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11. 发明申请

US20120116358A1 MODULAR INGESTIBLE DRUG DELIVERY CAPSULE 有权
标题翻译：模块不可食用药物输送胶囊
公开(公告)号：US20120116358A1
公开(公告)日：2012-05-10
申请号：US13262841
申请日：2010-04-02
申请人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
发明人： Johan Frederik Dijksman , Anke Pierik , Frits Tobi De Jongh , Jeff Shimizu , Hans Zou , Lucian Remus Albu , Olaf Weiner
IPC分类号： A61M37/00
CPC分类号： A61K9/4808 , A61K9/0009 , A61K9/0097 , A61M31/002
摘要： An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).
摘要翻译：提供用于输送药物的可摄取胶囊（10），所述胶囊（10）包括第一模块（11）和第二模块（12）。第一模块（11）具有至少一个用于包含一定量药物的药物隔室（13）。药物隔室（13）由具有嵌入的导电加热丝（15）的箔（14）密封。第二（12）模块包括用于向加热丝（15）提供电脉冲以便通过熔化箔（14）打开药物隔室（13）的电子器件（18）。第一模块（11）和第二模块（12）包括用于将第一模块（11）固定到第二模块（12）的可互操作的连接装置（19），使得电热丝（15）电连接到电子装置）。

12. 发明授权

US08597279B2 Swallowable multi-nozzle dosing device for releasing medicines in the gastrointestinal tract 有权
标题翻译：用于释放胃肠道药物的吞咽式多喷嘴给药装置
公开(公告)号：US08597279B2
公开(公告)日：2013-12-03
申请号：US12447808
申请日：2007-10-17
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Ivar Schram
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Ivar Schram
IPC分类号： A61K9/22 , A61M31/00 , A61K9/52
CPC分类号： A61B5/073 , A61B1/00016 , A61B1/041 , A61B5/4839 , A61M31/002
摘要： A capsule and methodology for dispensing a medicament in the gastrointestinal tract of a mammal is disclosed, the gastrointestinal tract having tissue sites of interest. The capsule may include a medicament reservoir; medicament dispensing means such as a plurality of piezoelectric droplet jet nozzle dispensers; a power source; electronic control circuitry means and/or detecting means capable of communicating with a medicament dispensing means for regulating the amount and time interval for dispensing of the medicament into the gastrointestinal tract by the medicament dispensing means; and a non-digestible outer protective shell housing, e.g., the medicament reservoir, medicament dispensing means and electronic control circuitry means. A plurality of the nozzle dispensers of the medicament dispensing means can be positioned tangentially to a surface of the housing such that during release of a medicament, the capsule is caused to rotate and/or translate so as to discharge the medicament homogeneously onto tissue sites of interest. In addition, by using multiple nozzles and releasing medicament at high speed, this facilitates medicament absorption by the intestines in the gastrointestinal tract.
摘要翻译：公开了用于在哺乳动物的胃肠道中分配药物的胶囊和方法，所述胃肠道具有感兴趣的组织部位。胶囊可以包括药物储存器; 药剂分配装置，例如多个压电滴喷嘴分配器; 电源; 电子控制电路装置和/或检测装置，其能够与药物分配装置通信，用于通过药物分配装置调节药物分配到胃肠道中的量和时间间隔; 以及不可消化的外部保护壳体外壳，例如药物储存器，药物分配装置和电子控制电路装置。药物分配装置的多个喷嘴分配器可以与壳体的表面相切地定位，使得在释放药物期间，使胶囊旋转和/或平移以将药物均匀地排出到组织位置利益。此外，通过使用多个喷嘴和高速释放药物，这有利于胃肠道中肠道的药物吸收。

13. 发明申请

US20100049120A1 DESIGN OF SWALLOWABLE MULTI-NOZZLE DOSING DEVICE FOR RELEASING MEDICINES IN THE GASTROINTESTINAL TRACT 有权
标题翻译：用于释放胃肠道诱导药物的易燃多喷射剂量装置的设计
公开(公告)号：US20100049120A1
公开(公告)日：2010-02-25
申请号：US12447808
申请日：2007-10-17
申请人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Ivar Schram
发明人： Johan Frederik Dijksman , Anke Pierik , Judith Margreet Rensen , Jeff Shimizu , Hans Zou , Ivar Schram
IPC分类号： A61M31/00
CPC分类号： A61B5/073 , A61B1/00016 , A61B1/041 , A61B5/4839 , A61M31/002
摘要： A capsule and methodology for dispensing a medicament in the gastrointestinal tract of a mammal is disclosed, the gastrointestinal tract having tissue sites of interest. The capsule may include a medicament reservoir; medicament dispensing means such as a plurality of piezoelectric droplet jet nozzle dispensers; a power source; electronic control circuitry means and/or detecting means capable of communicating with a medicament dispensing means for regulating the amount and time interval for dispensing of the medicament into the gastrointestinal tract by the medicament dispensing means; and a non-digestible outer protective shell housing, e.g., the medicament reservoir, medicament dispensing means and electronic control circuitry means. A plurality of the nozzle dispensers of the medicament dispensing means can be positioned tangentially to a surface of the housing such that during release of a medicament, the capsule is caused to rotate and/or translate so as to discharge the medicament homogeneously onto tissue sites of interest. In addition, by using multiple nozzles and releasing medicament at high speed, this facilitates medicament absorption by the intestines in the gastrointestinal tract.
摘要翻译：公开了用于在哺乳动物的胃肠道中分配药物的胶囊和方法，所述胃肠道具有感兴趣的组织部位。胶囊可以包括药物储存器; 药剂分配装置，例如多个压电滴喷嘴分配器; 电源; 电子控制电路装置和/或检测装置，其能够与药物分配装置通信，用于通过药物分配装置调节药物分配到胃肠道中的量和时间间隔; 以及不可消化的外部保护壳体外壳，例如药物储存器，药物分配装置和电子控制电路装置。药物分配装置的多个喷嘴分配器可以与壳体的表面相切地定位，使得在释放药物期间，使胶囊旋转和/或平移以将药物均匀地排出到组织位置利益。此外，通过使用多个喷嘴和高速释放药物，这有利于胃肠道中肠道的药物吸收。

14. 发明申请

US20100228082A1 DEVICE, SYSTEM AND METHOD FOR INTERACTING WITH A CELL OR TISSUE IN A BODY 审中-公开
标题翻译：用于与身体中的细胞或组织相互作用的装置，系统和方法
公开(公告)号：US20100228082A1
公开(公告)日：2010-09-09
申请号：US12376460
申请日：2007-04-12
申请人： Hans Zou , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Jan Frederik Suijver , Anke Pierik , Judith Margreet Rensen , Johan Frederik Dijksman , Jeff Shimizu , Jacob Marinus Jan Den Toonder
发明人： Hans Zou , Stein Kuiper , Bernardus Hendrikus Wilhelmus Hendriks , Jan Frederik Suijver , Anke Pierik , Judith Margreet Rensen , Johan Frederik Dijksman , Jeff Shimizu , Jacob Marinus Jan Den Toonder
IPC分类号： A61B1/00
CPC分类号： A61B5/6882 , A61B1/041 , A61B5/0031 , A61B5/073 , A61B5/4839
摘要： A device or support, system and method are provided for precisely targeted and/or highly controlled interaction with a targeted cell or tissue in a body, with the support providing an ergonomic connecting interface for selectively connecting the support to a cell or tissue with at least minimal adverse affect to such cell or tissue, the system providing a remote facility that may be operatively associated with the support, and the method providing steps for employing the support and/or system so as to, inter alia, improve treatment, diagnostic and/or monitoring techniques and increase sensitivity and specificity with respect to interacting with, for example, diseased or abnormal cells or tissue without adversely effecting surrounding healthy cells or tissue, and/or the body in general.
摘要翻译：提供了一种装置或支撑件，系统和方法，用于与身体中的靶细胞或组织精确地靶向和/或高度受控的相互作用，其中所述支持物提供符合人体工程学的连接界面，用于至少选择性地将支持体连接到细胞或组织对这种细胞或组织的最小的不利影响，该系统提供可能与支持物可操作地相关联的远程设施，以及提供使用支持和/或系统的方法，以便除其他外改善治疗，诊断和/ 或监测技术，并提高与例如患病或异常细胞或组织的相互作用的灵敏度和特异性，而不会不利地影响周围的健康细胞或组织和/或身体。

15. 发明授权

US09227011B2 Miniaturized threshold sensor 有权
标题翻译：小型阈值传感器
公开(公告)号：US09227011B2
公开(公告)日：2016-01-05
申请号：US12442961
申请日：2007-09-27
申请人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman , Anke Pierik , Judith Margaret Rensen
发明人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman , Anke Pierik , Judith Margaret Rensen
IPC分类号： G08B1/08 , A61M5/142 , A61B5/07 , A61M5/172
CPC分类号： A61M5/14276 , A61B5/073 , A61B2562/0214 , A61M5/1723 , A61M2005/1726 , A61M2210/1053
摘要： A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.
摘要翻译：一种传感器，包括具有微小尺寸和较低功率消耗的多个电极以及电极外部的涂层，其中所述涂层与目标条件相互作用，从而产生电极的电性能的变化，其中所述变化被转换成电极的电信号。另外，用于药物输送的系统包括这种传感器和丸剂。

16. 发明授权

US08911425B2 Electronic pill comprising a medicine reservoir 有权
标题翻译：电子药丸包含药物储存器
公开(公告)号：US08911425B2
公开(公告)日：2014-12-16
申请号：US12995817
申请日：2009-07-03
申请人： Johan Frederik Dijksman , Anke Pierik , Jeff Shimizu , Hans Zou
发明人： Johan Frederik Dijksman , Anke Pierik , Jeff Shimizu , Hans Zou
IPC分类号： A61K9/22 , A61K47/00 , A61K9/00 , A61K9/48 , A61M31/00
CPC分类号： A61K9/4808 , A61K9/0009 , A61K47/00 , A61K47/38 , A61M31/002
摘要： Electronic pill (1, 11) comprising at least one medicine reservoir (2, 12) with a solid powder or granulate medicine, a discharge opening (3, 13) and an actuator responsive to control circuitry for displacing medicine from the reservoir (2, 12) to the discharge opening (3, 13). The medicine comprises a dispersion of one or more active ingredients—e.g., solids in powder or granulate form—in an inert carrier matrix. Optionally, the active ingredients are dispersed using intestinal moisture absorbed into the pill via a semi-permeable wall section (14).
摘要翻译：包括具有固体粉末或颗粒药物的至少一个药物储存器（2,12）的电子药丸（1,11），排出口（3,13）和响应于控制电路的致动器，所述控制电路用于将药物从贮存器 12）到排出口（3,13）。药物包含一种或多种活性成分的分散体，例如粉末或颗粒形式的固体 - 在惰性载体基质中。任选地，活性成分通过经由半透壁部分（14）吸收到药丸中的肠水分散。

17. 发明申请

US20100033324A1 MINIATURIZED THRESHOLD SENSOR 有权
标题翻译： MINIATURIZED THRESHTH传感器
公开(公告)号：US20100033324A1
公开(公告)日：2010-02-11
申请号：US12442961
申请日：2007-09-27
申请人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman , Anke Pierik , Judith Margaret Rensen
发明人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman , Anke Pierik , Judith Margaret Rensen
IPC分类号： G08B21/00
CPC分类号： A61M5/14276 , A61B5/073 , A61B2562/0214 , A61M5/1723 , A61M2005/1726 , A61M2210/1053
摘要： A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.
摘要翻译：一种传感器，包括具有微小尺寸和较低功率消耗的多个电极以及电极外部的涂层，其中所述涂层与目标条件相互作用，从而产生电极的电性能的变化，其中所述变化被转换成电极的电信号。另外，用于药物输送的系统包括这种传感器和丸剂。

18. 发明授权

US10046109B2 Drug delivery device with compressible drug reservoir 有权
公开(公告)号：US10046109B2
公开(公告)日：2018-08-14
申请号：US13390111
申请日：2010-08-10
申请人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
发明人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
IPC分类号： A61M5/145 , A61M31/00
摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).

19. 发明申请

US20120143171A1 VALVELESS DRUG DELIVERY DEVICE 审中-公开
标题翻译：优质药物递送装置
公开(公告)号：US20120143171A1
公开(公告)日：2012-06-07
申请号：US13262861
申请日：2010-04-01
申请人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman
发明人： Jeff Shimizu , Hans Zou , Johan Frederik Dijksman
IPC分类号： A61M37/00 , A61M5/00
CPC分类号： A61M5/14244 , A61M5/14276 , A61M2206/12 , A61M2210/1042
摘要： A drug delivery device (10) comprising a drug reservoir (13), at least one dispensing hole (14), an actuator system (17) and an exit path (15). The drug reservoir (13) is provided for comprising a drug. The dispensing hole (14) delivers the drug to an environment of the drug delivery device (10) when the actuator system (17) pushes the drug from the drug reservoir (13) through the dispensing hole (14). The exit path (15) couples the drug reservoir (13) to the dispensing hole (14). The exit path (15) comprises at least one entry point (16) for coupling the exit path (15) to the drug reservoir (13) and is arranged in such a way that for any possible orientation of the drug delivery device (10) at least a part of the exit path (15) is situated above the gravity center of said drug reservoir or below the dispensing hole (14).
摘要翻译：包括药物储存器（13），至少一个分配孔（14），致动器系统（17）和出口路径（15）的药物输送装置（10）。提供药物储存器（13）以包含药物。当致动器系统（17）通过分配孔（14）将药物从药物储存器（13）推动时，分配孔（14）将药物输送到药物输送装置（10）的环境。出口路径（15）将药物储存器（13）连接到分配孔（14）。出口路径（15）包括用于将出口路径（15）耦合到药物储存器（13）的至少一个入口点（16），并且被布置成使得对于药物输送装置（10）的任何可能的取向，所述出口路径（15）的至少一部分位于所述药物储存器的重心的上方或所述分配孔（14）的下方。

20. 发明申请

US20130204233A1 DRUG DELIVERY DEVICE WITH COMPRESSIBLE DRUG RESERVOIR 审中-公开
标题翻译：具有可压缩药物储存的药物递送装置
公开(公告)号：US20130204233A1
公开(公告)日：2013-08-08
申请号：US13390111
申请日：2010-08-10
申请人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
发明人： Hans Zou , Jeff Shimizu , Johan Frederik Dijksman
IPC分类号： A61M5/145
CPC分类号： A61M5/1452 , A61M31/002
摘要： A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).
摘要翻译：提供了药物输送装置（50），其包括药物储存器（10）和活塞（11）。药物储存器（10）被设置成包括药物并且包括柔性壁（22）和用于将药物分配到药物递送装置（50）的环境中的分配孔（15）。活塞（11）用于压靠柔性壁（22）以压缩药物储存器（10），用于推动一定量的药物通过分配孔（15）。在活塞（11）的表面和柔性壁（22）之间的粘合界面（51）防止活塞（11）的表面和柔性壁（22）之间的滑动。

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