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11. 发明授权

US06835547B1 Methods for identifying modulators of CCX CKR activity 有权
标题翻译：识别CCX CKR活性调节剂的方法
公开(公告)号：US06835547B1
公开(公告)日：2004-12-28
申请号：US09721495
申请日：2000-11-21
申请人： Jennifa Gosling , Daniel J. Dairaghi , Michael Hanley , Zhenhua Miao , Dale Talbot , Thomas J. Schall
发明人： Jennifa Gosling , Daniel J. Dairaghi , Michael Hanley , Zhenhua Miao , Dale Talbot , Thomas J. Schall
IPC分类号： G01N3353
CPC分类号： C07K14/521 , C07K14/7158 , C07K2319/00 , G01N33/5088 , G01N33/531 , G01N33/6863 , G01N2500/00
摘要： The invention provides polypeptides and polynucleotides encoding a novel chemokine receptor, CCX CKR. The invention further provides reagents and methods for identifying agents that modulate the activity or expression of the receptors, as well as methods for detecting receptor expression.
摘要翻译：本发明提供编码新趋化因子受体CCX CKR的多肽和多核苷酸。本发明还提供了用于鉴定调节受体的活性或表达的试剂以及用于检测受体表达的方法的试剂和方法。

12. 发明授权

US06559160B1 Compounds and methods for modulating cxcr3 function 有权
标题翻译：调节cxcr3功能的化合物和方法
公开(公告)号：US06559160B1
公开(公告)日：2003-05-06
申请号：US09648329
申请日：2000-08-25
申请人： Thomas J. Schall , Daniel J. Dairaghi , Brian E. McMaster
发明人： Thomas J. Schall , Daniel J. Dairaghi , Brian E. McMaster
IPC分类号： C07D23988
CPC分类号： C07D239/91
摘要： The invention provides compounds and compositions of the formula: wherein the subscript n is an integer of from 0 to 4; Ar is a member selected from the group consisting of substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; R1 is a member selected from the group consisting of substituted or unsubstituted (C5-C15)alkyl; R2 is a member selected from the group consisting of substituted or unsubstituted (C1-C8)alkyl; each R3 is independently a substituent selected from -halogen, —OR′, —OC(O)R′, —NR′R″, —SR′, —R′, —CN, —NO2, —CO2R′, —CONR′R″, —C(O)R′, —OC(O)NR′R″, —NR″C(O)R′, —NR″C(O)2R′, , —NR′—C(O)NR″R′″, —NH—C(NH2)═NH, —NR′C(NH2)═NH, —NH—C(NH2)═NR—, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —N3, —CH(Ph)2, perfluoro(C1-C4)alkoxy, and perfluoro(C1-C4)alkyl, and where R′, R″ and R′″ are independently selected from hydrogen, (C1-C8)alkyl and heteroalkyl, unsubstituted aryl and heteroaryl, (unsubstituted aryl)-(C1-C4)alkyl, and (unsubstituted aryl)oxy-(C1-C4)alkyl; Y is a member selected from the group consisting of substituted or unsubstituted (C2-C8)alkylene and substituted or unsubstituted (C2-C8)heteroalkylene; and Z is —NR4R5, wherein R4 and R5 are independently selected from the group consisting of hydrogen and (C1-C8)alkyl. These compounds and compositions bind to the CXCR3 chemokine receptor and are useful for treating diseases and conditions responsive to the modulation of CXCR3 activity, such as multiple sclerosis, rheumatoid arthritis, psoriasis, cancer, infectious disease, angiogenesis, and graft rejection.
摘要翻译：本发明提供下式的化合物和组合物：其中下标n为0-4的整数; Ar为选自取代或未取代的芳基和取代或未取代的杂芳基的成员; R1为选自由取代或未取代的（C 5 -C 15）烷基组成; R 2为选自取代或未取代的（C 1 -C 8）烷基的成员;每个R 3独立地为选自卤素，-OR'，-OC（ O）R'，-NR'R“，-SR'，-R'，-CN，-NO 2，-CO 2 R'，-CONR'R”，-C（O）R'，-OC（O） NR'R“，-NR''C（O）R'，-NR''C（O）2 R'， - NR'-C（O）NR''R”'，-NH-C（ NH2）= NH，-NR'C（NH2）= NH，-NH-C（NH2）= NR-，-S（O）R'，-S（O）2R'，-S（O） '，-N3，-CH（Ph）2，全氟（C1-C4）烷氧基和全氟（C1-C4）烷基，其中R'，R“和R”'独立地选自氢，（ C1-C8）烷基和杂烷基，未取代的芳基和杂芳基，（未取代的芳基） - （C1-C4）烷基和（未取代的芳基）氧基 - （C1-C4）烷基; Y是选自取代或未取代的（C 2 -C 8）亚烷基和取代或未取代的（C 2 -C 8）杂亚烷基的基团; Z为-NR 4 R 5，其中R 4和R 5独立地选自氢和（C1- C8）烷基。这些化合物和组合物结合CXCR3趋化因子受体，并且可用于治疗对CXCR3活性调节作用的疾病和病症，例如多发性硬化症，类风湿性关节炎，牛皮癣，癌症，感染性疾病，血管生成和移植排斥。

13. 发明授权

US07777009B2 Compositions for detecting and treating diseases and conditions related to chemokine receptors 有权
标题翻译：用于检测和治疗与趋化因子受体相关的疾病和病症的组合物
公开(公告)号：US07777009B2
公开(公告)日：2010-08-17
申请号：US11820743
申请日：2007-06-19
申请人： Jennifer M. Burns , Bretton Summers , Maureen C. Howard , Thomas J. Schall
发明人： Jennifer M. Burns , Bretton Summers , Maureen C. Howard , Thomas J. Schall
IPC分类号： A61K39/395 , C07K16/24 , C12P21/08
CPC分类号： G01N33/6863 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/16 , C07D211/14 , C07D211/26 , C07D211/42 , C07D211/56 , C07D241/04 , C07D241/42 , C07D295/13 , C07D401/04 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , G01N2500/10
摘要： Antibodies that bind CCX-CKR2 are described.
摘要翻译：描述了结合CCX-CKR2的抗体。

14. 发明授权

US07279460B2 Chemokine TECK polypeptides 失效
标题翻译：趋化因子TECK多肽
公开(公告)号：US07279460B2
公开(公告)日：2007-10-09
申请号：US10754071
申请日：2004-01-07
申请人： Wei Wang , Kurt C. Gish , Thomas J. Schall , Alain Vicari , Albert Zlotnik
发明人： Wei Wang , Kurt C. Gish , Thomas J. Schall , Alain Vicari , Albert Zlotnik
IPC分类号： C07K14/52 , C07K14/475
CPC分类号： C07K16/24 , C07K14/523 , C07K14/7158
摘要： Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：来自哺乳动物的新型趋化因子，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述趋化因子的核酸。还提供趋化因子受体。还提供了使用所述试剂和诊断试剂盒的方法。

15. 发明授权

US07101894B2 Bicyclic compounds as inhibitors of chemokine binding to US28 有权
标题翻译：双环化合物作为趋化因子结合US28的抑制剂
公开(公告)号：US07101894B2
公开(公告)日：2006-09-05
申请号：US10233326
申请日：2002-08-29
申请人： Brian E. McMaster , Thomas J. Schall , Mark Penfold , J. J. Wright , Daniel J. Dairaghi
发明人： Brian E. McMaster , Thomas J. Schall , Mark Penfold , J. J. Wright , Daniel J. Dairaghi
IPC分类号： A61K31/44 , A61K31/47
CPC分类号： C07D207/08 , A61K31/075 , A61K31/135 , A61K31/4709 , C07D207/27 , C07D211/14 , C07D211/26 , C07D231/12 , C07D241/04 , C07D295/088 , C07D295/096 , C07D295/135 , C07D295/155 , C07D453/04
摘要： Methods for treating CMV or a CMV-related disease are provided that use compounds having the formula: wherein Ar is a substituted or unsubstituted 5–14 membered heteroaryl group having from 1 to 5 heteroatoms as ring members; R1 is selected from the group consisting of substituted or unsubstituted aryl(C1–C4)alkyl, heteroaryl(C1–C4)alkyl, —C(O)R11, and —C(O)NR11R12, wherein each R11 and R12 independently is substituted or unsubstituted aryl, substituted or unsubstituted aryl(C1–C4)alkyl, substituted or unsubstituted (C4–C8)cycloalkyl(C1–C4)alkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryl(C1–C4)alkyl and substituted or unsubstituted hetero(C4–C8)cycloalkyl(C1–C4)alkyl; R2 is H or (C1–C8)alkyl; and ZN is a substituted or unsubstituted hetero(C6–C10)bicycloalkyl group.
摘要翻译：提供了使用具有下式的化合物治疗CMV或CMV相关疾病的方法：其中Ar是具有1至5个杂原子作为环成员的取代或未取代的5-14元杂芳基; R 1选自取代或未取代的芳基（C 1 -C 4 -C 4）烷基，杂芳基（C 1 H 4） -C（O）R 11和-C（O）NR 11 R 12 > 12，其中每个R 11和R 12独立地是取代或未取代的芳基，取代或未取代的芳基（C 1〜 C 1 -C 4烷基，取代或未取代的（C 1 -C 4 -C 8）环烷基（C 1 -C 4 - 取代或未取代的杂芳基，取代或未取代的杂芳基（C 1 -C 4 -C 4）烷基和取代或未取代的杂原子（C

16. 发明授权

US06699677B1 Tethered ligands and methods of use 有权
标题翻译：束缚配体和使用方法
公开(公告)号：US06699677B1
公开(公告)日：2004-03-02
申请号：US09721908
申请日：2000-11-24
申请人： Thomas J. Schall , Brett Premack , Zhenhua Miao , Zheng Wei
发明人： Thomas J. Schall , Brett Premack , Zhenhua Miao , Zheng Wei
IPC分类号： G01N33567
CPC分类号： G01N33/6863 , C07K14/521 , C07K14/7158 , C07K2319/00 , G01N33/5088 , G01N33/531 , G01N2500/00
摘要： The invention provides methods, reagents and devices for analysis of receptor ligand interactions, determining the profile of receptor expression in cells and cell populations, and diagnostic and drug screening methods. The invention makes use of immobilized tethered ligand fusion proteins having a ligand domain, a stalk domain, and optionally an immobilization domain.
摘要翻译：本发明提供用于分析受体配体相互作用的方法，试剂和装置，确定细胞和细胞群体中受体表达的谱，以及诊断和药物筛选方法。本发明利用具有配体结构域，茎结构域和任选的固定结构域的固定化的束缚配体融合蛋白。

17. 发明授权

US06566503B2 Mammalian CX3C chemokine 失效
标题翻译：哺乳动物CX3C趋化因子基因
公开(公告)号：US06566503B2
公开(公告)日：2003-05-20
申请号：US09771023
申请日：2001-01-25
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B Bacon , Bazan Fernando J. , Thomas J. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B Bacon , Bazan Fernando J. , Thomas J. Schall , Albert Zlotnik
IPC分类号： C07K1452
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译：描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。还提供了使用所述试剂和相关诊断试剂盒的方法。

18. 发明授权

US06548654B1 DNA encoding mammalian CX3C chemokine genes 失效
标题翻译：编码哺乳动物CX3C趋化因子基因的DNA
公开(公告)号：US06548654B1
公开(公告)日：2003-04-15
申请号：US08649006
申请日：1996-05-16
申请人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , J. Fernando Bazan , Thomas J. Schall , Albert Zlotnik
发明人： Gerard T. Hardiman , Devora L. Rossi , Kevin B. Bacon , J. Fernando Bazan , Thomas J. Schall , Albert Zlotnik
IPC分类号： C07H2104
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S436/808
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译：描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。还提供了使用所述试剂和相关诊断试剂盒的方法。

19. 发明授权

US06512103B1 Mammalian chemokine reagents 失效
标题翻译：哺乳动物趋化因子试剂
公开(公告)号：US06512103B1
公开(公告)日：2003-01-28
申请号：US08567882
申请日：1995-12-08
申请人： Daniel J. Dairaghi , Takahiko Hara , Atsushi Miyajima , Thomas J. Schall , Wei Wang , Akihiko Yoshimura
发明人： Daniel J. Dairaghi , Takahiko Hara , Atsushi Miyajima , Thomas J. Schall , Wei Wang , Akihiko Yoshimura
IPC分类号： C07K100
CPC分类号： C07K14/521 , A61K38/00 , C07K14/523 , C07K14/7158 , C07K2319/00
摘要： A novel CC chemokine which is from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokine. A chemokine receptor is also provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：来自哺乳动物的新型CC趋化因子，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述趋化因子的核酸。还提供趋化因子受体。还提供了使用所述试剂和诊断试剂盒的方法。

20. 发明申请

US20110189123A1 MAMMALIAN CX3C CHEMOKINE ANTIBODIES 失效
标题翻译： MAMMALIAN CX3C CHEMOKINE抗体
公开(公告)号：US20110189123A1
公开(公告)日：2011-08-04
申请号：US12833069
申请日：2010-07-09
申请人： GERARD T. HARDIMAN , DEVORA L. ROSSI , KEVIN B. BACON , BAZAN FERNANDO J. , THOMAS J. SCHALL , ALBERT ZLOTNIK
发明人： GERARD T. HARDIMAN , DEVORA L. ROSSI , KEVIN B. BACON , BAZAN FERNANDO J. , THOMAS J. SCHALL , ALBERT ZLOTNIK
IPC分类号： A61K38/19 , C12P21/02 , C07K14/52 , C07K19/00
CPC分类号： C07K14/521 , A61K38/00 , C07K2319/00 , Y10S435/81
摘要： Nucleic acids encoding a new family of chemokines, the CX3C family, from a mammal, reagents related thereto, including specific antibodies, and purified proteins are described. Methods of using said reagents and related diagnostic kits are also provided.
摘要翻译：描述了编码来自哺乳动物的新家族趋化因子，CX3C家族的核酸，与其相关的试剂，包括特异性抗体和纯化的蛋白质。还提供了使用所述试剂和相关诊断试剂盒的方法。

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