专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US07956322B2 Mass spectrometer and mass spectrometric analysis method 有权
标题翻译：质谱仪和质谱分析方法
公开(公告)号：US07956322B2
公开(公告)日：2011-06-07
申请号：US12354245
申请日：2009-01-15
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Yasuaki Takada
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/0045
摘要： An MS/MS spectrometric analysis method obtains throughput and mass resolving power of precursor ions. In a mass spectrometer, ions, which are introduced and accumulated in an ion trap unit, are resonance-extracted mass-selectively. A profile of precursor ions at the m/z axis of the ion trap and a profile at the mass analyzer portion, which performs mass analysis of the ions extracted from a collision induced dissociation portion, is obtained by performing a measurement when the injection energy to the collision induced dissociation portion is low, and when the injection energy to the collision induced dissociation portion is high. The profile at the m/z axis of the ion trap of the obtained two-dimensional spectrum is substituted with the profile at the m/z axis of the mass analyzer portion. In this way, the m/z of both the precursor ions and the fragment ions can be determined with high mass resolving power.
摘要翻译： MS / MS光谱分析方法获得前体离子的通量和质量分辨能力。在质谱仪中，离子阱单元中引入和积聚的离子是质量选择性共振提取的。在离子阱的m / z轴处的前体离子的轮廓和质量分析器部分的轮廓，其进行从碰撞诱导的解离部分提取的离子的质量分析，通过在将注入能量碰撞诱导的解离部分低，并且当碰撞诱导解离部分的注入能量高时。所获得的二维光谱的离子阱的m / z轴的轮廓被质量分析器部的m / z轴的轮廓所取代。以这种方式，可以以高质量分辨能力确定前体离子和碎片离子两者的m / z。

12. 发明授权

US07829846B2 Analytical system and method utilizing the dependence of signal intensity on matrix component concentration 有权
标题翻译：利用信号强度对基质成分浓度的依赖性的分析系统和方法
公开(公告)号：US07829846B2
公开(公告)日：2010-11-09
申请号：US12037148
申请日：2008-02-26
申请人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
发明人： Yuichiro Hashimoto , Hideki Hasegawa , Masuyuki Sugiyama , Yasuaki Takada
IPC分类号： H01J49/40 , G06F19/00 , G01N31/00
CPC分类号： H01J49/0036
摘要： The present invention achieves accurate quantitative determination without reducing measurement throughput and also without having to add a multi-component reference standard. An analytical instrument of the present invention for determining the concentration of a target compound contained in a target sample includes: a means for ionizing a mixture having a specific compound added to the target sample; a means for performing mass analysis on resulting ions; and a database that stores dependence of signal intensity on the concentration of a specific matrix component for each of the target compound and the addition compound, wherein the database is used to calibrate the concentration of the target compound from a signal derived from the target compound and a signal derived from the addition compound, each signal obtained by the mass analysis means. The present invention achieves a multi-component analyzer using low-cost, high-throughput mass analysis, as compared to conventional technique.
摘要翻译：本发明可以在不降低测量吞吐量的情况下实现准确的定量测定，而且不必添加多组分参考标准。本发明的用于测定目标样品中包含的目标化合物的浓度的分析仪包括：将具有特定化合物的混合物电离于目标样品的装置; 对所得离子进行质量分析的手段; 以及数据库，其存储信号强度对于每种目标化合物和加成化合物的特定基质成分的浓度的依赖性，其中所述数据库用于从源自目标化合物的信号校准目标化合物的浓度，以及来自加成化合物的信号，通过质量分析装置得到的各信号。与现有技术相比，本发明实现了使用低成本，高吞吐量质量分析的多分量分析仪。

13. 发明申请

US20140151543A1 ANALYSIS DEVICE AND ANALYSIS METHOD 有权
标题翻译：分析装置和分析方法
公开(公告)号：US20140151543A1
公开(公告)日：2014-06-05
申请号：US13884755
申请日：2011-11-08
申请人： Hisashi Nagano , Yasutaka Suzuki , Hideo Kashima , Yuichiro Hashimoto , Masuyuki Sugiyama , Masakazu Sugaya , Yasunori Doi , Koichi Terada
发明人： Hisashi Nagano , Yasutaka Suzuki , Hideo Kashima , Yuichiro Hashimoto , Masuyuki Sugiyama , Masakazu Sugaya , Yasunori Doi , Koichi Terada
IPC分类号： H01J49/00 , H01J49/04
CPC分类号： H01J49/0422 , G01N1/2211 , G01N1/2214 , G01N33/0057 , G01N2001/028 , H01J49/00 , H01J49/0036 , H01J49/04 , H01J49/0459 , H01J49/0468 , Y02A50/25
摘要： Provided is a technique of analyzing particles in real time while collecting and condensing the particles continuously. Gas and/or particles as a detection target substance that are attached to an authentication target 2 are removed by air flow from a blowing region 5. The removed sample is sucked and is condensed and sampled at a sampling region 10, and ions of the sample are generated at an ion source 21 and are then subjected to mass analysis at a mass analysis region 23. Determination of the obtained mass spectrum is made as to the presence or not of a mass spectrum derived from the detection target substance, and a monitor 27 displays a result thereof. Thereby, the detection target substance attached to the authentication target 2 can be detected continuously in real time, promptly and with a less error rate.
摘要翻译：提供了一种在连续收集和冷凝颗粒时实时分析颗粒的技术。作为检测对象物质的作为检测对象物质的气体和/或颗粒被从吹扫区域5的空气流除去。将取出的样品抽吸并在采样区域10被冷凝并取样，并且样品的离子在离子源21处产生，然后在质量分析区域23进行质量分析。对获得的质谱进行测定，确定是否存在从检测目标物质得到的质谱，以及监测器27 显示其结果。因此，可以实时，及时且误码率较小的连续检测附着于认证对象2的检测对象物质。

14. 发明授权

US06580067B1 Sample analyzing monitor and combustion control system using the same 有权
标题翻译：采用分析监测和燃烧控制系统的样品分析
公开(公告)号：US06580067B1
公开(公告)日：2003-06-17
申请号：US09712132
申请日：2000-11-15
申请人： Masuyoshi Yamada , Yuichiro Hashimoto , Minoru Sakairi , Yasuaki Takada , Masami Sakamoto , Tomoyuki Tobita
发明人： Masuyoshi Yamada , Yuichiro Hashimoto , Minoru Sakairi , Yasuaki Takada , Masami Sakamoto , Tomoyuki Tobita
IPC分类号： H01J4900
CPC分类号： H01J49/0009 , F23G5/50 , G01N33/0049 , H01J49/0422
摘要： The present invention is to provide a monitoring device making it possible to measure the concentration of a target trace gas which has an ionization efficiency changed by the affect of impurities and which is absorbed on a pretreatment portion or piping, at a high accuracy and at real time, by adding an internal standard having a known concentration to the target trace gas. The concentration of the target trace gas is measured while an internal standard having substantially the same properties (such as ionization efficiency change and vapor pressure) as the target trace gas is added. The ion strengths of the target trace gas and the internal standard are compared to calibrate the concentration of the target trace gas. According to the present invention, the concentration of the target trace gas in gas containing impurities can be online measured at a real time and at high accuracy while being continuously calibrated.
摘要翻译：本发明提供一种监测装置，使得可以以高精度和实际地测量具有由杂质影响而改变并且被吸收在预处理部分或管道上的电离效率的目标痕量气体的浓度通过向目标痕量气体添加具有已知浓度的内标，测定目标痕量气体的浓度，同时测定作为目标痕量气体具有基本相同性质（如电离效率变化和蒸气压）的内标被添加。将目标痕量气体和内标的离子强度进行比较，校正目标痕量气体的浓度。根据本发明，可以在线测量含有杂质的气体中的痕量气体的浓度，在高精度的同时连续校准。

15. 发明授权

US06194716B1 Method for mass calibration 有权
标题翻译：质量校准方法
公开(公告)号：US06194716B1
公开(公告)日：2001-02-27
申请号：US09143399
申请日：1998-08-28
申请人： Yasuaki Takada , Takayuki Nabeshima , Minoru Sakairi , Yuichiro Hashimoto
发明人： Yasuaki Takada , Takayuki Nabeshima , Minoru Sakairi , Yuichiro Hashimoto
IPC分类号： B01D5944
CPC分类号： H01J49/424 , H01J49/0009 , H01J49/428
摘要： A method for performing a mass calibration under an application of a desired ion peak position of mass spectrum attained by a mass scanning of ions of substance having a known value of m/z and the known value of m/z is added with a step for ejecting an amount of unnecessary ions not contributing to the aforesaid mass calibration accumulated in the aforesaid ion trap type mass analysis region prior to the aforesaid mass scanning operation. An accumulation of a large amount of unnecessary ions in the ion trap type mass analysis region is restricted, a disturbance of electric field in the ion trap mass analysis region generated under an influence of a spatial charge caused by accumulation of the unnecessary ions can be prevented and the aforesaid mass calibration can be performed in an easy and accurate manner.
摘要翻译：在通过具有已知m / z值的物质的离子的质量扫描和已知的m / z值获得的质谱所需离子峰位置的施加下进行质量校准的方法添加了用于在上述质量扫描操作之前，排出在上述离子阱型质量分析区域中累积的对上述质量校准无贡献的不需要的离子的量。离子阱型质量分析区域中的大量不需要的离子的积聚受到限制，可以防止在由不需要的离子的积聚引起的空间电荷的影响下产生的离子阱质量分析区域中的电场的扰动并且可以容易且准确地进行上述质量校准。

16. 发明授权

US06423965B1 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US06423965B1
公开(公告)日：2002-07-23
申请号：US09378767
申请日：1999-08-23
申请人： Yuichiro Hashimoto , Takayuki Nabeshima , Yasuaki Takada , Minoru Sakairi , Masamichi Tsukada
发明人： Yuichiro Hashimoto , Takayuki Nabeshima , Yasuaki Takada , Minoru Sakairi , Masamichi Tsukada
IPC分类号： H01J4900
CPC分类号： H01J49/04
摘要： Plasma ion source mass spectrometers or liquid chromatograph/mass spectrometers are provided: wherein photon noises and matrix molecule ions produced by the ion source are decreased, the decrease of the quantity of signal is suppressed, and the apparatus maintenance is improved. The photon noises are decreased with a shielding plate and a 90 degrees deflector. The maintainability in cleaning is improved by a combination of a leading electrode, the shielding plate having a small hole, and a gate valve. The decrease in the quantity of signal is suppressed with the leading electrode, and a double cylindrical type static lens. Position adjustment of the leading electrode is performed with a flat plate having plural holes. Using an ion trap mass analyzer, matrix molecule ions are eliminated by applying a resonance voltage between its end cap electrodes. Decrease in the quantity of signals, which has been a problem, can be prevented, and a high transmission can be realized with a preferable reproducibility against disturbance of an electric field caused by ion lens and the like. A detectable limit of atomic ions of the sample can be improved by eliminating the matrix molecule ions.
摘要翻译：提供了等离子体离子源质谱仪或液相色谱仪/质谱仪：其中由离子源产生的光子噪声和基质分子离子减少，抑制了信号量的减少，从而改善了设备的维护。光子噪声随屏蔽板和90度偏转器而减小。通过前导电极，具有小孔的屏蔽板和闸阀的组合来提高清洁的可维护性。用前导电极和双圆柱形静电透镜抑制信号量的减少。引导电极的位置调整用具有多个孔的平板进行。使用离子阱质量分析仪，通过在其端盖电极之间施加谐振电压来消除基质分子离子。可以防止已经存在问题的信号量的减少，并且以离子透镜等引起的电场干扰的优选再现性可以实现高透射率。可以通过消除基质分子离子来改善样品的原子离子的可检测极限。

17. 发明授权

US09040905B2 Analysis device and analysis method 有权
公开(公告)号：US09040905B2
公开(公告)日：2015-05-26
申请号：US13884755
申请日：2011-11-08
申请人： Hisashi Nagano , Yasutaka Suzuki , Hideo Kashima , Yuichiro Hashimoto , Masuyuki Sugiyama , Masakazu Sugaya , Yasunori Doi , Koichi Terada
发明人： Hisashi Nagano , Yasutaka Suzuki , Hideo Kashima , Yuichiro Hashimoto , Masuyuki Sugiyama , Masakazu Sugaya , Yasunori Doi , Koichi Terada
IPC分类号： H01J49/04 , G01N1/22 , G01N1/02 , H01J49/00 , G01N33/00
CPC分类号： H01J49/0422 , G01N1/2211 , G01N1/2214 , G01N33/0057 , G01N2001/028 , H01J49/00 , H01J49/0036 , H01J49/04 , H01J49/0459 , H01J49/0468 , Y02A50/25
摘要： Provided is a technique of analyzing particles in real time while collecting and condensing the particles continuously. Gas and/or particles as a detection target substance that are attached to an authentication target 2 are removed by air flow from a blowing region 5. The removed sample is sucked and is condensed and sampled at a sampling region 10, and ions of the sample are generated at an ion source 21 and are then subjected to mass analysis at a mass analysis region 23. Determination of the obtained mass spectrum is made as to the presence or not of a mass spectrum derived from the detection target substance, and a monitor 27 displays a result thereof. Thereby, the detection target substance attached to the authentication target 2 can be detected continuously in real time, promptly and with a less error rate.

18. 发明授权

US07800058B2 Mass spectrometer and mass spectrometry method 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US07800058B2
公开(公告)日：2010-09-21
申请号：US11979811
申请日：2007-11-08
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/00
CPC分类号： H01J49/4225 , H01J49/4215
摘要： A mass spectrometer that is switchable to operate as a linear trap or as a mass filter, and attaining both high ejection efficiency when operated as a linear trap and high mass resolving power when operated as a mass filter. A mass spectrometer includes an ion source for ionizing a sample, a linear trap quadrupole rod lens supplied with ionized ions, a trap electrode for forming a potential to trap the supplied ions between one end of the quadrupole lens and the other end, a control unit to regulate the trap lens voltage, and a mass analyzer or detector to detect ions ejected from the linear trap, and characterized in switching between an operation where the supplied ions are trapped in a section quadrupole rod lens and ejected by the controller unit regulating the trap electrode voltage; and an operation where ions are selective passed through according to their mass. The ejection efficiency when operated as an ion trap, and the mass resolving power when operated as a quadrupole mass filter are vastly improved compared to conventional methods.
摘要翻译：可以切换为线性捕集器或质量过滤器的质谱仪，当作为质量过滤器操作时，作为线性捕集器操作时获得高喷射效率和高质量分辨能力的质谱仪。质谱仪包括用于电离样品的离子源，提供有离子化离子的线性捕获四极杆透镜，用于形成用于捕获四极透镜的一端与另一端之间的供应离子的电位的捕获电极，控制单元调节陷波透镜电压，以及质量分析器或检测器，用于检测从线性阱捕获的离子，并且其特征在于，在所提供的离子被捕获在四极杆棒状透镜中并由调节阱的控制器单元喷射的操作之间进行切换电极电压; 以及根据其质量选择性地通过离子的操作。当作为离子阱操作时的喷射效率以及当作为四极质量过滤器操作时的质量分辨能力与常规方法相比大大提高。

19. 发明申请

US20080121795A1 Mass spectrometer and mass spectrometry method 有权
标题翻译：质谱仪和质谱法
公开(公告)号：US20080121795A1
公开(公告)日：2008-05-29
申请号：US11979811
申请日：2007-11-08
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Hideki Hasegawa , Izumi Waki
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/4215
摘要： A mass spectrometer that is switchable to operate as a linear trap or as a mass filter, and attaining both high ejection efficiency when operated as a linear trap and high mass resolving power when operated as a mass filter. A mass spectrometer includes an ion source for ionizing a sample, a linear trap quadrupole rod lens supplied with ionized ions, a trap electrode for forming a potential to trap the supplied ions between one end of the quadrupole lens and the other end, a control unit to regulate the trap lens voltage, and a mass analyzer or detector to detect ions ejected from the linear trap, and characterized in switching between an operation where the supplied ions are trapped in a section quadrupole rod lens and ejected by the controller unit regulating the trap electrode voltage; and an operation where ions are selective passed through according to their mass. The ejection efficiency when operated as an ion trap, and the mass resolving power when operated as a quadrupole mass filter are vastly improved compared to conventional methods.
摘要翻译：可以切换为线性捕集器或质量过滤器的质谱仪，当作为质量过滤器操作时，作为线性捕集器操作时获得高喷射效率和高质量分辨能力的质谱仪。质谱仪包括用于电离样品的离子源，提供有离子化离子的线性捕获四极杆透镜，用于形成用于捕获四极透镜的一端与另一端之间的供应离子的电位的捕获电极，控制单元调节陷波透镜电压，以及质量分析器或检测器，用于检测从线性阱捕获的离子，并且其特征在于，在所提供的离子被捕获在四极杆棒状透镜中并由调节阱的控制器单元喷射的操作之间进行切换电极电压; 以及根据其质量选择性地通过离子的操作。当作为离子阱操作时的喷射效率以及当作为四极质量过滤器操作时的质量分辨能力与常规方法相比大大提高。

20. 发明授权

US08710430B2 Mass spectrometry method 有权
标题翻译：质谱法
公开(公告)号：US08710430B2
公开(公告)日：2014-04-29
申请号：US13527619
申请日：2012-06-20
申请人： Masuyuki Sugiyama , Yuichiro Hashimoto , Shun Kumano , Yohei Kawaguchi , Hidetoshi Morokuma
发明人： Masuyuki Sugiyama , Yuichiro Hashimoto , Shun Kumano , Yohei Kawaguchi , Hidetoshi Morokuma
IPC分类号： H01J49/42 , H01J49/26 , H01J49/00
CPC分类号： H01J49/4265 , H01J49/0009 , H01J49/0036
摘要： A mass spectrometry method that corrects the effects from space charge and that achieves both sensitivity and a dynamic range. The mass axis of the mass spectrum is corrected based on the counts of ions accumulated within the ion trap at the point in time each ion was extracted.
摘要翻译：一种校正空间电荷效应并实现灵敏度和动态范围的质谱法。基于在每个离子被提取的时间点内积聚在离子阱内的离子的计数校正质谱的质量轴。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式