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1. 发明申请

WO2021119391A1 HYBRID ANNULOPLASTY RING 审中-公开
公开(公告)号：WO2021119391A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/064443
申请日：2020-12-11
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： MIRAKI, Manouchehr, A. , HAN, Jingjia , TIAN, Bin , DA LA FUENTE, Angela, B. , GUI, Liqiong , SHANG, Hao , HOANG, Lien Houng Thi , DO, Vicky Hong
IPC分类号： A61L27/04 , A61L27/18 , A61L27/36 , A61L27/44
摘要： An annuloplasty ring prosthesis comprising a frame having an outer surface; and a cover surrounding the frame. The cover comprises a bioprosthetic tissue that can be regenerative or fixed and non-regenerative. The frame can be bioabsorbable or non- degradable. A ring prosthesis and a method of manufacturing a ring prosthesis is also provided. The ring prosthesis comprising an elongated rod member formed into a substantially ring shape, the elongated rod member being formed substantially from a flat bioprosthetic tissue.

2. 发明申请

WO2008073582A2 BIOLOGICAL TISSUE FOR SURGICAL IMPLANTATION 审中-公开
标题翻译：手术植入生物组织
公开(公告)号：WO2008073582A2
公开(公告)日：2008-06-19
申请号：PCT/US2007/082241
申请日：2007-10-23
申请人： EDWARDS LIFESCIENCES CORPORATION , TIAN, Bin , DAVIDSON, Jim
发明人： TIAN, Bin , DAVIDSON, Jim
IPC分类号： A01N1/02 , A61F2/24
CPC分类号： A61F2/2415 , A01N1/0215 , A61L27/3604 , A61L27/3687 , A61L27/507 , A61L2430/40
摘要： A method of treating a biological tissue that enables dry storage of said tissue is disclosed. In one embodiment, the method comprises contacting the biological tissue with a non-aqueous treatment solution comprising a polyhydric alcohol and a C 1 -C 3 alcohol and removing a portion of the treatment solution from the solution-treated biological tissue. Also disclosed is biological tissue prepared using the above process and prosthetic devices made with such tissue.
摘要翻译：公开了一种处理能够干燥储存所述组织的生物组织的方法。在一个实施方案中，该方法包括使生物组织与包含多元醇和C 1 -C 3醇的非水性处理溶液接触并除去处理溶液由溶液处理的生物组织。还公开了使用上述方法制备的生物组织和由这种组织制成的假体装置。

3. 发明申请

WO2022020335A1 ANTI-FOULING IMPLANTABLE MATERIAL AND METHOD OF MAKING 审中-公开
公开(公告)号：WO2022020335A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/042345
申请日：2021-07-20
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： TKATCHOUK, Ekaterina , DE LA FUENTE, Angela, B. , HAN, Jingjia , TIAN, Bin , GUI, Liqiong
IPC分类号： A61L27/14 , A61L27/34 , A61L27/50
摘要： An anti-fouling implantable material and a method of making the anti-fouling implantable material are disclosed. The anti-fouling implantable material includes a polymeric reinforcement layer, an intermediate layer comprising a protective polymer membrane, and an outer layer comprising an ionic polymer. The anti-fouling implantable material may have chemical and/or physical properties compatible with body tissue properties. The anti-fouling implantable material may be used for implantable medical devices, such as prosthetic heart valves and vascular grafts, among others.

4. 发明申请

WO2021118964A1 BIOPROSTHETIC TISSUE PREPARATION 审中-公开
公开(公告)号：WO2021118964A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/063728
申请日：2020-12-08
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： TIAN, Bin , DE LA FUENTE, Angela B. , WRIGHT, Gregory A. , HAN, Jingjia , SHANG, Hao
IPC分类号： A61L27/36
摘要： Methods for preparing bioprosthe tic tissue are provided. In some instances, bioprosthetic tissue is treated to remove antigenic biomolecules. In some instances, prepared bioprosthetic tissues are incorporated into a medical device.

5. 发明申请

WO2019236654A8 VALVE REPAIR DEVICES AND PROCEDURES 审中-公开
公开(公告)号：WO2019236654A8
公开(公告)日：2019-12-12
申请号：PCT/US2019/035495
申请日：2019-06-05
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： IVERSEN, Sven, Benjamin , YESTREPSKY, Adam, J. , MUNNELLY, Amy, E. , TIAN, Bin , BALDO, Danny, Barrientos, Jr. , CONKLIN, Brian, S. , CAMPBELL, Louis, A. , CARPENTER, John, Richard
IPC分类号： A61F2/24 , A61B17/04
摘要： Valve repair devices and anchors are suitable for a method for repairing or simulating the repair of a native valve of a patient during a non-open-heart procedure, which includes attaching two or more attachment members to the native valve. The method also includes applying a force to the two or more attachment members such that the two or more attachment members cause a cinching effect on at least a portion of the native valve. The method further includes securing the two or more attachment members with one or more anchor members such that the two or more attachment members maintain the cinching effect.

6. 发明申请

WO2019236654A2 VALVE REPAIR AND PROCEDURES 审中-公开
公开(公告)号：WO2019236654A2
公开(公告)日：2019-12-12
申请号：PCT/US2019/035495
申请日：2019-06-05
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： IVERSEN, Sven, Benjamin , YESTREPSKY, Adam, J. , MUNNELLY, Amy, E. , TIAN, Bin , BALDO, Danny, Barrientos , CONKLIN, Brian, S. , CAMPBELL, Louis, A. , CARPENTER, John, Richard
IPC分类号： A61F2/24 , A61B17/04
摘要： Valve repair devices and anchors are suitable for a method for repairing or simulating the repair of a native valve of a patient during a non-open-heart procedure, which includes attaching two or more attachment members to the native valve. The method also includes applying a force to the two or more attachment members such that the two or more attachment members cause a cinching effect on at least a portion of the native valve. The method further includes securing the two or more attachment members with one or more anchor members such that the two or more attachment members maintain the cinching effect.

7. 发明申请

WO2018175619A1 SYSTEM AND METHOD FOR IMPLANTING AND SECURING A BIOPROSTHETIC DEVICE TO WET TISSUE 审中-公开
公开(公告)号：WO2018175619A1
公开(公告)日：2018-09-27
申请号：PCT/US2018/023610
申请日：2018-03-21
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： TIAN, Bin , RODRIGUEZ, Rodolfo , CAMPBELL, Louis, A. , CLAESSENS, Steven, M. , MARTINEZ, Carolyn, Sue
IPC分类号： A61F2/24 , A61L24/04 , A61B17/00
摘要： Systems, devices, kits, and methods are described for securing a bioprosthetic heart valve within an anatomical feature of a patient. Kits can comprise a bioprosthetic heart valve, a curable composition, and an applicator configured to deliver the curable composition to a target area. The bioprosthetic heart valve can comprise a support structure and one or more valve leaflets coupled thereto. The support structure can comprise a sewing portion peripheral of the bioprosthetic heart valve. The support structure and the valve leaflets can define a central flow orifice. The curable composition can comprise a pre-polymer composition and an initiator. Methods can comprise positioning the bioprosthetic heart valve within the anatomical feature of a patient, applying the curable composition to one or both of the bioprosthetic heart valve and the anatomical feature, and curing the curable composition for a cure time. The applying can be performed before or after the positioning.

8. 发明申请

WO2016081279A1 INFLATABLE DEVICE WITH ETCHED MODIFICATIONS 审中-公开
标题翻译：具有蚀刻修改的可充电器件
公开(公告)号：WO2016081279A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/060443
申请日：2015-11-12
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： ZHOU, Pu , TIAN, Bin , ZHU, Yidong, M.
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61M2025/1031 , A61M2025/1086 , B23K26/0624 , B23K26/361 , B23K26/362 , B23K26/402 , B23K2203/42 , B23K2203/50
摘要： Inflatable devices are disclosed including a surface which has a network of polymer chains and is configured to be inflatable into a therapeutically or diagnostically useful shape, and at least one ultrashort laser pulse-formed modification in the surface. The network can, for example, include a network morphology that is substantially unchanged by modification with the ultrashort pulse laser. Ultrashort laser pulses can be laser pulses equal to or less than 1000 picoseconds in duration. Advantageously, the etching process uses a relatively low-heat laser to avoid significant heating of surrounding polymers while modifying the surface (and other structures) of the device. The process is configured so that the polymer chain morphology adjacent the modification is substantially unaffected by the low-heat laser. The resulting inflatable device has customized surface features while still retaining substantially homogenous polymer network morphology. This preserves the elasticity, especially the surface elasticity, of the inflatable device.
摘要翻译：公开了充气装置，其包括具有聚合物链网络并被配置为可膨胀成治疗或诊断上有用的形状的表面，以及表面中的至少一个超短激光脉冲形成的修饰。例如，网络可以包括通过使用超短脉冲激光器进行修改而基本上不变的网络形态。超短激光脉冲可以是等于或小于1000皮秒的激光脉冲。有利地，蚀刻工艺使用相对低热的激光器来避免周围聚合物的显着加热，同时改变装置的表面（和其它结构）。该方法被配置成使得邻近修饰的聚合物链形态基本上不受低热激光的影响。所得到的充气装置具有定制的表面特征，同时仍然保持基本均匀的聚合物网络形态。这保持了充气装置的弹性，特别是表面弹性。

9. 发明申请

WO2007044912A2 NON-NATIVE CONSTITUTIVELY ACTIVE OSTEOPONTIN 审中-公开
标题翻译：非局部组织活性OSTEOPONTIN
公开(公告)号：WO2007044912A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/040159
申请日：2006-10-11
申请人： EDWARDS LIFESCIENCES CORPORATION , TIAN, Bin
发明人： TIAN, Bin
IPC分类号： C07K14/43
CPC分类号： C07K14/52
摘要： Non-native constitutively phosphorylated forms of osteopontin are disclosed. Such osteopontin forms can be obtained, for example, using an expression vector comprising an isolated nucleic acid that encodes an osteopontin peptide, operably linked to a promoter wherein the osteopontin peptide is either constitutively phosphorylated or is capable of being constitutively phosphorylated. Also disclosed are mutant osteopontin peptides that are either constitutively phosphorylated, or are capable of being constitutively phosphorylated. The disclosed osteopontin forms have anti- calcification activity and, therefore, numerous applications. They can be used, for example, to create calcification-resistant tissue, or to treat calcification- related disease.
摘要翻译：公开了非天然组成型磷酸化形式的骨桥蛋白。这样的骨桥蛋白形式可以例如使用包含编码骨桥蛋白肽的分离的核酸的表达载体获得，其可操作地连接到启动子，其中骨桥蛋白肽被组成型磷酸化或能够被组成型磷酸化。还公开了组成型磷酸化或能够被组成型磷酸化的突变型骨桥蛋白肽。所公开的骨桥蛋白形式具有抗钙化活性，因此具有许多应用。例如，它们可用于产生抗钙化组织，或用于治疗与钙化有关的疾病。

10. 发明申请

WO2011119754A2 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 审中-公开
标题翻译：调节片生物组织的方法
公开(公告)号：WO2011119754A2
公开(公告)日：2011-09-29
申请号：PCT/US2011/029654
申请日：2011-03-23
申请人： EDWARDS LIFESCIENCES CORPORATION , DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
发明人： DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
IPC分类号： A61F2/24 , A61L27/38 , D06M10/00 , D06M10/04
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.
摘要翻译：生物假体材料调理方法采用牛心包膜。指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并平滑表面。选择激光器的波长，功率和脉冲速率，这将使纤维表面平滑，并将表面烧蚀到合适的厚度。或者，使用皮肤表面从膜的纤维表面去除一层材料。变薄也可能采用压缩。使用交联以稳定膜的逐步压缩来避免通过非弹性压缩损伤膜。相反，膜通过加成交联结合在弹性压缩状态。上述几种稀释技术可以一起使用以获得强的薄膜。然后可以通过封闭钙化成核位点和硼氢化钠还原来处理最终变薄的膜。传单可以形成为具有多于一个均匀厚度的区域，例如较厚的外围缝合区域。

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