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1. 发明申请

US20060034863A1 Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof 有权
标题翻译：可用作甲酰肽受体如1受体的配体的组合物及其使用方法
公开(公告)号：US20060034863A1
公开(公告)日：2006-02-16
申请号：US11175003
申请日：2005-07-05
申请人： Thomas Schall , Zhenhua Miao , Robert Berahovich , Zheng Wei , Maureen Howard , Brett Premack
发明人： Thomas Schall , Zhenhua Miao , Robert Berahovich , Zheng Wei , Maureen Howard , Brett Premack
IPC分类号： A61K39/02 , A61K38/10
CPC分类号： C07K14/523 , A61K38/00 , A61K39/39 , A61K2039/55522 , Y02A50/39 , Y02A50/401 , Y02A50/466 , Y02A50/484
摘要： The inventors have discovered that a CKβ8-1 truncation variant, CKβ8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKβ8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKβ8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKβ8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1. This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.
摘要翻译：本发明人已经发现CKbeta8-1截短变体CKbeta8-1（25-116）是两种不同GPCR，趋化因子受体CCR1和甲酰肽受体1（FPRL1）的双功能配体。因此，本发明人发现除了CCR1的功能活性外，CKbeta8-1（25-116）也是通过募集单核细胞和嗜中性粒细胞参与炎症反应和先天免疫的GPCR受体FPRL1的功能性配体。此外，本发明人已经发现了称为SHAAGTIDE的CKbeta8-1的可变剪接外显子。 SHAAGTIDE与其母体趋化因子CKbeta8-1（25-116）一起在已知表达FPRL1的单核细胞和嗜中性粒细胞上完全起作用。本申请一般涉及增强免疫应答。这种免疫应答可以通过疫苗施用引起。提供了诱导或增强对抗原的免疫应答的组合物和方法。组合物和方法可用于治疗和预防用途（免疫）和产生抗体的疫苗制剂。

2. 发明授权

US06699677B1 Tethered ligands and methods of use 有权
标题翻译：束缚配体和使用方法
公开(公告)号：US06699677B1
公开(公告)日：2004-03-02
申请号：US09721908
申请日：2000-11-24
申请人： Thomas J. Schall , Brett Premack , Zhenhua Miao , Zheng Wei
发明人： Thomas J. Schall , Brett Premack , Zhenhua Miao , Zheng Wei
IPC分类号： G01N33567
CPC分类号： G01N33/6863 , C07K14/521 , C07K14/7158 , C07K2319/00 , G01N33/5088 , G01N33/531 , G01N2500/00
摘要： The invention provides methods, reagents and devices for analysis of receptor ligand interactions, determining the profile of receptor expression in cells and cell populations, and diagnostic and drug screening methods. The invention makes use of immobilized tethered ligand fusion proteins having a ligand domain, a stalk domain, and optionally an immobilization domain.
摘要翻译：本发明提供用于分析受体配体相互作用的方法，试剂和装置，确定细胞和细胞群体中受体表达的谱，以及诊断和药物筛选方法。本发明利用具有配体结构域，茎结构域和任选的固定结构域的固定化的束缚配体融合蛋白。

3. 发明授权

US08088895B2 Antibodies that bind CXCR7 epitopes 有权
标题翻译：结合CXCR7表位的抗体
公开(公告)号：US08088895B2
公开(公告)日：2012-01-03
申请号：US11869883
申请日：2007-10-10
申请人： Brett Premack , Zhenhua Miao , Mark Penfold
发明人： Brett Premack , Zhenhua Miao , Mark Penfold
IPC分类号： C07K16/00
CPC分类号： C07K16/2866 , C07K2317/34 , C07K2317/76
摘要： Antibodies that bind CXCR7 epitopes, as well as methods of identifying CXCR7 modulators are described.
摘要翻译：描述了结合CXCR7表位的抗体以及鉴定CXCR7调节剂的方法。

4. 发明申请

US20050137179A1 Bis-aryl sulfonamides 有权
标题翻译：双芳基磺酰胺
公开(公告)号：US20050137179A1
公开(公告)日：2005-06-23
申请号：US10848836
申请日：2004-05-19
申请人： Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
发明人： Solomon Ungashe , Zheng Wei , J. J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
IPC分类号： A61K31/18 , A61K31/195 , A61K31/397 , A61K31/445 , A61K31/55 , C07D213/26 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
CPC分类号： C07D213/26 , A61K31/18 , A61K31/195 , A61K31/397 , A61K31/4245 , A61K31/433 , A61K31/445 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译：提供了作为趋化因子受体的有效拮抗剂的化合物。化合物通常为芳基磺酰胺衍生物，可用于药物组合物，治疗趋化因子受体介导的疾病的方法，以及用于鉴定趋化因子拮抗剂的测定中的对照。

5. 发明授权

US07572600B2 Enzymatic activities in chemokine-mediated inflammation 有权
标题翻译：趋化因子介导的炎症中的酶活性
公开(公告)号：US07572600B2
公开(公告)日：2009-08-11
申请号：US11198935
申请日：2005-08-04
申请人： Robert D. Berahovich , Zhenhua Miao , Brett Premack , Thomas J. Schall
发明人： Robert D. Berahovich , Zhenhua Miao , Brett Premack , Thomas J. Schall
IPC分类号： C12Q1/00 , C12Q1/37
CPC分类号： G01N33/6863 , A61K38/00 , C07K14/7158 , C12Q1/37 , G01N2500/00 , G01N2800/52
摘要： Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability of the truncated chemokines to activate CCR1 and/or FPRL1 are also disclosed. Methods using the truncated chemokines to inhibit or activate CCR1 and/or FPRL1 mediated biological activities are also disclosed.
摘要翻译：提供缺乏活化CCR1和/或FPRL1的N末端区域的截短趋化因子和含有截短趋化因子的组合物。还公开了通过调节截短的趋化因子的产生或截短的趋化因子活化CCR1和/或FPRL1的能力来鉴定调节CCR1和/或FPRL1活性的药剂的方法。还公开了使用截短的趋化因子抑制或激活CCR1和/或FPRL1介导的生物活性的方法。

6. 发明申请

US20050234004A1 Compositions and methods of use of W-peptides 审中-公开
标题翻译：组合物和使用W肽的方法
公开(公告)号：US20050234004A1
公开(公告)日：2005-10-20
申请号：US11043020
申请日：2005-01-25
申请人： Brett Premack , Thomas Schall
发明人： Brett Premack , Thomas Schall
IPC分类号： A61K39/07 , A61K39/39 , A61K48/00
CPC分类号： A61K39/07 , A61K39/39 , A61K2039/55516
摘要： The present invention relates to compositions and methods to modulating immune responses, such as those elicited by vaccination with W peptides. The compositions and methods are useful for, among other things, vaccine formulation for therapeutic and prophylactic vaccination (immunization) and for production of useful antibodies (e.g., monoclonal antibodies, for therapeutic or diagnostic use).
摘要翻译：本发明涉及调节免疫应答的组合物和方法，例如用W肽接种引发的那些。组合物和方法尤其可用于治疗性和预防性接种疫苗（免疫）和生产有用抗体（例如用于治疗或诊断用途的单克隆抗体）的疫苗制剂。

7. 发明申请

US20050176073A1 Cell proliferation associated with CCX CKR expression 审中-公开
标题翻译：与CCX CKR表达相关的细胞增殖
公开(公告)号：US20050176073A1
公开(公告)日：2005-08-11
申请号：US10773380
申请日：2004-02-06
申请人： Yu Wang , Brett Premack , Thomas Schall
发明人： Yu Wang , Brett Premack , Thomas Schall
IPC分类号： G01N33/50 , G01N33/574
CPC分类号： G01N33/5011 , G01N2333/715
摘要： Methods for screening agents to identify an agent that modulates CCX CKR proliferative activity are provided. Tissue generation methods are also disclosed that involve activating CCX CKR expression and activity levels, as are methods for promoting angiogenesis. Methods for treating various diseases associated with cell proliferation are also described.
摘要翻译：提供筛选试剂鉴定调节CCX CKR增殖活性的试剂的方法。还公开了包括活化CCX CKR表达和活性水平的组织产生方法，以及用于促进血管生成的方法。还描述了治疗与细胞增殖相关的各种疾病的方法。

8. 发明授权

US08637043B2 Compositions useful as ligands for the formyl peptide receptor like 1 receptor and methods of use thereof 有权
标题翻译：可用作甲酰肽受体如1受体的配体的组合物及其使用方法
公开(公告)号：US08637043B2
公开(公告)日：2014-01-28
申请号：US11175003
申请日：2005-07-05
申请人： Thomas J. Schall , Zhenhua Miao , Robert Berahovich , Zheng Wei , Maureen Howard , Brett Premack
发明人： Thomas J. Schall , Zhenhua Miao , Robert Berahovich , Zheng Wei , Maureen Howard , Brett Premack
IPC分类号： A61K39/02
CPC分类号： C07K14/523 , A61K38/00 , A61K39/39 , A61K2039/55522 , Y02A50/39 , Y02A50/401 , Y02A50/466 , Y02A50/484
摘要： The inventors have discovered that a CKβ8-1 truncation variant, CKβ8-1 (25-116), is a bifunctional ligand for two distinct GPCRs, chemokine receptor CCR1 and formyl peptide receptor like 1 (FPRL1). Hence, the inventors have discovered that, in addition to its functional activity on CCR1, CKβ8-1(25-116) is also a functional ligand for the GPCR receptor FPRL1 that is involved in inflammatory reactions and innate immunity by recruiting monocytes and neutrophils. In addition, the inventors have discovered an alternatively spliced exon of CKβ8-1, named SHAAGtide. SHAAGtide, along with its parent chemokine CKβ8-1 (25-116), is fully functional on both monocytes and neutrophils that are known to express FPRL1.This application relates generally to enhancing immune responses. Such immune responses may be elicited by vaccine administration. Compositions and methods for inducing or enhancing an immune response to an antigen are provided. The compositions and methods are useful for vaccine formulations for therapeutic and prophylactic use (immunization) and for production of antibodies.
摘要翻译：本发明人已经发现CKbeta8-1截短变体CKbeta8-1（25-116）是两种不同GPCR，趋化因子受体CCR1和甲酰肽受体1（FPRL1）的双功能配体。因此，本发明人发现除了CCR1的功能活性外，CKbeta8-1（25-116）也是通过募集单核细胞和嗜中性粒细胞参与炎症反应和先天免疫的GPCR受体FPRL1的功能性配体。此外，本发明人已经发现了称为SHAAGTIDE的CKbeta8-1的可变剪接外显子。 SHAAGTIDE与其母体趋化因子CKbeta8-1（25-116）一起在已知表达FPRL1的单核细胞和嗜中性粒细胞上完全起作用。本申请一般涉及增强免疫应答。这种免疫应答可以通过疫苗施用引起。提供了诱导或增强对抗原的免疫应答的组合物和方法。组合物和方法可用于治疗和预防用途（免疫）和产生抗体的疫苗制剂。

9. 发明申请

US20110257183A1 BIS-ARYL SULFONAMIDES 有权
公开(公告)号：US20110257183A1
公开(公告)日：2011-10-20
申请号：US13092615
申请日：2011-04-22
申请人： Solomon Ungashe , Zheng Wei , J.J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
发明人： Solomon Ungashe , Zheng Wei , J.J. Wright , Andrew Pennell , Brett Premack , Thomas Schall
IPC分类号： A61K31/535 , C07C311/21 , A61K31/18 , A61K31/4406 , A61K31/381 , C07D211/72 , C07D333/08 , C07D307/87 , A61K31/343 , A61K31/415 , C07D231/12 , C07D263/32 , A61K31/421 , A61K31/24 , C07D265/30 , C12N5/02
CPC分类号： C07D213/26 , A61K31/4245 , A61K31/433 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D213/50 , C07D213/70 , C07D213/74 , C07D213/84 , C07D213/89 , C07D241/12 , C07D413/12
摘要： Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.
摘要翻译：提供了作为趋化因子受体的有效拮抗剂的化合物。化合物通常为芳基磺酰胺衍生物，可用于药物组合物，治疗趋化因子受体介导的疾病的方法，以及用于鉴定趋化因子拮抗剂的测定中的对照。

10. 发明申请

US20090022717A1 ANTIBODIES THAT BIND CXCR7 EPITOPES 有权
标题翻译：抗体CXCR7抗体
公开(公告)号：US20090022717A1
公开(公告)日：2009-01-22
申请号：US11869883
申请日：2007-10-10
申请人： Brett Premack , Zhenhua Miao , Mark Penfold
发明人： Brett Premack , Zhenhua Miao , Mark Penfold
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , A61P19/02
CPC分类号： C07K16/2866 , C07K2317/34 , C07K2317/76
摘要： Antibodies that bind CXCR7 epitopes, as well as methods of identifying CXCR7 modulators are described.
摘要翻译：描述了结合CXCR7表位的抗体以及鉴定CXCR7调节剂的方法。

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