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11. 发明授权

US08144829B2 Cone-beam CT imaging scheme 有权
标题翻译：锥束CT成像方案
公开(公告)号：US08144829B2
公开(公告)日：2012-03-27
申请号：US12380585
申请日：2009-02-27
申请人： Lei Zhu , Lei Xing
发明人： Lei Zhu , Lei Xing
IPC分类号： A61B6/03
CPC分类号： G21K1/02 , A61B6/032 , A61B6/466 , A61B6/542 , A61N5/103 , G06T11/005
摘要： A general imaging scheme is proposed for applications of CBCT. The approach provides a superior CBCT image quality by effective scatter correction and noise reduction. Specifically, in its implementation of CBCT imaging for radiation therapy, the proposed approach achieves an accurate patient setup using a partially blocked CBCT with a significantly reduced radiation dose. The image quality improvement due to the proposed scatter correction and noise reduction also makes CBCT-based dose calculation a viable solution to adaptive treatment planning.
摘要翻译：提出了CBCT应用的一般成像方案。该方法通过有效的散射校正和降噪来提供卓越的CBCT图像质量。具体来说，在实施用于放射治疗的CBCT成像时，所提出的方法使用部分阻断的CBCT具有显着降低的辐射剂量的精确的患者设置。由于所提出的散射校正和降噪的图像质量改善也使基于CBCT的剂量计算成为适应性治疗计划的可行解决方案。

12. 发明申请

US20090208074A1 3D real-time tracking of human anatomy using combined kV and MV imaging 有权
标题翻译：使用组合的kV和MV成像对人体解剖结构的3D实时跟踪
公开(公告)号：US20090208074A1
公开(公告)日：2009-08-20
申请号：US12291829
申请日：2008-11-12
申请人： Rodney D. Wiersma , Lei Xing , Weihua Mao
发明人： Rodney D. Wiersma , Lei Xing , Weihua Mao
IPC分类号： G06K9/00
CPC分类号： G06T7/251 , G06T2207/10081 , G06T2207/10116 , G06T2207/30096 , G06T2207/30204
摘要： A medical imaging-based system and method uses both kV and MV images captured during a treatment period for organ motion tracking. 3D geometric locations of internal features are computationally tracked as a function of time from internal features, such as natural biological features or implanted fiducials, which are computationally extracted from the captured kV and MV images. A partial information method allows 3D tracking to be maintained in the event that imaging information is temporarily not available.
摘要翻译：基于医学成像的系统和方法使用在治疗期间捕获的用于器官运动跟踪的kV和MV图像。内部特征的3D几何位置作为时间的函数从内部特征（例如自然生物特征或植入的基准）计算地跟踪，其从捕获的kV和MV图像计算地提取。如果成像信息暂时不可用，则部分信息方法允许维护3D跟踪。

13. 发明授权

US08989469B2 Systems and methods for simultaneous acquisition of scatter and image projection data in computed tomography 有权
标题翻译：用于在计算机断层扫描中同时采集散射和图像投影数据的系统和方法
公开(公告)号：US08989469B2
公开(公告)日：2015-03-24
申请号：US13332212
申请日：2011-12-20
申请人： Benjamin Pooya Fahimian , Lei Xing , Bowen Meng
发明人： Benjamin Pooya Fahimian , Lei Xing , Bowen Meng
IPC分类号： G06K9/00 , A61B6/03 , A61B6/00 , G06T11/00 , A61N5/10
CPC分类号： A61B6/032 , A61B6/4021 , A61B6/4085 , A61B6/484 , A61B6/5282 , A61B6/583 , A61N5/1067 , A61N2005/1061 , G06T11/005 , G06T11/006 , G06T2211/421
摘要： A method of acquiring scatter data and image projection data in computed tomography is provided that includes attenuating a radiation source using a pattern of blockers arranged to provide blocked and unblocked regions of the radiation source, and acquiring image data and scatter data of a target using an imaging device. A scatter map in the projection image can be estimated by interpolation and/or extrapolation of the projection image using an appropriately programmed computer, subtracting the estimated scatter map from the projection image to obtain scatter-corrected projections, reconstructing a CBCT volume using a total variation regularization algorithm, and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume. Reconstructing a CBCT volume can include using a total variation regularization algorithm and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume, where scatter-induced artifacts are corrected in the projection image.
摘要翻译：提供了一种在计算机断层摄影中获取散射数据和图像投影数据的方法，其包括使用布置成提供辐射源的阻挡和未阻挡区域的阻挡器的图案来衰减辐射源，以及使用成像装置。可以通过使用适当编程的计算机的投影图像的插值和/或外推来估计投影图像中的散射图，从投影图像中减去估计的散射图以获得散射校正的投影，使用总变化重建CBCT体积正则化算法，并应用迭代正则化过程来抑制重建的CBCT体积上的噪声水平。重建CBCT卷可以包括使用总变差规则化算法并应用迭代正则化过程来抑制重建的CBCT体积上的噪声水平，其中在投影图像中校正散射引起的伪像。

14. 发明申请

US20130142310A1 DYNAMIC MULTI-AXES TRAJECTORY OPTIMIZATION AND DELIVERY METHOD FOR RADIATION TREATMENT 审中-公开
标题翻译：用于辐射处理的动态多轴测距优化和传送方法
公开(公告)号：US20130142310A1
公开(公告)日：2013-06-06
申请号：US13490450
申请日：2012-06-06
申请人： Benjamin Pooya Fahimian , Lei Xing , Sarah Geneser , Dimitre Hristov
发明人： Benjamin Pooya Fahimian , Lei Xing , Sarah Geneser , Dimitre Hristov
IPC分类号： A61N5/10
CPC分类号： A61N5/103 , A61N5/1047 , A61N5/1082
摘要： Embodiments of the present invention provide methods for improved radiation treatment and imaging of solid cancers utilizing radiation beam trajectory optimization techniques to obtain conformal radiation coverage of tissue that is targeted to receive radiation, while minimizing exposure of healthy tissue and organs to harmful, unnecessary radiation.
摘要翻译：本发明的实施例提供了用于利用辐射束轨迹优化技术改进放射治疗和固体癌成像的方法，以获得靶向接受辐射的组织的适形辐射覆盖，同时使健康组织和器官暴露于有害的不必要的辐射最小化。

15. 发明申请

US20120207370A1 Systems and Methods for Simultaneous Acquisition of Scatter and Image Projection Data in Computed Tomography 有权
标题翻译：在计算机断层扫描中同时采集散射和图像投影数据的系统和方法
公开(公告)号：US20120207370A1
公开(公告)日：2012-08-16
申请号：US13332212
申请日：2011-12-20
申请人： BENJAMIN Pooya FAHIMIAN , Lei Xing , Bowen Meng
发明人： BENJAMIN Pooya FAHIMIAN , Lei Xing , Bowen Meng
IPC分类号： G06K9/40 , A61B6/03
CPC分类号： A61B6/032 , A61B6/4021 , A61B6/4085 , A61B6/484 , A61B6/5282 , A61B6/583 , A61N5/1067 , A61N2005/1061 , G06T11/005 , G06T11/006 , G06T2211/421
摘要： A method of acquiring scatter data and image projection data in computed tomography is provided that includes attenuating a radiation source using a pattern of blockers arranged to provide blocked and unblocked regions of the radiation source, and acquiring image data and scatter data of a target using an imaging device. A scatter map in the projection image can be estimated by interpolation and/or extrapolation of the projection image using an appropriately programmed computer, subtracting the estimated scatter map from the projection image to obtain scatter-corrected projections, reconstructing a CBCT volume using a total variation regularization algorithm, and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume. Reconstructing a CBCT volume can include using a total variation regularization algorithm and applying an iterative regularization process to suppress the noise level on the reconstructed CBCT volume, where scatter-induced artifacts are corrected in the projection image.
摘要翻译：提供了一种在计算机断层摄影中获取散射数据和图像投影数据的方法，其包括使用布置成提供辐射源的阻挡和未阻挡区域的阻挡器的图案来衰减辐射源，以及使用成像装置。可以通过使用适当编程的计算机的投影图像的插值和/或外推来估计投影图像中的散射图，从投影图像中减去估计的散射图以获得散射校正的投影，使用总变化重建CBCT体积正则化算法，并应用迭代正则化过程来抑制重建的CBCT体积上的噪声水平。重建CBCT卷可以包括使用总变差规则化算法并应用迭代正则化过程来抑制重建的CBCT体积上的噪声水平，其中在投影图像中校正散射引起的伪像。

16. 发明申请

US20100316259A1 Using a moving imaging system to monitor anatomical position as a function of time 审中-公开
标题翻译：使用移动成像系统来监测解剖位置作为时间的函数
公开(公告)号：US20100316259A1
公开(公告)日：2010-12-16
申请号：US12802952
申请日：2010-06-16
申请人： Wu Liu , Rodney D. Wiersma , Nadeem Raiz , Jing Wang , Lei Xing
发明人： Wu Liu , Rodney D. Wiersma , Nadeem Raiz , Jing Wang , Lei Xing
IPC分类号： G06K9/00
CPC分类号： A61N5/1047 , A61N5/1042 , A61N5/1067 , A61N2005/1054 , A61N2005/1061 , G06T7/246 , G06T7/55 , G06T2207/10112 , G06T2207/30081
摘要： Real-time 3D tracking of anatomical positions during radiation therapy uses acquired image data from an MV treatment beam as it is rotated around the patient during arc radiotherapy treatment. The acquired image data and associated angular positions are computationally combined during the arc radiotherapy treatment to estimate in real time 3D positions of anatomical features of the patient, e.g., combining present image data and prior image data at earlier times. Supplementary image data from a kV imaging system may be acquired on an as-needed basis if MV position estimates indicate movement exceeding a predetermined threshold, and the supplementary kV image data combined with the acquired MV image data to improve an accuracy of the estimated 3D positions.
摘要翻译：放射治疗期间解剖学位置的实时3D跟踪使用来自MV治疗束的获取的图像数据，因为它们在电弧放疗期间围绕患者旋转。所获取的图像数据和相关的角位置在电弧放射治疗期间被计算地组合以估计患者的解剖特征的实时3D位置，例如在较早时间组合当前图像数据和先前图像数据。如果MV位置估计指示超过预定阈值的移动，并且与所获取的MV图像数据组合的辅助kV图像数据以提高估计的3D位置的精度，则可以根据需要在需要的基础上获取来自kV成像系统的补充图像数据。

17. 发明授权

US07656603B1 Pre-programming of a preamplifier in a disk drive to improve servo-writing characteristics 失效
标题翻译：在磁盘驱动器中预编程前置放大器以提高伺服写入特性
公开(公告)号：US07656603B1
公开(公告)日：2010-02-02
申请号：US11948019
申请日：2007-11-30
申请人： Lei Xing
发明人： Lei Xing
IPC分类号： G11B21/02
CPC分类号： G11B5/59633 , G11B5/59638 , G11B5/59666
摘要： Disclosed is a self servo-writing disk drive that pre-programs a preamplifier to improve servo-writing characteristics in writing servo sectors to a disk. The disk drive implements operations including: writing servo sectors to define track bands according to sets of write setting values wherein the preamplifier adjusts write signals utilizing a set of write setting values for each track band; reading servo variable gain amplifier values from the tracks bands; selecting a set of write setting values associated with a minimum servo variable gain amplifier value; programming the preamplifier's write settings with the selected set of write setting values; and self-servo writing the disk with servo sectors utilizing the selected set of write setting values that are pre-programmed in the preamplifier.
摘要翻译：公开了一种自伺服写盘驱动器，其预编程前置放大器以改善将伺服扇区写入盘的伺服写入特性。磁盘驱动器实现以下操作：包括：写入伺服扇区以根据写入设置值的集合来定义轨道带，其中前置放大器利用每个轨道带的一组写入设置值来调整写入信号; 从轨道带读取伺服可变增益放大器值; 选择与最小伺服可变增益放大器值相关联的一组写设置值; 使用所选择的写入设置值编程前置放大器的写入设置; 并且使用在前置放大器中预编程的所选择的写设置值集合，自伺服用伺服扇区写入盘。

18. 发明授权

US06891178B2 Method for checking positional accuracy of the leaves of a multileaf collimator 失效
标题翻译：检查多叶准直器叶片位置精度的方法
公开(公告)号：US06891178B2
公开(公告)日：2005-05-10
申请号：US10197232
申请日：2002-07-15
申请人： Lei Xing
发明人： Lei Xing
IPC分类号： G21K1/02 , A61N5/10
CPC分类号： A61N5/1075 , A61N5/1045 , A61N2005/1095 , G21K1/025
摘要： A method is provided for determining the positional accuracy of leaves of a multileaf collimator for delivering doses of radiation to a particular spatial location for treatment purpose. The method could be implemented as routine quality assurance check of the multileaf collimator leaf positioning errors. The method includes producing a first field and producing a second field, which is different from the first field. A dosimeter means is included for measuring a radiation dose difference or ratio between the first field and the second field at at least one spatial location. The dose difference or ratio is then used to determine the positional accuracy of the leaves by comparing with a known relationship between leaf positional errors and relative dosimeter outputs. The method provides a more simplified, accurate, efficient and reliable method over currently used methods.
摘要翻译：提供了一种用于确定用于将剂量的辐射递送到特定空间位置以用于治疗目的的多叶准直器的叶片的位置精度的方法。该方法可以作为多叶准直器叶定位误差的常规质量保证检查来实现。该方法包括产生第一场并产生与第一场不同的第二场。包括剂量计装置，用于在至少一个空间位置处测量第一场和第二场之间的辐射剂量差异或比率。然后通过与叶位置误差和相对剂量计输出之间的已知关系进行比较来确定叶片的位置精度。该方法提供了比目前使用的方法更简化，准确，有效和可靠的方法。

19. 发明申请

US20190110776A1 Methods for Computing Coronary Physiology Indexes Using a High Precision Registration Model 审中-公开
公开(公告)号：US20190110776A1
公开(公告)日：2019-04-18
申请号：US16153825
申请日：2018-10-08
申请人： Bo Yu , Haibo Jia , Sining Hu , Jiannan Dai , Lei Xing , Chenyang Xu , Zhao Wang , Shuai Zhang
发明人： Bo Yu , Haibo Jia , Sining Hu , Jiannan Dai , Lei Xing , Chenyang Xu , Zhao Wang , Shuai Zhang
IPC分类号： A61B8/08 , A61B5/00 , A61B8/06 , A61B5/027 , A61B8/12 , A61B6/12 , G06T7/33 , G06T7/70 , G06T7/20 , G06T7/00 , G16H30/20
摘要： This invention describes methods to compute coronary physiology indexes using a high precision registration model, which consists of acquiring coronary angiography images of coronary vessels, performing intravascular imaging, and registering the coronary angiography images with intravascular images to create a high precision registration model, based upon which the coronary flow, fractional flow reserve (FFR) and index of microcirculation resistance (IMR) can be computed. The methods described in this invention to compute coronary flow, FFR, IMR are based on both coronary angiography and intravascular images, and the accuracy is better than those derived from coronary angiography alone or intravascular imaging alone, and have high practical values.

20. 发明申请

US20150265851A1 Including fiducial markers in radiation therapy planning to facilitate real-time position monitoring during treatment delivery 有权
标题翻译：包括辐射治疗计划中的基准标记，以便于治疗期间的实时位置监测
公开(公告)号：US20150265851A1
公开(公告)日：2015-09-24
申请号：US12932666
申请日：2011-03-02
申请人： Yunzhi Ma , Paul J. Keall , Lei Xing
发明人： Yunzhi Ma , Paul J. Keall , Lei Xing
IPC分类号： A61N5/10 , A61B19/00
CPC分类号： A61N5/1031 , A61B2090/3966 , A61N5/1036 , A61N5/1037 , A61N5/1045 , A61N5/1047 , A61N5/1077 , A61N2005/1035 , A61N2005/1061
摘要： An inverse planning method that is capable of controlling the appearance of the implanted fiducial(s) in segmented IMRT fields for cine MV or combined MV/kV image-guided IMRT is provided. The method for radiation treatment includes computing a radiation treatment plan and delivering beams to a target in accordance with the radiation treatment plan, where computing the radiation treatment plan includes introducing a penalty in an inverse planning objective function optimization calculation to discourage or avoid blockage of one or more fiducials in optimized multi-leaf collimator (MLC) apertures.
摘要翻译：提供了一种能够控制电影MV或组合MV / kV图像引导IMRT的分段IMRT场中植入基准的外观的逆规划方法。放射治疗的方法包括计算辐射治疗计划并根据放射治疗计划将光束输送到目标，其中计算辐射治疗计划包括在逆规划目标函数优化计算中引入惩罚，以阻止或避免阻塞一个或更多的基准在优化的多叶准直器（MLC）孔。

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