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11. 发明申请

WO2019236654A3 VALVE REPAIR AND PROCEDURES 审中-公开
公开(公告)号：WO2019236654A3
公开(公告)日：2019-12-12
申请号：PCT/US2019/035495
申请日：2019-06-05
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： IVERSEN, Sven, Benjamin , YESTREPSKY, Adam, J. , MUNNELLY, Amy, E. , TIAN, Bin , BALDO, Danny, Barrientos , CONKLIN, Brian, S. , CAMPBELL, Louis, A. , CARPENTER, John, Richard
IPC分类号： A61F2/24 , A61B17/04
摘要： Valve repair devices and anchors are suitable for a method for repairing or simulating the repair of a native valve of a patient during a non-open-heart procedure, which includes attaching two or more attachment members to the native valve. The method also includes applying a force to the two or more attachment members such that the two or more attachment members cause a cinching effect on at least a portion of the native valve. The method further includes securing the two or more attachment members with one or more anchor members such that the two or more attachment members maintain the cinching effect.

12. 发明公开

EP3965841A1 BIOPROSTHETIC TISSUE PREPARATION 审中-实审
公开(公告)号：EP3965841A1
公开(公告)日：2022-03-16
申请号：EP20828493.5
申请日：2020-12-08
申请人： Edwards Lifesciences Corporation
发明人： TIAN, Bin , DE LA FUENTE, Angela B. , WRIGHT, Gregory A. , HAN, Jingjia , SHANG, Hao
IPC分类号： A61L27/36

13. 发明公开

EP3773337A2 VALVE REPAIR DEVICES AND PROCEDURES 审中-实审
公开(公告)号：EP3773337A2
公开(公告)日：2021-02-17
申请号：EP19733278.6
申请日：2019-06-05
申请人： Edwards Lifesciences Corporation
发明人： IVERSEN, Sven, Benjamin , YESTREPSKY, Adam, J. , MUNNELLY, Amy, E. , TIAN, Bin , BALDO, Danny, Barrientos, Jr. , CONKLIN, Brian, S. , CAMPBELL, Louis, A. , CARPENTER, John, Richard
IPC分类号： A61F2/24 , A61B17/04

14. 发明授权

EP2077718B1 BIOLOGICAL TISSUE FOR SURGICAL IMPLANTATION 有权
标题翻译：生物组织通过外科手术移植
公开(公告)号：EP2077718B1
公开(公告)日：2014-12-03
申请号：EP07871218.9
申请日：2007-10-23
申请人： Edwards Lifesciences Corporation
发明人： TIAN, Bin , DAVIDSON, Jim
IPC分类号： A61L27/36 , A61L27/50 , A01N1/02 , A61F2/24
CPC分类号： A61F2/2415 , A01N1/0215 , A61L27/3604 , A61L27/3687 , A61L27/507 , A61L2430/40
摘要： The present invention relates to methods of manufacturing a bioprosthetic heart valve, comprising the steps of providing a biological tissue and a stent, contacting the biological tissue with a treatment solution comprising a polyhydric alcohol and a C 1 -C 3 alcohol, and mounting the tissue to the stent to produce the bioprosthetic heart valve. The present invention further relates to a respective heart valve that is packaged in a non-fluid environment.

15. 发明公开

EP3600159A1 SYSTEM AND METHOD FOR IMPLANTING AND SECURING A BIOPROSTHETIC DEVICE TO WET TISSUE 有权
公开(公告)号：EP3600159A1
公开(公告)日：2020-02-05
申请号：EP18770181.8
申请日：2018-03-21
申请人： Edwards Lifesciences Corporation
发明人： TIAN, Bin , RODRIGUEZ, Rodolfo , CAMPBELL, Louis A. , CLAESSENS, Steven M. , MARTINEZ, Carolyn Sue
IPC分类号： A61F2/24 , A61L24/04 , A61B17/00

16. 发明公开

EP3636293A1 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 审中-公开
公开(公告)号：EP3636293A1
公开(公告)日：2020-04-15
申请号：EP19203220.9
申请日：2011-03-23
申请人： Edwards Lifesciences Corporation
发明人： DOVE, Jeffrey S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey S. , JANKOVIC, Ivan , MIGLIAZZA, John F. , WRIGHT, Gregory A. , YOUNG, James M. , CAMPBELL, Louis A.
IPC分类号： A61L27/36
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.

17. 发明授权

EP2549957B1 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 有权
公开(公告)号：EP2549957B1
公开(公告)日：2019-01-30
申请号：EP11760162.5
申请日：2011-03-23
申请人： Edwards Lifesciences Corporation
发明人： DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
IPC分类号： A61F2/24 , A61L27/36 , A61L27/50

18. 发明公开

EP2549957A2 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 有权
标题翻译：方法处理的圆盘状的生物假体组构
公开(公告)号：EP2549957A2
公开(公告)日：2013-01-30
申请号：EP11760162.5
申请日：2011-03-23
申请人： Edwards Lifesciences Corporation
发明人： DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
IPC分类号： A61F2/24 , A61L27/38 , D06M10/00 , D06M10/04
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.

19. 发明公开

EP2077718A2 BIOLOGICAL TISSUE FOR SURGICAL IMPLANTATION 有权
标题翻译：生物组织通过外科手术移植
公开(公告)号：EP2077718A2
公开(公告)日：2009-07-15
申请号：EP07871218.9
申请日：2007-10-23
申请人： Edwards Lifesciences Corporation
发明人： TIAN, Bin , DAVIDSON, Jim
IPC分类号： A01N1/02 , A61F2/24
CPC分类号： A61F2/2415 , A01N1/0215 , A61L27/3604 , A61L27/3687 , A61L27/507 , A61L2430/40
摘要： The present invention relates to methods of manufacturing a bioprosthetic heart valve, comprising the steps of providing a biological tissue and a stent, contacting the biological tissue with a treatment solution comprising a polyhydric alcohol and a C 1 -C 3 alcohol, and mounting the tissue to the stent to produce the bioprosthetic heart valve. The present invention further relates to a respective heart valve that is packaged in a non-fluid environment.

20. 发明公开

EP3220995A1 INFLATABLE DEVICE WITH ETCHED MODIFICATIONS 有权
标题翻译：具有蚀刻修改的充气装置
公开(公告)号：EP3220995A1
公开(公告)日：2017-09-27
申请号：EP15860079.1
申请日：2015-11-12
申请人： Edwards Lifesciences Corporation
发明人： ZHOU, Pu , TIAN, Bin , ZHU, Yidong M.
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/1086 , B23K26/0624 , B23K26/361 , B23K26/362 , B23K26/402 , B23K2203/42 , B23K2203/50
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
摘要翻译：公开了可充气装置，其包括具有聚合物链网络并且被配置为可膨胀成治疗或诊断有用形状的表面，以及在表面中的至少一个超短激光脉冲形成的修饰。例如，网络可以包括通过用超短脉冲激光进行修改而基本不变的网络形态。超短激光脉冲可以是等于或小于1000皮秒的激光脉冲。有利地，蚀刻过程使用相对低热量的激光器以避免周围聚合物的显着加热，同时修改装置的表面（和其他结构）。该工艺被配置为使得邻近修饰的聚合物链形态基本上不受低热激光的影响。得到的充气装置具有定制的表面特征，同时仍保持基本均匀的聚合物网络形态。这保持了充气装置的弹性，特别是表面弹性。

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