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11. 发明授权

US09108975B2 Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same 有权
标题翻译： 6,7-不饱和-7-氨基甲酰吗啡喃衍生物的结晶及其制备方法
公开(公告)号：US09108975B2
公开(公告)日：2015-08-18
申请号：US13884770
申请日：2011-11-11
申请人： Yoshinori Tamura , Kouichi Noguchi , Masanao Inagaki , Kenji Morimoto , Nobuhiro Haga , Shinichi Oda , Sohei Omura
发明人： Yoshinori Tamura , Kouichi Noguchi , Masanao Inagaki , Kenji Morimoto , Nobuhiro Haga , Shinichi Oda , Sohei Omura
IPC分类号： C07D471/00 , A61K31/44 , C07D489/08 , C07C51/41 , C07C53/10 , C07C303/32 , C07C309/30 , C07D271/06 , A61K9/16
CPC分类号： C07D489/08 , A61K9/1629 , C07B2200/13 , C07C51/412 , C07C53/10 , C07C303/32 , C07C309/30 , C07D271/06
摘要： Stable crystalline forms of a compound represented by the formula (IA): an acid addition salt, and/or a solvate thereof are provided by the present invention. Said crystalline forms are extremely useful as materials for preparing medicines. Novel processes for preparing 6,7-unsaturated-7-carbamoyl morphinan derivatives are also provided by the present invention.
摘要翻译：由式（IA）表示的化合物的稳定结晶形式：酸加成盐和/或其溶剂合物由本发明提供。所述结晶形式作为制备药物的材料非常有用。制备6,7-不饱和-7-氨基甲酰吗啡喃衍生物的新方法也由本发明提供。

12. 发明授权

US08932568B2 Hair conditioning composition 有权
标题翻译：头发调理组成
公开(公告)号：US08932568B2
公开(公告)日：2015-01-13
申请号：US12933626
申请日：2009-04-03
申请人： Juri Sata , Yoshinori Tamura , Hiromoto Mizushima
发明人： Juri Sata , Yoshinori Tamura , Hiromoto Mizushima
IPC分类号： A61Q5/12 , A61K8/81 , A61K8/39
CPC分类号： A61K8/39 , A61Q5/12
摘要： Provided is a low odor hair conditioning composition which is free of oily and greasy feel upon finish, and can impart good manageability and moisturized feel. Specifically provided is a hair conditioning composition including a component (A): a compound represented by a general formula (1) R1O—(PO)n/(EO)m—R2 (1), where R1 represents a straight or branched, alkyl or alkenyl group having 8 to 12 carbon atoms, PO represents a propyleneoxy group, EO represents an ethyleneoxy group, an average addition mole number “n” represents a number of 1.5 to 3.0, an average addition mole number “m” represents a number of 0 to 1.0, and R2 represents a hydrogen atom or a methyl group; and a component (B): a surfactant other than the component (A), wherein a content of R1OH, where R1 represents a straight or branched, alkyl or alkenyl group having 8 to 12 carbon atoms, is 80 ppm or less.
摘要翻译：提供了一种低气味的头发调理组合物，其在完成后不含油性和油腻感，并且可以赋予良好的可管理性和保湿感。具体提供的是包含组分（A）：由通式（1）R1O-（PO）n /（EO）m -R2（1）表示的化合物的头发调理组合物，其中R 1表示直链或支链烷基或碳原子数为8〜12的烯基，PO表示丙烯氧基，EO表示乙烯氧基，平均加成摩尔数“n”表示1.5〜3.0的数，平均加成摩尔数“m”表示 0〜1.0，R2表示氢原子或甲基; 和组分（B）：除组分（A）以外的表面活性剂，其中R1表示碳原子数为8〜12的直链或支链烷基或烯基的R1OH的含量为80ppm以下。

13. 发明授权

US08048842B2 Thickening/foam-promoting agent 有权
标题翻译：增稠/促泡剂
公开(公告)号：US08048842B2
公开(公告)日：2011-11-01
申请号：US12090970
申请日：2006-10-31
申请人： Yasuhiro Doi , Masaki Inoue , Kaoru Omae , Yoshinori Tamura
发明人： Yasuhiro Doi , Masaki Inoue , Kaoru Omae , Yoshinori Tamura
IPC分类号： C11D1/722 , A61K8/39 , A61Q5/02 , C07C43/11
CPC分类号： C11D1/722 , A61K8/046 , A61K8/39 , A61Q5/02 , A61Q19/10 , C07C41/03 , C07C43/11 , C11D1/721 , C11D3/0094
摘要： The present invention provides a thickening/foam-promoting agent having thickening/foam-promoting properties and a low odor, and a detergent composition containing the agent. The thickening/foam-promoting agent is composed of the following component (A):(A) a compound represented by the following formula (1): R1O—(PO)n/(EO)m—R2 (1), wherein R1 is a linear alkyl or an alkenyl group having 8 to 10 carbon atoms, PO is a propyleneoxy group, EO is an ethyleneoxy group, an average added molar number n is a number of 1.5 to 3.0, an average added molar number m is a number of 0 to 1.0, and R2 is a hydrogen atom or a methyl group, wherein the content of an alcohol of the formula (1), when n=0, m=0 and R2 is a hydrogen atom, is not more than 3000 ppm, and the detergent composition contains the component (A) and a surfactant (B).
摘要翻译：本发明提供具有增稠/促泡性和低气味的增稠/促泡剂和含有该试剂的洗涤剂组合物。增稠/增泡剂由以下组分（A）组成：（A）由下式（1）表示的化合物：R 1 O-（PO）n /（EO）m -R 2（1），其中R 1 是具有8〜10个碳原子的直链烷基或烯基，PO是亚丙氧基，EO是乙烯氧基，平均加成摩尔数n是1.5〜3.0的数，平均加成摩尔数m是数为0〜1.0，R2为氢原子或甲基，其中，当n = 0，m = 0，R2为氢原子时，式（1）的醇的含量为3000ppm以下，洗涤剂组合物含有成分（A）和表面活性剂（B）。

14. 发明申请

US20050159331A1 Detergent compositions 有权
标题翻译：洗涤剂组合物
公开(公告)号：US20050159331A1
公开(公告)日：2005-07-21
申请号：US11017847
申请日：2004-12-22
申请人： Yoshinori Tamura , Ryosuke Fujii , Tomoko Uchiyama
发明人： Yoshinori Tamura , Ryosuke Fujii , Tomoko Uchiyama
IPC分类号： C11D1/34 , C11D17/00
CPC分类号： C11D1/345
摘要： Provided is a detergent composition having components (A) and (B1): (A) a phosphate monoester (1), and (B1) a phosphate monoester (2), wherein n=1; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A), (B1) and (B2): (A) a phosphate monoester (1), (B1) a phosphate monoester (2), wherein n=1, and (B2) a phosphate monoester (2), wherein n=2; components (A) and (C): (A) a phosphate monoester (1), and (C) a phosphate monoester (3); or a phosphate-based surfactant produced by reacting a compound obtained by adding to an alcohol an alkylene oxide of 2 to 4 carbon atoms, with phosphoric acid, a polyphosphoric acid or P2O5: The detergent composition is mild to the skin, is high in versatility, and has a good foaming property in weak acidic water or in hard water.
摘要翻译：本发明提供一种具有成分（A）和（B 1）的洗涤剂组合物：（A）磷酸酯单酯（1）和（B 1/3）磷酸酯单酯（2 ），其中n = 1; 组分（A），（B 1/2）和（B 2）：（A）磷酸酯单酯（1），（B 1 H 2）磷酸酯单酯（2），其中n = 1，和（B 2 H 2）磷酸酯单酯（2），其中n = 2; 组分（A），（B 1/2）和（B 2）：（A）磷酸酯单酯（1），（B 1 H 2）磷酸酯单酯（2），其中n = 1，和（B 2 H 2）磷酸酯单酯（2），其中n = 2; 组分（A）和（C）：（A）磷酸酯单酯（1）和（C）磷酸酯单酯（3）; 或通过将通过向醇中加入2至4个碳原子的烯化氧获得的化合物与磷酸，多磷酸或P 2 O 5 O 5反应而制备的磷酸盐基表面活性剂，洗涤剂组合物对皮肤温和，通用性高，在弱酸性水或硬水中具有良好的起泡性。

15. 发明授权

US5858936A Detergent composition 失效
标题翻译：洗涤剂组成
公开(公告)号：US5858936A
公开(公告)日：1999-01-12
申请号：US821302
申请日：1997-03-20
申请人： Yoshinori Tamura , Yasuhiro Doi , Keiko Hasebe , Masafumi Shonaka , Tadashi Moriyama , Yuichi Hioki , Hiroshi Sonohara
发明人： Yoshinori Tamura , Yasuhiro Doi , Keiko Hasebe , Masafumi Shonaka , Tadashi Moriyama , Yuichi Hioki , Hiroshi Sonohara
IPC分类号： A61K8/00 , A61K8/33 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/43 , A61K8/44 , A61K8/46 , A61Q5/00 , A61Q5/02 , A61Q17/00 , C11D1/86
CPC分类号： A61K8/44 , A61K8/40 , A61K8/416 , A61K8/43 , A61K8/463 , A61Q17/005 , A61K2800/51 , A61Q19/10 , A61Q5/006 , A61Q5/02
摘要： Described is a detergent composition comprising (A) a sulfate ester surfactant, (B) at least one surfactant selected from amphoteric surfactants, amine oxide surfactants, alkanol amide surfactants and amide amino-acid surfactants, (C) a cationic bactericide and (D) a metal chelating agent, the weight ratio of said (A) to (B) being 1-50 and the content of said (C) being 0.2 wt. % to 5 wt. %.The detergent composition according to the present invention has excellent detergency, foamability and foam durability and at the same time, has high bactericidal effects because it can be mixed stably with a cationic bactericide.
摘要翻译：描述了一种洗涤剂组合物，其包含（A）硫酸酯表面活性剂，（B）选自两性表面活性剂，氧化胺表面活性剂，链烷醇酰胺表面活性剂和酰胺氨基酸表面活性剂中的至少一种表面活性剂，（C）阳离子杀菌剂和（D）金属螯合剂，所述（A）与（B）的重量比为1-50，所述（C）的含量为0.2重量％。％至5wt。％。根据本发明的洗涤剂组合物具有优异的洗涤性，发泡性和泡沫耐久性，同时具有高的杀菌效果，因为它可以与阳离子杀菌剂稳定地混合。

16. 发明授权

US5739168A Germicidal-disinfectant detergent composition 失效
公开(公告)号：US5739168A
公开(公告)日：1998-04-14
申请号：US925651
申请日：1997-09-09
申请人： Yuichi Hioki , Tadashi Moriyama , Chikako Ikeda , Juri Okamoto , Yoshinori Tamura
发明人： Yuichi Hioki , Tadashi Moriyama , Chikako Ikeda , Juri Okamoto , Yoshinori Tamura
IPC分类号： A01N33/12 , A01N47/44 , C11D1/02 , C11D3/06 , C11D3/20 , C11D3/33 , C11D3/36 , C11D3/37 , C11D3/48
CPC分类号： C11D3/48 , A01N33/12 , A01N47/44 , C11D1/02 , C11D3/06 , C11D3/2082 , C11D3/2086 , C11D3/33 , C11D3/36 , C11D3/361 , C11D3/3749 , C11D3/3765
摘要： A germicidal-disinfectant detergent composition comprising (a) a cationic germicide, (b) a metal chelating agent and (c) at least one surfactant selected from anionic surfactants, nonionic surfactants and amphoteric surfactants is described. Excellent detergency and germicidal action are provided.

17. 发明申请

US20130231485A1 CRYSTAL OF 6,7-UNSATURATED-7-CARBAMOYL MORPHINAN DERIVATIVE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译： 6,7-不饱和七碳烯醇衍生物的晶体及其生产方法
公开(公告)号：US20130231485A1
公开(公告)日：2013-09-05
申请号：US13884770
申请日：2011-11-11
申请人： Yoshinori Tamura , Kouichi Noguchi , Masanao Inagaki , Kenji Morimoto , Nobuhiro Haga , Shinichi Oda , Sohei Omura
发明人： Yoshinori Tamura , Kouichi Noguchi , Masanao Inagaki , Kenji Morimoto , Nobuhiro Haga , Shinichi Oda , Sohei Omura
IPC分类号： C07D489/08 , C07C303/32 , C07C53/10 , C07C51/41 , C07D271/06 , C07C309/30
CPC分类号： C07D489/08 , A61K9/1629 , C07B2200/13 , C07C51/412 , C07C53/10 , C07C303/32 , C07C309/30 , C07D271/06
摘要： Stable crystalline forms of a compound represented by the formula (IA): an acid addition salt, and/or a solvate thereof are provided by the present invention. Said crystalline forms are extremely useful as materials for preparing medicines. Novel processes for preparing 6,7-unsaturated-7-carbamoyl morphinan derivatives are also provided by the present invention.
摘要翻译：由式（IA）表示的化合物的稳定结晶形式：酸加成盐和/或其溶剂合物由本发明提供。所述结晶形式作为制备药物的材料非常有用。制备6,7-不饱和-7-氨基甲酰吗啡喃衍生物的新方法也由本发明提供。

18. 发明授权

US08349024B2 Hair treatment composition 有权
标题翻译：头发处理组成
公开(公告)号：US08349024B2
公开(公告)日：2013-01-08
申请号：US13387381
申请日：2010-09-28
申请人： Juri Sata , Tomoko Uchiyama , Yoshinori Tamura
发明人： Juri Sata , Tomoko Uchiyama , Yoshinori Tamura
IPC分类号： A61Q5/10
CPC分类号： A61Q5/10 , A61K8/33 , A61Q5/04 , A61Q5/065 , A61Q5/08
摘要： Provided is a hair treatment composition capable of imparting good manageability and excellent hair feel to the hair upon finishing permanent wave or hair dye treatment. The hair treatment composition has the following components (A) and (B): (A) a compound represented by the following formula (1): R1O—(PO)n(EO)m—R2 (1) wherein R1 represents a linear or branched C8-12 alkyl or alkenyl group, PO represents a propyleneoxy group, EO represents an ethyleneoxy group, n represents an average addition mole number and is from 1.5 to 5.0, m represents an average addition mole number and is from 0 to 1.0, and R2 represents a hydrogen atom or a methyl group, and (B) at least one selected from keratin reducing agents, oxidizing agents, alkaline agents, and dyes for hair dye, wherein a content of an R1OH wherein R1 represents a linear or branched C8-12 alkyl or alkenyl group is 300 ppm or less.
摘要翻译：提供一种头发处理组合物，其能够在完成永久烫发或染发剂处理时赋予头发良好的可处理性和优异的头发感觉。毛发处理组合物具有以下成分（A）和（B）：（A）由下式（1）表示的化合物：R1O-（PO）n（EO）m-R2（1）其中R1表示直链或支链C 8-12烷基或烯基，PO表示丙烯氧基，EO表示乙烯氧基，n表示平均加成摩尔数，为1.5〜5.0，m表示平均加成摩尔数，为0〜1.0， R 2表示氢原子或甲基，（B）选自角蛋白还原剂，氧化剂，碱性试剂和染发剂中的至少一种，其中R1OH的含量，其中R1表示直链或支链的C8 -12烷基或链烯基为300ppm以下。

19. 发明申请

US20110014145A1 HAIR CONDITIONING COMPOSITION 有权
标题翻译：头发调理组合物
公开(公告)号：US20110014145A1
公开(公告)日：2011-01-20
申请号：US12933626
申请日：2009-04-03
申请人： Juri Sata , Yoshinori Tamura , Hiromoto Mizushima
发明人： Juri Sata , Yoshinori Tamura , Hiromoto Mizushima
IPC分类号： A61K8/81 , A61Q5/12
CPC分类号： A61K8/39 , A61Q5/12
摘要： Provided is a low odor hair conditioning composition which is free of oily and greasy feel upon finish, and can impart good manageability and moisturized feel. Specifically provided is a hair conditioning composition including a component (A): a compound represented by a general formula (1) R1O—(PO)n/(EO)m—R2 (1), where R1 represents a straight or branched, alkyl or alkenyl group having 8 to 12 carbon atoms, PO represents a propyleneoxy group, EO represents an ethyleneoxy group, an average addition mole number “n” represents a number of 1.5 to 3.0, an average addition mole number “m” represents a number of 0 to 1.0, and R2 represents a hydrogen atom or a methyl group; and a component (B): a surfactant other than the component (A), wherein a content of R1OH, where R1 represents a straight or branched, alkyl or alkenyl group having 8 to 12 carbon atoms, is 80 ppm or less.
摘要翻译：提供了一种低气味的头发调理组合物，其在完成后不含油性和油腻感，并且可以赋予良好的可管理性和保湿感。具体提供的是包含组分（A）：由通式（1）R1O-（PO）n /（EO）m -R2（1）表示的化合物的头发调理组合物，其中R 1表示直链或支链烷基或碳原子数为8〜12的烯基，PO表示丙烯氧基，EO表示乙烯氧基，平均加成摩尔数“n”表示1.5〜3.0的数，平均加成摩尔数“m”表示 0〜1.0，R2表示氢原子或甲基; 和组分（B）：除组分（A）以外的表面活性剂，其中R1表示碳原子数为8〜12的直链或支链烷基或烯基的R1OH的含量为80ppm以下。

20. 发明授权

US6008177A Germicidal composition 失效
标题翻译：杀菌组成
公开(公告)号：US6008177A
公开(公告)日：1999-12-28
申请号：US77875
申请日：1998-06-08
申请人： Juri Sata , Yoshinori Tamura , Keiko Hasebe , Tadashi Moriyama
发明人： Juri Sata , Yoshinori Tamura , Keiko Hasebe , Tadashi Moriyama
IPC分类号： A61K8/30 , A01N25/02 , A01N33/12 , A01N57/12 , A61K8/00 , A61K8/34 , A61K8/41 , A61K8/42 , A61K8/60 , A61K8/73 , A61Q5/02 , A61Q5/12 , A61Q17/00 , A61Q19/10 , C11D3/48 , C11D7/32 , C11D1/62 , C11D7/36
CPC分类号： A61Q17/005 , A01N33/12 , A01N57/12 , A61K8/416 , A61Q19/10 , A61Q5/02 , A61K2800/59
摘要： A germicidal composition comprising: i) a compound of formula (1): ##STR1## wherein at least one of R.sup.1, R.sup.2 and R.sup.3 represents a linear or branched C.sub.8-30 alkyl or alkenyl group and the remaining groups are the same or different and individually represent a methyl, ethyl or benzyl group; R.sup.4 represents a methyl or ethyl group; R.sup.5 represents a linear or branched C.sub.1-30 alkyl or alkenyl group, or a polyoxyalkylene alkyl ether or polyoxyalkylene alkenyl ether having a linear or branched C.sub.1-30 alkyl or alkenyl group; and M represents a hydrogen atom or an alkali metal atom; andii) a compound of formula (2): ##STR2## wherein R.sup.1 to R.sup.4 have the same meanings as defined above and R.sup.6 and R.sup.7 are the same or different and individually have the same meanings as R.sup.5, wherein the weight ratio of compound (1) to compound (2) is from 99:1 to 80:20.
摘要翻译： PCT No.PCT / JP96 / 03451。 371日期：1998年6月5日 102（e）1998年6月8日PCT PCT 1996年11月26日PCT公布。公开号WO97 / 21348 日期：1997年6月19日一种杀菌组合物，其包含：i）式（1）化合物：其中R 1，R 2和R 3中的至少一个表示直链或支链C 8-30烷基或烯基，其余基团相同或不同且单独表示甲基，乙基或苄基; R4表示甲基或乙基; R5表示直链或支链C1-30烷基或烯基，或具有直链或支链C1-30烷基或烯基的聚氧化烯烷基醚或聚氧化烯链烯基醚; M表示氢原子或碱金属原子; 和ii）式（2）的化合物：其中R 1至R 4具有与上述相同的含义，R 6和R 7相同或不同，并且各自具有与R 5相同的含义，其中化合物（1）与化合物（2）为99:1至80:20。

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