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11. 发明申请

WO2011012271A2 METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS 审中-公开
标题翻译：制备N-取代的吡啶鎓化合物的方法和物质
公开(公告)号：WO2011012271A2
公开(公告)日：2011-02-03
申请号：PCT/EP2010/004524
申请日：2010-07-23
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , HEINDL, Dieter , GEBAUER, Peter
发明人： HEINDL, Dieter , GEBAUER, Peter
IPC分类号： C07D213/80 , C07D213/803
CPC分类号： C07D213/803 , C07D213/80
摘要： The present invention relates to a method for the synthesis of N-substituted carboxylated pyridinium compounds by reacting a pentamethine precursor with a primary amine. In this reaction an N-substituted alkoxycarbonyl pyridinium heterocycle is formed.
摘要翻译：本发明涉及通过使五甲胺前体与伯胺反应来合成N-取代的羧化吡啶鎓化合物的方法。在该反应中，形成N-取代的烷氧基羰基吡啶鎓杂环。

12. 发明申请

WO2008141799A1 OLIGOPHOSPHORAMIDATES 审中-公开
公开(公告)号：WO2008141799A1
公开(公告)日：2008-11-27
申请号：PCT/EP2008/004022
申请日：2008-05-20
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , HEINDL, Dieter , SEIDEL, Christoph , THUER, Wilma
发明人： HEINDL, Dieter , SEIDEL, Christoph , THUER, Wilma
IPC分类号： C07F9/24 , C08G79/04
CPC分类号： C07F9/585 , C07F9/5355 , C07F9/62 , C07F9/65062 , C07F9/65515 , C07F9/655363 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C08G79/04 , Y02P20/55
摘要： The trivalent phosphorous atom of a compound is reacted with a reagent in such a manner that a stable phosphate mimetic is formed. Phosphoramidites with a phosphorous atom containing at least one hydroxyl residue which is provided with a protective group are reacted for this purpose with a free hydroxyl group: In the first synthesis cycle the hydroxyl group is linked to a solid support via a cleavable or non-cleavable linker. In further synthesis cycles the hydroxyl group is created by cleavage of the protective group from the growing oligomer. This results in formation of a phosphorous acid triester which is reacted with azides. Compounds of Formula (I) are produced.
摘要翻译：使化合物的三价磷原子与试剂反应，形成稳定的磷酸酯模拟物。具有含有至少一个含有保护基团的羟基残基的磷原子的亚磷酰胺与该游离羟基反应：在第一个合成循环中，羟基通过可裂解或不可切割的方式与固体支持物连接连接。在进一步的合成循环中，通过从生长的低聚物中切割保护基而产生羟基。这导致形成与叠氮化物反应的亚磷酸三酯。制备式（I）的化合物。

13. 发明申请

WO2008052742A1 NEW DS DNA BINDING FLUORESCENT DYES 审中-公开
标题翻译：新DS DNA结合荧光染料
公开(公告)号：WO2008052742A1
公开(公告)日：2008-05-08
申请号：PCT/EP2007/009407
申请日：2007-10-30
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , JOSEL, Hans-Peter , HEINDL, Dieter , IRLINGER, Bernhard , WEILKE, Christian
发明人： JOSEL, Hans-Peter , HEINDL, Dieter , IRLINGER, Bernhard , WEILKE, Christian
IPC分类号： C09B23/04 , C12Q1/68
CPC分类号： C09B23/04
摘要： The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C-atom and (ii) the 5- and 6-positions of the pyrimidine ring are an integral part of a further aromatic ring structure.
摘要翻译：本发明涉及包含苯并噻唑鎓部分和通过单次甲基桥连接的嘧啶鎓部分的荧光染料，其特征在于（i）嘧啶的2-位携带以C原子开始的取代基和（ ii）嘧啶环的5-和6-位是另外的芳环结构的组成部分。

14. 发明申请

WO2022084362A1 DETECTION OF AN ANALYTE OF INTEREST BY NANOESI MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2022084362A1
公开(公告)日：2022-04-28
申请号：PCT/EP2021/079018
申请日：2021-10-20
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , KOBOLD, Uwe , REMPT, Martin , ZUTH, Christoph
IPC分类号： G01N33/68 , C07D249/06 , C07K1/36
摘要： The present invention relates to a method, a diagnostic system, a kit and the use thereof for efficiently detection of an analyte of interest by nanoESI mass spectrometry.

15. 发明申请

WO2021234004A1 IMIDAZOLIUM REAGENT FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2021234004A1
公开(公告)日：2021-11-25
申请号：PCT/EP2021/063298
申请日：2021-05-19
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HAHN, Robert , HEINDL, Dieter , JOSEL, Hans-Peter , KOBOLD, Uwe , KUCHELMEISTER, Hannes , MAZZIER, Daniela , PRENCIPE, Giuseppe , REMPT, Martin , SEIDEL, Christoph
IPC分类号： C07D233/90
摘要： The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

16. 发明申请

WO2021224361A2 SEMI-SYNTHESIS AND USE OF RACEMIC HEMATOXYLIN 审中-公开
公开(公告)号：WO2021224361A2
公开(公告)日：2021-11-11
申请号：PCT/EP2021/061930
申请日：2021-05-06
申请人： VENTANA MEDICAL SYSTEMS, INC. , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： DURRANT, Edward E. , HEINDL, Dieter , HUBER, Florian , KLEIN, Eric , KOSMEDER, Jerome W. Il , VOSS, Edgar
IPC分类号： G01N1/30
摘要： A racemic hematoxylin formulation is disclosed that includes one or both of a stabilizer compound and an antioxidant. The disclosed composition exhibits sufficient stability to be utilized in an automated staining process. Methods of using and making the stabilized composition also are disclosed.

17. 发明申请

WO2018115237A1 METHOD FOR IDENTIFYING A REAGENT DURING A PROCESS IN AN ANALYSIS SYSTEM 审中-公开
公开(公告)号：WO2018115237A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/084012
申请日：2017-12-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , KOBOLD, Uwe , SEIDEL, Christoph , REMPT, Martin
IPC分类号： G01N30/06 , G01N30/28 , G01N30/46 , G01N30/72 , G01N33/58
摘要： A method for identifying a reagent during a process in an analysis system (100) is disclosed. The analysis system (100) comprises a liquid chromatograph (102) and a mass spectrometer (104). The method comprises providing a reagent (130), adding at least one chemical substance (134) to the reagent (130) with a concentration being below a detection level of the mass spectrometer (104), enriching the chemical substance (134) within the liquid chromatograph (102) to a concentration above the detection level of the mass spectrometer (104), processing the reagent (130) together with the enriched chemical substance (134) by means of the analysis system (100), and identifying the reagent (130) based on a detection of a substance detection signal of the mass spectrometer (104) representing the chemical substance (134).

18. 发明申请

WO2016026959A1 REDOXINDICATORS 审中-公开
公开(公告)号：WO2016026959A1
公开(公告)日：2016-02-25
申请号：PCT/EP2015/069249
申请日：2015-08-21
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GEBAUER, Peter , HEINDL, Dieter , HORN, Carina , FOMIN, Maksim
IPC分类号： C07D401/06 , C07D241/40
CPC分类号： G01N33/52 , C07D241/40 , C07D241/42 , C07D401/06 , C07D403/06 , G01N33/5005
摘要： The present invention relates to a chemical compound or a salt or solvate thereof being a phenazine-, phenanthridine-, phenanthroline-, quinoline-, quinoxaline-, acridine- isoquinoline-, pyrazine- or pyridme-derivative comprising a conjugated π-system and a π-acceptor group, and to uses thereof. The present invention further relates to a chemistry matrix and to a test element comprising the chemical compound of the present invention. The present invention also relates to a method of determining the amount of an analyte in a test sample, comprising contacting said test sample with a chemical compound, with a chemistry matrix, or with a test element of the invention and estimating the amount of redox equivalents liberated or consumed by the chemical compound, by the chemical compound comprised in said chemistry matrix, or by the chemical compound comprised in said test element, in the presence of said test sample, thereby determining the amount of an analyte in said test sample. Moreover, the present invention relates to a system comprising a test element according to the present invention and a device comprising a sensor for measuring the amount of redox equivalents liberated or consumed.
摘要翻译：本发明涉及化合物或其盐或溶剂化物，其为包括共轭π系统的吩嗪，菲啶，菲咯啉，喹啉，喹喔啉，吖啶 - 异喹啉，吡嗪 - 或吡啶衍生物 π-受体基团及其用途。本发明还涉及化学基质和包含本发明化合物的测试元件。本发明还涉及确定测试样品中分析物的量的方法，包括使所述测试样品与化学基质或本发明的测试元件接触，并估算氧化还原当量的量由所述化学基质中包含的化合物或由所述测试元件中包含的化合物在所述测试样品存在下释放或消耗，从而确定所述测试样品中分析物的量。此外，本发明涉及包括根据本发明的测试元件的系统和包括用于测量释放或消耗的氧化还原当量的量的传感器的装置。

19. 发明申请

WO2015091958A1 COMPOUNDS COMPRISING ONE OR MORE HYDROPHOBIC DOMAINS AND A HYDROPHILIC DOMAIN COMPRISING PEG MOIETIES, USEFUL FOR BINDING CELLS 审中-公开
标题翻译：包含一个或多个疏水性域的化合物和包含PEG活性的亲水性域，有用于结合细胞
公开(公告)号：WO2015091958A1
公开(公告)日：2015-06-25
申请号：PCT/EP2014/078758
申请日：2014-12-19
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： JOSEL, Hans-Peter , HEINDL, Dieter , FROEHLICH, Thomas , FROEHNER, Stefanie
IPC分类号： G01N33/50 , C07J51/00 , C12N5/00 , C12N11/00 , C12N11/06 , G01N33/543
CPC分类号： G01N33/56972 , C07D311/04 , C07D311/82 , C07D495/04 , C07J9/00 , C07J17/00 , C07J51/00 , C12N11/06 , G01N33/5005 , G01N33/54353 , G01N33/56966 , G01N33/582
摘要： The present invention relates to novel compounds comprising one or more hydrophobic domains and a hydrophilic domain comprising PEG moieties, useful for binding cells, as well as uses and compositions related thereto. The compounds are useful for immobilizing and/or stabilizing cells.
摘要翻译：本发明涉及包含一个或多个疏水结构域和包含PEG部分的亲水结构域，可用于结合细胞的新型化合物，以及与其相关的用途和组合物。这些化合物可用于固定和/或稳定细胞。

20. 发明申请

WO2014195363A1 NOVEL COMPOUNDS USEFUL FOR FRET AND METHODS RELATED THERETO 审中-公开
标题翻译：有用的新型化合物和与之相关的方法
公开(公告)号：WO2014195363A1
公开(公告)日：2014-12-11
申请号：PCT/EP2014/061589
申请日：2014-06-04
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： HEINDL, Dieter , HOENES, Joachim , HORN, Carina , MEIER, Thomas , PETRICH, Wolfgang
IPC分类号： C12Q1/00 , C12Q1/26 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/573 , G01N33/58 , C12Q1/68
CPC分类号： C07H19/207 , C12Q1/26 , G01N21/6428 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/5735 , G01N33/581 , G01N33/582 , G01N2201/062 , G01N2333/90248
摘要： The invention relates to compounds, which are useful for intramolecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.
摘要翻译：本发明涉及可用于分子内荧光共振能量转移（FRET）的化合物，其包含基于carbaNADH的第一荧光团的氧化形式和在445至540nm的波长处可激发的第二荧光团，具有大于560nm的发射最大值，以及与其相关的方法，试剂盒和组合物。

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