀物之外的液体的液体处理部分在安装在输送装置上的容器内部，分离器，用于相对于安装在输送装置上的容器内的内容物和/或远离输送装置安装的容器进行分离;容器移动装置，用于引入并且相对于输送装置和/或分离器取出容器，以及用于对输送装置，分配部，液体处理部，容器移动装置和运送装置进行操作和控制的操作/控制部分隔器。

12. 发明申请

US20050105082A1 Method of evaluating non-linear optical crystal and device therefor and wavelength conversion method and device therefor 有权
标题翻译：评估非线性光学晶体的方法及其装置及其波长转换方法及其装置
公开(公告)号：US20050105082A1
公开(公告)日：2005-05-19
申请号：US10504290
申请日：2003-02-13
申请人： Satoshi Wada , Hideo Tashiro , Masataka Morita
发明人： Satoshi Wada , Hideo Tashiro , Masataka Morita
IPC分类号： G01M11/00 , G01N21/63 , G02F1/35 , G02F1/37 , G01N21/88
CPC分类号： G01N21/636 , G01M11/00 , G02F1/3501 , G02F1/37
摘要： A method of evaluating a non-linear optical crystal used for non-linear wavelength conversion of laser beam which enables the non-linear optical crystal to be evaluated before the crystal is actually used as a wavelength conversion element in order for the crystal to be constantly used for an extended time with a high conversion efficiency retained and without lowering in output when non-linear optical crystals for various non-linear wavelength conversions such as a CLBO crystal are used to convert laser beams, wherein the non-linear optical crystal is moved to changed a laser beam incident position to detect the output of a laser beam emitted from the non-linear optical crystal for each changing position.
摘要翻译：一种评估用于激光束的非线性波长转换的非线性光学晶体的方法，其使得在晶体实际用作波长转换元件之前能够评估非线性光学晶体以使晶体恒定用于延长的时间，保持高的转换效率，并且当用于各种非线性波长转换的非线性光学晶体（例如CLBO晶体）用于转换激光束时，输出不降低，其中非线性光学晶体被移动以改变激光束入射位置，以检测对于每个改变位置从非线性光学晶体发射的激光束的输出。

13. 发明授权

US08163767B2 Heterocyclic Janus Kinase 3 inhibitors 失效
标题翻译：杂环Janus激酶3抑制剂
公开(公告)号：US08163767B2
公开(公告)日：2012-04-24
申请号：US11995445
申请日：2006-07-13
申请人： Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
发明人： Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
IPC分类号： A61K31/44 , C07D471/14
CPC分类号： C07D471/14 , C07D519/00
摘要： The invention relates to compound of the formula (I) or its salt, wherein —R1, —R2, —R3, —R4, —R5, -M-, —X— and —Y═ are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中-R1，-R2，-R3，-R4，-R5，-M-，-X-和-Y =如说明书中所定义，它们使用as，药物，其制备方法和用于治疗JAK3介导的疾病。

14. 发明申请

US20090076070A1 HETERO COMPOUND 有权
标题翻译： HETERO化合物
公开(公告)号：US20090076070A1
公开(公告)日：2009-03-19
申请号：US12244102
申请日：2008-10-02
申请人： Hironori HARADA , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
发明人： Hironori HARADA , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
IPC分类号： A61K31/4245 , C07D413/14 , A61K31/437 , A61P35/02 , A61P19/02 , A61P1/00 , A61P9/10 , A61P37/06 , A61P35/00 , A61K31/4709
CPC分类号： C07D413/04 , C07D417/04 , C07D471/04
摘要： [Problems] To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.[Means for Solving] Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.
摘要翻译： [问题]提供一种有用的化合物作为活性成分，用于预防和/或治疗移植器官，骨髓或组织，自身免疫疾病等中的排斥反应，其具有优异的S1P1激动剂活动。 [解决手段]由于本发明的化合物具有S1P1激动剂活性，因此可用作由不利的淋巴细胞浸润引起的疾病的治疗或预防剂的活性成分，例如自身免疫性疾病例如移植排斥反应器官移植，骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺功能障碍哮喘，特应性皮炎，炎症性肠病，动脉粥样硬化，局部缺血再灌注损伤，炎症性疾病等疾病，以及癌症，白血病等细胞异常生长或积累引起的疾病。

15. 发明授权

US07442715B2 Thiazole derivatives 失效
标题翻译：噻唑衍生物
公开(公告)号：US07442715B2
公开(公告)日：2008-10-28
申请号：US11505321
申请日：2006-08-17
申请人： Akira Nagashima , Takayuki Inoue , Mitsuru Ohkubo , Kousei Yoshihara , Takashi Tojo , Masataka Morita
发明人： Akira Nagashima , Takayuki Inoue , Mitsuru Ohkubo , Kousei Yoshihara , Takashi Tojo , Masataka Morita
IPC分类号： A61K31/427
CPC分类号： C07D417/06 , C07D277/46 , C07D277/48 , C07D277/56 , C07D417/12
摘要： A compound of the formula (I): R1—NH—X—Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.
摘要翻译：式（I）化合物：其中各符号如说明书中所定义，或其药学上可接受的盐可用作血管粘附蛋白-1（1R） VAP-1）抑制剂，药物组合物，预防或治疗VAP-1相关疾病，尤其是黄斑水肿的方法，该方法包括将有效量的化合物或其药学上可接受的盐给予哺乳动物等。

16. 发明申请

US20070254931A1 Thiazole Derivatives Having Vap-1 Inhibitory Activity 审中-公开
标题翻译：具有Vap-1抑制活性的噻唑衍生物
公开(公告)号：US20070254931A1
公开(公告)日：2007-11-01
申请号：US11572772
申请日：2005-07-27
申请人： Takayuki Inoue , Takashi Tojo , Masataka Morita
发明人： Takayuki Inoue , Takashi Tojo , Masataka Morita
IPC分类号： A61K31/426 , A61P19/02 , A61P19/08 , A61P3/10 , A61P9/10 , C07D277/46
CPC分类号： C07D277/46
摘要： A compound of the formula (I), (II), (III) or (IV): wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a subject, and the like.
摘要翻译：式（I），（II），（III）或（IV）的化合物：其中每个符号如说明书中所定义，或其药学上可接受的盐可用作血管粘附蛋白-1（VAP-1）抑制剂，药物组合物，预防或治疗VAP-1相关疾病，特别是黄斑水肿的方法，该方法包括向受试者施用有效量的化合物或其药学上可接受的盐等。

17. 发明授权

US07214177B2 Culture tube and angle rotor receiving the tube in centrifuge 有权
标题翻译：培养管和角转子在离心机中接收管
公开(公告)号：US07214177B2
公开(公告)日：2007-05-08
申请号：US10422852
申请日：2003-04-25
申请人： Masaharu Aizawa , Masataka Morita
发明人： Masaharu Aizawa , Masataka Morita
IPC分类号： B04B5/02
CPC分类号： B01L3/5021 , B01L3/50825 , B04B5/0414 , C12M23/08 , C12M23/38 , C12M33/10
摘要： A culture/centrifugal tube includes a tube and a cap. The cap has a disk portion and an annular portion that define an annular groove therebetween. The annular groove opens at a position level with the surface of the disk portion. The open end of the tube extends into the annular groove, with the open end of the vessel in abutment against the surface of the disk portion when the cap is fully engaged on the tube. An angle rotor that is used in a centrifuge is formed with an accommodation hole that receives the culture/centrifugal tube. The accommodation hole including a smaller-diameter tube accommodating portion that accommodates the tube and a larger-diameter cap accommodating portion that accommodates the cap. The cap accommodating portion includes a region that entirely encompasses a corresponding portion of the outer periphery of the annular portion of the cap.
摘要翻译：培养/离心管包括管和帽。盖具有在其间限定环形槽的圆盘部分和环形部分。环形槽在与盘部分的表面的位置水平位置处打开。管的开口端延伸到环形槽中，当盖完全接合在管上时，容器的开口端抵靠盘部分的表面。在离心机中使用的角度转子形成有容纳培养/离心管的容纳孔。容纳孔包括容纳管的较小直径的管容纳部分和容纳盖的较大直径的盖容纳部分。盖容纳部分包括完全包围盖的环形部分的外周的相应部分的区域。

18. 发明授权

US07125901B2 Thiazole derivatives 有权
公开(公告)号：US07125901B2
公开(公告)日：2006-10-24
申请号：US10764529
申请日：2004-01-27
申请人： Takayuki Inoue , Takashi Tojo , Masataka Morita , Mitsuru Ohkubo , Kousei Yoshihara , Akira Nagashima
发明人： Takayuki Inoue , Takashi Tojo , Masataka Morita , Mitsuru Ohkubo , Kousei Yoshihara , Akira Nagashima
IPC分类号： A61K31/427 , C07D277/44
CPC分类号： C07D417/06 , C07D277/46 , C07D277/48 , C07D277/56 , C07D417/12
摘要： A compound of the formula (I): R1—NH—X—Y-Z (I) wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof useful as a vascular adhesion protein-1 (VAP-1) inhibitor, a pharmaceutical composition, a method for preventing or treating a VAP-1 associated disease, especially macular edema, which method includes administering an effective amount of the compound or a pharmaceutically acceptable salt thereof to a mammal, and the like.

19. 发明授权

US6045760A Micro-plate adapter 失效
标题翻译：微板适配器
公开(公告)号：US6045760A
公开(公告)日：2000-04-04
申请号：US756911
申请日：1996-11-26
申请人： Masaharu Aizawa , Masataka Morita , Yasuhiro Kawai , Iwao Yamazaki , Hiroshi Ono
发明人： Masaharu Aizawa , Masataka Morita , Yasuhiro Kawai , Iwao Yamazaki , Hiroshi Ono
IPC分类号： B01L9/00 , B04B5/04 , B01L3/00
CPC分类号： B01L9/523 , B04B5/0421 , B01L2300/0829 , B04B2005/0435
摘要： A micro-plate adapter for mounting a micro-plate onto a centrifugal separator rotor. The micro-plate has a sample injection hole portion containing a sample therein and as a box-like external wall. The adapter includes a bearing surface contacting a back bottom surface of the sample injection hole portion. A swing rotor for a centrifugal separator includes a rotor body attached to a driving shaft of the centrifugal separator and provided with a plurality of bucket storage portions; buckets all swingably engaged with the rotor body in the respective storage portions so that samples stored in the buckets are subjected to centrifugal separation by a centrifugal force generated by rotation of the swing rotor. Each of the buckets is formed to have a shape which adapts with a bottom surface of a micro-plate so as to contact with the back bottom surface of a sample injection hole portion of the micro-plate to bear a centrifugal load of the micro-plate. The swing rotor further includes a shell enclosing the rotor body and the buckets so as to rotate together with the rotor body and the buckets.
摘要翻译：用于将微板安装到离心分离器转子上的微板适配器。微板具有在其中包含样品的样品注入孔部分和作为盒状外壁。适配器包括接触样品注入孔部分的后底表面的支承表面。用于离心分离器的摆动转子包括安装在离心分离器的驱动轴上的转子体，并具有多个铲斗收纳部; 所有的转子都可摆动地与各个储存部分中的转子本体接合，使得通过旋转转子的旋转产生的离心力使储存在料斗中的样品进行离心分离。每个桶形成为具有与微板的底面适应的形状，以便与微板的样品注入孔部分的后底面接触以承受微孔板的离心载荷，盘子。摆动转子还包括壳体，其包围转子主体和铲斗，以便与转子主体和铲斗一起旋转。

20. 发明授权

US07951825B2 Hetero compound 有权
标题翻译：杂环化合物
公开(公告)号：US07951825B2
公开(公告)日：2011-05-31
申请号：US12696327
申请日：2010-01-29
申请人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
发明人： Hironori Harada , Kazuyuki Hattori , Kazuya Fujita , Masataka Morita , Sunao Imada , Yoshito Abe , Hiromichi Itani , Tatsuaki Morokata , Hideo Tsutsumi
IPC分类号： C07D413/02 , C07D413/14 , C07D401/02 , C07D401/14 , A61K31/443
CPC分类号： C07D413/04 , C07D417/04 , C07D471/04
摘要： To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 agonist activity.Since the compound of the invention has an S1P1 agonist activity, it is useful as an active ingredient for a treating or preventing agent for a disease caused by unfavorable lymphocytic infiltration, for example, an autoimmune disease such as graft rejection in the transplantation of an organ, bone marrow, or a tissue, a graft-versus-host disease, rheumatic arthritis, multiple sclerosis, systemic lupus erythematosus, a nephrotic syndrome, encephalomeningitis, myasthenia gravis, pancreatitis, hepatitis, nephritis, diabetes, pulmonary disorder, asthma, atopic dermatitis, inflammatory bowel disease, atherosclerosis, ischemia-reperfusion injury, or an inflammatory disease, and further, a disease caused by the abnormal growth or accumulation of cells such as cancer and leukemia.
摘要翻译：为了提供具有优异的S1P1激动剂活性的器官，骨髓或组织，自身免疫疾病等的移植中的预防和/或治疗剂的有效成分的有用化合物。由于本发明的化合物具有S1P1激动剂活性，因此可用作治疗或预防由不利淋巴细胞浸润引起的疾病的活性成分，例如自体免疫疾病例如器官移植中的移植排斥反应骨髓或组织，移植物抗宿主病，风湿性关节炎，多发性硬化症，系统性红斑狼疮，肾病综合征，脑炎，重症肌无力，胰腺炎，肝炎，肾炎，糖尿病，肺病，哮喘，特应性皮炎炎症性肠病，动脉粥样硬化，缺血再灌注损伤或炎性疾病，以及由细胞如癌症和白血病的异常生长或积累引起的疾病。

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