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1. 发明申请

US20090264399A1 HETEROCYCLIC JANUS KINASE 3 INHIBITORS 失效
标题翻译：杂交种JANUS KINASE 3抑制剂
公开(公告)号：US20090264399A1
公开(公告)日：2009-10-22
申请号：US11995445
申请日：2006-07-13
申请人： Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
发明人： Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
IPC分类号： A61K31/437 , C07D471/04 , C07D413/14 , C07D471/14 , A61K31/5377 , A61K31/397 , A61P25/00 , A61P37/06 , A61P35/00 , A61P35/02 , A61P11/06
CPC分类号： C07D471/14 , C07D519/00
摘要： The invention relates to compound of the formula (I) or its salt, wherein —R1, —R2, —R3, —R4, —R5, -M-, —X— and —Y═ are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.
摘要翻译：本发明涉及式（I）或其盐的化合物，其中-R1，-R2，-R3，-R4，-R5，-M-，-X-和-Y-如说明书中所定义，它们使用as，药物，其制备方法和用于治疗JAK3介导的疾病。

2. 发明授权

US08163767B2 Heterocyclic Janus Kinase 3 inhibitors 失效
标题翻译：杂环Janus激酶3抑制剂
公开(公告)号：US08163767B2
公开(公告)日：2012-04-24
申请号：US11995445
申请日：2006-07-13
申请人： Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
发明人： Takayuki Inoue , Takashi Tojo , Masataka Morita , Yutaka Nakajima , Keiko Hatanaka , Shohei Shirakami , Hiroshi Sasaki , Akira Tanaka , Fumie Takahashi , Koichiro Mukoyoshi , Yasuyuki Higashi , Akira Okimoto , Takeshi Hondo , Hitoshi Sawada
IPC分类号： A61K31/44 , C07D471/14
CPC分类号： C07D471/14 , C07D519/00
摘要： The invention relates to compound of the formula (I) or its salt, wherein —R1, —R2, —R3, —R4, —R5, -M-, —X— and —Y═ are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中-R1，-R2，-R3，-R4，-R5，-M-，-X-和-Y =如说明书中所定义，它们使用as，药物，其制备方法和用于治疗JAK3介导的疾病。

3. 发明申请

US20090270376A1 HETEROCYCLIC JANUS KINASE 3 INHIBITORS 有权
标题翻译：杂交种JANUS KINASE 3抑制剂
公开(公告)号：US20090270376A1
公开(公告)日：2009-10-29
申请号：US12065234
申请日：2006-12-25
申请人： Takayuki Inoue , Akira Tanaka , Kazuo Nakai , Hiroshi Sasaki , Fumie Takahashi , Shohei Shirakami , Keiko Hatanaka , Yutaka Nakajima , Koichiro Mukoyoshi , Hisao Hamaguchi , Shigeki Kunikawa , Yasuyuki Higashi
发明人： Takayuki Inoue , Akira Tanaka , Kazuo Nakai , Hiroshi Sasaki , Fumie Takahashi , Shohei Shirakami , Keiko Hatanaka , Yutaka Nakajima , Koichiro Mukoyoshi , Hisao Hamaguchi , Shigeki Kunikawa , Yasuyuki Higashi
IPC分类号： A61K31/437 , C07D471/04 , C07D471/14 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P37/00 , A61P25/28 , A61P35/00
CPC分类号： C07D451/04 , C07D471/04 , C07D471/14 , C07D519/00
摘要： The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases inflammatory diseases, and allergic diseases. The compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
摘要翻译：本发明提供了具有优异的JAK3抑制活性的式（I）化合物，并且可用作治疗和/或预防各种免疫疾病，包括自身免疫性疾病炎性疾病和过敏性疾病的药剂的活性成分。根据本发明的化合物对JAK3具有抑制活性，因此可用作治疗或预防由不良细胞因子信号传导引起的疾病（例如器官/组织移植期间的排斥，自身免疫性疾病，多发性硬化症）的活性成分，类风湿性关节炎，牛皮癣，哮喘，特应性皮炎，阿尔茨海默病和动脉粥样硬化疾病）或由异常细胞因子信号传导引起的疾病（例如癌症和白血病）。

4. 发明申请

US20110039822A1 HETEROCYCLIC JANUS KINASE 3 INHIBITORS 审中-公开
标题翻译：杂交种JANUS KINASE 3抑制剂
公开(公告)号：US20110039822A1
公开(公告)日：2011-02-17
申请号：US12914475
申请日：2010-10-28
申请人： Takayuki INOUE , Akira Tanaka , Kazuo Nakai , Hiroshi Sasaki , Fumie Takahashi , Shohei Shirakami , Keiko Hatanaka , Yutaka Nakajima , Koichiro Mukoyoshi , Hisao Hamaguchi , Shigeki Kunikawa , Yasuyuki Higashi
发明人： Takayuki INOUE , Akira Tanaka , Kazuo Nakai , Hiroshi Sasaki , Fumie Takahashi , Shohei Shirakami , Keiko Hatanaka , Yutaka Nakajima , Koichiro Mukoyoshi , Hisao Hamaguchi , Shigeki Kunikawa , Yasuyuki Higashi
IPC分类号： A61K31/437 , C07D471/04 , C07D471/14 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/541 , A61P17/06 , A61P19/02 , A61P37/00 , A61P37/06
CPC分类号： C07D451/04 , C07D471/04 , C07D471/14 , C07D519/00
摘要： The present invention provides a compound having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases, inflammatory diseases, and allergic diseases.As a result of studies on a novel condensed heterocyclic derivative, the inventors have found that a compound having a cross-linked structure has an excellent JAK3 inhibition activity, and have completed the present invention.In other words, it is verified that the compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
摘要翻译：本发明提供具有优异的JAK3抑制活性的化合物，可用作治疗和/或预防各种免疫疾病，包括自身免疫性疾病，炎症性疾病和过敏性疾病的药剂的活性成分。作为研究新型稠合杂环衍生物的结果，本发明人发现具有交联结构的化合物具有优异的JAK3抑制活性，并且完成了本发明。换句话说，证实了本发明的化合物对JAK3具有抑制活性，因此可用作治疗或预防由不期望的细胞因子信号传导引起的疾病的药剂的活性成分（例如器官/ 组织移植，自身免疫性疾病，多发性硬化，类风湿性关节炎，牛皮癣，哮喘，特应性皮炎，阿尔茨海默病和动脉粥样硬化疾病）或由异常细胞因子信号传导引起的疾病（例如癌症和白血病）。

5. 发明授权

US07879844B2 Heterocyclic janus kinase 3 inhibitors 有权
标题翻译：杂环janus激酶3抑制剂
公开(公告)号：US07879844B2
公开(公告)日：2011-02-01
申请号：US12065234
申请日：2006-12-25
申请人： Takayuki Inoue , Akira Tanaka , Kazuo Nakai , Hiroshi Sasaki , Fumie Takahashi , Shohei Shirakami , Keiko Hatanaka , Yutaka Nakajima , Koichiro Mukoyoshi , Hisao Hamaguchi , Shigeki Kunikawa , Yasuyuki Higashi
发明人： Takayuki Inoue , Akira Tanaka , Kazuo Nakai , Hiroshi Sasaki , Fumie Takahashi , Shohei Shirakami , Keiko Hatanaka , Yutaka Nakajima , Koichiro Mukoyoshi , Hisao Hamaguchi , Shigeki Kunikawa , Yasuyuki Higashi
IPC分类号： A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , C07D471/14 , A61P37/00 , A61P25/28 , A61P35/00
CPC分类号： C07D451/04 , C07D471/04 , C07D471/14 , C07D519/00
摘要： The present invention provides a compound of formula (I) having an excellent JAK3 inhibition activity and being useful as an active ingredient of an agent for treating and/or preventing various immune diseases including autoimmune diseases inflammatory diseases, and allergic diseases. The compound according to the present invention has an inhibition activity against JAK3 and is thus useful as an active ingredient of an agent for treating or preventing diseases caused by undesirable cytokine signal transmission (e.g., rejection during organ/tissue transplantation, autoimmune diseases, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, atopic dermatitis, Alzheimer's disease, and atherosclerotic disease), or diseases caused by abnormal cytokine signal transmission (e.g., cancer and leukemia).
摘要翻译：本发明提供了具有优异的JAK3抑制活性的式（I）化合物，并且可用作治疗和/或预防各种免疫疾病，包括自身免疫性疾病炎性疾病和过敏性疾病的药剂的活性成分。根据本发明的化合物对JAK3具有抑制活性，因此可用作治疗或预防由不良细胞因子信号传导引起的疾病（例如器官/组织移植期间的排斥，自身免疫性疾病，多发性硬化症）的活性成分，类风湿性关节炎，牛皮癣，哮喘，特应性皮炎，阿尔茨海默病和动脉粥样硬化疾病）或由异常细胞因子信号传导引起的疾病（例如癌症和白血病）。

6. 发明申请

US20110159019A1 2,4-DIAMINOPYRIMIDINE COMPOUND 审中-公开
标题翻译： 2,4-二氨基吡啶化合物
公开(公告)号：US20110159019A1
公开(公告)日：2011-06-30
申请号：US13061311
申请日：2009-08-31
申请人： Akira Tanaka , Koichiro Mukoyoshi , Shigeki Kunikawa , Yuji Takasuna , Jun Maeda , Noboru Chida , Shinya Nagashima
发明人： Akira Tanaka , Koichiro Mukoyoshi , Shigeki Kunikawa , Yuji Takasuna , Jun Maeda , Noboru Chida , Shinya Nagashima
IPC分类号： A61K31/551 , C07D403/12 , C07D401/12 , C07D239/48 , C07D413/12 , C07D405/12 , C07D409/12 , C07D405/14 , C07D413/14 , A61K31/506 , A61K31/505 , A61K31/5377 , A61P37/06
CPC分类号： C07D239/48
摘要： Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKCθ inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. The present inventors have conducted extensive studies on a compound having a PKCθ inhibition activity, and as a result, they have found that a compound having a structure such as aralkyl and the like on an amino group at the 2-position and also having a structure such as an adamantylalkyl group and the like on an amino group at the 4-position of 2,4-diaminopyrimidine, or a salt thereof has an excellent PKCθ inhibition activity, thereby completing the present invention. The 2,4-diaminopyrimidine compound of the present invention can be used as a PKCθ inhibitor or an inhibitor of acute rejection occurring in transplantation.
摘要翻译：提供可用作具有PKC和药物的药物的活性成分的化合物; 特别是用于抑制移植中发生急性排斥反应的药物组合物。本发明人对具有PKC的化合物进行了广泛的研究; 抑制活性，结果发现，在2-位的氨基上具有芳烷基等结构的化合物，还具有金刚烷基烷基等的结构，氨基上的氨基上 2,4-二氨基嘧啶的4位或其盐具有优异的PKC和重量; 从而完成了本发明。本发明的2,4-二氨基嘧啶化合物可以用作PKC＆amp; 抑制剂或移植中发生的急性排斥抑制剂。

7. 发明申请

US20220326632A1 TONER, DEVELOPING AGENT, TONER HOUSING UNIT, IMAGE FORMING APPARATUS, AND A METHOD OF FORMING IMAGES 有权
公开(公告)号：US20220326632A1
公开(公告)日：2022-10-13
申请号：US17657471
申请日：2022-03-31
申请人： Keiji MAKABE , Akira Tanaka , Hidekazu Kakinuma , Tsukiko Takahashi
发明人： Keiji MAKABE , Akira Tanaka , Hidekazu Kakinuma , Tsukiko Takahashi
IPC分类号： G03G9/097 , G03G15/08 , G03G9/08
摘要： [Object] An object of the invention is to provide a toner that can both achieve a higher level of low temperature fixability and suppression of the toner scattering.
[Means of Achieving the Object]
The disclosure is to provide a toner, including base-particles, and an external-additive, wherein a glass-transition temperature obtained from a DSC-curve at a second-warming of a THF-insoluble component is −50° C. or higher and 10° C. or lower, wherein an average circularity of the toner is 0.975 or more and 0.985 or lower, wherein the toner satisfies the following formula: 1.5≤Bt−0.025−Ct≤3.0, wherein the Bt [m2/g] is a BET-specific-surface area of the toner-particles, and the Ct [%] is a coverage by the external-additive, and, at least a portion of a surface of the external-additive is coated with either an oxide of a metallic element, a hydroxide of the metallic element, or both.

8. 发明授权

US10303072B2 Toner, developer, and image forming device 有权
公开(公告)号：US10303072B2
公开(公告)日：2019-05-28
申请号：US15889461
申请日：2018-02-06
申请人： Akira Tanaka , Hiroyuki Takeda , Junichi Awamura , Hiroshi Yamada , Daichi Hisakuni , Yasuo Kamada
发明人： Akira Tanaka , Hiroyuki Takeda , Junichi Awamura , Hiroshi Yamada , Daichi Hisakuni , Yasuo Kamada
IPC分类号： G03G9/087 , C08G63/42 , C08G63/20 , G03G15/00 , C08G63/195 , C08G63/16 , C08G63/66 , C08G18/75 , C08G18/42
摘要： A toner is provided. The toner contains a polyester resin. The toner has a glass transition temperature (Tg1st) at first temperature rising of differential scanning calorimetry (DSC) of from 45° C. to 65° C. The toner includes a component insoluble in tetrahydrofuran (THF) having two glass transition temperatures (Tga1st and Tgb1st) at the first temperature rising of DSC, where Tga1st is in a range of −45° C. to 5° C. and Tgb1st is in a range of 45° C. to 70° C. The toner includes a component soluble in THF having a glass transition temperature (Tg2nd) at second temperature rising of DSC of from 40° C. to 65° C.

9. 发明授权

US08686398B2 Semiconductor light emitting device 失效
标题翻译：半导体发光器件
公开(公告)号：US08686398B2
公开(公告)日：2014-04-01
申请号：US13599852
申请日：2012-08-30
申请人： Akira Tanaka , Yoko Motojima
发明人： Akira Tanaka , Yoko Motojima
IPC分类号： H01L29/06
CPC分类号： H01L33/06 , H01L33/0079 , H01L33/22 , H01L33/32 , H01L33/38 , H01L33/382 , H01L33/387 , H01L33/405 , H01L33/42 , H01L2924/0002 , H01L2924/00
摘要： A semiconductor light emitting device includes a first conductivity-type first semiconductor layer, a second conductivity-type second semiconductor layer, a semiconductor light emitting layer, and first and second electrodes. The semiconductor light emitting layer is provided between the first semiconductor layer and the second semiconductor layer, and includes a multiple quantum well structure. The quantum well structure includes well layers and barrier layers each laminated alternately, each of the well layers being not less than 6 nm and not more than 10 nm. The first and second electrodes are electrically connected to the first and second semiconductor layers such that current flows in a direction substantially vertical to the main surface.
摘要翻译：半导体发光器件包括第一导电型第一半导体层，第二导电型第二半导体层，半导体发光层以及第一和第二电极。半导体发光层设置在第一半导体层和第二半导体层之间，并且包括多量子阱结构。量子阱结构包括交替层叠的阱层和势垒层，每个阱层不小于6nm且不大于10nm。第一和第二电极电连接到第一和第二半导体层，使得电流在基本垂直于主表面的方向上流动。

10. 发明授权

US08570240B2 Communication sheet structure 有权
标题翻译：通讯单结构
公开(公告)号：US08570240B2
公开(公告)日：2013-10-29
申请号：US12996839
申请日：2008-06-27
申请人： Akira Tanaka , Machiko Oouchida , Hiroyuki Mori
发明人： Akira Tanaka , Machiko Oouchida , Hiroyuki Mori
IPC分类号： H01Q1/36
CPC分类号： H04B13/00
摘要： A communication sheet structure for transmitting electromagnetic waves, and thereby performing communication, is characterized in that the communication sheet structure includes a planar base material with a relative dielectric constant at a frequency of from 800 MHz to 10 GHz of from 1.0 to 15.0, and one side of the base material includes conductor A existing portion and non-existing portion, and the other side of the base material includes a conductor B existing over 90% or more thereof. The communication sheet structure enables communication in two dimensions, and the communication sheet structure is extremely excellent in communication performances.
摘要翻译：用于传送电磁波，从而进行通信的通信片结构的特征在于，通信片结构包括平面基底材料，其相对介电常数在800MHz至10GHz的频率范围为1.0至15.0，一个基体材料的一侧包括导体A存在部分和不存在部分，并且基材的另一侧包括存在于其中90％以上的导体B. 通信片结构使得能够在二维方面进行通信，并且通信片结构在通信性能方面非常优异。

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