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    • 15. 发明授权
    • Process for producing isomer mixtures containing high proportions of
cis-2-methyl-3-pentenoic acid
    • 制备含高比例顺式-2-甲基-3-戊烯酸的异构体混合物的方法
    • US3931306A
    • 1976-01-06
    • US490717
    • 1974-07-22
    • John B. HallManfred Hugo VockJoaquin VinalsEdward J. Shuster
    • John B. HallManfred Hugo VockJoaquin VinalsEdward J. Shuster
    • A23L27/20A24B3/12A61K8/36A61Q13/00C07C17/08C07C51/00C07C51/36C07C57/03C07C57/18C07C67/00C11B9/00C11D9/44C07C57/02
    • C11B9/0019A23L27/2028C07C17/08C07C51/36C07C57/18
    • A method for producing mixtures containing greater than 50% cis 2-methyl-3-pentenoic acid comprising first reacting methyl acetylene with a methyl magnesium halide to form a methylacetylene magnesium halide Grignard reagent; then reacting the methyl acetylene magnesium halide Grignard reagent with acetaldehyde to form a 3-pentyn-2-ol magnesium halide salt; then hydrolyzing the magnesium halide salt to form 3-pentyn-2-ol; then halogenating the 3-pentyn-2-ol to form a 4-halo-2-pentyne; then reacting magnesium with the 4-halo-2-pentyne to produce a 4-magnesium halo-2-pentyne Grignard reagent; then reacting the 4-magnesium halo-2-pentyne Grignard reagent with carbon dioxide to form a magnesium halo-carboxylate salt mixture of compounds having the structures: ##EQU1## (wherein X is halogen); then hydrolyzing the magnesium halo-carboxylate salt mixture to form a mixture of carboxylic acids having the structures: ##EQU2## then hydrogenating the aforementioned mixture of carboxylic acids to form a mixture containing 80% cis-2-methyl-3-pentenoic acid and 20% of 2-methyl-2-pentenoic acid.
    • 包括含有大于50%的顺式2-甲基-3-戊烯酸的混合物的方法,其包括首先使甲基乙炔与甲基卤化镁反应以形成甲基乙炔卤化物格氏试剂; 然后使甲基乙炔卤化物格氏试剂与乙醛反应,形成3-戊炔-2-醇卤化镁盐; 然后水解卤化镁盐形成3-戊炔-2-醇; 然后将3-戊炔-2-醇卤化以形成4-卤代-2-戊炔; 然后使镁与4-卤代-2-戊炔反应,生成4-镁卤-2-戊炔格氏试剂; 然后使4-镁卤-2-戊炔格氏试剂与二氧化碳反应,形成具有以下结构的化合物的镁卤代羧酸盐盐混合物:CH3O | CH3-C3BOC CCC ANGLE HOMGX和CH3OH CH3-C = C = CC ANGLE OMgX(其中X为卤素); 然后水解镁卤代羧酸盐盐混合物以形成具有以下结构的羧酸的混合物:CH 3 O | CH 3 -C 3 O C C C H ANHLE HOH和CH 3 O | CH 3 -C = C = CC ANGLE HOH,然后将上述羧酸混合物氢化成 形成含有80%顺式-2-甲基-3-戊烯酸和20%2-甲基-2-戊烯酸的混合物。