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    • 17. 发明授权
    • Microporous drug delivery system
    • 微孔药物输送系统
    • US06361780B1
    • 2002-03-26
    • US09190902
    • 1998-11-12
    • Gregory R. LeyChristopher Paul Knapp
    • Gregory R. LeyChristopher Paul Knapp
    • A61K900
    • A61M31/002A61F2250/0067A61M31/00A61M2025/0057
    • A drug delivery device is described comprising a porous biocompatible solid having at least one therapeutic drug within its pores, the therapeutic drug being removable from the pores by immersion in an aqueous solution. This may also be described as a drug delivery device comprising a porous annulus comprising a biocompatible solid having at least one therapeutic drug within its pores, the therapeutic drug being removable from the pores by immersion in an aqueous solution, the annulus having a top outer surface with an outside diameter, an inner surface with an inside diameter, and a side surface, at least one of the side surface and the top outer surface having openings of the pores exposed on that surface. The device may comprise pores having an average size of the greatest dimensions within the pores of between about 10−6 and 10−1 mm. The device may have a medical device or component of a medical device pass through an opening in the annulus. Examples of such medical devices may include, but not be limited to medical devices or components of medical devices selected from the group consisting of catheters, tubes, and electrical leads. A catheter or electrical lead may have at least a portion of its length surrounded by the porous drug delivery device. A more specific description of an aspect of the present invention would include a catheter or cardiac lead having a collar comprising a porous, solid material surrounding at least a length of the catheter or cardiac lead, the collar comprising a porous material selected from the group consisting of inorganic oxides, metals, polymers, and composite materials, the porous material having pores with an average greatest dimension of between about 10−6 and 10−1 mm, and the collar having a largest dimension of less than 5 mm.
    • 描述了药物递送装置,其包含在其孔内具有至少一种治疗药物的多孔生物相容性固体,所述治疗药物可通过浸入水溶液中而从孔中除去。 这也可以被描述为包括多孔环的药物递送装置,所述多孔环包含在其孔内具有至少一种治疗药物的生物相容性固体,所述治疗药物可通过浸入水溶液而从孔中除去,所述环具有顶部外表面 具有外径,具有内径的内表面和侧表面,所述侧表面和所述顶外表面中的至少一个具有暴露在所述表面上的孔的开口。所述装置可以包括具有平均尺寸 孔内的最大尺寸在约10-6和10-1mm之间。该装置可以具有通过环形空间中的开口的医疗装置的医疗装置或部件。 这样的医疗装置的示例可以包括但不限于从由导管,管和电引线组成的组中选择的医疗装置或医疗装置的部件。 导管或电引线可以具有由多孔药物输送装置包围的其长度的至少一部分。本发明的一个方面的更具体的描述将包括导管或心脏引线,其​​具有包括围绕 所述导管或心脏引线的至少一段长度,所述套环包括选自无机氧化物,金属,聚合物和复合材料的多孔材料,所述多孔材料具有平均最大尺寸在约10-6之间的孔 和10-1mm,并且所述套环具有小于5mm的最大尺寸。