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1. 发明申请

WO2019006387A1 DOCKING STATIONS TRANSCATHETER VALVES 审中-公开
公开(公告)号：WO2019006387A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040425
申请日：2018-06-29
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： TAYEB, Liron , GOLDBERG, Eran , MAIMON, David , CARMI, Adi , TYLIS, Arie , WITZMAN, Ofir , SCHNEIDER, Ralph , JAFARI, Mohammad , CAO, Hengchu , ABBOTT, Eason, Michael , ARMER, Dustin P. , FRANKLIN, Michael, D. , SAAR, Tomer , DVORSKY, Anatoly , DESROSIERS, John, J. , MURRAY, Daniel, James , VALDEZ, Michael, G. , BACH, Assaf , BLUMENFELD, Amir , AXELROD, Noa , ATIAS, Eitan
IPC分类号： A61F2/24 , A61B17/34
摘要： Docking stations for transcatheter valves are described. The docking stations can include an expandable frame, at least one sealing portion, and a valve seat. The expandable frame can be configured to conform to an interior shape of a portion of the circulatory system when expanded inside the circulatory system. The sealing portion can be configured to contact an interior surface of the circulatory system to create a seal. The valve seat can be connected to the expandable frame and can be configured to support an expandable transcatheter valve. The docking stations are adaptable to different anatomies/locations to allow implantation of a transcatheter valve in a variety of anatomies/locations.

2. 发明申请

WO2019199692A1 EXPANDABLE SHEATH 审中-公开
公开(公告)号：WO2019199692A1
公开(公告)日：2019-10-17
申请号：PCT/US2019/026383
申请日：2019-04-08
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： GOLDBERG, Eran , AXELROD, Noa , NEUMANN, Yair, A. , MANASH, Boaz , MAIMON, David , LEIBA, Eyal , SCHNEIDER, Ralph , TAYEB, Liron
IPC分类号： A61F2/24 , A61F2/962
摘要： An expandable sheath is disclosed herein, which has a first polymeric layer and a braided layer positioned radially outward of the first polymeric layer. The braided layer includes a plurality of filaments braided together. The expandable sheaths further include a resilient elastic layer positioned radially outward of the braided layer. The elastic layer is configured to apply radial force to the braided layer and the first polymeric layer. The expandable sheath further includes a second polymeric layer positioned radially outward of the elastic layer and bonded to the first polymeric layer such that the braided layer and the elastic layer are encapsulated between the first and second polymeric layers. Methods of making and using the devices disclosed herein are also disclosed, as are crimping devices that may be used in methods of making the devices disclosed herein.

3. 发明申请

WO2016094680A1 MULTIPLE-FIRING SECURING DEVICE AND METHODS FOR USING AND MANUFACTURING SAME 审中-公开
标题翻译：多重安全保护装置及其使用和制造方法
公开(公告)号：WO2016094680A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/065033
申请日：2015-12-10
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： DEVILLE, Derek, Dee , SMITH, Kevin, W. , KIRK, Michael, Walter , RIVERA, Carlos , NUNEZ, George , BALES, Jr., Thomas, O. , KLINE, Korey , PALMER, Matthew, A. , MCBRAYER, M., Sean , CARTLEDGE, Richard , MENDEZ, Max, Pierre , CAO, Hengchu , CARCIA, Anthony, Peter , DANG, Kevin , HENDSBEE, Carey , HOFFMAN, Brent, K. , JACOBS, Brian R. , JAFARI, Mohammad , JANISH, Brian , MAHONEY, Jeffrey, L. , MAZZEI, Raffaele , MIRAKI, Manouchehr, A. , MOEHLE, Ryan , MORGAN, Jeremiah , MURAD, Michael C. , OBA, Travis Zenyo , SCHNEIDER, Ralph , SCHROEDER, Fabian Daniel , SMITH, Tyler Douglas , WU, Ming H
IPC分类号： A61B17/03 , A61B17/04 , A61B17/128
CPC分类号： A61B17/0485 , A61B17/0487 , A61B2017/00358 , A61B2017/0488
摘要： A multiple-fire securing device includes a hollow outer shaft, a reloader, a reloader movement assembly, a rail, and securing structures each defining an inner securing orifice. The reloader longitudinally moves within the outer shaft and has a distal end shaped to temporarily contact one of the securing structures. The rail is disposed within the reloader and has an installing location. The securing structures are disposed on the rail. The reloader movement assembly moves the reloader longitudinally in a distal direction to deliver a first securing structure to the installing location from a first proximal position and moves the reloader proximally away from the installing location without the first securing structure to a position in which the distal end of the reloader temporarily contacts a second one of the securing structures. The second and successive securing structures are moved one at a time to the installing location.
摘要翻译：多重火焰固定装置包括中空的外轴，重新装载机，重装机运动组件，轨道和固定结构，每个限定内部固定孔。重新装载机在外轴内纵向移动并且具有成形为临时接触其中一个固定结构的远端。轨道设置在重新装载机内并具有安装位置。固定结构设置在轨道上。重新装载机构移动组件沿远侧方向纵向运动重新装载机，以将第一固定结构从第一近端位置传送到安装位置，并将重新装载机向近侧移动远离安装位置，而不用第一固定结构移动到远端的重新加载器临时接触第二个固定结构。第二和连续的固定结构一次一个地移动到安装位置。

4. 发明申请

WO2018009316A1 DEVICE AND METHOD FOR TREATING VASCULAR INSUFFICIENCY 审中-公开
标题翻译：装置和方法治疗血管功能不全
公开(公告)号：WO2018009316A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/037461
申请日：2017-06-14
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： FRESCHAUF, Lauren, R. , SCHNEIDER, Ralph
IPC分类号： A61F2/24 , A61L27/50
摘要： Embodiments of a leaflet clip device and method of reducing regurgitation through a native heart valve are disclosed. A leaflet clip device can include an elongated clipping member having a first end portion and a second end portion and a tensioning mechanism coupled to the clipping member. The leaflet clip device can further include one or more tensioning members disposed within a lumen of the clipping member, wherein the one or more tensioning members are operatively connected to the tensioning mechanism to transform the clipping member from a delivery configuration to an implantation configuration.
摘要翻译：公开了小叶夹装置和通过天然心脏瓣膜减少反流的方法的实施例。小叶夹装置可以包括具有第一端部和第二端部的细长夹持构件以及联接到夹持构件的张紧机构。小叶夹持装置可进一步包括设置在夹持构件的内腔内的一个或多个张紧构件，其中所述一个或多个张紧构件可操作地连接至张紧机构以将夹持构件从递送构型转变为植入构型。 / p>

5. 发明申请

WO2015077610A1 SEALING DEVICES, RELATED DELIVERY APPARATUSES, AND USES THEREOF 审中-公开
标题翻译：密封设备，相关的传送设备及其用途
公开(公告)号：WO2015077610A1
公开(公告)日：2015-05-28
申请号：PCT/US2014/066895
申请日：2014-11-21
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： DELGADO, Sergio , SCHNEIDER, Ralph , ROWE, Stanton, J. , WU, Ming, H. , JAFARI, Mohammad , BOOMGARDEN, Jon
IPC分类号： A61B17/03 , A61B17/12 , A61M25/01 , A61M25/088
CPC分类号： A61B17/0057 , A61B17/0401 , A61B17/0644 , A61B17/068 , A61B17/3209 , A61B17/3423 , A61B17/3431 , A61B17/3462 , A61B17/3468 , A61B17/3478 , A61B2017/00247 , A61B2017/00252 , A61B2017/00477 , A61B2017/00526 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00623 , A61B2017/00668 , A61B2017/00867 , A61B2017/00986 , A61B2017/0414 , A61B2017/0427 , A61B2017/0464 , A61B2017/0641 , A61B2017/0645 , A61B2017/3425 , A61B2017/3458 , A61B2017/346 , A61B2017/3464
摘要： Embodiments of the present disclosure are directed to implantable sealing devices, delivery apparatuses, and methods of their use, for closing surgical openings or defects in a sidewall of a vessel in a subject. In several embodiments, the disclosed implantable sealing devices, delivery apparatuses, and methods can be used to close a surgical opening in a sidewall of the heart.
摘要翻译：本公开的实施例涉及可植入密封装置，递送装置及其使用方法，用于封闭受试者中血管侧壁中的手术开口或缺陷。在几个实施例中，所公开的可植入密封装置，递送装置和方法可用于封闭心脏侧壁中的手术开口。

6. 发明申请

WO2011119754A2 METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE 审中-公开
标题翻译：调节片生物组织的方法
公开(公告)号：WO2011119754A2
公开(公告)日：2011-09-29
申请号：PCT/US2011/029654
申请日：2011-03-23
申请人： EDWARDS LIFESCIENCES CORPORATION , DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
发明人： DOVE, Jeffrey, S. , TIAN, Bin , SCHNEIDER, Ralph , COHEN, Jeffrey, S. , JANKOVIC, Ivan , MIGLIAZZA, John, F. , WRIGHT, Gregory, A. , YOUNG, James, M. , CAMPBELL, Louis, A.
IPC分类号： A61F2/24 , A61L27/38 , D06M10/00 , D06M10/04
CPC分类号： A61F2/2415 , A61B18/20 , A61F2/02 , A61F2/24 , A61F2/2409 , A61F2/2418 , A61F2002/30324 , A61F2250/0036 , A61L27/3604 , A61L27/3625 , A61L27/3691 , A61L27/507 , A61L2300/60 , A61L2430/20 , B65B55/18 , B65B63/02
摘要： Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region.
摘要翻译：生物假体材料调理方法采用牛心包膜。指向膜的纤维表面并相对于其移动的激光将膜的厚度减小到特定的均匀厚度并平滑表面。选择激光器的波长，功率和脉冲速率，这将使纤维表面平滑，并将表面烧蚀到合适的厚度。或者，使用皮肤表面从膜的纤维表面去除一层材料。变薄也可能采用压缩。使用交联以稳定膜的逐步压缩来避免通过非弹性压缩损伤膜。相反，膜通过加成交联结合在弹性压缩状态。上述几种稀释技术可以一起使用以获得强的薄膜。然后可以通过封闭钙化成核位点和硼氢化钠还原来处理最终变薄的膜。传单可以形成为具有多于一个均匀厚度的区域，例如较厚的外围缝合区域。

7. 发明申请

WO2021025882A1 HEART WALL IMPLANT AND METHOD 审中-公开
公开(公告)号：WO2021025882A1
公开(公告)日：2021-02-11
申请号：PCT/US2020/043598
申请日：2020-07-24
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： VREEKE, Mark Simon , SCHNEIDER, Ralph , BAK-BOYCHUK, Gregory , VALENCIA, Juan , KARAPETIAN, Emil , HERNANDEZ, Cristobal, R.
IPC分类号： A61F2/24
摘要： An anchor device for implantation in heart tissue includes a helical anchor and a helical delivery component. The helical delivery component can be hollow and the helical anchor can be disposed inside the helical delivery component for delivery. The helical anchor can be hollow and the helical delivery component can be disposed inside the hollow helical anchor.

8. 发明申请

WO2019006387A8 DOCKING STATIONS FOR TRANSCATHETER VALVES 审中-公开
公开(公告)号：WO2019006387A8
公开(公告)日：2019-01-03
申请号：PCT/US2018/040425
申请日：2018-06-29
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： TAYEB, Liron , GOLDBERG, Eran , MAIMON, David , CARMI, Adi , TYLIS, Arie , WITZMAN, Ofir , SCHNEIDER, Ralph , JAFARI, Mohammad , CAO, Hengchu , ABBOTT, Eason, Michael , ARMER, Dustin P. , FRANKLIN, Michael, D. , SAAR, Tomer , DVORSKY, Anatoly , DESROSIERS, John, J. , MURRAY, Daniel, James , VALDEZ, Michael, G. , BASH, Assaf , BLUMENFELD, Amir , AXELROD, Noa , ATIAS, Eitan
IPC分类号： A61F2/24 , A61B17/34
摘要： Docking stations for transcatheter valves are described. The docking stations can include an expandable frame, at least one sealing portion, and a valve seat. The expandable frame can be configured to conform to an interior shape of a portion of the circulatory system when expanded inside the circulatory system. The sealing portion can be configured to contact an interior surface of the circulatory system to create a seal. The valve seat can be connected to the expandable frame and can be configured to support an expandable transcatheter valve. The docking stations are adaptable to different anatomies/locations to allow implantation of a transcatheter valve in a variety of anatomies/locations.

9. 发明申请

WO2017136287A1 TRANS-SEPTAL CLOSURE AND PORT DEVICE 审中-公开
标题翻译： TRANS-SEPTAL CLOSURE和PORT DEVICE
公开(公告)号：WO2017136287A1
公开(公告)日：2017-08-10
申请号：PCT/US2017/015662
申请日：2017-01-30
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： ROWE, Stanton, J. , WU, Ming, H. , LEE, Jinny , SCHNEIDER, Ralph , DELGADO, Sergio , TAMIR, Ilan
IPC分类号： A61B17/34 , A61B17/00
CPC分类号： A61B17/0218 , A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00606 , A61B2017/00623 , A61B2017/00632 , A61B2017/0225 , A61B2017/0237 , A61F2/2427
摘要： A septal closure and port device for implantation in the artrial septum of a patient's heart includes an expandable frame having a central portion defining a lumen, and first and second opposing end portions. The frame is configured to expand and contract between a compressed, tubular configuration for delivery through the patient's vasculature and an expanded configuration in which the first and second end portions extend radially outwardly from the opposite ends of the central portion. The device can further include a valve member supported on the frame and positioned to block at least the flow of blood from the left atrium to the right atrium through the lumen of the frame. The valve member is configured to permit a medical instrument to be inserted through the lumen and into the left atrium, such as for performing a subsequent medical procedure in the left side of the heart.
摘要翻译：用于植入患者心脏的动脉中隔中的隔膜闭合和端口装置包括具有限定内腔的中心部分以及第一和第二相对端部的可扩张框架。该框架被配置为在用于通过患者的脉管系统递送的压缩的管状构造和扩张构造之间扩张和收缩，其中第一和第二端部从中心部分的相对端径向向外延伸。该装置可以进一步包括瓣膜构件，该瓣膜构件被支撑在框架上并且被定位成至少阻止血液从框架内腔通过框架内腔从左心房流向右心房。该阀构件被配置成允许医疗器械通过内腔插入并进入左心房，例如用于在心脏左侧执行随后的医疗过程。

10. 发明申请

WO2016149283A1 SUTURE SECUREMENT DEVICES 审中-公开
标题翻译：保护装置
公开(公告)号：WO2016149283A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/022495
申请日：2016-03-15
申请人： EDWARDS LIFESCIENCES CORPORATION
发明人： MIRAKI, Manouchehr, A. , CAO, Hengchu , SCHNEIDER, Ralph
IPC分类号： A61B17/06 , A61B17/04
CPC分类号： A61B17/0487 , A61B2017/0404 , A61B2017/0438 , A61B2017/0454
摘要： Some disclosed suture securement devices comprise a flat, thin, generally planar body that has one or more suture engagement slots extending into the body from a perimeter inlet for receiving sutures laterally into the device. The slots can be resiliently widened to receive a suture and then released to clamp onto the suture. Some embodiments include two or more such suture engagement slots that independently receive and secure different sutures. Some embodiments include one or more locking tabs that have a closed position that retains the slots against widening and blocks the inlet to the slot. In some embodiment two or more slots are position next to each other on the same side of the device, while in other embodiments slots are positioned on opposite sides of the device. Other types of suture securement devices are also disclosed.
摘要翻译：一些公开的缝合线固定装置包括平坦的，薄的，大致平坦的主体，其具有一个或多个缝合线接合槽，其从周边入口延伸到主体中，用于将缝合线横向接纳到装置中。狭槽可以弹性扩大以接收缝合线，然后释放以夹紧到缝合线上。一些实施例包括两个或更多个这样的缝合接合槽，其独立地接收和固定不同的缝合线。一些实施例包括一个或多个锁定突片，其具有闭合位置，该关闭位置保持狭槽以防止加宽并阻塞到狭槽的入口。在一些实施例中，两个或更多个槽位于装置的相同侧上彼此相邻的位置，而在其它实施例中，狭槽位于装置的相对侧上。还公开了其他类型的缝线固定装置。

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