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11. 发明授权

US08361485B2 Conditioned cell culture medium compositions and methods of use 有权
标题翻译：有条件的细胞培养基组合物和使用方法
公开(公告)号：US08361485B2
公开(公告)日：2013-01-29
申请号：US11538380
申请日：2006-10-03
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
IPC分类号： A61K38/00 , A61P17/00
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.
摘要翻译：描述了包含调节细胞培养基组合物和使用方法的新产品。本发明的条件细胞培养基组合物可以由任何已知的定义或未定义的培养基组成，并且可以使用任何真核细胞类型进行调节。介质可以由基质细胞，实质细胞，间充质干细胞，肝储备细胞，神经干细胞，胰干细胞和/或胚胎干细胞调节。另外，细胞可以被遗传修饰。优选三维组织构建体。一旦本发明的细胞培养基被调节，它可以在任何状态下使用。条件培养基的物理实施方案包括但不限于液体或固体，冷冻，冻干或干燥成粉末。另外，介质配制有药学上可接受的载体作为内部给药载体，直接施用于用药膏或软膏配制用于局部应用的食品或产品，或者例如制成或添加到手术胶中通过侵入性手术加快缝合线愈合。此外，可以进一步处理介质以浓缩或减少介质中包含的一种或多种因素或组分。

12. 发明授权

US07118746B1 Conditioned cell culture medium compositions and methods of use 有权
公开(公告)号：US07118746B1
公开(公告)日：2006-10-10
申请号：US09979813
申请日：2000-05-12
申请人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
发明人： Gail K. Naughton , David L. Horwitz , Mark A. Applegate , Joan Zeltinger , Jonathan N. Mansbridge , Andreas Kern , Lee K. Landeen , Anthony Ratcliffe , R. Emmett Pinney
IPC分类号： A61K38/17 , C12N5/08 , C12N5/22
CPC分类号： A23L33/10 , A23V2002/00 , A61K8/02 , A61K8/0208 , A61K8/64 , A61K8/65 , A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/35 , A61K35/36 , A61K35/50 , A61K38/18 , A61K38/1825 , A61K38/39 , A61K45/06 , A61K2800/86 , A61K2800/91 , A61L31/044 , A61L31/047 , A61L31/16 , A61L2300/414 , A61L2430/36 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C12N5/0603 , C12N5/0606 , C12N5/0625 , C12N5/0629 , C12N5/0656 , C12N5/069 , C12N2502/1323 , C12P21/00 , A61K2300/00
摘要： Novel products comprising conditioned cell culture medium compositions and methods of use are described. The conditioned cell medium compositions of the invention may be comprised of any known defined or undefined medium and may be conditioned using any eukaryotic cell type. The medium may be conditioned by stromal cells, parenchymal cells, mesenchymal stem cells, liver reserve cells, neural stem cells, pancreatic stem cells and/or embryonic stem cells. Additionally, the cells may be genetically modified. A three-dimensional tissue construct is preferred. Once the cell medium of the invention is conditioned, it may be used in any state. Physical embodiments of the conditioned medium include, but are not limited to, liquid or solid, frozen, lyophilized or dried into a powder. Additionally, the medium is formulated with a pharmaceutically acceptable carrier as a vehicle for internal administration, applied directly to a food item or product, formulated with a salve or ointment for topical applications, or, for example, made into or added to surgical glue to accelerate healing of sutures following invasive procedures. Also, the medium may be further processed to concentrate or reduce one or more factors or components contained within the medium.

13. 发明申请

US20110029078A1 SYNTHETIC STRUCTURE FOR SOFT TISSUE REPAIR 有权
标题翻译：软组织修复的合成结构
公开(公告)号：US20110029078A1
公开(公告)日：2011-02-03
申请号：US12533473
申请日：2009-07-31
申请人： Anthony Ratcliffe , Andreas Kern , Mohammad Sotoudeh , Fatemeh Ratcliffe
发明人： Anthony Ratcliffe , Andreas Kern , Mohammad Sotoudeh , Fatemeh Ratcliffe
IPC分类号： A61F2/08 , A61F2/02 , B32B43/00 , B29C65/06
CPC分类号： A61L27/50 , A61F2/08 , Y10T29/49826
摘要： Synthetic structures for soft tissue repair include a multi-layer planar fibrillar structure having layers which are intermittently secured to each other and which approximates mechanical properties comparable to those of soft tissue. In embodiments, the fibrillar structure possesses an intermittently secured edge portion secured by intermittent welds. In embodiments, the multi layer planar fibrillar structure includes a bioactive agent.
摘要翻译：用于软组织修复的合成结构包括多层平面纤维结构，其具有彼此间歇地固定并且近似与软组织相似的机械性能的层。在实施例中，纤维结构具有通过间歇焊接固定的间歇固定的边缘部分。在实施方案中，多层平面纤维结构包括生物活性剂。

14. 发明授权

US08415265B2 Method for producing melamine 失效
标题翻译：三聚氰胺生产方法
公开(公告)号：US08415265B2
公开(公告)日：2013-04-09
申请号：US12664426
申请日：2008-05-21
申请人： Christian Kuhrs , Andreas Kern , Tilo John , Wolfgang Steiner , Heiko Maas
发明人： Christian Kuhrs , Andreas Kern , Tilo John , Wolfgang Steiner , Heiko Maas
IPC分类号： B01J29/06 , C07D251/12 , C07D251/60 , C07D251/62
CPC分类号： C07D251/60
摘要： A process for the preparation of melamine by decomposition of urea with the use of a catalyst, the catalyst comprising a) 10-90% by weight of zeolite, b) 10-90% by weight of a matrix comprising silica, alumina, silicon aluminum oxides and/or clay minerals, and c) 0-10% by weight of additives and the total content of nickel and vanadium in the catalyst being less than 500 ppm.
摘要翻译：一种通过使用催化剂分解尿素来制备三聚氰胺的方法，所述催化剂包含a）10-90重量％的沸石，b）10-90重量％的包含二氧化硅，氧化铝，硅铝的基体氧化物和/或粘土矿物，和c）0-10重量％的添加剂，催化剂中镍和钒的总含量小于500ppm。

15. 发明申请

US20120174752A1 Composite material with a ballistic protective effect 有权
标题翻译：复合材料具有弹道保护作用
公开(公告)号：US20120174752A1
公开(公告)日：2012-07-12
申请号：US12436415
申请日：2009-05-06
申请人： Jens-Ulrik Becker , Harald Hofmann , Christian Hockling , Andreas Kern , Udo Schriever , Horst Walter Tamler , Hans-Joachim Tschersich
发明人： Jens-Ulrik Becker , Harald Hofmann , Christian Hockling , Andreas Kern , Udo Schriever , Horst Walter Tamler , Hans-Joachim Tschersich
IPC分类号： F41H5/04 , B32B15/01
CPC分类号： F41H5/045 , B32B15/011 , C21D9/42
摘要： A composite material with a ballistic protective effect having a first, outer layer made of a first steel alloy and at least one second layer which is arranged under the first layer and is made of a second steel alloy. The composite material with a ballistic protective effect allows for a reduction in the weight or the wall thicknesses of the composite material in comparison to conventional composite ballistic materials, by utilizing a first steel alloy of the first layer that has the following alloy constituents in percent by weight (% by weight): 0.06%≦C≦1.05%, 0.05%≦Si≦1.65%, 0.3%≦Mn≦2.65%, 0.015%≦Al≦1.55%; Cr≦1.2%, Ti≦0.13%, Mo≦0.7%, Nb≦0.1%, B≦0.005%, P≦0.08%, S≦0.01%, Ni≦4.0%, and V≦0.05%, the remainder being Fe and inevitable impurities. The second layer of the composite material having a higher elongation than the first layer.
摘要翻译：一种具有防弹效果的复合材料，具有由第一钢合金制成的第一外层和至少一个第二层，该第二层布置在第一层下方并由第二钢合金制成。具有弹道保护作用的复合材料与传统的复合材料弹道材料相比，能够减少复合材料的重量或壁厚，通过利用具有以下合金成分的第一层的第一钢合金的百分比乘以重量（重量％）：0.06％＆nlE; C＆lt; l1; 1.05％，0.05％＆nlE; Si＆NlE; 1.65％，0.3％＆amp; NlE; Mn＆amp; NlE; 2.65％，0.015％＆lt; A1; Al＆NlE; 1.55％ Cr＆nlE; 1.2％，Ti＆NlE; 0.13％，Mo＆NlE; 0.7％，Nb＆nlE; 0.1％，B＆amp; NEE; 0.005％，P＆NlE; 0.08％，S＆NlE; 0.01％，Ni＆NlE; 4.0％，V＆NlE; 0.05％和不可避免的杂质。复合材料的第二层具有比第一层高的伸长率。

16. 发明申请

US20100222582A1 PROCESS FOR PREPARING MELAMINE 有权
标题翻译：制备梅林的方法
公开(公告)号：US20100222582A1
公开(公告)日：2010-09-02
申请号：US12738049
申请日：2008-10-14
申请人： Andreas Kern , Hans-Ulrich Pröbstle , Tilo John , Wolfgang Steiner , Heiko Maas
发明人： Andreas Kern , Hans-Ulrich Pröbstle , Tilo John , Wolfgang Steiner , Heiko Maas
IPC分类号： C07D251/60
CPC分类号： C07D251/60 , C07D251/62
摘要： Process for preparing melamine by converting urea in the presence of a solid catalyst in one reactor or in a plurality of reactors connected in series in the temperature range from 370° C. to 430° C., cooling and filtering the gas formed in the urea conversion, removing the melamine by desublimation and recycling a portion of the gas present after the melamine removal (“cycle gas”) into the reactor or the reactors, which comprises performing all of the above stages at a pressure in the range from 4 bar abs. to 10 bar abs.
摘要翻译：在固体催化剂存在下，通过在一个反应器或多个在370℃至430℃的温度范围内串联连接的多个反应器的反应器中转化尿素来制备三聚氰胺的方法，冷却和过滤形成在尿素中的气体将三聚氰胺除去（“循环气体”）之后存在的气体的一部分进入反应器或反应器，从而将三聚氰胺除去，并将其中的一部分再循环到反应器或反应器中，其中包括在4巴。至10巴绝对

17. 发明申请

US20120034084A1 PROCESS FOR PRODUCING A TURBINE WHEEL FOR AN EXHAUST GAS TURBOCHARGER 审中-公开
标题翻译：用于生产用于排气涡轮增压器的涡轮轮的方法
公开(公告)号：US20120034084A1
公开(公告)日：2012-02-09
申请号：US13263135
申请日：2010-04-01
申请人： Andreas Kern , Martin Bloemacher , Franz-Dieter Martischius , Markus Steffen , Johan Ter Maat , Hans Wohlfromm
发明人： Andreas Kern , Martin Bloemacher , Franz-Dieter Martischius , Markus Steffen , Johan Ter Maat , Hans Wohlfromm
IPC分类号： F01D5/02 , B22F3/12 , B22F5/10
CPC分类号： B22F5/009 , B22F3/225 , B22F2001/0066 , F01D5/048 , F02C6/12 , F05D2230/211 , F05D2230/23
摘要： The invention relates to a process for producing a turbine wheel for an exhaust gas turbocharger by metal powder injection molding, which comprises the following steps: (a) provision of a feedstock comprising a metal powder and a binder, (b) provision of a tool which comprises a negative mold of the turbine wheel to be produced for metal powder injection molding of the turbine wheel, (c) introduction of a rotationally symmetrical core comprising a binder into the negative mold of the tool provided in process step (b) and alignment of the core so that it is aligned symmetrically about the axis of rotation of the turbine wheel to be produced, (d) production of a green body by metal powder injection molding of the feedstock provided in process step (a) around the core, (e) carrying out of a binder removal step to remove the binder from the green body in order to obtain a molding in the shape of the turbine wheel, and (f) sintering of the molding.
摘要翻译：本发明涉及一种用于通过金属粉末注射成型制造用于排气涡轮增压器的涡轮机叶轮的方法，其包括以下步骤：（a）提供包含金属粉末和粘合剂的原料，（b）提供工具其包括用于涡轮机叶轮的金属粉末注射成型的涡轮机叶轮的负模具，（c）将包括粘合剂的旋转对称芯体引入在工艺步骤（b）中提供的工具的负模具中并且对准的核心，使得其围绕要生产的涡轮机叶轮的旋转轴线对称地对准，（d）通过在工艺步骤（a）中提供的原料的金属粉末注射成型围绕芯部生产生坯体（ e）进行粘合剂去除步骤以从生坯中除去粘合剂，以获得涡轮机轮的形状的模制品，和（f）模制品的烧结。

18. 发明授权

US06360700B1 Refractory lining for tubular wall 有权
$Refractory lining for tubular wall$
标题翻译：管状壁耐火衬
公开(公告)号：US06360700B1
公开(公告)日：2002-03-26
申请号：US09530455
申请日：2000-04-28
申请人： Andreas Kern
发明人： Andreas Kern
IPC分类号： F22B1702
CPC分类号： F23M5/04 , F23M5/08 , Y10S122/13
摘要： A refractory tube wall lining comprises a multiplicity of refractory tiles (1) which are arranged next to and above one another and each have two T-shaped slots (16) which extend over the entire height of the tile. The tiles (1) are held on the lined tube wall (2) by means of in each case two screw-like tile holders (11). Brackets which are independent of the tile holders (11) are used to support the tiles (1). Stepped top and bottom edges of the tiles (1) allow the tiles (1) to move vertically with respect to one another without the seal of the tube wall lining being lost. For the same purpose, the two side edges (14, 15) of each tile (1) are fitted with a tongue (141) or a groove (151).
摘要翻译：耐火管壁衬里包括多个彼此相邻并且彼此相邻布置的耐火砖（1），并且每个具有在瓷砖的整个高度上延伸的两个T形槽（16）。瓦片（1）通过两个螺旋状瓦片保持器（11）在每个壳体中保持在衬里管壁（2）上。独立于瓦片支架（11）的托架用于支撑瓦片（1）。瓷砖（1）的台阶顶部和底部边缘允许瓷砖（1）相对于彼此垂直移动，而不会损失管壁衬里的密封。为了相同的目的，每个瓦片（1）的两个侧边缘（14,15）装配有舌片（141）或凹槽（151）。

19. 发明授权

US09233879B2 Process for the continuous thermal removal of binder from a metallic and/or ceramic shaped body produced by injection molding, extrusion or pressing using a thermoplastic molding composition 有权
公开(公告)号：US09233879B2
公开(公告)日：2016-01-12
申请号：US13379894
申请日：2010-06-22
申请人： Johan ter Maat , Hans Wohlfromm , Martin Bloemacher , Arnd Thom , Andreas Kern
发明人： Johan ter Maat , Hans Wohlfromm , Martin Bloemacher , Arnd Thom , Andreas Kern
IPC分类号： B22F3/12 , C04B35/56 , B22F3/10 , C04B35/111 , C04B35/14 , C04B35/46 , C04B35/478 , C04B35/486 , C04B35/505 , C04B35/563 , C04B35/565 , C04B35/58 , C04B35/581 , C04B35/583 , C04B35/584 , C04B35/634 , C04B35/638
摘要： The invention relates to a process for the continuous thermal removal of binder from a metallic and/or ceramic shaped body which has been produced by injection molding, extrusion or pressing using a thermoplastic composition and comprises at least one polyoxymethylene homopolymer or copolymer as binder in a binder removal oven, which comprises the steps (a) removal of binder from the shaped body in a binder removal oven at a temperature which is from 5 to 20° C. below, preferably from 10 to 15° C. below, the temperature of a second temperature stage over a period of from 4 to 12 hours in a first temperature stage in an oxygen-comprising atmosphere, (b) removal of binder from the shaped body at a temperature in the range >160 to 200° C. over a period of from 4 to 12 hours in an oxygen-comprising atmosphere in a second temperature stage and (c) removal of binder from the shaped body at a temperature in the range from 200 to 600° C. over a period of from 2 to 8 hours in a third temperature stage in an oxygen-comprising or neutral or reducing atmosphere, with the shaped bodies being transported through the binder removal oven during process steps (a) and (b).

20. 发明授权

US08545993B2 Composite material with a ballistic protective effect 有权
标题翻译：复合材料具有弹道保护作用
公开(公告)号：US08545993B2
公开(公告)日：2013-10-01
申请号：US12436415
申请日：2009-05-06
申请人： Jens-Ulrik Becker , Harald Hofmann , Christian Höckling , Andreas Kern , Udo Schriever , Horst Walter Tamler , Hans-Joachim Tschersich
发明人： Jens-Ulrik Becker , Harald Hofmann , Christian Höckling , Andreas Kern , Udo Schriever , Horst Walter Tamler , Hans-Joachim Tschersich
IPC分类号： F41H5/06 , B32B15/18
CPC分类号： F41H5/045 , B32B15/011 , C21D9/42
摘要： A composite material with a ballistic protective effect having a first, outer layer made of a first steel alloy and at least one second layer which is arranged under the first layer and is made of a second steel alloy. The composite material with a ballistic protective effect allows for a reduction in the weight or the wall thicknesses of the composite material in comparison to conventional composite ballistic materials, by utilizing a first steel alloy of the first layer that has the following alloy constituents in percent by weight (% by weight): 0.06%≦C ≦1.05%, 0.05%≦Si≦1.65%, 0.3%≦Mn≦2.65%, 0.015%≦Al≦1.55%; Cr≦1.2%, Ti≦0.13%, Mo≦0.7%, Nb≦0.1%, B≦0.005%, P≦0.08%, S≦0.01%, Ni≦4.0%, and V≦0.05%, the remainder being Fe and inevitable impurities. The second layer of the composite material having a higher elongation than the first layer.
摘要翻译：一种具有防弹效果的复合材料，具有由第一钢合金制成的第一外层和至少一个第二层，该第二层布置在第一层下方并由第二钢合金制成。具有弹道保护作用的复合材料与传统的复合材料弹道材料相比，能够减少复合材料的重量或壁厚，通过利用具有以下合金成分的第一层的第一钢合金的百分比乘以重量（重量％）：0.06％@ C @ 1.05％，0.05％@ Si @ 1.65％，0.3％@ Mn @ 2.65％，0.015％@ Al @ 1.55％ Cr@1.2%，Ti@0.13%，Mo@0.7%，Nb@0.1%，B@0.005%，P@0.08%，S@0.01%，Ni@4.0%，V@0.05%，其余为Fe 和不可避免的杂质。复合材料的第二层具有比第一层高的伸长率。

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