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1. 发明专利

DE1162139B 未知
公开(公告)号：DE1162139B
公开(公告)日：1964-01-30
申请号：DEB0056038
申请日：1959-12-24
申请人： EVA MARIA LAMERS GEB BOEGER
发明人： BREUER GERTRUD BOEGER GEB
IPC分类号： F16L57/06

2. 发明申请

US20070020253A1 Spleen tyrosine kinase catalytic domain:crystal structure and binding pockets thereof 审中-公开
标题翻译：脾脏酪氨酸激酶催化结构域：晶体结构和结合口袋
公开(公告)号：US20070020253A1
公开(公告)日：2007-01-25
申请号：US10531532
申请日：2003-10-16
申请人： David Williams , Maria Lamers , Michael Cherry , Stephanie Smith
发明人： David Williams , Maria Lamers , Michael Cherry , Stephanie Smith
IPC分类号： A61K38/48 , A61K38/08 , G06F19/00 , C12N9/12
CPC分类号： C12N9/1205 , C07K2299/00 , C12Y207/10002
摘要： The present invention provides crystalline molecules and molecular complexes that comprise binding pockets of Sykcat and its homologues. The invention also provides crystals comprising the catalytic domain of Syk protein. The invention further provides a computer comprising a data storage medium encoded with the structure coordinates of Sykcat binding pockets and methods for using a computer to evaluate the ability of a chemical entity or compounds to bind to a crystalline molecule or molecular complex of the invention. This invention also provides methods of using the structure coordinates to solve the structure homologous proteins or protein complexes. The invention further provides methods of using the structure coordinates to screen for, design and optimize chemical entities or compounds, including inhibitory compounds, that bind to the catalytic domain of Syk or homologues thereof.
摘要翻译：本发明提供包含Sykcat及其同系物的结合口袋的结晶分子和分子复合物。本发明还提供包含Syk蛋白的催化结构域的晶体。本发明还提供一种计算机，其包括用Sykcat结合口袋的结构坐标编码的数据存储介质，以及使用计算机评估化学实体或化合物结合本发明的结晶分子或分子复合物的能力的方法。本发明还提供了使用结构坐标来解决结构同源蛋白质或蛋白质复合物的方法。本发明还提供了使用结构坐标来筛选，设计和优化结合Syk或其同系物的催化结构域的化学实体或化合物（包括抑制化合物）的方法。

3. 发明专利

DE1232865B 未知
公开(公告)号：DE1232865B
公开(公告)日：1967-01-19
申请号：DEB0058077
申请日：1960-06-01
申请人： EVA MARIA LAMERS GEB BOEGER
发明人： BREUER GERTRUD BOEGER GEB
IPC分类号： C04B33/13

4. 发明授权

US08562716B2 Device and method for degassing a liquid 有权
标题翻译：用于对液体进行脱气的装置和方法
公开(公告)号：US08562716B2
公开(公告)日：2013-10-22
申请号：US13055107
申请日：2008-07-24
申请人： Antonius Gerardus Wilhelmus Maria Lamers
发明人： Antonius Gerardus Wilhelmus Maria Lamers
IPC分类号： B01D19/00
CPC分类号： B01D19/0047 , B01D19/0063
摘要： A method for degassing a liquid of a substantially closed liquid circulation system at a working pressure may include passing at least a partial flow of the liquid through a restriction into a chamber in which a degassing pressure is maintained, the degassing pressure being higher than atmospheric pressure and lower than the working pressure; separating gas withdrawn from the partial flow of liquid from the partial flow; removing the gas from the chamber; and pumping the degassed partial flow of the liquid back into the substantially closed circulation system. The restriction may include a nozzle, and the step of passing at least the partial flow of the liquid through the restriction into the chamber may include spraying at least the partial flow of the liquid through the nozzle into the chamber for obtaining a jet and/or mist of the liquid in the chamber.
摘要翻译：用于在工作压力下对基本上封闭的液体循环系统的液体进行脱气的方法可以包括使至少部分液体流过限制器流入其中保持脱气压力的室，脱气压力高于大气压并低于工作压力; 从所述部分流中分离从所述部分液体流中取出的气体; 从腔室中取出气体; 并将脱气的部分液体泵送回基本上封闭的循环系统。该限制可以包括喷嘴，并且使至少部分液体流过限制器的气流进入腔室的步骤可以包括将至少部分液体流经喷嘴喷射到腔室中以获得射流和/或液体在室内的雾气。

5. 发明授权

US06926631B2 Continuously variable transmission, endless flexible belt for torque transmission and adjustable pulley 失效
标题翻译：连续可变传动，扭矩传递和可调滑轮的无端柔性带
公开(公告)号：US06926631B2
公开(公告)日：2005-08-09
申请号：US10276855
申请日：2001-05-23
申请人： Arjen Brandsma , Paulus Maria Smeets , Gerardus Johannes Maria Lamers
发明人： Arjen Brandsma , Paulus Maria Smeets , Gerardus Johannes Maria Lamers
IPC分类号： F16G5/00 , F16G5/16 , F16H9/16 , F16H55/56 , F16H61/662
CPC分类号： F16H9/125 , F16G5/16 , F16H55/56 , F16H2061/66277
摘要： A continuously variable transmission, provided with two adjustable pulleys, each pulley comprising a pair of mutually displaceable essentially frusto-conical pulley sheaves having a radial dimension provided on a pulley shaft, each sheave having a sheave face, whereby the sheave faces of a pulley are mutually oriented at a pulley angle, and with an endless flexible belt for transmitting torque comprising two lateral side faces, which are mutually oriented at a belt angle (alpha) such that the flexible belt tapers radially inwardly and which are intended for interacting with the sheave faces of a pulley under the influence of a clamping force to be exerted on the flexible belt by the sheaves. The belt angle is marginally, but notionally, larger than the pulley angle (beta) of at least one pulley for at least a substantial part of the radial dimension of the pulley sheaves.
摘要翻译：一种无级变速器，其具有两个可调节的滑轮，每个滑轮包括一对具有径向尺寸的可相互位移的基本上截头圆锥形的滑轮滑轮，每个滑轮具有滑轮面，滑轮的滑轮面为以带轮的角度相互取向，并且具有用于传递扭矩的环形柔性带，该扭矩包括两个横向侧面，这两个侧面相对于带的角度（α）相互取向，使得柔性带径向向内逐渐变细并且用于与绳轮相互作用在由滑轮施加在柔性带上的夹紧力的作用下，滑轮的表面。皮带角度在滑轮滑轮的至少大部分径向尺寸的至少一个皮带轮的边缘角度上略微大于皮带轮角度（β）。

6. 发明授权

US5800299A Continuously variable transmission 失效
标题翻译：连续可变传动
公开(公告)号：US5800299A
公开(公告)日：1998-09-01
申请号：US627071
申请日：1996-04-03
申请人： Gerardus Johannes Maria Lamers , Johannes gerardus Ludovicus Maria Van Spijk , Franciscus Cristianus Antonius Hubertus Willems
发明人： Gerardus Johannes Maria Lamers , Johannes gerardus Ludovicus Maria Van Spijk , Franciscus Cristianus Antonius Hubertus Willems
IPC分类号： F16H9/00 , F16H57/04 , F16H57/05 , F16H61/00 , F16H61/662
CPC分类号： F16H57/0456 , F16H57/0421 , F16H57/0489 , F16H61/662
摘要： The invention relates to a continuously variable transmission, consisting of at least a transmission housing which accommodates a pulley/drive belt unit, a hydraulic circuit, in particular for the control and/or lubrication of the transmission, and a fluid reservoir. The transmission housing and/or the hydraulic circuit are provided with a way of promoting the flow of fluid to the bottom of the transmission housing from the rest of the transmission housing.
摘要翻译：本发明涉及一种无级变速器，其至少包括容纳滑轮/传动带单元的变速器壳体，特别是用于变速器的控制和/或润滑的液压回路以及流体储存器。变速器壳体和/或液压回路设置有促进流体从变速器壳体的其余部分流到变速器壳体的底部的方式。

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