专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20060014756A1 Benzimidazoles 有权
标题翻译：苯并咪唑
公开(公告)号：US20060014756A1
公开(公告)日：2006-01-19
申请号：US11029064
申请日：2005-01-04
申请人： Michael Edwards , Paul Cox , Shelley Amendola , Stephanie Deprets , Timothy Gillespy , Christopher Edlin , Andrew Morley , Charles Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir Majid , John Reader , Lloyd Payne , Nawaz Khan , Michael Cherry
发明人： Michael Edwards , Paul Cox , Shelley Amendola , Stephanie Deprets , Timothy Gillespy , Christopher Edlin , Andrew Morley , Charles Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir Majid , John Reader , Lloyd Payne , Nawaz Khan , Michael Cherry
IPC分类号： A61K31/496 , A61K31/4184 , C07D43/02
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.
摘要翻译：本发明涉及通式（Ix）的生理活性化合物和含有这些化合物及其前药以及这些化合物及其前药的药学上可接受的盐和溶剂合物的组合物，以及式（Ix）范围内的新化合物 Ix），以及它们的制备过程。这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

12. 发明申请

US20050176733A1 Chk-1 inhibitors 审中-公开
标题翻译： Chk-1抑制剂
公开(公告)号：US20050176733A1
公开(公告)日：2005-08-11
申请号：US11031544
申请日：2005-01-07
申请人： Robert Boyle , Hassan Imogai , Michael Cherry , Nawaz Khan
发明人： Robert Boyle , Hassan Imogai , Michael Cherry , Nawaz Khan
IPC分类号： C07D213/75 , C07D213/82 , C07D213/85 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/497 , A61K31/444 , C07D41/02 , C07D43/02
CPC分类号： C07D213/75 , C07D213/82 , C07D213/85 , C07D241/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： This invention provides compounds and methods for treating cancer. More particularly, the invention provides compounds that inhibit Chk-1. These compounds potentiate the action of DNA-damaging agents such as chemotherapy and radiation therapy.
摘要翻译：本发明提供了治疗癌症的化合物和方法。更具体地，本发明提供抑制Chk-1的化合物。这些化合物增强DNA损伤剂如化学疗法和放射治疗的作用。

13. 发明申请

US20050108688A1 Method and system for assigning and publishing applications 有权
标题翻译：用于分配和发布应用程序的方法和系统
公开(公告)号：US20050108688A1
公开(公告)日：2005-05-19
申请号：US11010499
申请日：2004-12-13
申请人： Mark Lucovsky , Michael Cherry , Daniel Plastina , Bharat Shah , Debi Mishra , David Kays , Markus Horstmann
发明人： Mark Lucovsky , Michael Cherry , Daniel Plastina , Bharat Shah , Debi Mishra , David Kays , Markus Horstmann
IPC分类号： G06F9/44 , G06F9/445
CPC分类号： G06F8/61
摘要： A method and system for managing and deploying applications across a computer network by assigning and publishing applications to user and computer policy recipients. Assigned applications are automatically applied via a script to the policy recipients, thereby ensuring that the recipient has an administrator-specified workstation configuration. Assigned applications are advertised so as to appear available to the user, by adding an application shortcut to the start menu, and by populating the machine registry with appropriate application information. Other applications may be published to users, whereby those applications are optionally available for use by users. Published application information is maintained in a centralized store of information on the network. Assigned and published applications may be installed on demand, such as when the application is activated.
摘要翻译：一种用于通过向用户和计算机策略接收者分配和发布应用程序来跨计算机网络管理和部署应用程序的方法和系统。分配的应用程序将通过脚本自动应用于策略收件人，从而确保收件人具有管理员指定的工作站配置。通过向开始菜单添加应用程序快捷方式，并通过使用适当的应用程序信息填充机器注册表，分配的应用程序将通告给用户。其他应用可以被发布给用户，由此这些应用可选地可供用户使用。发布的应用信息被维护在网络上的信息的集中存储中。分配和发布的应用程序可以按需安装，例如应用程序激活时。

14. 发明授权

US07202244B2 Chk-1 inhibitors 失效
标题翻译： Chk-1抑制剂
公开(公告)号：US07202244B2
公开(公告)日：2007-04-10
申请号：US10446627
申请日：2003-05-28
申请人： Robert George Boyle , Hassan Julien Imogai , Michael Cherry
发明人： Robert George Boyle , Hassan Julien Imogai , Michael Cherry
IPC分类号： A01N43/58 , A61K31/50 , C07D241/00
CPC分类号： C07D213/75 , C07D213/81 , C07D213/82 , C07D239/42 , C07D241/20 , C07D241/44 , C07D251/14 , C07D253/07 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.
摘要翻译：公开了Chk-1的新型抑制剂及其用于治疗的方法。

15. 发明申请

US20060265708A1 Method and system for managing lifecycles of deployed applications 有权
标题翻译：管理部署应用程序生命周期的方法和系统
公开(公告)号：US20060265708A1
公开(公告)日：2006-11-23
申请号：US11441746
申请日：2006-05-26
申请人： Stephen Blanding , Michael Cherry , David Kays, , James Masson , Debi Mishra , Daniel Plastina
发明人： Stephen Blanding , Michael Cherry , David Kays, , James Masson , Debi Mishra , Daniel Plastina
IPC分类号： G06F9/445
CPC分类号： G06F8/61 , G06F8/65
摘要： Described is managing the changing of software implementations such as applications deployed to enterprise client users or machines. Precedence relationships between deployed applications are specified. To determine which applications to install for a given client, the precedence is applied to the subset of applications assigned or published to the client. At logon or machine reboot, an upgrade process evaluates the deployed applications and any upgrade relationships, setting applications for removal or installation. A user may also install an application that has been designated as optional. Also described is an application lifecycle model for replacing applications. For example, administrators can phase in upgrades as a pilot to a small group of users, roll out upgrades to a larger group, and then provide the application to all users. Upgrades may be mandatory or optional, and replaced programs may be removed and then replaced, or overlaid during installation.
摘要翻译：描述了管理软件实现的变化，例如部署到企业客户端用户或机器的应用程序。指定部署应用程序之间的优先级关系。要确定为给定客户端安装哪些应用程序，优先级将应用于分配或发布到客户端的应用程序子集。在登录或机器重新启动时，升级过程会评估部署的应用程序和任何升级关系，设置移除或安装应用程序。用户还可以安装已被指定为可选的应用程序。还描述了用于替换应用程序的应用程序生命周期模型。例如，管理员可以将升级阶段升级为一小群用户，将升级推广到更大的组，然后将应用程序提供给所有用户。升级可能是强制性的或可选的，替换的程序可能会在安装过程中被删除，然后被替换或覆盖。

16. 发明申请

US20050245563A1 Chk-1 inhibitors 审中-公开
标题翻译： Chk-1抑制剂
公开(公告)号：US20050245563A1
公开(公告)日：2005-11-03
申请号：US10857620
申请日：2004-05-28
申请人： Robert Boyle , Hassan Imogai , Michael Cherry , Alfred Humphries , Eva Navarro , David Owen , Natalie Dales , Matthew LaMarche , Courtney Cullis , Alexandra Gould
发明人： Robert Boyle , Hassan Imogai , Michael Cherry , Alfred Humphries , Eva Navarro , David Owen , Natalie Dales , Matthew LaMarche , Courtney Cullis , Alexandra Gould
IPC分类号： A61K31/435 , A61K31/4745 , A61K45/06 , C07D471/04 , C07D471/14 , C07F5/02 , C07F7/08
CPC分类号： C07D471/04 , A61K31/435 , A61K45/06 , C07D471/14 , C07F7/0814 , A61K2300/00
摘要： Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.
摘要翻译：公开了Chk-1的新型抑制剂及其用于治疗的方法。

17. 发明授权

US08288425B2 Benzimidazoles 有权
标题翻译：苯并咪唑
公开(公告)号：US08288425B2
公开(公告)日：2012-10-16
申请号：US11029064
申请日：2005-01-04
申请人： Michael L. Edwards , Paul J. Cox , Shelley Amendola , Stephanie D. Deprets , Timothy A. Gillespy , Christopher D. Edlin , Andrew D. Morley , Charles J. Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir N. Majid , John C. Reader , Lloyd J. Payne , Nawaz M. Khan , Michael Cherry
发明人： Michael L. Edwards , Paul J. Cox , Shelley Amendola , Stephanie D. Deprets , Timothy A. Gillespy , Christopher D. Edlin , Andrew D. Morley , Charles J. Gardner , Brian Pedgrift , Herve Bouchard , Didier Babin , Laurence Gauzy , Alain Le-Brun , Tahir N. Majid , John C. Reader , Lloyd J. Payne , Nawaz M. Khan , Michael Cherry
IPC分类号： A61K31/4184 , C07D235/18
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.
摘要翻译：本发明涉及通式（Ix）的生理活性化合物和含有这些化合物及其前药以及这些化合物及其前药的药学上可接受的盐和溶剂合物的组合物，以及式（Ix）范围内的新化合物 Ix），以及它们的制备过程。这些化合物和组合物具有有价值的药物特性，特别是抑制激酶的能力。

18. 发明申请

US20070020253A1 Spleen tyrosine kinase catalytic domain:crystal structure and binding pockets thereof 审中-公开
标题翻译：脾脏酪氨酸激酶催化结构域：晶体结构和结合口袋
公开(公告)号：US20070020253A1
公开(公告)日：2007-01-25
申请号：US10531532
申请日：2003-10-16
申请人： David Williams , Maria Lamers , Michael Cherry , Stephanie Smith
发明人： David Williams , Maria Lamers , Michael Cherry , Stephanie Smith
IPC分类号： A61K38/48 , A61K38/08 , G06F19/00 , C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00 , C12Y207/10002
摘要： The present invention provides crystalline molecules and molecular complexes that comprise binding pockets of Sykcat and its homologues. The invention also provides crystals comprising the catalytic domain of Syk protein. The invention further provides a computer comprising a data storage medium encoded with the structure coordinates of Sykcat binding pockets and methods for using a computer to evaluate the ability of a chemical entity or compounds to bind to a crystalline molecule or molecular complex of the invention. This invention also provides methods of using the structure coordinates to solve the structure homologous proteins or protein complexes. The invention further provides methods of using the structure coordinates to screen for, design and optimize chemical entities or compounds, including inhibitory compounds, that bind to the catalytic domain of Syk or homologues thereof.
摘要翻译：本发明提供包含Sykcat及其同系物的结合口袋的结晶分子和分子复合物。本发明还提供包含Syk蛋白的催化结构域的晶体。本发明还提供一种计算机，其包括用Sykcat结合口袋的结构坐标编码的数据存储介质，以及使用计算机评估化学实体或化合物结合本发明的结晶分子或分子复合物的能力的方法。本发明还提供了使用结构坐标来解决结构同源蛋白质或蛋白质复合物的方法。本发明还提供了使用结构坐标来筛选，设计和优化结合Syk或其同系物的催化结构域的化学实体或化合物（包括抑制化合物）的方法。

19. 发明申请

US20060035920A1 Chk-1 inhibitors 审中-公开
标题翻译： Chk-1抑制剂
公开(公告)号：US20060035920A1
公开(公告)日：2006-02-16
申请号：US11140553
申请日：2005-05-27
申请人： Robert Boyle , Hassan Imogai , Michael Cherry , Alfred Humphries , Eva Navarro , David Owen , Natalie Dales , Matthew LaMarche , Courtney Cullis , Alexandra Gould , Paul Greenspan
发明人： Robert Boyle , Hassan Imogai , Michael Cherry , Alfred Humphries , Eva Navarro , David Owen , Natalie Dales , Matthew LaMarche , Courtney Cullis , Alexandra Gould , Paul Greenspan
IPC分类号： A61K31/4745 , C07D471/14
CPC分类号： C07D471/04
摘要： Disclosed are novel inhibitors of Chk-1 and methods of using the same for therapy.
摘要翻译：公开了Chk-1的新型抑制剂及其用于治疗的方法。

20. 发明授权

US06786537B2 One piece plastic water management system for sunroof 失效
标题翻译：一体式塑胶水管理系统
公开(公告)号：US06786537B2
公开(公告)日：2004-09-07
申请号：US10319283
申请日：2002-12-12
申请人： Troy Allan , Steven J. Engelgau , Hyong Chol Park , Joachim Roeder , Daniel Cooney , Michael Cherry , John Long , Keith Roberts , Gregory Kerwin
发明人： Troy Allan , Steven J. Engelgau , Hyong Chol Park , Joachim Roeder , Daniel Cooney , Michael Cherry , John Long , Keith Roberts , Gregory Kerwin
IPC分类号： B60J7/02
CPC分类号： B60J7/022
摘要： A water management system of the present invention provides a sunroof drain member formed as a continuous piece. The drain member supports a sunroof guide track, and removes water from the guide track and sunroof area. The sunroof guide track is secured to the drain member by a plurality of interlocking features. By forming the interlocking features as integral parts of the guide track and drain member this prevents leakage in weakening in the areas where fastening devices would otherwise need to be attached.
摘要翻译：本发明的水管理系统提供形成为连续件的天窗排水部件。排水构件支撑天窗导轨，并且从导轨和天窗区域移除水。天窗导轨通过多个互锁特征固定到排水构件。通过将互锁特征形成为导轨和排出构件的整体部件，防止在紧固装置另外需要附接的区域中的弱化泄漏。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式