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11. 发明授权

US5482699A Multinuclear complexes for x-ray imaging 失效
标题翻译：用于x射线成像的多核复合物
公开(公告)号：US5482699A
公开(公告)日：1996-01-09
申请号：US122461
申请日：1993-09-24
申请人： Torsten Almen , Arne Berg , C. Allen Chang , Michael Droege , Harald Dugstad , Jere D. Fellman , Sook-Hui Kim , Jo Klaveness , Scott M. Rocklage , Pal Rongved , Brent Segal , Alan D. Watson
发明人： Torsten Almen , Arne Berg , C. Allen Chang , Michael Droege , Harald Dugstad , Jere D. Fellman , Sook-Hui Kim , Jo Klaveness , Scott M. Rocklage , Pal Rongved , Brent Segal , Alan D. Watson
IPC分类号： A61K49/00 , A61K49/06 , C07C229/16 , C07C237/08 , C07F11/00 , C07F13/00 , C07F15/00 , C07F15/02 , A61K49/04
CPC分类号： C07F11/005 , A61K49/06 , C07F15/025 , Y10S514/836 , Y10S977/903 , Y10S977/928 , Y10S977/929
摘要： An imaging contrast medium comprising a physiologically tolerable multinuclear complex (as defined in claim 1) is disclosed. The multinuclear complex contains at least two, but preferably three or more contrast enhancing atoms. For X-ray or ultrasound imaging techniques heavy metal atoms are used to enhance contrast, whereas in Magnetic Resonance Imaging paramagnetic metal atoms are contrast enhancing. Molybdenum and tungsten are preferred contrast enhancing atoms. The medium may also be used therapeutically.
摘要翻译： PCT No.PCT / EP92 / 00698 Sec。 371日期：1993年9月24日 102（e）日期1993年11月24日PCT 1991年3月27日PCT公布。出版物WO92 / 17215 公开了包含生理上可耐受的多核复合物（如权利要求1所定义）的成像造影剂。多核络合物包含至少两个，但优选三个或更多对比增强原子。对于X射线或超声成像技术，重金属原子用于增强对比度，而在磁共振成像顺磁金属原子是对比度增强。钼和钨是优选的对比度增强原子。培养基也可以治疗使用。

12. 发明授权

US07408025B2 Lipopeptides as antibacterial agents 有权
公开(公告)号：US07408025B2
公开(公告)日：2008-08-05
申请号：US09737908
申请日：2000-12-15
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
IPC分类号： C07K7/50
CPC分类号： C07K7/08 , A61K38/00
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.

13. 发明授权

US5364613A Polychelants containing macrocyclic chelant moieties 失效
标题翻译：含有大环螯合剂部分的聚合物
公开(公告)号：US5364613A
公开(公告)日：1994-11-15
申请号：US464865
申请日：1990-01-16
申请人： Paul F. Sieving , Alan D. Watson , Steven C. Quay , Scott M. Rocklage
发明人： Paul F. Sieving , Alan D. Watson , Steven C. Quay , Scott M. Rocklage
IPC分类号： A61K39/395 , A61K47/48 , A61K49/00 , A61K49/08 , A61K49/12 , A61K51/00 , A61K51/06 , A61P39/02 , C08G69/48 , A61K37/00 , A61K39/00 , A61K49/04
CPC分类号： A61K49/143 , A61K47/48315 , A61K49/085 , A61K49/12 , A61K49/128 , A61K49/146 , A61K49/16 , A61K51/065 , A61K51/081 , A61K51/088 , C08G69/48
摘要： There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g, DOTA residues, conjugated to a polyamine backbone molecule, e.g, polylysine. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein.
摘要翻译：提供了可用于诊断成像和放射治疗中的多价螯合剂及其金属螯合物，其包含与多胺主链分子例如聚赖氨酸缀合的多个大环螯合剂部分，例如DOTA残基。为了产生位点特异性聚合物，一种或多种携带骨架分子的大环螯合剂可以与位点定向的大分子结合，例如蛋白质

14. 发明申请

US20080287347A1 Novel Lipopeptides as Antibacterial Agents 审中-公开
标题翻译：新型脂肽作为抗菌剂
公开(公告)号：US20080287347A1
公开(公告)日：2008-11-20
申请号：US12163299
申请日：2008-06-27
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xiang Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
IPC分类号： A61K38/12 , C07K7/54 , A61P31/04
CPC分类号： C07K7/08 , A61K38/00
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译：本发明涉及新型脂肽化合物。本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。

15. 发明授权

US06911525B2 Lipopeptides as antibacterial agents 有权
标题翻译：脂肽作为抗菌剂
公开(公告)号：US06911525B2
公开(公告)日：2005-06-28
申请号：US09738742
申请日：2000-12-15
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
IPC分类号： A61K45/00 , A61K38/00 , A61P31/04 , C07K1/06 , C07K7/08 , C07K7/50
CPC分类号： C07K7/08 , A61K38/00
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译：本发明涉及新型脂肽化合物。本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。

16. 发明授权

US06794490B2 Lipopeptides as antibacterial agents 有权
标题翻译：脂肽作为抗菌剂
公开(公告)号：US06794490B2
公开(公告)日：2004-09-21
申请号：US09739535
申请日：2000-12-15
申请人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
发明人： Jason Hill , Ian Parr , Michael Morytko , Jim Siedlecki , Xian Yang Yu , Jared Silverman , Dennis Keith , John Finn , Dale Christensen , Tsvetelina Lazarova , Alan D. Watson , Yan Zhang
IPC分类号： A61K3812
CPC分类号： C07K7/08 , A61K38/00
摘要： The present invention relates to novel lipopeptide compounds. The invention also relates to pharmaceutical compositions of these compounds and methods of using these compounds as antibacterial compounds. The invention also relates to methods of producing these novel lipopeptide compounds and intermediates used in producing these compounds.
摘要翻译：本发明涉及新型脂肽化合物。本发明还涉及这些化合物的药物组合物和使用这些化合物作为抗菌化合物的方法。本发明还涉及生产这些新型脂肽化合物的方法和用于生产这些化合物的中间体。

17. 发明授权

US5932190A Multinuclear complexes for X-ray imaging 失效
标题翻译：用于X射线成像的多核配合物
公开(公告)号：US5932190A
公开(公告)日：1999-08-03
申请号：US473574
申请日：1995-06-07
申请人： Torsten Almen , Arne Berg , Michael Droege , Harald Dugstad , Jere D. Fellman , Sook-Hui Kim , Jo Klaveness , Scott M. Rocklage , Pal Rongved , Brent Segal , Alan D. Watson
发明人： Torsten Almen , Arne Berg , Michael Droege , Harald Dugstad , Jere D. Fellman , Sook-Hui Kim , Jo Klaveness , Scott M. Rocklage , Pal Rongved , Brent Segal , Alan D. Watson
IPC分类号： A61K49/00 , A61K49/06 , C07C229/16 , C07C237/08 , C07F11/00 , C07F13/00 , C07F15/00 , C07F15/02 , A61K49/04
CPC分类号： C07F11/005 , A61K49/06 , C07F15/025 , Y10S514/836 , Y10S977/903 , Y10S977/928 , Y10S977/929
摘要： An x-ray contrast medium containing a multinuclear complex of the formula (M.sub.6 (.mu..sub.3 B).sub.8 A.sub.v).sub.x L.sub.w, wherein M is Mo, W, Re Tc, V, Nb, Ta, Ru, or Fe; .mu..sub.3 B represent a tridentate bridging atom; A is a non-bridging atom; L is a ligand coordinately bonded to at least one M atom; x is a positive integer; and v and w are independently zero or positive integers.
摘要翻译：含有式（M6（mu 3B）8Av）×Lw的多核配合物的X射线造影剂，其中M为Mo，W，Re Tc，V，Nb，Ta，Ru或Fe; mu 3B代表三齿桥接原子; A是非桥连原子; L是与至少一个M原子配位键合的配体; x是正整数; v和w分别为零或正整数。

18. 发明授权

US5554748A Adducts of macrocyclic chelants 失效
标题翻译：大环螯合剂的加合物
公开(公告)号：US5554748A
公开(公告)日：1996-09-10
申请号：US175989
申请日：1993-12-30
申请人： Paul F. Sieving , Alan D. Watson
发明人： Paul F. Sieving , Alan D. Watson
IPC分类号： A61K47/48 , A61K49/08 , A61K49/12 , A61K51/06 , C08G69/48 , C07D255/02 , C07D257/02 , C07D273/00
CPC分类号： A61K49/143 , A61K47/48076 , A61K47/48315 , A61K49/085 , A61K49/106 , A61K49/128 , A61K49/146 , A61K51/065 , C08G69/48
摘要： There are provided polychelants and their metal chelates which are useful in diagnostic imaging and in radiotherapy and which comprise a plurality of macrocyclic chelant moieties, e.g. DOTA residues, conjugated to a polyamine backbone molecule, e.g. polylysine. To produce a site-specific polychelate, one or more of the macrocyclic chelant carrying backbone molecules may be conjugated to a site-directed macromolecule, e.g. a protein. For example, adducts of a macrocyclic chelant can be formed by the process of (a) dispersing a carboxylic macrocyclic chelant in a polar, anhydrous solvent, (b) adding a base with a pKa sufficient to remove all carboxyl protons to create an amine salt of the chelant soluble in the solvent, (c) chilling the reaction mixture to between about 5.degree. C. and 55.degree. C. above the freezing point of the solvent, and (d) adding substantial equimolar amount of chilled alkylhaloformate under anhydrous conditions so as to form a slurry containing the mixture carboxycarbonic anhydride of the chelant.
摘要翻译：提供了可用于诊断成像和放射治疗中的多层螯合物及其金属螯合物，其包含多个大环螯合剂部分，例如，与多胺主链分子缀合的DOTA残基。聚赖氨酸为了产生位点特异性聚合物，一种或多种携带骨架分子的大环螯合剂可以与位点定向的大分子结合，例如蛋白质例如，大环螯合剂的加合物可以通过以下方法形成：（a）将羧基大环螯合剂分散在极性无水溶剂中，（b）加入足以除去所有羧基质子以产生胺盐的pKa碱的螯合剂溶于溶剂中，（c）将反应混合物冷却至高于溶剂凝固点的约5℃至55℃，和（d）在无水条件下加入基本上等摩尔量的冷却的卤代烷基卤化物，以形成含有螯合剂的羧基碳酸酐混合物的浆料。

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