专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US07627373B2 Method and apparatus for cell and electrical therapy of living tissue 有权
标题翻译：活体组织细胞和电疗法的方法和装置
公开(公告)号：US07627373B2
公开(公告)日：2009-12-01
申请号：US10723258
申请日：2003-11-25
申请人： Steven D. Girouard , Rodney W. Salo , Bruce H. KenKnight
发明人： Steven D. Girouard , Rodney W. Salo , Bruce H. KenKnight
IPC分类号： A61N1/00
CPC分类号： A61N1/362
摘要： A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
摘要翻译：一种用于生物组织的细胞和电疗法的方法，包括将外源细胞施用到损伤组织的区域中并施加电能。在一个应用中，组合的细胞和电疗法在体内应用于损伤的心脏组织。在这样的应用中，使用微创手术来应用细胞治疗，并且通过可植入脉冲发生器提供电疗法。在一个应用中，可以使用植入式起搏器进行VDD模式，与内在房室延迟相比，房室延迟保持相对较短。

12. 发明申请

US20090254137A1 Temperature Based Systems and Methods for Tachycardia Discrimination and Therapy 有权
标题翻译：基于温度的系统和方法用于心动过速鉴别和治疗
公开(公告)号：US20090254137A1
公开(公告)日：2009-10-08
申请号：US12411157
申请日：2009-03-25
申请人： Rodney W. Salo , Allan Charles Shuros , Dan Li
发明人： Rodney W. Salo , Allan Charles Shuros , Dan Li
IPC分类号： A61N1/05
CPC分类号： A61N1/3622 , A61N1/3962
摘要： Embodiments of the invention are related to an implantable medical system, amongst other things. In an embodiment, the invention includes a processor, an electrical sensor, and a temperature sensor. The processor is configured to monitor myocardial electrical activity with input from the electrical sensor; identify myocardial electrical activity indicative of an arrhythmia, measure temperature of blood in the coronary venous system with input from the temperature sensor; determine if the arrhythmia is hemodynamically stable or hemodynamically unstable based on the temperature of blood in the coronary venous system, and initiate high-voltage shock therapy if the arrhythmia is hemodynamically unstable. Other embodiments are also included herein.
摘要翻译：本发明的实施例涉及可植入医疗系统等。在一个实施例中，本发明包括处理器，电传感器和温度传感器。处理器被配置为通过来自电传感器的输入来监测心肌电活动; 识别指示心律失常的心肌电活动，用来自温度传感器的输入测量冠状静脉系统中血液的温度; 根据冠状静脉系统中的血液温度，确定心律失常是否为血液动力学稳定或血液动力学不稳定，如果心律失常是血液动力学不稳定的话，开始进行高压休克治疗。本文还包括其它实施例。

13. 发明授权

US07580745B2 Method and apparatus for using heart rate variability to control maximum tracking rate in pacing therapy 有权
标题翻译：心率变异性控制起搏治疗最大跟踪率的方法和装置
公开(公告)号：US07580745B2
公开(公告)日：2009-08-25
申请号：US11037723
申请日：2005-01-18
申请人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
发明人： Joseph M. Pastore , Rodney W. Salo , Gerrard M. Carlson , Andrew P. Kramer , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/365
CPC分类号： A61B5/02405 , A61B5/4035 , A61N1/36114 , A61N1/36592 , A61N1/368
摘要： A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used to adjust a maximum tracking rate in an atrial tracking pacing mode.
摘要翻译：心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。在一个实施例中，HRV参数用于调整心房跟踪起搏模式中的最大跟踪率。

14. 发明申请

US20090062895A1 MEDICAL DEVICE ELECTRODES INCLUDING NANOSTRUCTURES 失效
标题翻译：包括纳米结构的医疗器械电极
公开(公告)号：US20090062895A1
公开(公告)日：2009-03-05
申请号：US11846246
申请日：2007-08-28
申请人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
发明人： Jeffrey E. Stahmann , Rodney W. Salo , Jihong Qu
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/056 , A61N1/0565 , A61N1/375 , Y10S977/931
摘要： Electrodes for tissue stimulation and sensing can comprise a support with nanostructures disposed on the support. Pairs of the electrodes can be placed in close proximity to one another. When electrical energy is supplied to the electrodes, an electrical field (and possibly an electrical current) can be established between the nanostructures on the electrodes. The nanostructures may have cells disposed thereon, for example myocardial cells, myocardial progenitor cells, neural cells and/or stem cells. In addition, the electrodes can be arranged in arrays.
摘要翻译：用于组织刺激和感测的电极可以包括具有设置在支撑体上的纳米结构的支撑体。电极对可以彼此靠近放置。当向电极提供电能时，可以在电极上的纳米结构之间建立电场（和可能的电流）。纳米结构可以具有设置在其上的细胞，例如心肌细胞，心肌祖细胞，神经细胞和/或干细胞。此外，电极可以排列成阵列。

15. 发明申请

US20080234772A1 METHOD AND DEVICE FOR MYOCARDIAL STRESS REDISTRIBUTION 有权
标题翻译：用于心肌应激再分配的方法和装置
公开(公告)号：US20080234772A1
公开(公告)日：2008-09-25
申请号：US11689032
申请日：2007-03-21
申请人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
发明人： Allan C. Shuros , Rodney W. Salo , Shantha Arcot-Krishnamurthy
IPC分类号： A61N1/362
CPC分类号： A61N1/3627
摘要： Methods and devices are described for delivering electrical stimulation to the heart in a manner that advantageously redistributes myocardial stress during systole for therapeutic purposes in the treatment of, for example, post-MI and HF patients. Pre-excitation pacing may be applied to deliberately de-stress a particular myocardial region that may be expected to undergo deleterious remodeling, such an the area around a myocardial infarct or a hypertrophying region or to deliberately stress a region remote from the pre-excitation pacing site in order to exert a cardioprotective conditioning effect, similar to the beneficial effects of exercise. Pre-excitation pacing may be advantageously combined with inotropic electrical stimulation applied to the stressed region.
摘要翻译：描述了将方法和装置以有效地将收缩期内的心肌应力重新分配到治疗目的的治疗目的的心脏和心脏病和心脏病患者的方式，以向心脏递送电刺激。预激发起搏可用于故意减压可能预期会发生有害重塑的特定心肌区域，例如心肌梗塞或肥大区域周围的区域，或故意压迫远离预激励起搏的区域为了发挥心脏保护性调理作用，类似于运动的有益效果。预激发起搏可以有利地与施加到应激区域的变力电刺激组合。

16. 发明申请

US20080195174A1 SYSTEMS AND METHODS FOR ELECTRICAL STIMULATION OF BLOOD VESSELS 失效
标题翻译：血管电刺激系统与方法
公开(公告)号：US20080195174A1
公开(公告)日：2008-08-14
申请号：US11674463
申请日：2007-02-13
申请人： Joseph Walker , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Eric Mokelke
发明人： Joseph Walker , Rodney W. Salo , Anand Iyer , Joseph M. Pastore , Eric Mokelke
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Disclosed herein, among other things, is a system for electrical stimulation of blood vessels. An embodiment of the system includes at least one electrode having electrical contact with a blood vessel. The embodiment also includes a stimulation circuit electrically connected to the electrode, the circuit adapted to provide stimulation to the vessel. The embodiment further includes a controller connected to the circuit, the controller adapted to select frequency and voltage parameters for the stimulation circuit to selectively affect vascular therapy, including constriction of the vessel and dilation of the vessel. According to various embodiments, the stimulation circuit and controller are contained within an implantable medical device (IMD). The system also includes a sensor connected to the controller, and the controller initiates and adjusts therapy based on a signal received from the sensor, in varying embodiments.
摘要翻译：此处公开的是用于电刺激血管的系统。该系统的一个实施例包括至少一个与血管电接触的电极。该实施例还包括电连接到电极的刺激电路，该电路适于向容器提供刺激。该实施例还包括连接到电路的控制器，所述控制器适于选择用于刺激电路的频率和电压参数，以选择性地影响血管治疗，包括容器收缩和血管扩张。根据各种实施例，刺激电路和控制器被包含在可植入医疗装置（IMD）内。该系统还包括连接到控制器的传感器，并且在不同的实施例中，控制器基于从传感器接收的信号来启动和调整治疗。

17. 发明申请

US20080188730A1 DEVICE FOR MONITORING FLUID STATUS 有权
标题翻译：用于监测流体状态的装置
公开(公告)号：US20080188730A1
公开(公告)日：2008-08-07
申请号：US12098644
申请日：2008-04-07
申请人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
发明人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61B5/05
CPC分类号： A61B5/0538 , A61B5/053 , A61B5/14535 , A61N1/36521
摘要： A technique for determining a patient's hematocrit by an electrical impedance measurement is described. An implantable device may be configured to utilize the technique in order to assess a cardiac patient's fluid status. In order to determine the hematocrit, the electrical impedance of the blood is measured and mapped by a mapping function to a corresponding hematocrit value.
摘要翻译：描述了通过电阻抗测量来确定患者的血细胞比容的技术。可植入装置可被配置为利用该技术来评估心脏病人的流体状态。为了确定血细胞比容，测量血液的电阻抗并通过映射函数映射到相应的血细胞比容值。

18. 发明申请

US20080086036A1 METHOD AND APPARATUS FOR CONTROLLING CARDIAC THERAPY USING ULTRASOUND TRANSDUCER 有权
标题翻译：使用超声波传感器控制心脏治疗的方法和装置
公开(公告)号：US20080086036A1
公开(公告)日：2008-04-10
申请号：US11539939
申请日：2006-10-10
申请人： Jesse W. Hartley , Joseph M. Pastore , Rodney W. Salo , Andrew P. Kramer , Jeffrey E. Stahmann
发明人： Jesse W. Hartley , Joseph M. Pastore , Rodney W. Salo , Andrew P. Kramer , Jeffrey E. Stahmann
IPC分类号： A61N1/08
CPC分类号： A61N1/3627 , A61N1/36528
摘要： A cardiac rhythm management (CRM) system provides for post-myocardial infarction (MI) therapy with closed-loop control using one or more ultrasound transducers sensing one or more ultrasound signals indicative of cardiac dimensions. Cardiac size parameters are produced using the one or more ultrasound signals to represent, for example, cardiac chamber diameter, cardiac chamber volume, cardiac wall thickness, infarct size, and degree of change in any of these parameters over time or between measurements. In various embodiments, such cardiac size parameters provide for titration, safety check, and acute optimization of the post-MI therapy.
摘要翻译：心律控制（CRM）系统通过使用一个或多个超声换能器感测一个或多个指示心脏尺寸的超声信号，通过闭环控制提供心肌梗死后心肌梗死（MI）治疗。使用一个或多个超声信号产生心脏尺寸参数，以表示例如心脏室直径，心室容积，心壁厚度，梗塞面积以及随时间或测量之间的任何这些参数的变化程度。在各种实施方案中，这种心脏尺寸参数提供滴定，安全性检查和MI后治疗的急性优化。

19. 发明授权

US07194307B2 Pacing method and device for preserving native conduction system 失效
标题翻译：起搏方法和保存天然传导系统的装置
公开(公告)号：US07194307B2
公开(公告)日：2007-03-20
申请号：US10744952
申请日：2003-12-22
申请人： Rodney W. Salo , Bruce H. KenKnight , Joseph M. Pastore , Steven D. Girouard
发明人： Rodney W. Salo , Bruce H. KenKnight , Joseph M. Pastore , Steven D. Girouard
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： An implantable device for delivering cardiac pacing therapy in order to improve cardiac function is programmed to allow some amount of intrinsic activity to occur without otherwise the disturbing the pacing algorithm used to deliver therapy. Intrinsic cardiac cycles utilize the heart's native conduction system and thus serve to prevent the atrophy which may otherwise result from continuous pacing.
摘要翻译：用于递送心脏起搏治疗以改善心脏功能的可植入装置被编程为允许发生一定量的内在活动，而无需另外打扰用于递送治疗的起搏算法。内在心脏周期利用心脏的天然传导系统，从而用于预防由连续起搏引起的萎缩。

20. 发明授权

US07177688B2 Cardiac rhythm management system with optimization of cardiac performance using heart rate 有权
标题翻译：心脏节律管理系统使用心率优化心脏性能
公开(公告)号：US07177688B2
公开(公告)日：2007-02-13
申请号：US11018124
申请日：2004-12-21
申请人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
发明人： Rodney W. Salo , Kenneth L. Baker , Lawrence S. Baumann
IPC分类号： A61N1/18
CPC分类号： A61N1/3702 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688
摘要： A method of optimizing inter-site delay is disclosed for a cardiac rhythm management device that includes a dual chamber pacemaker, especially designed for treating congestive heart failure by pacing a plurality of sites. A microcontroller is operative to adjust the pacing mode and inter-site delay of the pacemaker so as to achieve optimum hemodynamic performance. Atrial cycle lengths measured during transient (immediate) time intervals following a change in the mode inter-site delay are signal processed and a determination can then be made as to which particular configuration yields the optimum performance. Performance is optimized when the patient is at rest and when the patient exercises so that a rate-adapted dynamic value of the optimum performance can be applied.
摘要翻译：公开了一种用于心脏节律管理装置的优化站间延迟的方法，其包括双室起搏器，其特别设计用于通过起搏多个部位来治疗充血性心力衰竭。微控制器可用于调节起搏器的起搏模式和站间延迟，以达到最佳的血流动力学性能。信号处理后的瞬时（即时）时间间隔内测量的心房周期长度被信号处理，然后可以确定哪个特定配置产生最佳性能。当患者处于静止状态并且患者锻炼时优化性能，以便可以应用最佳性能的速率适应动态值。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式