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11. 发明申请

WO2006016357A1 FOOD PRODUCTS FOR DIABETICS 审中-公开
标题翻译：用于糖尿病的食品
公开(公告)号：WO2006016357A1
公开(公告)日：2006-02-16
申请号：PCT/IL2005/000854
申请日：2005-08-09
申请人： ENZYMOTEC LTD. , SHULMAN, Avidor , PELLED, Dori , COHEN, Tzafra
发明人： SHULMAN, Avidor , PELLED, Dori , COHEN, Tzafra
IPC分类号： A61P7/00
CPC分类号： A23D9/013 , A21D2/02 , A21D2/16 , A21D2/263 , A21D2/266 , A21D2/32 , A21D13/062 , A23C9/13 , A23C9/158 , A23C11/103 , A23C2240/10 , A23G1/32 , A23G1/36 , A23L2/38 , A23L27/60 , A23L33/105 , A23L33/11 , A23L33/12 , A23L33/19 , A23L33/40 , A23V2002/00 , A61K45/06 , A23V2200/328 , A23V2250/5488 , A23V2250/2136 , A23V2250/1852 , A23V2250/2132
摘要： Disclosed is a novel food product characterized by a low glucose or glucose free content, a balanced functional fat content, and a proactive agent aimed for the diabetic and diabetic-prone populations. The food product of the invention is a functional food which may be used clinically to lower the lipid level in people suffering from an imbalanced lipid profile and which may progress towards diabetes complications and coronary vascular disorders. In particular embodiments the proactive agent can be any of a naturally occurring lipid, a synthetic or mimetic lipid which is not digestible by humans and interferes with body weight gain/loss, plant extracts and substances derived therefrom, antioxidants, animal-derived substances, minerals and pharmaceuticals, and any mixture thereof.
摘要翻译：公开了一种新型食品，其特征在于低葡萄糖或无葡萄糖含量，平衡的功能性脂肪含量和针对糖尿病和易患糖尿病的人群的前摄药剂。本发明的食品是一种功能性食品，其可以临床用于降低患有脂质分布不平衡并且可能发展为糖尿病并发症和冠状血管疾病的人的脂质水平。在具体的实施方案中，前摄剂可以是天然存在的脂质，不能被人类消化并干扰体重增加/减少的合成或模拟脂质，植物提取物和由其衍生的物质，抗氧化剂，动物衍生物质，矿物质和药物，以及它们的任何混合物。

12. 发明申请

WO2004069150A2 OILS ENRICHED WITH DIACYLGLYCEROLS AND PHYTOSTEROL ESTERS FOR USE IN THE REDUCTION OF CHOLESTEROL AND TRIGLYCERIDES 审中-公开
标题翻译：富含二酰基甘油和植物酯的油可用于减少胆固醇和甘油三酯
公开(公告)号：WO2004069150A2
公开(公告)日：2004-08-19
申请号：PCT/IL2004/000131
申请日：2004-02-10
申请人： ENZYMOTEC LTD. , PLATT, Dorit , PELLED, Dori , SHULMAN, Avidor
发明人： PLATT, Dorit , PELLED, Dori , SHULMAN, Avidor
IPC分类号： A61K
CPC分类号： A61K45/06 , A23D9/013 , A23L33/11 , A23L33/12 , A23V2002/00 , A61K31/20 , A61K31/23 , A61K31/56 , A61K31/575 , A61K2300/00 , A23V2250/182 , A23V2250/2136
摘要： The present invention relates to the use of a composition comprising a combination of diacylglycerol(s) (DAG), mainly 1,3-diacylglycerol(s), and phytosterol and/or phytostanol ester(s) (PSE) dissolved or dispersed in edible oil and/or edible fat, particularly olive, canola and fish oil, in the manufacture of nutritional supplements and orally administrable pharmaceutical preparations which are capable of reducing blood levels of both cholesterol and triglycerides and/or for lowering serum, serum LDL and macrophage oxidation levels, inhibiting the formation of foam cells and/or preventing the deleterious effects generated by lipid-induced oxidative stress. In addition, the composition of the invention, as well as the pharmaceutical preparations thereof, is suitable for the treatment and prevention of conditions related to atherosclerosis, such as cardiovascular disease (CVD), coronary heart disease (CHD) and diabetes mellitus.
摘要翻译：本发明涉及包含二酰基甘油（DAG）（主要是1,3-二酰基甘油）和植物甾醇和/或植物甾烷醇酯（一种或多种）的组合的组合物的用途，（PSE），其溶解或分散于食用油和/或食用脂肪，尤其是橄榄油，低芥酸菜子油和鱼油中，用于制造营养补充剂和可口服药物制剂，其能够降低胆固醇和甘油三酯两者的血液水平和/或降低血清，血清LDL和巨噬细胞氧化水平，抑制泡沫细胞的形成和/或防止由脂质诱导的氧化应激产生的有害作用。此外，本发明的组合物及其药物制剂适用于治疗和预防与动脉粥样硬化有关的疾病，例如心血管疾病（CVD），冠心病（CHD）和糖尿病。 p>

13. 发明申请

WO2005040334A2 SELECTIVE LIPASES AND METHODS OF SCREENING THEREFOR 审中-公开
标题翻译：选择性材料及其筛选方法
公开(公告)号：WO2005040334A2
公开(公告)日：2005-05-06
申请号：PCT/IL2004/000966
申请日：2004-10-24
申请人： ENZYMOTEC LTD. , PLATT, Dorit , SHULMAN, Avidor , FARKASH, Orly , KAIYAL, Muhammad , KATZ, Ariel , BASHEER, Sobhi
发明人： PLATT, Dorit , SHULMAN, Avidor , FARKASH, Orly , KAIYAL, Muhammad , KATZ, Ariel , BASHEER, Sobhi
IPC分类号： C12N
CPC分类号： C12N9/20 , C12P7/62 , C12P7/6418 , C12P7/6445 , C12P7/6454 , C12P7/6472 , C12Q1/045 , C12Q1/44 , G01N2333/918
摘要： The present invention relates to a novel lipase having enhanced selectivity towards the sn -2 position of glycerides and to one-step catalytic reactions using same. The one step catalytic reaction are directed to the synthesis and/or hydrolysis of glycerides and derivatives thereof at the sn -2 position. The present invention further relates to methods of screening for lipases with significantly enhanced regio-selectivity, in particular, sn -2 selectivity.
摘要翻译：本发明涉及对甘油酯的sn-2位置具有增强选择性的新型脂肪酶和使用其的一步催化反应。一步催化反应涉及在sn-2位置的甘油酯及其衍生物的合成和/或水解。本发明还涉及具有显着增强的区域选择性，特别是sn-2选择性的脂肪酶筛选方法。

14. 发明申请

WO2002090560A3 PROCESS FOR THE PRODUCTION OF PHOSPHOLIPIDS 审中-公开
公开(公告)号：WO2002090560A3
公开(公告)日：2002-11-14
申请号：PCT/IL2002/000344
申请日：2002-05-02
申请人： ENZYMOTEC LTD. , BASHEER, Sobhi , ZUABI, Rassan , SHULMAN, Avidor , MAR-CHAIM, Neta
发明人： BASHEER, Sobhi , ZUABI, Rassan , SHULMAN, Avidor , MAR-CHAIM, Neta
IPC分类号： C12P9/00
摘要： The present invention provides a new enzymatic process for preparing 1,2-diacylated phospholipids comprising the use of an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process of the present invention are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA 1 or PLA 1,2 ) and a solvent, in a microaqueous medium.

15. 发明申请

WO2012098537A1 NUCLEIC ACID CONSTRUCT FOR EXPRESSION OF ALPHA-GALACTOSIDASE IN PLANTS AND PLANT CELLS 审中-公开
标题翻译：用于在植物和植物细胞中表达ALPHA-糖蛋白酶的核酸构建体
公开(公告)号：WO2012098537A1
公开(公告)日：2012-07-26
申请号：PCT/IL2011/000719
申请日：2011-09-07
申请人： PROTALIX LTD. , SHULMAN, Avidor , HANANNIA, Uri , KIZHNER, Tati , SHAALTIEL, Yoseph
发明人： SHULMAN, Avidor , HANANNIA, Uri , KIZHNER, Tati , SHAALTIEL, Yoseph
IPC分类号： C12N9/40 , A61K38/47 , C12N15/82 , A61P3/00 , A61P43/00
CPC分类号： C12N9/2465 , A61K38/47 , C12N15/8257
摘要： Nucleic acid expression constructs are provided and, more particularly, nucleic acid constructs for expression of human alpha-galactosidase in plant cells, cells expressing the nucleic acid construct, producing the human alpha-galactosidase and uses thereof.
摘要翻译：提供核酸表达构建体，更具体地，涉及在植物细胞中表达人α-半乳糖苷酶的核酸构建体，表达核酸构建体的细胞，产生人α-半乳糖苷酶及其用途。

16. 发明申请

WO2011107990A1 STABILIZED ALPHA-GALACTOSIDASE AND USES THEREOF 审中-公开
标题翻译：稳定的阿尔法胶质糖苷酶及其用途
公开(公告)号：WO2011107990A1
公开(公告)日：2011-09-09
申请号：PCT/IL2011/000209
申请日：2011-03-02
申请人： PROTALIX LTD. , SHULMAN, Avidor , RUDERFER, Ilya , BEN-MOSHE, Tehila , SHEKHTER, Talia , AZULAY, Yaniv , SHAALTIEL, Yoseph , KIZHNER, Tali
发明人： SHULMAN, Avidor , RUDERFER, Ilya , BEN-MOSHE, Tehila , SHEKHTER, Talia , AZULAY, Yaniv , SHAALTIEL, Yoseph , KIZHNER, Tali
IPC分类号： C12N9/40
CPC分类号： C12Y302/01022 , C12N9/2465
摘要： Multimeric protein structures comprising at least two alpha-galactosidase monomers being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and methods of treating Fabry disease via administration of a multimeric protein structure. The disclosed multimeric protein structures exhibit an improved performance, in terms of enhanced activity and/or a longer lasting activity under both lysosomal conditions and in a serum environment.
摘要翻译：本文公开了包含通过连接部分彼此共价连接的至少两个α-半乳糖苷酶单体的多聚体蛋白质结构，以及其制备方法，以及通过施用多聚体蛋白质结构来治疗法布里病的方法。根据在溶酶体条件和血清环境中增强的活性和/或更持久的活性方面，所公开的多聚体蛋白质结构表现出改进的性能。

17. 发明申请

WO2011107992A2 MULTIMERIC FORMS OF THERAPEUTIC PROTEINS AND USES THEREOF 审中-公开
标题翻译：治疗性蛋白质的多种形式及其用途
公开(公告)号：WO2011107992A2
公开(公告)日：2011-09-09
申请号：PCT/IL2011/000211
申请日：2011-03-02
申请人： PROTALIX LTD. , RUDERFER, Ilya , SHILOVITTZKY, Orit , SHULMAN, Avidor , SHAALTIEL, Yoseph , BEN-MOSHE, Tehila , SHEKHTER, Talia , AZULAY, Yaniv
发明人： RUDERFER, Ilya , SHILOVITTZKY, Orit , SHULMAN, Avidor , SHAALTIEL, Yoseph , BEN-MOSHE, Tehila , SHEKHTER, Talia , AZULAY, Yaniv
IPC分类号： C07K14/525
CPC分类号： C07K14/525
摘要： Multimeric protein structures are disclosed herein, as well a process for preparing same, and methods employing same for treating various diseases or disorders. The multimeric protein structures comprise at least two monomers of a therapeutic protein, including a TNF-alpha, a luteinizing hormone, an immunoglobin, a TNF-alpha receptor, a CTLA-4, a urate oxidase, a VEGF, a PDGF, a VEGF receptor, a PDGF receptor, an interleukin-17, and/or fragments thereof, the monomers being covalently linked to one another via a linking moiety. The multimeric protein structures exhibit improved performance as compared to the corresponding native proteins, including a longer lasting activity in vivo.
摘要翻译：本文公开了多聚蛋白质结构，以及制备它们的方法，以及使用它们治疗各种疾病或病症的方法。多聚蛋白质结构包含至少两种治疗性蛋白质的单体，包括TNF-α，黄体生成素，免疫球蛋白，TNF-α受体，CTLA-4，尿酸氧化酶，VEGF，PDGF，VEGF 受体，PDGF受体，白细胞介素-17和/或其片段，所述单体通过连接部分彼此共价连接。与相应的天然蛋白质相比，多聚体蛋白质结构表现出改善的性能，包括体内持久的持久活性。

18. 发明申请

WO2011107991A1 GLUCOCEREBROSIDASE MULTIMERS AND USES THEREOF 审中-公开
标题翻译：葡萄糖苷酶多聚体及其用途
公开(公告)号：WO2011107991A1
公开(公告)日：2011-09-09
申请号：PCT/IL2011/000210
申请日：2011-03-02
申请人： PROTALIX LTD. , RUDERFER, Ilya , KIZHNER, Tali , SHULMAN, Avidor , SHAALTIEL, Yoseph
发明人： RUDERFER, Ilya , KIZHNER, Tali , SHULMAN, Avidor , SHAALTIEL, Yoseph
IPC分类号： C12N9/24
CPC分类号： C07K14/525
摘要： Multimeric protein structures comprising at least two glucocerebrosidase molecules being covalently linked to one another via a linking moiety are disclosed herein, as well a process for preparing same, and uses thereof in the treatment of Gaucher disease. The multimeric protein structures are characterized by longer-lasting activity as compared to native glucocerebrosidase both in serum and in lysosomes.
摘要翻译：本文公开了包含通过连接部分彼此共价连接的至少两种葡糖脑苷脂酶分子的多聚体蛋白质结构，以及其制备方法及其在治疗戈谢病中的用途。与血浆和溶酶体中的天然葡糖脑苷脂酶相比，多聚体蛋白质结构的特征在于持久的活性。

19. 发明申请

WO2009024977A3 SACCHARIDE-CONTAINING PROTEIN CONJUGATES AND USES THEREOF 审中-公开
公开(公告)号：WO2009024977A3
公开(公告)日：2009-02-26
申请号：PCT/IL2008/001143
申请日：2008-08-20
申请人： PROTALIX LTD. , SHULMAN, Avidor , RUDERFER, Ilya
发明人： SHULMAN, Avidor , RUDERFER, Ilya
IPC分类号： A61K47/48 , A61P43/00
摘要： Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.

20. 发明公开

EP1412511A2 PROCESS FOR THE PRODUCTION OF PHOSPHOLIPIDS 有权
标题翻译：生产磷脂的方法
公开(公告)号：EP1412511A2
公开(公告)日：2004-04-28
申请号：EP02728001.5
申请日：2002-05-02
申请人： Enzymotec Ltd.
发明人： BASHEER, Sobhi , ZUABI, Rassan , SHULMAN, Avidor , MAR-CHAIM, Neta
IPC分类号： C12P9/00 , C07F9/10 , C12P7/62 , C12P13/00
CPC分类号： C07F9/10 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： The present invention provides a new enzymatic process for preparing 1,2-diacylated phospholipids comprising the use of an enzyme preparation possessing phospholipase activity towards acylation at the sn-1 and sn-2 sites in a microaqueous reaction system. More particularly, the 1,2-diacyl-phospholipids produced according to the esterification/transesterification process of the present invention are obtainable in high yield and purity and carry identical desired carboxylic acid, preferably fatty acid, acyl groups at the sn-1 and sn-2 positions. The process involves esterification/transesterification (acylation) of a glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of the above mentioned appropriate enzyme preparation. The process of the invention further relates to a process for the production of 1-acyl-2-lyso-glycerophospholipid, preferably 2-lyso-PC by reacting glycerophospholipid, preferably glycerophosphoryl choline (GPC) with a desired carboxylic acid, preferably fatty acid, or their derivatives in the presence of a sn-1 specific phospholipase (PLA1 or PLA1,2) and a solvent, in a microaqueous medium.
摘要翻译：本发明提供了一种用于制备1,2-二酰化磷脂的新的酶促方法，包括在微水相反应体系中使用具有磷脂酶活性的酶制剂，用于在sn-1和sn-2位点进行酰化。更特别地，根据本发明的酯化/酯交换方法制备的1,2-二酰基 - 磷脂可以以高收率和纯度获得，并且在sn-1和sn上携带相同的期望的羧酸，优选脂肪酸，酰基 -2个职位。该方法包括在上述合适的酶制剂存在下，将甘油磷脂，优选甘油磷酰胆碱（GPC）与期望的羧酸，优选脂肪酸或其衍生物进行酯化/酯交换（酰化）。本发明的方法还涉及通过使甘油磷脂，优选甘油磷酰胆碱（GPC）与所需羧酸，优选脂肪酸反应来生产1-酰基-2-溶血甘油磷脂，优选2-溶血PC的方法，或它们的衍生物在存在sn-1特异性磷脂酶（PLA1或PLA1,2）和溶剂的情况下在微水介质中进行。

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