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11. 发明授权

US07650804B2 Mechanochemical sensor 失效
标题翻译：机械化学传感器
公开(公告)号：US07650804B2
公开(公告)日：2010-01-26
申请号：US10566355
申请日：2004-07-27
申请人： Yutaka Yamagata , Kozo Inoue , Hitoshi Ohmori , Joon-wan Kim
发明人： Yutaka Yamagata , Kozo Inoue , Hitoshi Ohmori , Joon-wan Kim
IPC分类号： G01L1/22
CPC分类号： C12Q1/6825 , G01N5/02
摘要： There is provided a mechanochemical sensor including a minute mechanical structure body having the functional membrane formed at least on one part of its surface, a supporting part for supporting the minute mechanical structure body; and a detection part for detecting the change of a mechanical property of the minute mechanical structure body. According to the invention, it is possible to provide improved adhesion between the functional membrane and the minute mechanical structure body since the functional membrane is integrally formed in advance on the minute mechanical structure body, which will contribute to the increase of detection signal, and improvement of measurement precision and sensitivity.
摘要翻译：提供了一种机械化学传感器，其包括具有形成在其表面的至少一部分上的功能膜的微小机械结构体，用于支撑微小机械结构体的支撑部分; 以及用于检测微机械结构体的机械特性的变化的检测部。根据本发明，由于功能膜预先在微小的机械结构体上一体形成功能膜，因此能够提供功能膜与微机械结构体之间的粘附性，这将有助于检测信号的增加和改善的测量精度和灵敏度。

12. 发明授权

US06244939B1 Micro-discharge truing device and fine machining method using the device 失效
标题翻译：微量排料装置和精加工方法采用该装置
公开(公告)号：US06244939B1
公开(公告)日：2001-06-12
申请号：US09376002
申请日：1999-08-19
申请人： Hitoshi Ohmori , Yutaka Yamagata
发明人： Hitoshi Ohmori , Yutaka Yamagata
IPC分类号： B24B700
CPC分类号： B24B53/053 , B24B53/001
摘要： There are provided an electrically conductive grindstone 12 for machining a workpiece 1, a disc-shaped discharge electrode 14 having an outer peripheral edge 14a which can be disposed in the vicinity of a machining surface 12a of the grindstone, an electrode rotating unit 16 for rotating the electrode around an axial center Z, a position controller 18 for controlling a relative position of the outer peripheral edge of the electrode and the grindstone, a voltage applying unit 20 for applying a predetermined voltage between the grindstone and the electrode in a pulse manner, and a machining liquid supply unit 22 for supplying an alkaline liquid between the grindstone and the electrode. By stably generating micro-discharge between the outer peripheral edge 14a of the rotating discharge electrode 14 and the machining surface 12a of the electrically conductive grindstone 12, a metal bonded portion of the electrically conductive grindstone is molten/removed with no contact therewith and with high efficiency and precision, and a grindstone surface is corrected to a desired shape.
摘要翻译：设置有用于加工工件1的导电磨石12，具有可设置在磨石加工表面12a附近的外周边缘14a的圆盘形放电电极14，用于旋转的电极旋转单元16 围绕轴心Z的电极，用于控制电极和磨石的外周边缘的相对位置的位置控制器18，用于以脉冲方式在磨石与电极之间施加预定电压的电压施加单元20，以及用于在磨石与电极之间供给碱性液体的加工液供给单元22。通过在旋转放电电极14的外周边缘14a和导电磨石12的加工面12a之间稳定地产生微电镀，导电磨石的金属接合部熔融/去除，不与其接触，并具有高的效率和精度，并且磨石表面被校正为期望的形状。

13. 发明申请

US20060219030A1 Mechanochemical type sensor 失效
标题翻译：机械化学型传感器
公开(公告)号：US20060219030A1
公开(公告)日：2006-10-05
申请号：US10566355
申请日：2004-07-27
申请人： Yutaka Yamagata , Kozo Inoue , Hitoshi Ohmori , Joon-wan Kim
发明人： Yutaka Yamagata , Kozo Inoue , Hitoshi Ohmori , Joon-wan Kim
IPC分类号： G01L1/22
CPC分类号： C12Q1/6825 , G01N5/02
摘要： There is provided a mechanochemical sensor including a minute mechanical structure body having the functional membrane formed at least on one part of its surface, a supporting part for supporting the minute mechanical structure body; and a detection part for detecting the change of a mechanical property of the minute mechanical structure body. According to the invention, it is possible to provide improved adhesion between the functional membrane and the minute mechanical structure body since the functional membrane is integrally formed in advance on the minute mechanical structure body, which will contribute to the increase of detection signal, and improvement of measurement precision and sensitivity.
摘要翻译：提供了一种机械化学传感器，其包括具有形成在其表面的至少一部分上的功能膜的微小机械结构体，用于支撑微小机械结构体的支撑部分; 以及用于检测微机械结构体的机械特性的变化的检测部。根据本发明，由于功能膜预先在微小的机械结构体上一体形成功能膜，因此能够提供功能膜与微机械结构体之间的粘附性，这将有助于检测信号的增加和改善的测量精度和灵敏度。

14. 发明授权

US06699105B1 Method and apparatus for cutting and grinding single crystal SiC 失效
标题翻译：单晶SiC切割研磨的方法和装置
公开(公告)号：US06699105B1
公开(公告)日：2004-03-02
申请号：US09530658
申请日：2000-07-05
申请人： Hitoshi Ohmori , Yutaka Yamagata , Nobuhide Itoh , Nobuyuki Nagato , Kotaro Yano , Naoki Oyanagi
发明人： Hitoshi Ohmori , Yutaka Yamagata , Nobuhide Itoh , Nobuyuki Nagato , Kotaro Yano , Naoki Oyanagi
IPC分类号： B24B100
CPC分类号： B28D5/023 , B24B7/228 , B24B27/0658 , B24B53/001 , B24D5/12 , B28D5/022
摘要： The present invention comprises a metal bond grind stone having a flat plate portion 10a and a tapered portion 10b; an electrode 13 opposed to the metal bond grind stone with a gap therebetween; voltage applying means 12 for applying a direct-current pulse voltage between the metal bond grind stone and the electrode; conductive liquid supplying means 14 for supplying a conductive liquid 15 between the metal bond grind stone and the electrode; and grind stone moving means 16 for moving the metal bond grind stone in a direction orthogonal to the shaft center thereof, and an ingot 1 of a single crystal SiC is thereby cut at the tapered portion 10b of the metal bond grind stone and the cut surface is then specular-worked at the flat plate portion 10a.
摘要翻译：本发明包括具有平板部分10a和锥形部分10b的金属结合磨石; 与金属结合研磨石相对的电极13，其间具有间隙; 电压施加装置12，用于在金属结合研磨石与电极之间施加直流脉冲电压; 用于在金属结合研磨石和电极之间供应导电液体15的导电液体供给装置14; 并且研磨用于使金属粘结研磨石沿与其轴心正交的方向移动的石块移动装置16，从而在金属结合研磨石的锥形部分10b上切割单晶SiC锭，切割面然后在平板部分10a进行镜面加工。

15. 发明授权

US06723347B1 Proces for producing protein powder 失效
标题翻译：生产蛋白粉的方法
公开(公告)号：US06723347B1
公开(公告)日：2004-04-20
申请号：US10088142
申请日：2002-03-15
申请人： Yutaka Yamagata , Takayuki Doen , Naoki Asakawa , Shigeyuki Takada
发明人： Yutaka Yamagata , Takayuki Doen , Naoki Asakawa , Shigeyuki Takada
IPC分类号： A61K914
CPC分类号： A61K9/0024 , A61K9/1647 , A61K9/19 , Y10S514/964
摘要： A process for conveniently producing a stable protein powder retaining the higher-order structure at a high level which comprises freezing a protein-containing solution at a cooling rate of about −300 to −10° C./min. and then drying.
摘要翻译：用于方便地制备以高水平保持高级结构的稳定的蛋白质粉末的方法，其包括以约-300至-10℃/分钟的冷却速率冷冻含蛋白质的溶液。然后干燥。

16. 发明授权

US5628993A Sustained releasable parenteral pharmaceutical preparations and method of producing the same 失效
标题翻译：持续可释放的肠胃外药物制剂及其制备方法
公开(公告)号：US5628993A
公开(公告)日：1997-05-13
申请号：US294972
申请日：1994-08-24
申请人： Yutaka Yamagata , Katsumi Iga , Hiroaki Okada
发明人： Yutaka Yamagata , Katsumi Iga , Hiroaki Okada
IPC分类号： A61K9/14 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/70 , A61K38/00 , A61K38/20 , A61K38/21 , A61K38/28 , A61K47/14 , A61K38/02
CPC分类号： A61K9/2013 , A61K38/2013 , A61K38/212 , A61K38/28 , A61K9/1617 , A61K9/70 , A61K9/0024
摘要： A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid form at room temperature. The molecular weight of the physiologically active peptide or protein is 2,000 dalton or more. The saturated fatty acid includes fatty acids having about 16 to 30 carbon atoms such as palmitic acid, stearic acid, etc. The matrix may be in a pillar or granular form. The parenteral pharmaceutical preparation can be used as an injectable solid administered subcutaneously or intramuscularly (for example, a pellet or tablet for implantation), a suppository or the like, and can release the physiologically active peptide or protein sustainedly for a prolonged period of one week or more.
摘要翻译：肠胃外药物制剂包含含有生理活性肽或蛋白质的基质和饱和脂肪酸的聚甘油二酯，并且所述基质在室温下为固体形式。生理活性肽或蛋白质的分子量为2,000道尔顿或更多。饱和脂肪酸包括具有约16至30个碳原子的脂肪酸，例如棕榈酸，硬脂酸等。基质可以是柱状或颗粒形式。肠胃外药物制剂可以用作皮下或肌肉内给药的可注射固体（例如，用于植入的丸粒或片剂），栓剂等，并且可以持续释放生理活性肽或蛋白质一周的长时间或者更多。

17. 发明申请

US20120244223A1 ORALLY DISPERSIBLE TABLET 有权
公开(公告)号：US20120244223A1
公开(公告)日：2012-09-27
申请号：US13491887
申请日：2012-06-08
申请人： Yutaka Tanoue , Tetsuya Matsuura , Yutaka Yamagata , Naoki Nagahara
发明人： Yutaka Tanoue , Tetsuya Matsuura , Yutaka Yamagata , Naoki Nagahara
IPC分类号： A61K9/16 , A61P25/18 , A61K31/343
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/5015 , A61K31/343 , A61K47/26 , A61K47/38 , A61K47/40
摘要： The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.
摘要翻译：本发明提供了具有改善的崩解性的制剂，显示药物的生物利用度提高的制剂，其制备方法等。一种快速崩解制剂，其包含颗粒，其包含涂覆有含有糖或糖醇的涂层的药物; 和崩解剂。一种快速崩解制剂的制备方法，包括生产颗粒的步骤，其包括药物，在所得颗粒上形成含有糖或糖醇的包衣层的步骤，以及将包衣颗粒与崩解剂混合并模制该混合物的步骤。

18. 发明授权

US06528279B2 Method and apparatus for analyzing three-dimensional internal structure 失效
公开(公告)号：US06528279B2
公开(公告)日：2003-03-04
申请号：US09852912
申请日：2001-05-11
申请人： Hideo Yokota , Akitake Makinouchi , Toshiro Higuchi , Yutaka Yamagata
发明人： Hideo Yokota , Akitake Makinouchi , Toshiro Higuchi , Yutaka Yamagata
IPC分类号： G01N130
CPC分类号： G02B21/008 , G02B21/0044
摘要： A sample extrusion device 12 for sequentially extruding a sample 1 in a predetermined direction, a sample cutting device 14 for sequentially cutting the extruded sample, and a con-focal image pickup device 16 for focusing an illuminating light at a section portion that was cut to pick up two-dimensional images of the cut section from a reflected light thereof are provided to reconstruct an internal structure of the sample from many two-dimensional images (continuous section images) that differ in the cutting positions. The sample can be continuously cut to continuously observe the sectional images thereof under no influence of the sample being seen transparently, the entirety of the sample can be observed in almost the same condition even though the sample is colored with a fluorescent dye, and thereby, the internal structure of the sample can be reconstructed with a high precision.

19. 发明授权

US06482864B1 Sustained-release preparation of physiologically active polypeptide and production thereof 失效
标题翻译：生理活性多肽的缓释制剂及其制备
公开(公告)号：US06482864B1
公开(公告)日：2002-11-19
申请号：US09319023
申请日：1999-05-28
申请人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
发明人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
IPC分类号： A61K4732
CPC分类号： A61K9/1647 , A61K38/27 , Y10S514/964
摘要： A method for producing a sustained-release preparation, which comprises dispersing a physiologically active polypeptide into an organic solvent solution of a biodegradable polymer and removing the organic solvent, wherein the polypeptide is a powder obtained by lyophilizing an aqueous solution of the polypeptide which solution has a water-miscible organic solvent and/or a volatile salt; which improves the ease of handling of the physiologically active polypeptide powder in the process for producing the preparation; which makes it possible to industrially produce the sustained-release preparation in large scale; which provides a sustained-release preparation showing high and stable concentration of the active component in blood in long term, low initial release ratio of the physiologically active polypeptide, and high entrapment ratio of the polypeptide into the sustained-release preparation.
摘要翻译：一种缓释制剂的制备方法，其包括将生理活性多肽分散到生物可降解聚合物的有机溶剂溶液中并除去有机溶剂，其中所述多肽是通过将多肽溶液冻干得到的粉末水混溶性有机溶剂和/或挥发性盐; 这提高了在制备该制剂的过程中易于处理生理活性多肽粉末; 这使得可以大规模地工业生产缓释制剂; 其提供持续释放制剂，其显示出高生产活性多肽的长期，低的初始释放比例以及所述多肽进入缓释制剂的高滞留比，从而高效稳定血液中活性成分的浓度。

20. 发明授权

US5750100A Sustained releasable parenteral pharmaceutical preparations and method of producing the same 失效
标题翻译：持续可释放的肠胃外药物制剂及其制备方法
公开(公告)号：US5750100A
公开(公告)日：1998-05-12
申请号：US734636
申请日：1996-10-21
申请人： Yutaka Yamagata , Katsumi Iga , Hiroaki Okada
发明人： Yutaka Yamagata , Katsumi Iga , Hiroaki Okada
IPC分类号： A61K9/14 , A61K9/00 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26 , A61K9/70 , A61K38/00 , A61K38/20 , A61K38/21 , A61K38/28 , A61K47/14 , A61K38/02
CPC分类号： A61K9/2013 , A61K38/2013 , A61K38/212 , A61K38/28 , A61K9/1617 , A61K9/70 , A61K9/0024
摘要： A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid form at room temperature. The molecular weight of the physiologically active peptide or protein is 2,000 dalton or more. The saturated fatty acid includes fatty acids having about 16 to 30 carbon atoms such as palmitic acid, stearic acid, etc. The matrix may be in a pillar or granular form. The parenteral pharmaceutical preparation can be used as an injectable solid administered subcutaneously or intramuscularly (for example, a pellet or tablet for implantation), a suppository or the like, and can release the physiologically active peptide or protein sustainedly for a prolonged period of one week or more.
摘要翻译：肠胃外药物制剂包含含有生理活性肽或蛋白质的基质和饱和脂肪酸的聚甘油二酯，并且所述基质在室温下为固体形式。生理活性肽或蛋白质的分子量为2,000道尔顿或更多。饱和脂肪酸包括具有约16至30个碳原子的脂肪酸，例如棕榈酸，硬脂酸等。基质可以是柱状或颗粒形式。肠胃外药物制剂可以用作皮下或肌肉内给药的可注射固体（例如，用于植入的丸粒或片剂），栓剂等，并且可以持续释放生理活性肽或蛋白质一周的长时间或者更多。

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