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11. 发明授权

US6013582A Method for etching silicon oxynitride and inorganic antireflection coatings 失效
标题翻译：蚀刻氮氧化硅和无机抗反射涂层的方法
公开(公告)号：US6013582A
公开(公告)日：2000-01-11
申请号：US986911
申请日：1997-12-08
申请人： Pavel Ionov , Sung Ho Kim , Dean Li
发明人： Pavel Ionov , Sung Ho Kim , Dean Li
IPC分类号： H01L21/302 , H01L21/027 , H01L21/3065 , H01L21/3213 , H01L21/44
CPC分类号： H01L21/32139 , H01L21/0276
摘要： The present disclosure pertains to a method for plasma etching a semiconductor patterning stack. The patterning stack includes at least one layer comprising either a dielectric-comprising antireflective material or an oxygen-comprising material. In many instances the dielectric-comprising antireflective material will be an oxygen-comprising material, but it need not be limited to such materials. In one preferred embodiment of the method, the chemistry enables the plasma etching of both a layer of the dielectric-comprising antireflective material or oxygen-comprising material and an adjacent or underlying layer of material. In another preferred embodiment of the method, the layer of dielectric-comprising antireflective material or oxygen-comprising material is etched using one chemistry, while the adjacent or underlying layer is etched using another chemistry, but in the same process chamber. Of particular interest is silicon oxynitride, an oxygen-comprising material which functions as an antireflective material. A preferred embodiment of the method provides for the use of a source of carbon and an appropriate halogen-comprising plasma, to achieve selective etch of one oxygen-containing material compared with another material which contains a more limited amount of oxygen.
摘要翻译：本公开涉及用于等离子体蚀刻半导体图案化叠层的方法。图案化叠层包括至少一层，其包括含电介质的抗反射材料或含氧材料。在许多情况下，包含电介质的抗反射材料将是含氧材料，但不限于此类材料。在该方法的一个优选实施方案中，该化学物质能够对包含电介质的抗反射材料或含氧材料的层和相邻或下层材料进行等离子体蚀刻。在该方法的另一个优选实施方案中，使用一种化学方法蚀刻包含电介质的抗反射材料层或含氧材料层，而使用另一种化学物质在相同的处理室中蚀刻相邻层或下层。特别令人感兴趣的是氧氮化硅，其作为抗反射材料起作用的含氧材料。该方法的优选实施方案提供了使用碳源和合适的含卤素等离子体，与含有更多有限量的氧气的另一种材料相比，可实现一种含氧材料的选择性蚀刻。

12. 发明申请

US20130102534A1 COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY 审中-公开
标题翻译：治疗病态血管生成和血管渗透性的组合物和方法
公开(公告)号：US20130102534A1
公开(公告)日：2013-04-25
申请号：US13644614
申请日：2012-10-04
申请人： Dean Li , Christopher Jones , Nyall London
发明人： Dean Li , Christopher Jones , Nyall London
IPC分类号： A61K38/17
CPC分类号： A61K38/17 , A61K38/00 , C07K14/70503 , G01N33/5023 , G01N2800/164
摘要： Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein.
摘要翻译：本文描述了用于抑制血管通透性和病理性血管生成的化合物，组合物和方法。本文还描述了生产和筛选能够抑制血管通透性和病理性血管生成的化合物和组合物的方法。药物组合物包括在本文所述的组合物中。本文描述的组合物可用于例如抑制血管通透性和病理性血管生成的方法，包括抑制由特异性血管生成，通透性和炎性因子（例如VEGF，bFGF和凝血酶）诱导的血管通透性和病理性血管发生的方法。本文还提供了治疗特定疾病和病症的方法。

13. 发明申请

US20120129757A1 COMPOSITIONS AND METHODS FOR PROMOTING VASCULAR BARRIER FUNCTION AND TREATING PULONARY FIBROSIS 审中-公开
标题翻译：用于促进血管阻滞功能和治疗血管性纤维化的组合物和方法
公开(公告)号：US20120129757A1
公开(公告)日：2012-05-24
申请号：US13000802
申请日：2009-12-11
申请人： Dean Li , Nyall London , Weiquan Zhu
发明人： Dean Li , Nyall London , Weiquan Zhu
IPC分类号： A61K31/4196 , A61P9/00 , A61K38/17
CPC分类号： A61K38/1709
摘要： Active agents and compositions that promote barrier function or that inhibit permeability of the vascular endothelium associated with pulmonary inflammation are described.
摘要翻译：描述了促进屏障功能或抑制与肺部炎症相关的血管内皮的通透性的活性剂和组合物。

14. 发明申请

US20110263483A1 COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY 有权
标题翻译：治疗病态血管生成和血管渗透性的组合物和方法
公开(公告)号：US20110263483A1
公开(公告)日：2011-10-27
申请号：US13111776
申请日：2011-05-19
申请人： Dean Li , Christopher Jones , Nyall London
发明人： Dean Li , Christopher Jones , Nyall London
IPC分类号： A61K38/17 , C07K14/705 , C07H21/00 , A61P9/00 , A61K48/00 , A61P11/00 , A61P9/10 , A61P27/02 , G01N33/573 , C12N15/63
CPC分类号： A61K38/17 , A61K38/00 , C07K14/70503 , G01N33/5023 , G01N2800/164
摘要： Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein.
摘要翻译：本文描述了用于抑制血管通透性和病理性血管生成的化合物，组合物和方法。本文还描述了生产和筛选能够抑制血管通透性和病理性血管生成的化合物和组合物的方法。药物组合物包括在本文所述的组合物中。本文描述的组合物可用于例如抑制血管通透性和病理性血管生成的方法，包括抑制由特异性血管生成，通透性和炎性因子（例如VEGF，bFGF和凝血酶）诱导的血管通透性和病理性血管发生的方法。本文还提供了治疗特定疾病和病症的方法。

15. 发明授权

US07994130B2 Compositions and methods for treating ocular pathologic angiogenesis and vascular permeability 有权
标题翻译：用于治疗眼病理性血管生成和血管通透性的组合物和方法
公开(公告)号：US07994130B2
公开(公告)日：2011-08-09
申请号：US12518730
申请日：2007-12-11
申请人： Dean Li , Christopher Jones , Nyall London
发明人： Dean Li , Christopher Jones , Nyall London
IPC分类号： A61K38/16 , A61K38/17 , C07K14/435
CPC分类号： A61K38/17 , A61K38/00 , C07K14/70503 , G01N33/5023 , G01N2800/164
摘要： Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein.
摘要翻译：本文描述了用于抑制血管通透性和病理性血管生成的化合物，组合物和方法。本文还描述了生产和筛选能够抑制血管通透性和病理性血管生成的化合物和组合物的方法。药物组合物包括在本文所述的组合物中。本文描述的组合物可用于例如抑制血管通透性和病理性血管发生的方法，包括抑制由特异性血管生成，通透性和炎性因子（例如VEGF，bFGF和凝血酶）诱导的血管通透性和病理性血管发生的方法。本文还提供了治疗特定疾病和病症的方法。

16. 发明申请

US20070004193A1 Method for reworking low-k dual damascene photo resist 审中-公开
标题翻译：低k双重镶嵌光刻胶修复方法
公开(公告)号：US20070004193A1
公开(公告)日：2007-01-04
申请号：US11173275
申请日：2005-07-01
申请人： Tsang-Jiuh Wu , Chen-Nan Yeh , Dean Li , Hui Ouyang
发明人： Tsang-Jiuh Wu , Chen-Nan Yeh , Dean Li , Hui Ouyang
IPC分类号： H01L21/4763
CPC分类号： H01L21/76808
摘要： A new method of forming a dual damascene structure involves forming a via-level precursor structure on a substrate and spin coating an oxide protective layer over the bottom anti-reflective coating, which is the last layer of the via-level precursor structure. A trench-level photoresist layer is deposited over the oxide protective layer to form a trench pattern etch mask. The oxide protective layer protects the BARC layer and the via plugs from photoresist removing process. When and if the trench-level photoresist layer is to be reworked, the trench-level photoresist layer is simply removed without removing the BARC layer and the via plugs under the oxide protective layer.
摘要翻译：形成双镶嵌结构的新方法包括在基底上形成通孔级前体结构，并在作为通孔级前体结构的最后一层的底部抗反射涂层上旋转涂覆氧化物保护层。沟槽级光致抗蚀剂层沉积在氧化物保护层上以形成沟槽图案蚀刻掩模。氧化物保护层保护BARC层和通孔插塞免受光致抗蚀剂的去除。当沟槽层光致抗蚀剂层要被再加工时，沟槽层光致抗蚀剂层被简单地去除，而不去除氧化物保护层下的BARC层和通孔塞。

17. 发明申请

US20110112053A1 PHARMACOLOGICAL TARGETING OF VASCULAR MALFORMATIONS 审中-公开
标题翻译：血管造影的药理学靶点
公开(公告)号：US20110112053A1
公开(公告)日：2011-05-12
申请号：US12937336
申请日：2009-04-16
申请人： Dean Li , Kevin Whitehead , Aubrey Chan , Nyall London , Sutip Navankasattusas
发明人： Dean Li , Kevin Whitehead , Aubrey Chan , Nyall London , Sutip Navankasattusas
IPC分类号： A61K31/675 , A61K31/366 , A61K31/663 , A61K31/4164 , A61K31/216 , A61K31/4409 , A61K31/5513 , A61P25/08 , A61P9/00 , A61P9/10
CPC分类号： A61K31/40
摘要： Disclosed herein are compositions and methods for decreasing vascular permeability in a blood vessel and treating or preventing conditions associated with defects or injuries of vascular endothelium. For example, the disclosed compositions and methods can be used to treat a vascular dysplasia such as cerebral cavernous malformation (CCM). These methods relate generally to the use of compositions that inhibit RhoA GTPase levels or activity, such as inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.
摘要翻译：本文公开了用于降低血管中的血管通透性并治疗或预防与血管内皮的缺陷或损伤相关的病症的组合物和方法。例如，所公开的组合物和方法可用于治疗诸如脑海绵体畸形（CCM）的血管发育不良。这些方法一般涉及抑制RhoA GTP酶水平或活性的组合物的用途，例如3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶的抑制剂。

18. 发明申请

US20100222401A1 COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY 审中-公开
标题翻译：治疗病态血管生成和血管渗透性的组合物和方法
公开(公告)号：US20100222401A1
公开(公告)日：2010-09-02
申请号：US12667168
申请日：2009-04-16
申请人： Dean Li , Christopher Jones , Nyall London
发明人： Dean Li , Christopher Jones , Nyall London
IPC分类号： A61K31/4196 , C07K14/435 , C07D249/08 , C07D405/02
CPC分类号： A61K31/4196 , A61K38/1709
摘要： Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis by modulating a signaling pathway delineated herein are described. Moreover, methods for producing and screening compounds and compositions capable of modulating the signaling pathway described herein, inhibiting vascular permeability, and inhibiting pathologic angiogenesis are also provided.
摘要翻译：描述了通过调节本文描述的信号传导途径来抑制血管通透性和病理性血管生成的化合物，组合物和方法。此外，还提供了用于生产和筛选能够调节本文所述的信号传导途径，抑制血管通透性和抑制病理性血管生成的化合物和组合物的方法。

19. 发明申请

US20060160729A1 Methods and compositions for manipulating the guided navigation of endothelial tubes during angiogenesis 审中-公开
标题翻译：在血管生成过程中操纵内皮细胞导管导管的方法和组合物
公开(公告)号：US20060160729A1
公开(公告)日：2006-07-20
申请号：US10519342
申请日：2003-06-27
申请人： Dean Li , Kye Park
发明人： Dean Li , Kye Park
IPC分类号： A61K38/17 , C07K14/705
CPC分类号： C12N5/0691 , A61K38/00 , C07K14/4702 , C07K14/705 , C07K14/70503
摘要： Methods and compositions for manipulating the directed navigation of physiological tracking tubular structures are provided. A novel cell-bound receptor, roundabout-4 (Robo-4), is described. The Robo-4 receptor shows sequence and structural similarity to members of the roundabout family of receptors. Also, the Robo-4 receptor binds Slit ligand, a known receptor of the roundabout receptors. Polynucleotides and polypeptides of the Robo-4 receptor are described.
摘要翻译：提供了用于操纵生理跟踪管状结构的定向导航的方法和组合物。描述了一种新的细胞结合受体，环状蛋白-4（Robo-4）。 Robo-4受体显示与迂回家族受体的成员的序列和结构相似性。此外，Robo-4受体结合了Slit配体，这是迂回受体的已知受体。描述了Robo-4受体的多核苷酸和多肽。

20. 发明申请

US20060079439A1 Elastin prevents occlusion of body vessels by vascular smooth muscle cells 审中-公开
标题翻译：弹性蛋白阻止血管平滑肌细胞阻塞体液
公开(公告)号：US20060079439A1
公开(公告)日：2006-04-13
申请号：US10509472
申请日：2003-03-27
申请人： Dean Li , Satyajit Karnik
发明人： Dean Li , Satyajit Karnik
IPC分类号： A61K48/00 , A61K38/17 , A61K31/4745 , A61K31/337 , C40B40/10
CPC分类号： A61K31/337 , A61K31/4745 , A61K38/39 , A61K38/46 , A61L29/16 , A61L31/16 , A61L2300/416 , C12Y306/05002 , G01N33/5041 , G01N33/5061 , G01N33/6887 , G01N2333/78 , G01N2500/00 , G01N2800/323
摘要： The present invention provides methods and compositions for promoting elastin signaling in smooth muscle cells including vascular smooth muscle cell. The present invention further provides methods of identifying additional agents that promote elasfin signaling.
摘要翻译：本发明提供用于在包括血管平滑肌细胞的平滑肌细胞中促进弹性蛋白信号传导的方法和组合物。本发明进一步提供鉴定促进elasfin信号传导的其他试剂的方法。

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