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    • 13. 发明授权
    • Condensed purine derivatives
    • 凝血嘌呤衍生物
    • US06306847B1
    • 2001-10-23
    • US09090936
    • 1998-06-05
    • Hiroshi TsumukiMayumi SakiHiromi NonakaMichio IchimuraJunichi ShimadaFumio SuzukiShunji IchikawaNobuo Kosaka
    • Hiroshi TsumukiMayumi SakiHiromi NonakaMichio IchimuraJunichi ShimadaFumio SuzukiShunji IchikawaNobuo Kosaka
    • C07D48714
    • C07D487/14
    • The present invention provides condensed purine derivatives or pharmacologically acceptable salts thereof exhibiting adenosine A3 acceptor antagonising activity, and having an antiasthmatic action, a bronchodilator action, an antiantiitching action, etc., and represented by the following formula (I): (wherein R1 represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group; R2 represents hydrogen, lower alkyl, alicyclic alkyl, substituted or unsubstituted aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group; R3 represents hydrogen, lower alkyl, or substituted or unsubstituted aralkyl; X1 and X2 are the same or different and each represents hydrogen, lower alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted aryl; and n represents an integer of 0 to 3).
    • 本发明提供具有腺苷A3受体拮抗活性的缩合嘌呤衍生物或其药理学上可接受的盐,并具有抗哮喘作用,支气管扩张剂作用,抗脱除作用等,并由下式(I)表示:(其中R1表示 取代或未取代的芳基或取代或未取代的芳族杂环基; R 2表示氢,低级烷基,脂环族烷基,取代或未取代的芳烷基,取代或未取代的芳基或取代或未取代的芳族杂环基; R 3表示氢,低级烷基或 取代或未取代的芳烷基; X 1和X 2相同或不同,各自表示氢,低级烷基,取代或未取代的芳烷基或取代或未取代的芳基; n表示0〜3的整数。
    • 17. 发明授权
    • Process for producing thermoplastic copolymer powder
    • 生产热塑性共聚物粉末的方法
    • US5521231A
    • 1996-05-28
    • US381888
    • 1995-02-24
    • Fumio SuzukiHaruki SatoMasaki SugiharaWataru Hadano
    • Fumio SuzukiHaruki SatoMasaki SugiharaWataru Hadano
    • C08F291/00C08J3/12C08J3/16C08F6/22
    • C08F291/00C08J3/12C08J3/16C08J2321/02
    • A process for producing a thermoplastic polymer powder which comprises adding a polymer (B) and/or an inorganic compound (C) to a coagulation slurry or a powder of a thermoplastic polymer (A) obtained from emulsion polymerization and having a glass transition temperature Tg defined by the following equation (1), in an amount of 0.1-10 parts by weight to 100 parts by weight of the thermoplastic polymer (A), compacting the thermoplastic polymer (A) at a temperature in a range of (Tg-30) to (Tg+50).degree. C., and comminuting it:Tg=W.sub.1 .times.Tg.sub.1 +W.sub.2 .times.Tg.sub.2 + . . . +W.sub.n .times.Tg.sub.n ( 1)wherein n is the number of the monomers forming the thermoplastic polymer (A); W.sub.1, W.sub.2, . . . W.sub.n each represents weight fraction of each monomer i (i=1, 2, . . . n) in the polymer (A); and Tg.sub.1, Tg.sub.2, . . . Tg.sub.n each represents the glass transition temperature of the polymer composed of each monomer i. According to the present invention, it is possible to remarkably enhance bulk specific gravity of thermoplastic polymers as compared with the case using the methods known in the art.
    • PCT No.PCT / JP93 / 01221 Sec。 371日期:1995年2月24日 102(e)1995年2月24日PCT PCT 1993年8月31日PCT公布。 出版物WO94 / 05722 日本特开2002-1933年所述的热塑性聚合物粉末的制造方法,其特征在于,将聚合物(B)和/或无机化合物(C)添加到由乳液聚合得到的凝固浆料或热塑性聚合物(A)的粉末中 并且具有由下式(1)定义的玻璃化转变温度Tg,相对于100重量份热塑性聚合物(A)为0.1-10重量份,在热塑性聚合物(A)的温度下压制热塑性聚合物 (Tg-30)至(Tg + 50)℃的范围,并粉碎:Tg = W1xTg1 + W2xTg2 +。 。 。 + WnxTgn(1)其中n是形成热塑性聚合物(A)的单体数目; W1,W2,。 。 。 Wn分别表示聚合物(A)中各单体i(i = 1,2,...)的重量分数。 和Tg1,Tg2。 。 。 Tgn各自表示由各单体i构成的聚合物的玻璃化转变温度。 根据本发明,与使用本领域已知方法的情况相比,可以显着提高热塑性聚合物的体积比重。