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11. 发明申请

US20120303036A1 BONE TREATMENT SYSTEMS AND METHODS 审中-公开
标题翻译：骨治疗系统和方法
公开(公告)号：US20120303036A1
公开(公告)日：2012-11-29
申请号：US13488183
申请日：2012-06-04
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi
IPC分类号： A61B17/58
CPC分类号： A61B17/8836 , A61B17/864 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. A method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material via an energy emitter.
摘要翻译：本发明在某些实施例中涉及用于治疗诸如椎体压缩性骨折的骨整形术程序的医疗装置。更具体地，本发明的实施例涉及通过控制引入松质骨的填充材料的几何形状来可控地恢复椎体高度的仪器和方法。治疗骨的方法包括将一定体积的填充材料注入骨骼中，并选择性地改变骨填充物的粘度以控制骨中填充材料的流动方向。使用这种方法治疗骨骼的系统包括用于将填充材料输送到骨骼中的导引器和能够选择性地与填充材料耦合的能量源，以经由能量发射器改变填充材料的粘度。

12. 发明授权

US08192442B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US08192442B2
公开(公告)日：2012-06-05
申请号：US12502163
申请日：2009-07-13
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
IPC分类号： A61B17/00 , A61F2/44
CPC分类号： A61B17/8836 , A61B17/864 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. A method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material via an energy emitter in the introducer.
摘要翻译：本发明在某些实施例中涉及用于治疗诸如椎体压缩性骨折的骨整形术程序的医疗装置。更具体地，本发明的实施例涉及通过控制引入松质骨的填充材料的几何形状来可控地恢复椎体高度的仪器和方法。治疗骨的方法包括将一定体积的填充材料注入骨骼中，并选择性地改变骨填充物的粘度以控制骨中填充材料的流动方向。使用该方法治疗骨的系统包括用于将填充材料输送到骨中的导引器和能够选择性地与填充材料相连的能量源，以经由引入器中的能量发射器改变填充材料的粘度。

13. 发明授权

US07678116B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US07678116B2
公开(公告)日：2010-03-16
申请号：US11165651
申请日：2005-06-24
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
IPC分类号： A61B17/00
CPC分类号： A61B17/8836 , A61B17/7095 , A61B17/7098 , A61B17/864 , A61B17/8811 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. An exemplary system utilizes Rf energy in combination a conductive bone fill material for polymerizing the surface of the inflow plume to control the geometry of the fill material and the application of force caused by inflows of fill material. In another embodiment, method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of a selected portion of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material as it flows out of the introducer.
摘要翻译：本发明在某些实施例中涉及用于治疗诸如椎体压缩性骨折的骨整形术程序的医疗装置。更具体地，本发明的实施例涉及通过控制引入松质骨的填充材料的几何形状来可控地恢复椎体高度的仪器和方法。示例性系统利用Rf能量组合导电骨填充材料，用于聚合流入羽流的表面以控制填充材料的几何形状以及由填充材料的流入引起的力的施加。在另一个实施方案中，治疗骨的方法包括将一定体积的填充材料注入骨中，并选择性地改变骨填充物的选定部分的粘度以控制填充材料在骨内的流动方向。使用这种方法治疗骨骼的系统包括用于将填充材料输送到骨骼中的导引器，以及选择性地与填充材料耦合的能量源，以改变填充材料流出导引器时的粘度。

14. 发明申请

US20090198242A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20090198242A1
公开(公告)日：2009-08-06
申请号：US12345937
申请日：2008-12-30
申请人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , Andrew Kohm , John H. Shadduck
IPC分类号： A61B17/58
CPC分类号： A61B17/8836 , A61B17/8816 , A61B17/8822 , A61B2017/00022 , A61B2017/00411 , A61B2017/00955 , A61B2017/8844 , A61B2090/064
摘要： Systems and methods for treating vertebral compression fractures are discussed. In an embodiment, a method includes mixing bone cement precursors thereby causing a first chemical curing reaction characterized by a first time-viscosity profile, controllably applying energy to the bone cement from an external source to modify the first time-viscosity profile to a second time-viscosity profile, and injecting the cement into bone at a substantially constant viscosity greater than about 1000 Pa·s to greater than about 5000 Pa·s over an extended working time. In another embodiment, a bone cement injector system is provided that includes a first handle component that is detachably coupled to a second sleeve component having a distal end for positioning in bone and a flow channel extending through the first and second components. The system includes first and second thermal energy emitters for delivering energy to bone cement flows in a flow channel portion in the first and second components, respectively.
摘要翻译：讨论了治疗椎体压缩骨折的系统和方法。在一个实施方案中，一种方法包括混合骨水泥前体，从而引起第一化学固化反应，其特征在于第一时间粘度分布，可控地从外部来源向骨粘固剂施加能量以将第一时间粘度分布修改为第二次 - 粘度分布，并且在延长的工作时间内以大于约1000Pa.s至大于约5000Pa.s的基本上恒定的粘度将骨水泥注入骨中。在另一个实施例中，提供一种骨粘固剂注射器系统，其包括第一手柄部件，该第一手柄部件可拆卸地联接到具有用于定位在骨头中的远端的第二套筒部件和延伸穿过第一和第二部件的流动通道。该系统包括第一和第二热能发射器，用于分别在第一和第二部件中的流动通道部分中向骨水泥流输送能量。

15. 发明授权

US07559932B2 Bone treatment systems and methods 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US07559932B2
公开(公告)日：2009-07-14
申请号：US11165652
申请日：2005-06-24
申请人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
发明人： Csaba Truckai , John H. Shadduck , Robert Luzzi , Grace A. Carlson , C. Travis Rappleye
IPC分类号： A61B17/00
CPC分类号： A61B17/8836 , A61B17/864 , A61B2017/00022 , A61B2017/00026 , A61B2017/00084 , A61F2/44
摘要： The present invention relates in certain embodiments to medical devices for treating osteoplasty procedures such as vertebral compression fractures. More particularly, embodiments of the invention relate to instruments and methods for controllably restoring vertebral body height by controlling the geometry of fill material introduced into cancellous bone. An exemplary system utilizes Rf energy in combination a conductive bone fill material for polymerizing the surface of the inflow plume to control the geometry of the fill material and the application of force caused by inflows of fill material. In another embodiment, method of treating bone includes injecting a volume of fill material into a bone and selectively modifying a viscosity of a selected portion of the bone filler to control the direction of flow of the fill material within the bone. A system for treating bone using this method includes an introducer for delivering fill material into the bone and an energy source selectively coupleable to the fill material to alter the viscosity of the fill material as it flows out of the introducer.
摘要翻译：本发明在某些实施例中涉及用于治疗诸如椎体压缩性骨折的骨整形术程序的医疗装置。更具体地，本发明的实施例涉及通过控制引入松质骨的填充材料的几何形状来可控地恢复椎体高度的仪器和方法。示例性系统利用Rf能量组合导电骨填充材料，用于聚合流入羽流的表面以控制填充材料的几何形状以及由填充材料的流入引起的力的施加。在另一个实施方案中，治疗骨的方法包括将一定体积的填充材料注入骨中，并选择性地改变骨填充物的选定部分的粘度以控制填充材料在骨内的流动方向。使用这种方法治疗骨骼的系统包括用于将填充材料输送到骨骼中的导引器，以及选择性地与填充材料耦合的能量源，以改变填充材料流出导引器时的粘度。

16. 发明申请

US20080255571A1 BONE TREATMENT SYSTEMS AND METHODS 有权
公开(公告)号：US20080255571A1
公开(公告)日：2008-10-16
申请号：US12062384
申请日：2008-04-03
申请人： Csaba Truckai , Robert Luzzi , John H. Shadduck
发明人： Csaba Truckai , Robert Luzzi , John H. Shadduck
IPC分类号： A61B17/58 , A61B18/04
CPC分类号： A61B17/8836 , A61B17/8822 , A61B2017/00022
摘要： Systems and methods for delivering bone cement into a bone can include a handle body defining a flow path, a thermal emitter in the handle body to apply energy to bone cement passing through the flow path, a source of bone cement and an injection cannula. The cannula can be in communication with the flow path such that inserting the cannula into a bone can allow a flow of bone cement therethrough to an opening at a distal end of the cannula. Other systems and methods for delivering bone cement into a bone can include an injector body with a handle portion, and a cannula, a bone cement container, a low pressure drive mechanism configured to effect a flow of bone cement from said container to the injector body and a high pressure drive mechanism configured to effect a flow of bone cement through the injector body into the bone.

17. 发明申请

US20080188858A1 BONE TREATMENT SYSTEMS AND METHODS 审中-公开
标题翻译：骨治疗系统和方法
公开(公告)号：US20080188858A1
公开(公告)日：2008-08-07
申请号：US12024969
申请日：2008-02-01
申请人： Robert Luzzi , John H. Shadduck , Csaba Truckai
发明人： Robert Luzzi , John H. Shadduck , Csaba Truckai
IPC分类号： A61B17/58
CPC分类号： A61L24/0084 , A61B17/8822 , A61B17/8836 , A61B2017/00026 , A61B2017/00088 , A61B2017/00101 , A61L24/02 , A61L24/06 , A61L27/16 , A61L27/46 , A61L27/50 , A61L2430/02 , C08L33/12
摘要： Bone cement formulations are provided that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures. In one embodiment, a settable bone cement includes a polymerizable composition with a powder component comprising an X-Ray contrast medium and a liquid component, wherein the setting time of the cement is at least about 25 minutes, at least about 30 minutes, at least about 35 minutes, and at least about 40 minutes.
摘要翻译：提供骨水泥配方，其具有用于椎体成形术和其它成骨术程序的延长的工作时间。在一个实施方案中，可固化骨粘固剂包括具有包含X射线造影剂和液体组分的粉末组分的可聚合组合物，其中所述胶泥的凝固时间至少为约25分钟，至少约30分钟，至少约35分钟，至少约40分钟。

18. 发明授权

US08487021B2 Bone treatment systems and methods 有权
公开(公告)号：US08487021B2
公开(公告)日：2013-07-16
申请号：US12395532
申请日：2009-02-27
申请人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
发明人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
IPC分类号： C08K9/12 , A61F2/28 , A61L24/06
CPC分类号： A61L24/0094 , A61B17/7095 , A61B17/8822 , A61B17/8833 , A61B17/8836 , A61B2017/00022 , A61K31/78 , A61L24/001 , A61L24/0084 , A61L24/0089 , A61L24/06 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/12
摘要： The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.

19. 发明申请

US20070299445A1 SPINE TREATMENT DEVICES AND METHODS 审中-公开
标题翻译：脊柱治疗装置和方法
公开(公告)号：US20070299445A1
公开(公告)日：2007-12-27
申请号：US11767402
申请日：2007-06-22
申请人： John Shadduck , Csaba Truckai , Robert Luzzi
发明人： John Shadduck , Csaba Truckai , Robert Luzzi
IPC分类号： A61B17/58
CPC分类号： A61B17/7059 , A61B17/7011 , A61B17/7044 , A61B17/7055 , A61B17/7067 , A61B2017/00867
摘要： A modular implant system and method for dynamic stabilization of a spine segment that can be implanted in a minimally invasive posterior approach. In one embodiment, the implant device has an inferior body portion configured for fixation in a sacrum or ilium and a superior body portion configured for engaging one or more spinous processes to limit extension and optionally flexion while off-loading a spine segment. The implant system can be configured to stabilize a spine segment, re-distribute loads with the spine segment and still allow spine lateral bending and torsion. Besides being far less invasive than other procedures, the system and method is reversible and adjustable post-implant.
摘要翻译：用于动态稳定脊柱段的模块化植入物系统和方法，其可以以微创后路方法植入。在一个实施例中，植入装置具有被配置为固定在骶骨或髂骨中的下主体部分和被配置为接合一个或多个棘突以限制延伸和可选地屈曲同时卸载脊椎段的上身部分。植入系统可以被配置为稳定脊柱段，使用脊柱部分重新分布负载，并且还允许脊柱横向弯曲和扭转。除了其他程序的侵入性要小得多，该系统和方法是可逆的和可调整的植入后。

20. 发明申请

US20100016467A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20100016467A1
公开(公告)日：2010-01-21
申请号：US12395527
申请日：2009-02-27
申请人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
发明人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
IPC分类号： C08L33/12
CPC分类号： A61L24/06 , A61B17/8805 , A61B17/8822 , A61B17/8833 , A61B2017/00022 , A61L24/0084 , A61L24/02 , A61L24/043 , A61L27/16 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/12
摘要： The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.
摘要翻译：本公开内容涉及具有用于椎体成形术程序和其它骨成形术程序的延长工作时间的骨水泥制剂以及水泥注射器，其包括用于按需控制水泥粘度和流动参数的能量输送系统。骨水泥制剂可以包括具有至少一种单体和包含聚合物颗粒和过氧化苯甲酰（BPO））的非液体组分的液体组分。非液体组分可以进一步构造成允许BPO受控地暴露于液体单体，以便能够控制骨水泥组合物的粘度。

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